Review and Analysis of Models for a European Digital Building Logbook

The concept of a Digital Building Logbook (DBL) was first introduced with the European strategy ‘Renovation Wave’. It is considered as one of two fundamental parts of which the Building Renovation Passport is composed: the DBL and a Renovation Roadmap. As the implementation of the DBL is a European priority, this paper reviews the existing literature and analyses the most developed European Digital Building Logbook models. The analysis includes iBRoad, ALDREN, X-tendo, and the Study on the Development of a European Union Framework for Buildings’ Digital Logbook, from the perspective of seven key aspects: References used as a starting point for the model definition; Identification of the relevant stakeholders in the DBL; Identified potential user needs; Proposed structure of indicators; Data sources; Potential functionalities; and Operation and use. The results show that important advancement has been made, although there is still no consensus about crucial subjects, such as the indicators to be collected or how to collect and use them. This is probably due to the fact that the final functionalities (objective and scope) that the logbook should provide are not fully clear. © 2022 by the authors. Licensee MDPI, Basel, Switzerland

Neutrophil gelatinase-associated lipocalin (NGAL) is related with the proteinuria degree and the microscopic kidney findings in leishmania-infected dogs

Early diagnosis of renal damage in Leishmania infected dogs may allow appropriate treatments and prevent some deaths. This study investigates neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of kidney disease in dogs experimentally infected with Leishmania infantum. Serum, urine, and kidney samples were collected from 30 infected beagle dogs and six uninfected control dogs. Based on proteinuria and azotemia values, dogs were initially classified. NGAL was measured in urine and serum samples. Then, the urinary NGAL to creatinine ratio (uNGAL/C) was calculated. Kidney samples were taken for histopathological studies, and the dogs were classified according to the severity of glomerular and tubulointerstitial lesions. In Leishmania-infected dogs, the uNGAL/C was significantly higher in proteinuric non-azotemic dogs compared with non-proteinuric non-azotemic dogs (p = 0.038). Serum NGAL (sNGAL) concentration did not differ between groups. Microscopic studies revealed several degrees of glomerulonephritis and slight focal lymphoplasmacytic interstitial nephritis in 89% and 55% of infected dogs, respectively. Urinary protein to creatinine ratio (UPC) and uNGAL/C were significantly higher in dogs with affected glomeruli compared to infected dogs without renal lesions (p = 0.045 and p = 0.043, respectively). The results show that uNGAL/C correlates with proteinuria and the presence of moderate glomerular lesions in non-azotemic dogs experimentally infected with L. infantum

ACTUALIZACIÓN DE LOS CUIDADOS DE ENFERMERÍA EN LA ADMINISTRACIÓN DE FIBRINOLÍTICOS.

The objective of our article is, on one hand, to remember the main fibrinolytics used in the sharp coronary syndrome, in what refers to the specific cares of infirmary, and for other, to describe one of the last used fibrinolytics, the tenecteplase (Metalyse ®); indications, administration, control of adverse effects and interactions.El objetivo de nuestro artículo es, por un lado, recordar los principales fibrinolíticos utilizados en el síndrome coronario agudo (SCA), en lo que se refiere a los cuidados específicos de enfermería, y por otro, describir uno de los últimos fibrinolíticos utilizados, la tenecteplasa (Metalyse®); indicaciones, posología, control de efectos adversos e interacciones

Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness

Objectives To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity. Methods Plasma interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8–11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry. Results IL-6 (β = −0.136) and VEGF (β = −0.099) were associated with TBLH BMC, while TNF-α (β = −0.345) and IL-1β (β = 0.212) were associated with LS BMC (P < 0.05). The interaction effect of muscular fitness showed a trend in the association of VEGF with TBLH BMC (P = 0.122) and TNF-α with LS BMC (P = 0.057). Stratified analyses by muscular fitness levels showed an inverse association of VEGF with TBLH BMC (β = −0.152) and TNF-α with LS BMC (β = −0.491) in the low-fitness group, while no association was found in the high-fitness group. Conclusion IL-6, VEGF, TNF-α, and IL-1β are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-α on bone mass

