Pyometra presenting in conjunction with bowel cancer in a post-menopausal women: a case report

This case describes a 71 year old, post-menopausal woman who developed vaginal discharge. This complaint ultimately led to the discovery of bowel cancer in conjunction with a large sterile pyometra

Investigating the challenges for adopting and implementing of information and communication technologies (ICT) by Isfahan high schools teachers: Based on the model of barriers in ICT usage

Relevance and usefulness of information and communication technologies (ICT) have been investigated in many researches. There are many challenges for ICT users, especially for teachers that act as inhibitor factors for using ICT in their jobs. The main purpose of this paper was to investigate these challenges in the view point of high school teachers in Isfahan city based on ICT use barriers model. In the model, barriers have divided into four groups: organizational, managerial, educational, and financial-instrumental. The research was based on qualitative method. For analyzing data descriptive-analysis method was used. For gathering data, researcher made questionnaire including 5 open ended had been used. Survey population included teachers of all high schools in Isfahan city in 1387-88 academic years. 110 teachers were selected by using cluster random sampling method. For data analysis, content analysis method was used to calculate the mean and frequencies. Findings indicated that most teachers have explained the lack of proper in-service training programs for their use of ICT as the most important obstacles for using ICT in teaching. Lack of suitable managerial strategies for implementing ICT in curriculum, lack of organizational support and lack of financial resources and equipments in schools, respectively, were other barriers in using ICT in Iranian high schools

Investigating the challenges for adopting and implementing of information and communication technologies (ICT) by Isfahan High Schools teachers: Based on the model of barriers in ICT usage

Relevance and usefulness of information and communication technologies (ICT) have been investigated in many researches. There are many challenges for ICT users, especially for teachers that act as inhibitor factors for using ICT in their jobs. The main purpose of this paper was to investigate these challenges in the view point of high school teachers in Isfahan city based on ICT use barriers model. In the model, barriers have divided into four groups: organizational, managerial, educational, and financial-instrumental. The research was based on qualitative method. For analyzing data descriptive-analysis method was used. For gathering data, researcher made questionnaire including 5 open ended had been used. Survey population included teachers of all high schools in Isfahan city in 1387-88 academic years. 110 teachers were selected by using cluster random sampling method. For data analysis, content analysis method was used to calculate the mean and frequencies. Findings indicated that most teachers have explained the lack of proper in-service training programs for their use of ICT as the most important obstacles for using ICT in teaching. Lack of suitable managerial strategies for implementing ICT in curriculum, lack of organizational support and lack of financial resources and equipments in schools, respectively, were other barriers in using ICT in Iranian high schools

Liquid Cell Transmission Electron Microscopy Sheds Light on The Mechanism of Palladium Electrodeposition

Electrodeposition is widely used to fabricate tunable nanostructured materials in applications ranging from biosensing to energy conversion. A model based on 3D island growth is widely accepted in the explanation of the initial stages of nucleation and growth in electrodeposition. However, there are regions in the electrodeposition parameter space where this model becomes inapplicable. We use liquid cell transmission electron microscopy along with post situ scanning electron microscopy to investigate electrodeposition in this parameter space, focusing on the effect of the supporting electrolyte, and to shed light on the nucleation and growth of palladium. Using a collection of electron microscopy images and current time transients recorded during electrodeposition, we discover that electrochemical aggregative growth, rather than 3D island growth, best describes the electrodeposition process. We then use this model to explain the change in the morphology of palladium electrodeposits from spherical to open clusters with nonspherical morphology when HCl is added to the electrolyte solution. The enhanced understanding of the early stages of palladium nucleation and growth and the role of electrolyte in this process provides a systematic route toward the electrochemical fabrication of nanostructured materials

Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy

PURPOSE:We have previously identified specific epithelial proteins with altered expression in human diabetic central corneas. Decreased hepatocyte growth factor receptor (c-met) and increased proteinases were functionally implicated in the changes of these proteins in diabetes. The present study examined whether limbal stem cell marker patterns were altered in diabetic corneas and whether c-met gene overexpression could normalize these patterns.METHODS:Cryostat sections of 28 ex vivo and 26 organ-cultured autopsy human normal and diabetic corneas were examined by immunohistochemistry using antibodies to putative limbal stem cell markers including ATP-binding cassette sub-family G member 2 (ABCG2), N-cadherin, \u394Np63\u3b1, tenascin-C, laminin \u3b33 chain, keratins (K) K15, K17, K19, \u3b2(1) integrin, vimentin, frizzled 7, and fibronectin. Organ-cultured diabetic corneas were studied upon transduction with adenovirus harboring c-met gene.RESULTS:Immunostaining for ABCG2, N-cadherin, \u394Np63\u3b1, K15, K17, K19, and \u3b2(1) integrin, was significantly decreased in the stem cell-harboring diabetic limbal basal epithelium either by intensity or the number of positive cells. Basement membrane components, laminin \u3b33 chain, and fibronectin (but not tenascin-C) also showed a significant reduction in the ex vivo diabetic limbus. c-Met gene transduction, which normalizes diabetic marker expression and epithelial wound healing, was accompanied by increased limbal epithelial staining for K17, K19, \u394Np63\u3b1, and a diabetic marker \u3b1(3)\u3b2(1) integrin, compared to vector-transduced corneas.CONCLUSIONS:The data suggest that limbal stem cell compartment is altered in long-term diabetes. Gene therapy, such as with c-met overexpression, could be able to restore normal function to diabetic corneal epithelial stem cells

A new multi-modal dataset for human affect analysis

In this paper we present a new multi-modal dataset of spontaneous three way human interactions. Participants were recorded in an unconstrained environment at various locations during a sequence of debates in a video conference, Skype style arrangement. An additional depth modality was introduced, which permitted the capture of 3D information in addition to the video and audio signals. The dataset consists of 16 participants and is subdivided into 6 unique sections. The dataset was manually annotated on a continuously scale across 5 different affective dimensions including arousal, valence, agreement, content and interest. The annotation was performed by three human annotators with the ensemble average calculated for use in the dataset. The corpus enables the analysis of human affect during conversations in a real life scenario. We first briefly reviewed the existing affect dataset and the methodologies related to affect dataset construction, then we detailed how our unique dataset was constructed

Optimal iterative methods for finding multiple roots of nonlinear equations using free parameters

