374 research outputs found
Attitudes among hospital physicians to the reporting of adverse drug reactions in Sweden
Attitudes of undergraduate nursing students to cultural diversity: (Portuguese-Spanish) in a transboundary context.
Our main goal was to identify the attitudes of nursing students to cultural diversity in a healthcare setting, and find the potential relationship between this and the students' national background and their knowledge of cultural diversity. A descriptive observational study comparing two culturally different populations within a cross-border area (Algarve-Huelva) was conducted. The attitudes of the participants were measured across six categories: this study will describe the most significant ones. The cultural context is essential to the development of attitudes to immigration. Nursing care is a communicative act and encountering the "other" the core of the nursing professionals' work. (C) 2017 The Authors. Published by Elsevier Ltd
The FERRUM project: Transition probabilities for forbidden lines in [FeII] and experimental metastable lifetimes
Accurate transition probabilities for forbidden lines are important
diagnostic parameters for low-density astrophysical plasmas. In this paper we
present experimental atomic data for forbidden [FeII] transitions that are
observed as strong features in astrophysical spectra.
Aims: To measure lifetimes for the 3d^6(^3G)4s a ^4G_{11/2} and 3d^6(^3D)4s b
^4D_{1/2} metastable levels in FeII and experimental transition probabilities
for the forbidden transitions 3d^7 a ^4F_{7/2,9/2}- 3d^6(^3G)4s a ^4G_{11/2}.
Methods: The lifetimes were measured at the ion storage ring facility CRYRING
using a laser probing technique. Astrophysical branching fractions were
obtained from spectra of Eta Carinae, obtained with the Space Telescope Imaging
Spectrograph onboard the Hubble Space Telescope. The lifetimes and branching
fractions were combined to yield absolute transition probabilities.
Results: The lifetimes of the a ^4G_{11/2} and the b ^4D_{1/2} levels have
been measured and have the following values, 0.75(10) s and 0.54(3) s
respectively. Furthermore, we have determined the transition probabilities for
two forbidden transitions of a ^4F_{7/2,9/2}- a ^4G_{11/2} at 4243.97 and
4346.85 A. Both the lifetimes and the transition probabilities are compared to
calculated values in the literature.Comment: 5 pages, accepted for publication in A&
Integrating isotopes and documentary evidence : dietary patterns in a late medieval and early modern mining community, Sweden
We would like to thank the Archaeological Research Laboratory, Stockholm University, Sweden and the Tandem Laboratory (Ă
ngström Laboratory), Uppsala University, Sweden, for undertaking the analyses of stable nitrogen and carbon isotopes in both human and animal collagen samples. Also, thanks to Elin Ahlin Sundman for providing the ÎŽ13C and ÎŽ15N values for animal references from VĂ€sterĂ„s. This research (BĂ€ckströmâs PhD employment at Lund University, Sweden) was supported by the Berit Wallenberg Foundation (BWS 2010.0176) and Jakob and Johan Söderbergâs foundation. The âSala projectâ (excavations and analyses) has been funded by Riksens Clenodium, Jernkontoret, Birgit and Gad Rausingâs Foundation, SAUâs Research Foundation, the Royal Physiographic Society of Lund, Berit Wallenbergs Foundation, Ă
ke Wibergs Foundation, Lars Hiertas Memory, Helge Ax:son Johnsonâs Foundation and The Royal Swedish Academy of Sciences.Peer reviewedPublisher PD
Site-specific O-glycosylation on the MUC_{2} mucin protein inhibits cleavage by the porphyromonas gingivalis secreted cysteine protease (RgpB)
The colonic epithelial surface is protected by an inner mucus layer that the commensal microflora cannot penetrate. We previously demonstrated that Entamoeba histolytica secretes a protease capable of dissolving this layer that is required for parasite penetration. Here, we asked whether there are bacteria that can secrete similar proteases. We screened bacterial culture supernatants for such activity using recombinant fragments of the MUC2 mucin, the major structural component, and the only gel-forming mucin in the colonic mucus. MUC2 has two central heavily O-glycosylated mucin domains that are protease-resistant and has cysteine-rich N and C termini responsible for polymerization. Culture supernatants of Porphyromonas gingivalis, a bacterium that secretes proteases responsible for periodontitis, cleaved the MUC2 C-terminal region, whereas the N-terminal region was unaffected. The active enzyme was isolated and identified as Arg-gingipain B (RgpB). Two cleavage sites were localized to IRâTT and NRâQA. IRâTT cleavage will disrupt the MUC2 polymers. Because this site has two potential O-glycosylation sites, we tested whether recombinant GalNAc-transferases (GalNAc-Ts) could glycosylate a synthetic peptide covering the IRTT sequence. Only GalNAc-T3 was able to glycosylate the second Thr in IRTT, rendering the sequence resistant to cleavage by RgpB. Furthermore, when GalNAc-T3 was expressed in CHO cells expressing the MUC2 C terminus, the second threonine was glycosylated, and the protein became resistant to RgpB cleavage. These findings suggest that bacteria can produce proteases capable of dissolving the inner protective mucus layer by specific cleavages in the MUC2 mucin and that this cleavage can be modulated by site-specific O-glycosylation
Characteristics of safety information obtained from postmarketing observational studies for re-examination in Japan
Importance of GluA1 Subunit-Containing AMPA Glutamate Receptors for Morphine State-Dependency
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