Mitos del amor romántico y autoestima en adolescentes

The myths of romantic love are socially constructed upon irrational beliefs about the nature of love, which stipulates what “true love” is, which the desirable characteristics are in a future partner, the importance of love, future expectations and the type of relationship. The presence of these romantic beliefs favours or maintains gender violence within the couple and constitutes the essence of control-based relationships, which are mainly characterized by lower self-esteem. The purpose of this study is to consider the internalization of the myths of romantic love among a group of adolescents and to analyse their relationship in relation with their self-esteem. To achieve this objective, a sample of 321 participants (52% men and 48% women), amongst 11 and 18 years of age, completed the Rosenberg Self-Esteem Questionnaire and the Romantic Love Myths Scale, by Luzón, Ramos, Recio and De La Peña. The analysis showed significant differences in the internalization of romantic myths according to the gender in favour of man, specifically in the miths of jealousy (Chi2=25,50; p smaller than .001), omnipotence (Chi2=28,96; p smaller than .001), marriage (Chi2=7,60; p=.006), total submission (Chi2=13,80; p=.001) and in the groups of myths “Love is the most importat and requires total delivery” (Chi2=33,80; p smaller than .001), “Love as possession and exclusivity” (Chi2=26,59; p smaller than .001) and “Love can do anything” (Chi2=25,19; p smaller than .001). On the other hand, is observed in the total sample a significant and inverse relationship between self-esteem and the group of myths “Love can do everything” (rho=-.121*) and the myths of omnipotence (rho=-.121*) and exclusivity (rho=-.128*). In view of these results, two conclusions are reached. On the one hand, that men assume more romantic beliefs than woman. On the other hand, that people with lower self-steem have a stronguer internalization of romantic beliefs. Based on these findings, both differences between genders about the internalization of romantic myths and the role of self-esteem should be considered in future interventions.Los mitos del amor romántico son creencias irracionales socialmente construidas sobre la naturaleza del amor, las cuales estipulan qué es el “amor verdadero”, cuáles son las características deseables al seleccionar pareja, la importancia del amor, las expectativas de futuro y el tipo de relación. La presencia de estas creencias románticas favorece o mantiene la violencia de género en la pareja y las relaciones basadas en el control, las cuales se relacionan con una menor autoestima. El objetivo de este estudio es registrar la interiorización de los mitos del amor romántico en un grupo de adolescentes y analizar su relación con la autoestima. Para la consecución de dicho objetivo, una muestra formada por un total de 321 participantes (52% hombres y 48% mujeres) de entre 11 y 18 años de edad, cumplimentó el Cuestionario de Autoestima de Rosenberg y la Escala de Mitos Hacia del Amor Romántico de Luzón, Ramos, Recio y de la Peña (2011). Los análisis mostraron diferencias significativas en la interiorización de mitos románticos en función del género a favor de los hombres, concretamente en los mitos de los celos (Chi2=25,50; p menor que .001), de la omnipotencia (Chi2=28,96; p menor que .001), del matrimonio (Chi2=7,60; p=.006), de la entrega total (Chi2=13,80; p=.001)  y en los grupos de mitos “El amor es lo más importante y requiere entrega total” (Chi2=33,80; p menor que .001), “Amor como posesión y exclusividad” (Chi2=26,59; p menor que .001) y “El amor lo puede todo” (Chi2=25,19; p menor que .001). Por otro lado, se observa en el total de la muestra una relación significativa e inversa entre la autoestima y el grupo de mitos “el amor lo puede todo” (rho=-.121*) y los mitos de la omnipotencia (rho=-.121*) y exclusividad (rho=-.128*). A la vista de dichos resultados se concluye, por un lado, que los hombres asumen más creencias románticas que las mujeres y por otro, que las personas con menor autoestima presentan una mayor interiorización de las creencias románticas. En base a dichas conclusiones, tanto las diferencias entre géneros por lo que respecta a la interiorización de los mitos románticos como el papel de la autoestima deberían ser considerados en futuras intervenciones.

The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic implications

Background Solid tumour growth is the consequence of a complex interplay between cancer cells and their microenvironment. Recently, a new global transcriptomic immune classification of solid tumours has identified six immune subtypes (ISs) (C1–C6). Our aim was to specifically characterise ISs in colorectal cancer (CRC) and assess their interplay with the consensus molecular subtypes (CMSs). Methods Clinical and molecular information, including CMSs and ISs, were obtained from The Cancer Genome Atlas (TCGA) (N = 625). Immune cell populations, differential gene expression and gene set enrichment analysis were performed to characterise ISs in the global CRC population by using CMSs. Results Only 5 ISs were identified in CRC, predominantly C1 wound healing (77%) and C2 IFN-γ dominant (17%). CMS1 showed the highest proportion of C2 (53%), whereas C1 was particularly dominant in CMS2 (91%). CMS3 had the highest representation of C3 inflammatory (7%) and C4 lymphocyte depleted ISs (4%), whereas all C6 TGF-β dominant cases belonged to CMS4 (2.3%). Prognostic relevance of ISs in CRC substantially differed from that reported for the global TCGA, and ISs had a greater ability to stratify the prognosis of CRC patients than CMS classification. C2 had higher densities of CD8, CD4 activated, follicular helper T cells, regulatory T cells and neutrophils and the highest M1/M2 polarisation. C2 had a heightened activation of pathways related to the immune system, apoptosis and DNA repair, mTOR signalling and oxidative phosphorylation, whereas C1 was more dependent of metabolic pathways. Conclusions The correlation of IS and CMS allows a more precise categorisation of patients with relevant clinical and biological implications, which may be valuable tools to improve tailored therapeutic interventions in CRC patients.This work was funded by projects DTS15/00157 , PI16/01827 and CIBER-ONC CB16/12/00442 from the Instituto de Salud Carlos III ( Ministry of Economy, Industry and Competitiveness, Spain ) and cofunded by the European Regional Development Fund (ERDF, European Union), and approved by the Ethics Committee or our Institution. BS is funded by AECC (Spain). MCR is funded by Instituto de Salud Carlos III and SEOM (Spain) CCP and BRC are funded by CAM (Programa de Empleo Juvenil (YEI)

