Effect of combined metal-carbon additions on the microstructure and structure of Sm2Fe17

The effect of combined alloying additions on the structure and scale of rapidly solidified Sm–Fe alloys was investigated. Transition metal additions tend to promote the formation of the disordered TbCu7-type structure in Sm2Fe17 alloys, as determined by monitoring the long-range order parameter. Essentially no order was observed for M = Ti, Zr, V, or Nb. Thus, the structure was close to the prototypical TbCu7-type structure. With M = Si, a large amount of order was observed (S = 0.62), resulting in a structure closer to the well-ordered Th2Zn17-type. The microstructural scale was also affected by alloying. In this case, refinement depended on the substituent and also on carbon for microstructural refinement. The scale of the as-solidified grain structures ranged from 100 nm for SiC-modified alloys to 13 nm for NbC-modified alloys. The degree of refinement was directly related to the atomic size of the M addition. The refinement was the result of solute partitioning to grain boundaries, resulting in a solute drag effect that lowered the growth rates

Dress Parade March and Two - Step

https://digitalcommons.library.umaine.edu/mmb-ps/2614/thumbnail.jp

An Integrated Decision-Support Information System on the Impact of Extreme Natural Hazards on Critical Infrastructure

In this paper, we introduce an Integrated Decision-Support Tool (IDST v2.0) which was developed as part of the INFRARISK project (https://www.infrarisk-fp7.eu/). The IDST is an online tool which demonstrates the implementation of a risk-based stress testing methodology for analyzing the potential impact of natural hazards on transport infrastructure networks. The IDST is enabled with a set of software workflow processes that allow the definition of multiple cascading natural hazards, geospatial coverage and impact on important large infrastructure, including those which are critical to transport networks in Europe. Stress tests on these infrastructure are consequently performed together with the automated generation of useful case study reports for practitioners. An exemplar stress test study using the IDST is provided in this paper. In this study, risks and consequences of an earthquake-triggered landslide scenario in Northern Italy is described. Further, it provides a step-by-step account of the developed stress testing overarching methodology which is applied to the impact on a road network of the region of interest

Verbal labeling, rehearsal, and short-term memory

The effects of verbal labeling in a serial position short-term memory (STM) task were investigated in two studies. In the first, 32 children at each of the grades 4, 6, and 8 were tested. In the second, 40 college students were tested. The stimuli consisted of eight cards with a central and an incidental picture on each. Half of the subjects overtly labeled the central pictures as they were presented; half did not. In Study I there were eight trials; in Study II there were additional trials in which stimuli contained only the central pictures. In Study I labeling did not affect overall performance; in Study II labeling was found to decrease performance significantly. For both studies labeling had differential effects at the primacy and recency portions of the serial-position data. There was no effect of one versus two stimuli per card in Study II. The findings were discussed in terms of issues concerning verbal mediation and rehearsal strategies. A developmental model for the processes involved in serial-position STM was presented.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32831/1/0000206.pd

MLF-DRS: A Multi-level Fair Resource Allocation Algorithm in Heterogeneous Cloud Computing Systems

Cloud computing is a novel paradigm which provides on demand, scalable and pay-as-you-use computing resources in a virtualized form. With cloud computing, users are able to access large pools of resources anywhere without any limitation. In order to use the provided facilities by the cloud in an efficient way, the management of resources is an undeniable fact that should be considered in different aspects. Among all those aspects, resource allocation has received much attentions. Given the fact that the cloud is heterogeneous, the allocation of resources has to become more sophisticated. As a first promising work to deal with that problem, Dominant Resource Fairness (DRF) has been proposed which takes into account dominant shares of users. Although DRF has a sort of desirable fairness properties, it has some limitations that have already been identified in the literature. Unfortunately, DRF and its recent developments are not intuitively fair with respect to various resource demands. In this paper, we propose a Multi-level Fair Dominant Resource Scheduling (MLF-DRS) algorithm as a new allocation model inspired by Max-Min fairness and proportionality. Unlike other works that they equalize dominant shares of different resource types which leads to starvation in the maximization of allocation for some users, our algorithm guarantees that each user receives the resources they desire for based on dominant shares. As can be deducted from the mathematical proofs, MLF-DRS provides a full utilization of resources and meets some of the desirable fair allocation properties and it is applicable to be used in a naïve extension form in the presence of multiple servers as wel

