Logistics service provider selection for disaster preparation: a socio-technical systems perspective

Since 1990s, the world has seen a lot of advances in providing humanitarian aid through sophisticated logistics operations. The current consensus seems to be that humanitarian relief organizations (HROs) can improve their relief operations by collaborating with logistics service providers (CLSPs) in the commercial sector. The question remains: how can HROs select the most appropriate CLSP for disaster preparation? Despite its practical significance, no explicit effort has been done to identify the criteria/factors in prioritising and selecting a CLSP for disaster relief. The present study aims to address this gap by consolidating the list of criteria from a socio-technical systems (STS) perspective. Then, to handle the interdependence among the criteria derived from the STS, we develop a hybrid multi-criteria decision making model for CLSP selection in the disaster preparedness stage. The proposed model is then evaluated by a real-life case study, providing insights into the decision-makers in both HROs and CLSPs

Context-based personalization of web services composition and provisioning

This paper presents an approach that aims at personalizing Web services composition and provisioning using context. Composition addresses the situation of a user\u27s request that cannot be satisfied by any available service, and thus requires the combination of several Web services. Provisioning focuses on the deployment of Web services according to users\u27 preferences. A Web service is an accessible application that other applications and humans can discover and trigger. Context is the information that characterizes the interactions between humans, applications, and the surrounding environment. Web services are subject to personalization if there is a need of accommodating users\u27 preferences during service performance and outcome delivery. To be able to track personalization in terms of what happened, what is happening, and what might happen three types of context are devised, and they are referred to as user-, Web service-, and resource-context

THE RELATIONSHIP BETWEEN OBESITY AND DIETARY INTAKE OF OBESE AND PRE-OBESE FEMALE STUDENTS – AJA CAMPUS HAIL UNIVERSITY

Globally obesity has reached to epidemic proportions, and the people of the Gulf countries have also affected, especially high income, oilproducing countries. Recent data clearly indicate a high prevalence of adult obesity particularly in women in the Kingdom. This paper aims to identify the relationship between obesity and dietary intake of obese and pre-obese female students in Hail University–KSA. Descriptive analytical approach was used in this paper. BMI was calculated and related to dietary intake using food frequency questionnaire. Results shows prevalence of obesity grades was n(%); 43(43%) obesity grade I, 17(17%) obesity grade II, and 8(8%) were grade III obesity. Thirty one subjects were pre-obese and only one subject was overweight. Basic food groups consumption as stated in frequency per week revealed that: female students consumed more servings (>6 times/ week ) of fruits; vegetables; and dairy products, alternatives, sweets and candies, eggs, legumes, rice macaroni and other starch foods, non-alcoholic beverages. Whereas they consumed less servings (≤Once/ week) of breads, fruit juices, carbonated drinks and potato. The majority of the subjects 65% ate chicken with rice (Kabsa) as staple food, whereas 4% ate other starchy food. High consumption of energy dense foods might be responsible for increased deposition of calories in the form adipose tissue. Conclusion: It is crucial to enumerate awareness programs to modify dietary behavior and eating habits of female students and Hail community with respect to food intake. This will be effective in the treatment of obesity, especially in Saudi Arabia

CCL3L1 copy number, CCR5 genotype and susceptibility to tuberculosis

Background: Tuberculosis is a major infectious disease and functional studies have provided evidence that both the chemokine MIP-1α and its receptor CCR5 play a role in susceptibility to TB. Thus by measuring copy number variation of CCL3L1, one of the genes that encode MIP-1α, and genotyping a functional promoter polymorphism -2459A > G in CCR5 (rs1799987) we investigate the influence of MIP-1α and CCR5, independently and combined, in susceptibility to clinically active TB in three populations, a Peruvian population (n = 1132), a !Xhosa population (n = 605) and a South African Coloured population (n = 221). The three populations include patients with clinically diagnosed pulmonary TB, as well as other, less prevalent forms of extrapulmonary TB. Methods and results: Copy number of CCL3L1 was measured using the paralogue ratio test and exhibited ranges between 0–6 copies per diploid genome (pdg) in Peru, between 0–12 pdg in !Xhosa samples and between 0–10 pdg in South African Coloured samples. The CCR5 promoter polymorphism was observed to differ significantly in allele frequency between populations (*A; Peru f = 0.67, !Xhosa f = 0.38, Coloured f = 0.48). Conclusions: The case–control association studies performed however find, surprisingly, no evidence for an influence of variation in genes coding for MIP-1α or CCR5 individually or together in susceptibility to clinically active TB in these populations

Impact of chemotherapy for HIV-1 related lymphoma on residual viremia and cellular HIV-1 DNA in patients on suppressive antiretroviral therapy

The first cure of HIV-1 infection was achieved through complex, multimodal therapy including myeloablative chemotherapy, total body irradiation, anti-Thymocyte globulin, and allogeneic stem cell transplantation with a CCR5 delta32 homozygous donor. The contributions of each component of this therapy to HIV-1 eradication are unclear. To assess the impact of cytotoxic chemotherapy alone on HIV-1 persistence, we longitudinally evaluated low-level plasma viremia and HIV-1 DNA in PBMC from patients in the ACTG A5001/ALLRT cohort on suppressive antiretroviral therapy (ART) who underwent chemotherapy for HIV-1 related lymphoma without interrupting ART. Plasma HIV-1 RNA, total HIV-1 DNA and 2-LTR circles (2-LTRs) in PBMC were measured using sensitive qPCR assays. In the 9 patients who received moderately intensive chemotherapy for HIV-1 related lymphoma with uninterrupted ART, low-level plasma HIV-1 RNA did not change significantly with chemotherapy: median HIV-1 RNA was 1 copy/mL (interquartile range: 1.0 to 20) pre-chemotherapy versus 4 copies/mL (interquartile range: 1.0 to 7.0) post-chemotherapy. HIV-1 DNA levels also did not change significantly, with median prechemotherapy HIV-1 DNA of 355 copies/106 CD4+ cells versus 228 copies/106 CD4+ cells post-chemotherapy. 2-LTRs were detectable in 2 of 9 patients pre-chemotherapy and in 3 of 9 patients post-chemotherapy. In summary, moderately intensive chemotherapy for HIV-1 related lymphoma in the context of continuous ART did not have a prolonged impact on HIV-1 persistence. © 2014 Cillo et al

PI3Kδ and primary immunodeficiencies.

