674 research outputs found
Fermi-surface transformation across the pseudogap critical point of the cuprate superconductor LaNdSrCuO
The electrical resistivity and Hall coefficient R of the
tetragonal single-layer cuprate Nd-LSCO were measured in magnetic fields up to
T, large enough to access the normal state at , for closely
spaced dopings across the pseudogap critical point at .
Below , both coefficients exhibit an upturn at low temperature, which
gets more pronounced with decreasing . Taken together, these upturns show
that the normal-state carrier density at drops upon entering the
pseudogap phase. Quantitatively, it goes from at to at . By contrast, the mobility does not change appreciably, as
revealed by the magneto-resistance. The transition has a width in doping and
some internal structure, whereby R responds more slowly than to the
opening of the pseudogap. We attribute this difference to a Fermi surface that
supports both hole-like and electron-like carriers in the interval , with compensating contributions to R. Our data are in excellent
agreement with recent high-field data on YBCO and LSCO. The quantitative
consistency across three different cuprates shows that a drop in carrier
density from to is a universal signature of the pseudogap
transition at . We discuss the implication of these findings for the
nature of the pseudogap phase.Comment: 11 pages, 12 figure
Staphylococcus aureus bacteremia, Australia
Staphylococcus aureus bacteremia (SAB) is common and increasing worldwide. A retrospective review wyas undertaken to quantify the number of cases, their place of acquisition, and the proportions caused by methicillin-resistant S. aureus (MRSA) in 17 hospitals in Australia. Of 3,192 episodes, 1,571 (49%) were community onset. MRSA caused 40% of hospital-onset episodes and 12% of community-onset episodes. The median rate of SAB was 1.48/1,000 admissions (range 0.61-3.24; median rate for hospital-onset SAB was 0.7/1,000 and for community onset 0.8/1,000 admissions). Using these rates, we estimate that ≈6,900 episodes of SAB occur annually in Australia (35/100,000 population). SAB is common, and a substantial proportion of cases may be preventable. The epidemiology is evolving, with >10% of community-onset SAB now caused by MRSA. This is an emerging infectious disease concern and is likely to impact on empiric antimicrobial drug prescribing in suspected cases of SAB
Staphylococcus aureus Bacteremia, Australia
S. aureus bacteremia in Australia is increasingly caused by MRSA, which is likely to affect empiric prescribing of antimicrobial drugs in suspected cases
Salmonella enterica bacteraemia: a multi-national population-based cohort study
<p>Abstract</p> <p>Background</p> <p><it>Salmonella enterica </it>is an important emerging cause of invasive infections worldwide. However, population-based data are limited. The objective of this study was to define the occurrence of <it>S. enterica </it>bacteremia in a large international population and to evaluate temporal and regional differences.</p> <p>Methods</p> <p>We conducted population-based laboratory surveillance for all salmonella bacteremias in six regions (annual population at risk 7.7 million residents) in Finland, Australia, Denmark, and Canada during 2000-2007.</p> <p>Results</p> <p>A total of 622 cases were identified for an annual incidence of 1.02 per 100,000 population. The incidence of typhoidal (serotypes Typhi and Paratyphi) and non-typhoidal (other serotypes) disease was 0.21 and 0.81 per 100,000/year. There was major regional and moderate seasonal and year to year variability with an increased incidence observed in the latter years of the study related principally to increasing rates of non-typhoidal salmonella bacteremias. Advancing age and male gender were significant risk factors for acquiring non-typhoidal salmonella bacteremia. In contrast, typhoidal salmonella bacteremia showed a decreasing incidence with advancing age and no gender-related excess risk.</p> <p>Conclusions</p> <p><it>Salmonella enterica </it>is an important emerging pathogen and regional determinants of risk merits further investigation.</p
Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2
Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo. We report that the Ca2+ channel Polycystin-2 (Pkd2) is required specifically in the perinodal crown cells for sensing the nodal flow. Examination of mutant forms of Pkd2 shows that the ciliary localization of Pkd2 is essential for correct L-R patterning. Whereas Kif3a mutant embryos, which lack all cilia, failed to respond to an artificial flow, restoration of primary cilia in crown cells rescued the response to the flow. Our results thus suggest that nodal flow is sensed in a manner dependent on Pkd2 by the cilia of crown cells located at the edge of the node.CREST of the Japan Science and Technology Corporation; NIH [P30 DK090744]; Human Frontier Science Program [ST00246/2003C]; Deutsche Forschungsgemeinschaft [PE 853/2]; Japan Society for the Promotion of Science; American Heart Association [R10682]info:eu-repo/semantics/publishedVersio
Rationale for and protocol of a multi-national population-based bacteremia surveillance collaborative
<p>Abstract</p> <p>Background</p> <p>Bloodstream infections are frequent causes of human illness and cause major morbidity and death. In order to best define the epidemiology of these infections and to track changes in occurrence, adverse outcome, and resistance rates over time, population based methodologies are optimal. However, few population-based surveillance systems exist worldwide, and because of differences in methodology inter-regional comparisons are limited. In this report we describe the rationale and propose first practical steps for developing an international collaborative approach to the epidemiologic study and surveillance for bacteremia.</p> <p>Findings</p> <p>The founding collaborative participants represent six regions in four countries in three continents with a combined annual surveillance population of more than 8 million residents.</p> <p>Conclusion</p> <p>Future studies from this collaborative should lead to a better understanding of the epidemiology of bloodstream infections.</p
Automatic Calibration of Artificial Neural Networks for Zebrafish Collective Behaviours using a Quality Diversity Algorithm
During the last two decades, various models have been proposed for fish
collective motion. These models are mainly developed to decipher the biological
mechanisms of social interaction between animals. They consider very simple
homogeneous unbounded environments and it is not clear that they can simulate
accurately the collective trajectories. Moreover when the models are more
accurate, the question of their scalability to either larger groups or more
elaborate environments remains open. This study deals with learning how to
simulate realistic collective motion of collective of zebrafish, using
real-world tracking data. The objective is to devise an agent-based model that
can be implemented on an artificial robotic fish that can blend into a
collective of real fish. We present a novel approach that uses Quality
Diversity algorithms, a class of algorithms that emphasise exploration over
pure optimisation. In particular, we use CVT-MAP-Elites, a variant of the
state-of-the-art MAP-Elites algorithm for high dimensional search space.
Results show that Quality Diversity algorithms not only outperform classic
evolutionary reinforcement learning methods at the macroscopic level (i.e.
group behaviour), but are also able to generate more realistic biomimetic
behaviours at the microscopic level (i.e. individual behaviour).Comment: 8 pages, 4 figures, 1 tabl
Wiedemann-Franz law and abrupt change in conductivity across the pseudogap critical point of a cuprate superconductor
The thermal conductivity of the cuprate superconductor
LaNdSrCuO was measured down to 50 mK in seven
crystals with doping from to , both in the superconducting
state and in the magnetic field-induced normal state. We obtain the electronic
residual linear term as across the pseudogap critical
point . In the normal state, we observe an abrupt drop in
upon crossing below , consistent with a drop in carrier
density from to , the signature of the pseudogap phase inferred
from the Hall coefficient. A similar drop in is observed at ,
showing that the pseudogap critical point and its signatures are unaffected by
the magnetic field. In the normal state, the Wiedemann-Franz law,
, is obeyed at all dopings, including at the critical
point where the electrical resistivity is -linear down to . We conclude that the non-superconducting ground state of the pseudogap
phase at is a metal whose fermionic excitations carry heat and charge as
conventional electrons do.Comment: 10 pages, including Supplementary Materia
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