Resiliencia en el consumo de agua por parte de abastecimientos y regadíos ante las sequías en el Sureste de España

El objeto de estudio es analizar y comparar cómo responden regantes y abastecimientos a situaciones de sequía en el Sureste de España en el siglo XXI, con el ejemplo de las de 2005-2008 y 2017-2018. Metodológicamente es un estudio de geografía regional con análisis cualitativo y cuantitativo, diacrónico y comparado, y trabajo de campo. Entre las fuentes utilizadas sobresalen la consulta de archivos históricos, los datos de AEMET, los consumos de agua en abastecimientos y regadíos, y las entrevistas a gestores y usuarios. La respuesta ante las sequías del siglo XXI ha sido dispar. En la de 2005-2008, en el regadío hubo que reducir la superficie de arbolado; en abastecimientos, se recurrió a pozos de sequía y cesiones de derechos. En la de 2017-2018, se han aplicado nuevas tecnologías en sistemas de riego y de cultivo, aparte de algunos aportes de desalinización; en el caso de los abastecimientos, se ha completado la oferta con agua producto de la desalación. La gestión del agua se enfrenta al reto de escenarios de cambio climático en el que serán más frecuentes sucesos extremos como sequías e inundaciones que generarán dificultades (fallo de garantía de suministro) para satisfacer las demandas hídrica y alimentaria de una población creciente

A vision about lifelong learning and its barriers

Around 25 years ago, some researchers argued for moving towards innovative learning models characterized by being more personalized and where the students would have a more active role in deciding what to learn, when to learn and how to learn. Nowadays, there is a need for a flexible, efficient, universal and lifelong education. Lifelong learning is fully integrated into our society and, from the student point of view, it is very different from regular learning. Among these differences there is the maturity of students, the fact that the domains of interest are much broader, the way how learning occurs at different depths, the fact that the topics to study may be related both to work, family and leisure, and that students have little availability due to their necessity to conciliate home, work, leisure and learning. Lifelong learning requires personalized models that adapt to students'' needs and constraints, but lifelong learners keep suffering from models that are neither adapted to their necessities, nor to the needs of society. This paper reflects on the actual situation of lifelong learning, analyses some of the relevant literature and discusses the challenges to conceptualize, from a transdisciplinary point of view, innovative e-learning models that promote self-determination of students

¿Qué opinan los futuros maestros sobre el aprendizaje de las ciencias a través de la indagación y sobre sus necesidades formativas?

The application of an open-ended questionnaire allows us to detect some ideas about inquiry in preservice Primary teachers. A first analysis allows us to categorize the type of answers. In general, the majority of students ask for more theoretical contents about science, since they are not confidence in being involved in science teaching without this background. A great scattering of answers appears when students are asked for inquiry in the Primary classrooms. Finally, no coherent answers are detected when students declare that they want to learn “more scientific contents” (90%), whereas less than 50% of them would like to be taught about this issue

Water reconditioning by high power ultrasound combined with residual chemical sanitizers to inactivate foodborne pathogens associated with fresh-cut products

The suitability of high power ultrasound (HPU, 20 kHz, 0.28 kW/l) combined with residual chemical sanitizers for water reconditioning was studied. A synergetic disinfection effect was observed when HPU was combined with peroxyacetic acid (PAA) or a commercial mix of organic acids and phenolic compounds (OA/PC). In recycled water (RW) with a chemical oxygen demand (COD) of 500 mg O2/l, PAA inactivated 2 log units of Escherichia coli O157:H7 at concentrations of 3.2, 6.4, 16 mg/l after 7 min, 2 min, 29 s, respectively. The OA/PC or HPU treatments alone needed 26 min treatments to achieve the same reduction. The addition of TiO2 (5 g/l) to HPU (sonocatalysis) did not improve E. coli O157:H7 inactivation. However, when HPU was combined with a residual concentration of PAA (3.2 mg/l), the total inactivation of E. coli O157:H7 and Salmonella (6 log unit reductions) occurred after 11 min, but for Listeria monocytogenes only 1.7 log reductions were detected after 20 min. When HPU was combined with OA/PC, a synergistic effect for the inactivation of E. coli O157:H7 was also observed, but this sanitizer significantly modified the physical-chemical quality characteristics of the RW. These results show that the residual PAA concentration that can be found in the wash water combined with HPU could result in an environmentally friendlier and toxicologically safer strategy for water reconditioning of the fresh-cut industry. The use of the sanitizer alone requires higher concentrations and/or longer contacts times. Even though the residual PAA in combination with HPU was adequate for water reconditioning, it is not appropriate for the process wash water because this wash water must be instantaneously disinfected.Ciencias de la Alimentació