[EN] In this paper, we propose a family of optimal eighth order convergent iterative methods for multiple roots with known multiplicity with the introduction of two free parameters and three univariate weight functions. Also numerical experiments have applied to a number of academical test functions and chemical problems for different special schemes from this family that satisfies the conditions given in convergence result.This research was partially supported by Ministerio de Economia y Competitividad MTM2014-52016-C02-2-P and Generalitat Valenciana PROMETEO/2016/089.Zafar, F.; Cordero Barbero, A.; Quratulain, R.; Torregrosa Sánchez, JR. (2018). Optimal iterative methods for finding multiple roots of nonlinear equations using free parameters. Journal of Mathematical Chemistry. 56(7):1884-1901. https://doi.org/10.1007/s10910-017-0813-1S18841901567R. Behl, A. Cordero, S.S. Motsa, J.R. Torregrosa, On developing fourth-order optimal families of methods for multiple roots and their dynamics. Appl. Math. Comput. 265(15), 520–532 (2015)R. Behl, A. Cordero, S.S. Motsa, J.R. Torregrosa, V. Kanwar, An optimal fourth-order family of methods for multiple roots and its dynamics. Numer. Algor. 71(4), 775–796 (2016)R. Behl, A. Cordero, S.S. Motsa, J.R. Torregrosa, An eighth-order family of optimal multiple root finders and its dynamics. Numer. Algor. (2017). doi: 10.1007/s11075-017-0361-6F.I. Chicharro, A. Cordero, J. R. Torregrosa, Drawing dynamical and parameters planes of iterative families and methods. Sci. World J. ID 780153 (2013)A. Constantinides, N. Mostoufi, Numerical Methods for Chemical Engineers with MATLAB Applications (Prentice Hall PTR, New Jersey, 1999)J.M. Douglas, Process Dynamics and Control, vol. 2 (Prentice Hall, Englewood Cliffs, 1972)Y.H. Geum, Y.I. Kim, B. Neta, A class of two-point sixth-order multiple-zero finders of modified double-Newton type and their dynamics. Appl. Math. Comput. 270, 387–400 (2015)Y.H. Geum, Y.I. Kim, B. Neta, A sixth-order family of three-point modified Newton-like multiple-root finders and the dynamics behind their extraneous fixed points. Appl. Math. Comput. 283, 120–140 (2016)J.L. Hueso, E. Martınez, C. Teruel, Determination of multiple roots of nonlinear equations and applications. J. Math. Chem. 53, 880–892 (2015)L.O. Jay, A note on Q-order of convergence. BIT Numer. Math. 41, 422–429 (2001)S. Li, X. Liao, L. Cheng, A new fourth-order iterative method for finding multiple roots of nonlinear equations. Appl. Math. Comput. 215, 1288–1292 (2009)S.G. Li, L.Z. Cheng, B. Neta, Some fourth-order nonlinear solvers with closed formulae for multiple roots. Comput. Math. Appl. 59, 126–135 (2010)B. Liu, X. Zhou, A new family of fourth-order methods for multiple roots of nonlinear equations. Nonlinear Anal. Model. Control 18(2), 143–152 (2013)M. Shacham, Numerical solution of constrained nonlinear algebraic equations. Int. J. Numer. Method Eng. 23, 1455–1481 (1986)M. Sharifi, D.K.R. Babajee, F. Soleymani, Finding the solution of nonlinear equations by a class of optimal methods. Comput. Math. Appl. 63, 764–774 (2012)J.R. Sharma, R. Sharma, Modified Jarratt method for computing multiple roots. Appl. Math. Comput. 217, 878–881 (2010)F. Soleymani, D.K.R. Babajee, T. Lofti, On a numerical technique forfinding multiple zeros and its dynamic. J. Egypt. Math. Soc. 21, 346–353 (2013)F. Soleymani, D.K.R. Babajee, Computing multiple zeros using a class of quartically convergent methods. Alex. Eng. J. 52, 531–541 (2013)R. Thukral, A new family of fourth-order iterative methods for solving nonlinear equations with multiple roots. J. Numer. Math. Stoch. 6(1), 37–44 (2014)R. Thukral, Introduction to higher-order iterative methods for finding multiple roots of nonlinear equations. J. Math. Article ID 404635 (2013)X. Zhou, X. Chen, Y. Song, Constructing higher-order methods for obtaining the muliplte roots of nonlinear equations. J. Comput. Math. Appl. 235, 4199–4206 (2011)X. Zhou, X. Chen, Y. Song, Families of third and fourth order methods for multiple roots of nonlinear equations. Appl. Math. Comput. 219, 6030–6038 (2013

Protocol for the Collection of Cross-cultural Comparative Data on Local Indicators of Climate Change Impacts

Unidad de excelencia María de Maeztu CEX2019-000940-MThis protocol has been designed to collect local perceptions of climate change impacts on climatic (e.g. rainfall patterns change), physical (e.g., shrinking glaciers), biological (e.g., phenological changes), and socioeconomic systems (e.g., crop failure due to rainfall patterns change), but also adaptations to those impacts, local agricultural calendars and local narratives to allow the reconstruction of historical and relevant events using a combination of quantitative and qualitative methodologies

A collaborative approach to bring insights from local observations of climate change impacts into global climate change research

Bringing insights from Indigenous and local knowledge into climate change research requires addressing the transferability, integration, and scalability of this knowledge. Using a review of research on place-based observations of climate change impacts, we explore ways to address these challenges. Our search mostly captured scientist-led qualitative research, which - while facilitating place-based knowledge transferability to global research - did not include locally led efforts documenting climate change impacts. We classified and organized qualitative multi-site place-based information into a hierarchical system that fosters dialogue with global research, providing an enriched picture of climate change impacts on local social-ecological systems. A network coordinating the scalability of place-based research on climate change impacts is needed to bring Indigenous and local knowledge into global research and policy agendas.Peer reviewe