Area change of glaciers in the Canadian Rocky Mountains, 1919 to 2006

Glaciers in the Canadian Rocky Mountains constitute an important freshwater resource. To enhance our understanding of the influence climate and local topography have on glacier area, large numbers of glaciers of different sizes and attributes need to be monitored over periods of many decades. We used Interprovincial Boundary Commission Survey (IBCS) maps of the Alberta–British Columbia (BC) border (1903–1924), BC Terrain Resource Information Management (TRIM) data (1982–1987), and Landsat Thematic Mapper (TM) and Enhanced Thematic Mapper (ETM+) imagery (2000–2002 and 2006) to document planimetric changes in glacier cover in the central and southern Canadian Rocky Mountains between 1919 and 2006. Over this period, glacier cover in the study area decreased by 590 ± 70 km<sup>2</sup> (40 ± 5%), 17 of 523 glaciers disappeared and 124 glaciers fragmented into multiple ice masses. Glaciers smaller than 1.0 km<sup>2</sup> experienced the greatest relative area loss (64 ± 8%), and relative area loss is more variable with small glaciers, suggesting that the local topographic setting controls the response of these glaciers to climate change. Small glaciers with low slopes, low mean/median elevations, south to west aspects, and high insolation experienced the largest reduction in area. Similar rates of area change characterize the periods 1919–1985 and 1985–2001; −6.3 ± 0.6 km<sup>2</sup> yr<sup>−1</sup> (−0.4 ± 0.1% yr<sup>−1</sup>) and −5.0 ± 0.5 km<sup>2</sup> yr<sup>−1</sup> (−0.5 ± 0.1% yr<sup>−1</sup>), respectively. The rate of area loss, however, increased over the period 2001–2006; −19.3 ± 2.4 km<sup>2</sup> yr<sup>−1</sup> (−2.0 ± 0.2% yr<sup>−1</sup>). Applying size class-specific scaling factors, we estimate a total reduction in glacier cover in the central and southern Canadian Rocky Mountains for the period 1919–2006 of 750 km<sup>2</sup> (30%)

Preeruptive flow focussing in dikes feeding historical pillow ridges on the Juan de Fuca and Gorda Ridges

Linear, hummocky pillow mound volcanism dominates at slow and intermediate spreading rate mid-ocean ridges. Volcanic hummocks are thought to be formed by low effusion rates or as a result of flow focussing during effusive fissure style eruptions in which the initial dike intercepts the seafloor and erupts along its entire length. In this study, high-resolution autonomous underwater vehicle (AUV) bathymetry is used to accurately map the extents of four historical fissure eruptions of the Juan de Fuca and Gorda ridges: on the North Gorda, North Cleft, and CoAxial ridge segments. The four mapped eruptions take the form of pillow mounds, which are similar in both lithology and dimension to hummocks on the Mid-Atlantic Ridge. Pillow mounds may be isolated, or coalesce to form composite mounds, aligned as ridges or as clustered groups. In three of the four mapped sites, the eruptions were discontinuous along their lengths, with pillow mounds and composite mounds commonly separated by areas of older seafloor. This style of discontinuous eruption is inconsistent with typical en echelon fissure eruptions and is probably due to a mildly overpressured, fingering dike intersecting the seafloor along parts of its length

Structure of Lo'ihi Seamount, Hawai'i and lava flow morphology from high-resolution mapping.

© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Clague, D. A., Paduan, J. B., Caress, D. W., Moyer, C. L., Glazer, B. T., & Yoerger, D. R. Structure of Lo'ihi Seamount, Hawai'i and lava flow morphology from high-resolution mapping. Frontiers in Earth Science, 7, (2019):58, doi:10.3389/feart.2019.00058.The early development and growth of oceanic volcanoes that eventually grow to become ocean islands are poorly known. In Hawai‘i, the submarine Lō‘ihi Seamount provides the opportunity to determine the structure and growth of such a nascent oceanic island. High-resolution bathymetric data were collected using AUV Sentry at the summit and at two hydrothermal vent fields on the deep south rift of Lō‘ihi Seamount. The summit records a nested series of caldera and pit crater collapse events, uplift of one resurgent block, and eruptions that formed at least five low lava shields that shaped the summit. The earliest and largest caldera, formed ∼5900 years ago, bounds almost the entire summit plateau. The resurgent block was uplifted slightly more than 100 m and has a tilted surface with a dip of about 6.5° toward the SE. The resurgent block was then modified by collapse of a pit crater centered in the block that formed West Pit. The shallowest point on Lō‘ihi’s summit is 986 m deep and is located on the northwest edge of the resurgent block. Several collapse events culminated in formation of East Pit, and the final collapse formed Pele’s Pit in 1996. The nine mapped collapse and resurgent structures indicate the presence of a shallow crustal magma chamber, ranging from depths of ∼1 km to perhaps 2.5 km below the summit, and demonstrate that shallow sub-caldera magma reservoirs exist during the late pre-shield stage. On the deep south rift zone are young medium- to high-flux lava flows that likely erupted in 1996 and drained the shallow crustal magma chamber to trigger the collapse that formed Pele’s Pit. These low hummocky and channelized flows had molten cores and now host the FeMO hydrothermal field. The Shinkai Deep hydrothermal site is located among steep-sided hummocky flows that formed during low-flux eruptions. The Shinkai Ridge is most likely a coherent landslide block that originated on the east flank of Lō‘ihi.Funding for the collection of the data was provided by the National Science Foundation OCE1155756 to CM and the Schmidt Ocean Institute to BG. Support for DC and JP to process the data and write the manuscript was provided by a grant from the David and Lucile Packard Foundation to MBARI

Toward mountains without permanent snow and ice

The cryosphere in mountain regions is rapidly declining, a trend that is expected to accelerate over the next several decades due to anthropogenic climate change. A cascade of effects will result, extending from mountains to lowlands with associated impacts on human livelihood, economy, and ecosystems. With rising air temperatures and increased radiative forcing, glaciers will become smaller and, in some cases, disappear, the area of frozen ground will diminish, the ratio of snow to rainfall will decrease, and the timing and magnitude of both maximum and minimum streamflow will change. These changes will affect erosion rates, sediment, and nutrient flux, and the biogeochemistry of rivers and proglacial lakes, all of which influence water quality, aquatic habitat, and biotic communities. Changes in the length of the growing season will allow low-elevation plants and animals to expand their ranges upward. Slope failures due to thawing alpine permafrost, and outburst floods from glacier- and moraine-dammed lakes will threaten downstream populations. Societies even well beyond the mountains depend on meltwater from glaciers and snow for drinking water supplies, irrigation, mining, hydropower, agriculture, and recreation. Here, we review and, where possible, quantify the impacts of anticipated climate change on the alpine cryosphere, hydrosphere, and biosphere, and consider the implications for adaptation to a future of mountains without permanent snow and ice

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive and fast assay to quantify in vitro DUB enzyme activity using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Unlike other current assays, this method uses unmodified substrates, such as diubiquitin topoisomers. By analyzing 42 human DUBs against all diubiquitin topoisomers we provide an extensive characterization of DUB activity and specificity. Our results confirm the high specificity of many members of the OTU and JAMM DUB families and highlight that all USPs tested display low linkage selectivity. We also demonstrate that this assay can be deployed to assess the potency and specificity of DUB inhibitors by profiling 11 compounds against a panel of 32 DUBs

Network adaptation improves temporal representation of naturalistic stimuli in drosophila eye: II Mechanisms

Retinal networks must adapt constantly to best present the ever changing visual world to the brain. Here we test the hypothesis that adaptation is a result of different mechanisms at several synaptic connections within the network. In a companion paper (Part I), we showed that adaptation in the photoreceptors (R1-R6) and large monopolar cells (LMC) of the Drosophila eye improves sensitivity to under-represented signals in seconds by enhancing both the amplitude and frequency distribution of LMCs' voltage responses to repeated naturalistic contrast series. In this paper, we show that such adaptation needs both the light-mediated conductance and feedback-mediated synaptic conductance. A faulty feedforward pathway in histamine receptor mutant flies speeds up the LMC output, mimicking extreme light adaptation. A faulty feedback pathway from L2 LMCs to photoreceptors slows down the LMC output, mimicking dark adaptation. These results underline the importance of network adaptation for efficient coding, and as a mechanism for selectively regulating the size and speed of signals in neurons. We suggest that concert action of many different mechanisms and neural connections are responsible for adaptation to visual stimuli. Further, our results demonstrate the need for detailed circuit reconstructions like that of the Drosophila lamina, to understand how networks process information