The Expression of Transcription Factors Mecp2 and CREB Is Modulated in Inflammatory Pelvic Pain

Early activation of transcription factors is one of the epigenetic mechanisms contributing to the induction and maintenance of chronic pain states. Previous studies identified the changes in a number of nociception-related genes, such as calcitonin gene-related peptide (CGRP), substance P (SP), and brain-derived neurotropic factor (BDNF) in the pelvic organs after transient colonic inflammation. The gene and protein expression of these neuropeptides could be modulated by transcription factors Methyl-CpG-binding protein 2 (Mecp2) and cAMP response element-binding protein (CREB). In this study, we aimed to evaluate time-dependent changes in the expression levels of Mecp2 and CREB in the lumbosacral (LS) spinal cord and sensory ganglia after inflammation-induced pelvic pain in rat. Adult Sprague-Dawley rats were treated with 2,4,6-trinitrobenzenesulfonic acid (TNBS) to induce transient colonic inflammation. LS (L6-S2) spinal cord segments and respective dorsal root ganglias (DRGs) were isolated from control and experimental animals at 1, 2, 6, 24 h and 3 days post-TNBS treatment. Immunohistochemical (IHC) labeling and Western blotting experiments were performed to assess the expression of Mecp2, CREB and their phosphorylated forms. Total Mecp2 expression, but not phosphorylated p-Mecp2 (pS421Mecp2) expression was detected in the cells of the spinal dorsal horn under control conditions. Colonic inflammation triggered a significant decrease in the number of Mecp2-expressing neurons in parallel with elevated numbers of pS421Mecp2-expressing cells at 2 h and 6 h post-TNBS. The majority of Mecp2-positive cells (80 ± 6%) co-expressed CREB. TNBS treatment caused a transient up-regulation of CREB-expressing cells at 1 h post-TNBS only. The number of cells expressing phosphorylated CREB (pS133CREB) did not change at 1 h and 2 h post-TNBS, but was down-regulated by three folds at 6 h post-TNBS. Analysis of DRG sections revealed that the number of Mecp2-positive neurons was up-regulated by TNBS treatment, reaching three-fold increase at 2 h post-TNBS, and eight-fold increase at 6 h post-TNBS (p ≤ 0.05 to control). These data showed early changes in Mecp2 and CREB expression in the dorsal horn of the spinal cord and sensory ganglia after colonic inflammation, suggesting a possible contribution Mecp2 and CREB signaling in the development of visceral hyperalgesia and pelvic pain following peripheral inflammation

An Alternative Interpretation of Statistical Mechanics

In this paper I propose an interpretation of classical statistical mechanics that centers on taking seriously the idea that probability measures represent complete states of statistical mechanical systems. I show how this leads naturally to the idea that the stochasticity of statistical mechanics is associated directly with the observables of the theory rather than with the microstates (as traditional accounts would have it). The usual assumption that microstates are representationally significant in the theory is therefore dispensable, a consequence which suggests interesting possibilities for developing non-equilibrium statistical mechanics and investigating inter-theoretic answers to the foundational questions of statistical mechanics

Healthcare designers’ use of prescriptive and performance-based approaches

In the UK, healthcare built environment design is guided by a series of long-established design standards and guidance issued by the Department of Health. More recently, healthcare design focus has broadened to encompass new approaches, supported by large bodies of credible research evidence. It is therefore timely to rethink how healthcare design standards and guidance should be best expressed to suit ‘designerly ways’ of using evidence, to improve their use and effectiveness in practice. This research explored how designers use performance and prescriptive approaches during the healthcare design process. Three in-depth healthcare built environment case studies were used to explore how designers employed such approaches during the design of selected exemplar design elements. Results show that design elements in the pre and conceptual design phases significantly employed performance-based approaches, and due to project-unique circumstances, prescriptive solutions were often significantly modified based on performance criteria. For design elements in the detailed and technical design phases, there was a significant use of solutions based on prescriptive approaches, whilst performance-based criteria were used to evaluate design solutions. This research proposes a performance-based, specification-driven healthcare design with supplementary prescriptive specifications provided for optimum healthcare environment design