Primary immunodeficiencies are inherited disorders of the immune system, often caused by the mutation of genes required for lymphocyte development and activation. Recently, several studies have identified gain-of-function mutations in the phosphoinositide 3-kinase (PI3K) genes PIK3CD (which encodes p110δ) and PIK3R1 (which encodes p85α) that cause a combined immunodeficiency syndrome, referred to as activated PI3Kδ syndrome (APDS; also known as p110δ-activating mutation causing senescent T cells, lymphadenopathy and immunodeficiency (PASLI)). Paradoxically, both loss-of-function and gain-of-function mutations that affect these genes lead to immunosuppression, albeit via different mechanisms. Here, we review the roles of PI3Kδ in adaptive immunity, describe the clinical manifestations and mechanisms of disease in APDS and highlight new insights into PI3Kδ gleaned from these patients, as well as implications of these findings for clinical therapy

Using death to one's advantage: HIV modulation of apoptosis

Infection by human immunodeficiency virus (HIV) is associated with an early immune dysfunction and progressive destruction of CD4+ T lymphocytes. This progressive disappearance of T cells leads to a lack of immune control of HIV replication and to the development of immune deficiency resulting in the increased occurrence of opportunistic infections associated with acquired immune deficiency syndrome (AIDS). The HIV-induced, premature destruction of lymphocytes is associated with the continuous production of HIV viral proteins that modulate apoptotic pathways. The viral proteins, such as Tat, Env, and Nef, are associated with chronic immune activation and the continuous induction of apoptotic factors. Viral protein expression predisposes lymphocytes, particularly CD4+ T cells, CD8+ T cells, and antigen-presenting cells, to evolve into effectors of apoptosis and as a result, to lead to the destruction of healthy, non-infected T cells. Tat and Nef, along with Vpu, can also protect HIV-infected cells from apoptosis by increasing anti-apoptotic proteins and down- regulating cell surface receptors recognized by immune system cells. This review will discuss the validity of the apoptosis hypothesis in HIV disease and the potential mechanism(s) that HIV proteins perform in the progressive T cell depletion observed in AIDS pathogenesis. Originally published Leukemia, Vol. 15, No. 3, Mar 200

Online Recruitment of Qualitative Study Participants: Lessons Learned

The COVID-19 pandemic contributed to an increase in online recruitment of research participants as in-person interactions were limited. For quantitative and self-administered surveys, fraud and bot detection methods have been initiated to verify intended participants. However, there is limited information on participant authentication during recruitment process for qualitative studies. This study aimed to describe the recruitment and verification process for focus groups and interview participants for two qualitative studies. Participants were recruited through social media, emails, and snowball sampling online. All participants for both studies were screened based on the eligibility criteria. In the first project, 134 respondents met the eligibility criteria. Among those eligible, 46% were suspected to be fraudulent (i.e., fake identity or posed as meeting inclusion criteria when they do not) and up to 39% did not show up for their scheduled focus groups. Suspected participants were identified during screening and identification stage prior to the focus groups. In the second project, 102 respondents met the eligibility criteria for one of the samples; however, 54% of respondents were suspected to be fraudulent. In the second sample, 211 respondents met the eligibility criteria and 88% were suspected to be fraudulent. Additional protocols, such as ReCAPTCHA, ID checks, monitoring recruitment during social media posts, were initiated to further authenticate participants. This paper highlights the challenges of virtual and online recruitment strategies. Findings emphasize the need for researchers to put in place effective and innovative strategies to recruit and authenticate study participants

Screening of Ionic Liquids and Deep Eutectic Solvents for Physical CO2Absorption by Soft-SAFT Using Key Performance Indicators

RC2-2019-007 PID2019108014RB-C21 SFRH/BD/130965/2017 UID/QUI/50006/2019The efficient screening of solvents for CO2 capture requires a reliable and robust equation of state to characterize and compare their thermophysical behavior for the desired application. In this work, the potentiality of 14 ionic liquids (ILs) and 7 deep eutectic solvents (DESs) for CO2 capture was examined using soft-SAFT as a modeling tool for the screening of these solvents based on key process indicators, namely, cyclic working capacity, enthalpy of desorption, and CO2 diffusion coefficient. Once the models were assessed versus experimental data, soft-SAFT was used as a predictive tool to calculate the thermophysical properties needed for evaluating their performance. Results demonstrate that under the same operating conditions, ILs have a far superior performance than DESs primarily in terms of amount of CO2 captured, being at least two-folds more than that captured using DESs. The screening tool revealed that among all the examined solvents and conditions, [C4 py][NTf2] is the most promising solvent for physical CO2 capture. The collection of the acquired results confirms the reliability of the soft-SAFT EoS as an attractive and valuable screening tool for CO2 capture and process modeling.publishersversionpublishe