Constructing a new understanding of the environment under postsocialism

This paper introduces a special grouping of papers on the theme of the environment and postsocialism. After the collapse of state socialism in Europe between 1989 and 1991, many immediate approaches to environmental reconstruction assumed that economic liberalisation and democratisation would alleviate problems. Since then, critics have argued that these proposed solutions were themselves problematic, and too closely reflected Western European and North American conceptions of environmental quality and democracy. The result has been a counterreaction focusing on detail and specificity at national levels and below. In this paper, we summarise debates about the environment and postsocialism since the period 1989 - 91. In particular, we examine whether an essentialistic link can be made between state socialism and environmental problems, and how far civil society -- or environmentalism -- may result in an improvement in perceived environmental quality. Finally, we consider the possibility for developing an approach to the environment and postsocialism that lies between crude generalisation and microscale studies

Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells

Carbon nanotubes (CNTs) are at present being considered as potential nanovectors with the ability to deliver therapeutic cargoes into living cells. Previous studies established the ability of CNTs to enter cells and their therapeutic utility, but an appreciation of global intracellular trafficking associated with their cellular distribution has yet to be described. Despite the many aspects of the uptake mechanism of CNTs being studied, only a few studies have investigated internalization and fate of CNTs inside cells in detail. In the present study, intracellular localization and trafficking of RNA-wrapped, oxidized double-walled CNTs (oxDWNT–RNA) is presented. Fixed cells, previously exposed to oxDWNT–RNA, were subjected to immunocytochemical analysis using antibodies specific to proteins implicated in endocytosis; moreover cell compartment markers and pharmacological inhibitory conditions were also employed in this study. Our results revealed that an endocytic pathway is involved in the internalization of oxDWNT–RNA. The nanotubes were found in clathrin-coated vesicles, after which they appear to be sorted in early endosomes, followed by vesicular maturation, become located in lysosomes. Furthermore, we observed co-localization of oxDWNT–RNA with the small GTP-binding protein (Rab 11), involved in their recycling back to the plasma membrane via endosomes from the trans-golgi network

The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation

Epstein-Barr virus (EBV) is a human herpesvirus that persists as a largely subclinical infection in the vast majority of adults worldwide. Recent evidence indicates that an important component of the persistence strategy involves active interference with the MHC class I antigen processing pathway during the lytic replication cycle. We have now identified a novel role for the lytic cycle gene, BILF1, which encodes a glycoprotein with the properties of a constitutive signaling G-protein-coupled receptor (GPCR). BILF1 reduced the levels of MHC class I at the cell surface and inhibited CD8+ T cell recognition of endogenous target antigens. The underlying mechanism involves physical association of BILF1 with MHC class I molecules, an increased turnover from the cell surface, and enhanced degradation via lysosomal proteases. The BILF1 protein of the closely related CeHV15 c1-herpesvirus of the Rhesus Old World primate (80% amino acid sequence identity) downregulated surface MHC class I similarly to EBV BILF1. Amongst the human herpesviruses, the GPCR encoded by the ORF74 of the KSHV c2-herpesvirus is most closely related to EBV BILF1 (15% amino acid sequence identity) but did not affect levels of surface MHC class I. An engineered mutant of BILF1 that was unable to activate G protein signaling pathways retained the ability to downregulate MHC class I, indicating that the immune-modulating and GPCR-signaling properties are two distinct functions of BILF1. These findings extend our understanding of the normal biology of an important human pathogen. The discovery of a third EBV lytic cycle gene that cooperates to interfere with MHC class I antigen processing underscores the importance of the need for EBV to be able to evade CD8+ T cell responses during the lytic replication cycle, at a time when such a large number of potential viral targets are expressed

A robust sar speckle tracking workflow for measuring and interpreting the 3d surface displacement of landslides

We present a workflow for investigating large, slow‐moving landslides which combines the synthetic aperture radar (SAR) technique, GIS post‐processing, and airborne laser scanning (ALS), and apply it to Fels landslide in Alaska, US. First, we exploit a speckle tracking (ST) approach to derive the easting, northing, and vertical components of the displacement vectors across the rock slope for two five‐year windows, 2010–2015 and 2015–2020. Then, we perform post‐processing in a GIS environment to derive displacement magnitude, trend, and plunge maps of the landslide area. Finally, we compare the ST‐derived displacement data with structural lineament maps and profiles extracted from the ALS dataset. Relying on remotely sensed data, we estimate that the thickness of the slide mass is more than 100 m and displacements occur through a combination of slumping at the toe and planar sliding in the central and upper slope. Our approach provides information and interpretations that can assist in optimizing and planning fieldwork activities and site investigations at landslides in remote locations