1,360 research outputs found
Spreading, Nonergodicity, and Selftrapping: a puzzle of interacting disordered lattice waves
Localization of waves by disorder is a fundamental physical problem
encompassing a diverse spectrum of theoretical, experimental and numerical
studies in the context of metal-insulator transitions, the quantum Hall effect,
light propagation in photonic crystals, and dynamics of ultra-cold atoms in
optical arrays, to name just a few examples. Large intensity light can induce
nonlinear response, ultracold atomic gases can be tuned into an interacting
regime, which leads again to nonlinear wave equations on a mean field level.
The interplay between disorder and nonlinearity, their localizing and
delocalizing effects is currently an intriguing and challenging issue in the
field of lattice waves. In particular it leads to the prediction and
observation of two different regimes of destruction of Anderson localization -
asymptotic weak chaos, and intermediate strong chaos, separated by a crossover
condition on densities. On the other side approximate full quantum interacting
many body treatments were recently used to predict and obtain a novel many body
localization transition, and two distinct phases - a localization phase, and a
delocalization phase, both again separated by some typical density scale. We
will discuss selftrapping, nonergodicity and nonGibbsean phases which are
typical for such discrete models with particle number conservation and their
relation to the above crossover and transition physics. We will also discuss
potential connections to quantum many body theories.Comment: 13 pages in Springer International Publishing Switzerland 2016 1 M.
Tlidi and M. G. Clerc (eds.), Nonlinear Dynamics: Materials, Theory and
Experiment, Springer Proceedings in Physics 173. arXiv admin note: text
overlap with arXiv:1405.112
Bifurcations of two coupled classical spin oscillators
Two classical, damped and driven spin oscillators with an isotropic exchange
interaction are considered. They represent a nontrivial physical system whose
equations of motion are shown to allow for an analytic treatment of local
codimension 1 and 2 bifurcations. In addition, numerical results are presented
which exhibit a Feigenbaum route to chaos.Comment: 16 pages, .dvi and postscrip
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Sirtuins are a highly conserved class of NAD(+)-dependent lysine deacylases. The human isotype Sirt2 has been implicated in the pathogenesis of cancer, inflammation and neurodegeneration, which makes the modulation of Sirt2 activity a promising strategy for pharmaceutical intervention. A rational basis for the development of optimized Sirt2 inhibitors is lacking so far. Here we present high-resolution structures of human Sirt2 in complex with highly selective drug-like inhibitors that show a unique inhibitory mechanism. Potency and the unprecedented Sirt2 selectivity are based on a ligand-induced structural rearrangement of the active site unveiling a yet-unexploited binding pocket. Application of the most potent Sirtuin-rearranging ligand, termed SirReal2, leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1, consistent with Sirt2 inhibition in vivo. Our structural insights into this unique mechanism of selective sirtuin inhibition provide the basis for further inhibitor development and selective tools for sirtuin biology
Lower limb stiffness and maximal sprint speed in 11-16-year-old boys
The purpose of the study was to examine the relationship between vertical stiffness, leg stiffness and maximal sprint speed in a large cohort of 11-16-year-old boys. Three-hundred and thirty-six boys undertook a 30 m sprint test using a floor-level optical measurement system, positioned in the final 15 m section. Measures of speed, step length, step frequency, contact time and flight time were directly measured whilst force, displacement, vertical stiffness and leg stiffness, were modeled from contact and flight times, from the two fastest consecutive steps for each participant over two trials. All force, displacement and stiffness variables were significantly correlated with maximal sprint speed (p 0.7) relationship with sprint speed, while vertical center of mass displacement, absolute vertical stiffness, relative peak force, and maximal leg spring displacement had large (r > 0.5) relationships. Relative vertical stiffness and relative peak force did not significantly change with advancing age (p > 0.05), but together with maximal leg spring displacement accounted for 96% of the variance in maximal speed. It appears that relative vertical stiffness and relative peak force are important determinants of sprint speed in boys aged 11-16 years, but are qualities that may need to be trained due to no apparent increases from natural development. Practitioners may wish to utilize training modalities such as plyometrics and resistance training to enable adaptation to these qualities due to their importance as predictors of speed in youth
Forward Jet Production at small x in Next-to-Leading Order QCD
The production of forward jets of transverse energy E_T\simeq Q and large
momentum fraction x_jet >> x is calculated in next-to-leading order including
consistently direct and resolved virtual photon contributions. The predictions
are compared to recent ZEUS and H1 data. Good agreement with the data is found.Comment: 11 pages, 3 eps figues; text in 2.1 clearified, figure 2 slightly
changed; version to appear in Phys. Lett.
From white to green : Snow cover loss and increased vegetation productivity in the European Alps
Mountains are hotspots of biodiversity and ecosystem services, but they are warming about twice as fast as the global average. Climate change may reduce alpine snow cover and increase vegetation productivity, as in the Arctic. Here, we demonstrate that 77% of the European Alps above the tree line experienced greening (productivity gain) andPeer reviewe
Axial Torsion-Dirac spin Effect in Rotating Frame with Relativistic Factor
In the framework of spacetime with torsion and without curvature, the Dirac
particle spin precession in the rotational system is studied. We write out the
equivalent tetrad of rotating frame, in the polar coordinate system, through
considering the relativistic factor, and the resultant equivalent metric is a
flat Minkowski one. The obtained rotation-spin coupling formula can be applied
to the high speed rotating case, which is consistent with the expectation.Comment: 6 page
Combining Parton Showers with Next-to-Leading Order QCD Matrix Elements in Deep-Inelastic eP Scattering
We have implemented a systematic procedure for combining parton shower
algorithms with next-to-leading order QCD calculations for the case of jet
production in deep-inelastic electron-proton scattering. Using this method we
have computed inclusive jet cross sections and jet shapes for the case of
single-jet production and compared them to data from the ZEUS collaboration at
HERA. We found good agreement between the data and our calculations, both for
the jet shapes and the inclusive spectra.Comment: 13 pages, 4 eps figure
Manifesto for a European research network into Problematic Usage of the Internet
Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.The Internet is now all-pervasive across much of the globe. While it has positive uses (e.g. prompt access to information, rapid news dissemination), many individuals develop Problematic Use of the Internet (PUI), an umbrella term incorporating a range of repetitive impairing behaviours. The Internet can act as a conduit for, and may contribute to, functionally impairing behaviours including excessive and compulsive video gaming, compulsive sexual behaviour, buying, gambling, streaming or social networks use. There is growing public and National health authority concern about the health and societal costs of PUI across the lifespan. Gaming Disorder is being considered for inclusion as a mental disorder in diagnostic classification systems, and was listed in the ICD-11 version released for consideration by Member States (http://www.who.int/classifications/icd/revision/timeline/en/). More research is needed into disorder definitions, validation of clinical tools, prevalence, clinical parameters, brain-based biology, socio-health-economic impact, and empirically validated intervention and policy approaches. Potential cultural differences in the magnitudes and natures of types and patterns of PUI need to be better understood, to inform optimal health policy and service development. To this end, the EU under Horizon 2020 has launched a new four-year European Cooperation in Science and Technology (COST) Action Programme (CA 16207), bringing together scientists and clinicians from across the fields of impulsive, compulsive, and addictive disorders, to advance networked interdisciplinary research into PUI across Europe and beyond, ultimately seeking to inform regulatory policies and clinical practice. This paper describes nine critical and achievable research priorities identified by the Network, needed in order to advance understanding of PUI, with a view towards identifying vulnerable individuals for early intervention. The network shall enable collaborative research networks, shared multinational databases, multicentre studies and joint publications.Peer reviewe
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