Patrones espaciales asociados a la distribución de estadios inmaduros de Aedes aegypti en tres municipios de alto riesgo para el departamento del Cauca, Colombia

Aedes aegypti mosquitoes are the main vector of human arbovirosis in tropical and subtropical areas.  Its adaptation to urban and rural environments generates infestations inside households. Therefore, entomological surveillance in association with spatio-temporal analysis is an innovative approach to vector control and dengue management. The main aim was to inspect immature pupal stages in households belonging to municipalities at high risk of dengue in Cauca, Colombia by implementing entomological indices and relating how they influence adult mosquito density. Here, we provide novel data for the geographical distribution of 3,806 immature pupal stages of Ae. aegypti. We also report entomological indices and spatial characterization. The results suggest that for Ae. aegypti species, pupal productivity generates high densities of adults in neighbouring households, evidencing seasonal behaviour. This dataset is of great importance as it provides an innovative strategy for vector-borne disease mitigation using vector spatial patterns and their association with entomological indicators and breeding sites in high-risk neighbourhoods.Los mosquitos Aedes aegypti son el principal vector de las arbovirosis humanas en zonas tropicales y subtropicales. Su adaptación a entornos urbanos y rurales genera infestaciones en el intradomicilio de las viviendas. De aquí que, la vigilancia entomológica en asociación con el análisis espacial y el análisis espacio-temporal sean un enfoque innovador para el control de vectores y la gestión del dengue.El objetivo principal de la investigación fue realizar una comparación de la vigilancia entomológica, mediante el uso de índices cuantitativos de pupas y de adultos en tres municipios de alto riesgo de dengue Patía (El Bordo), Miranda y Piamonte del departamento del Cauca, con el fin de examinar cómo influye la productividad de pupas, entre índices entomológicos, en la densidad de mosquitos adultos y otros patrones espaciales y temporales. Ae. aegypti , sus índices entomológicos y su caracterización espacial. Los resultados sugieren que, para las especies de Ae. aegypti , la productividad de pupas genera altas densidades de adultos en las viviendas vecinas, evidenciando un comportamiento estacional.Estos resultados son de gran importancia ya que proporciona una estrategia innovadora para la mitigación de enfermedades transmitidas por vectores utilizando patrones espaciales de los vectores y su asociación con indicadores entomológicos y lugares de cría en barrios de alto riesgo para la transmisión del dengue

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

First low-frequency Einstein@Home all-sky search for continuous gravitational waves in Advanced LIGO data

We report results of a deep all-sky search for periodic gravitational waves from isolated neutron stars in data from the first Advanced LIGO observing run. This search investigates the low frequency range of Advanced LIGO data, between 20 and 100 Hz, much of which was not explored in initial LIGO. The search was made possible by the computing power provided by the volunteers of the Einstein@Home project. We find no significant signal candidate and set the most stringent upper limits to date on the amplitude of gravitational wave signals from the target population, corresponding to a sensitivity depth of 48.7 [1/root Hz]. At the frequency of best strain sensitivity, near 100 Hz, we set 90% confidence upper limits of 1.8 x 10(-25). At the low end of our frequency range, 20 Hz, we achieve upper limits of 3.9 x 10(-24). At 55 Hz we can exclude sources with ellipticities greater than 10(-5) within 100 pc of Earth with fiducial value of the principal moment of inertia of 10(38) kg m(2)

Search for intermediate mass black hole binaries in the first observing run of Advanced LIGO

During their first observational run, the two Advanced LIGO detectors attained an unprecedented sensitivity, resulting in the first direct detections of gravitational-wave signals produced by stellar-mass binary black hole systems. This paper reports on an all-sky search for gravitational waves (GWs) from merging intermediate mass black hole binaries (IMBHBs). The combined results from two independent search techniques were used in this study: the first employs a matched-filter algorithm that uses a bank of filters covering the GW signal parameter space, while the second is a generic search for GW transients (bursts). No GWs from IMBHBs were detected; therefore, we constrain the rate of several classes of IMBHB mergers. The most stringent limit is obtained for black holes of individual mass 100 M ⊙, with spins aligned with the binary orbital angular momentum. For such systems, the merger rate is constrained to be less than 0.93 Gpc−3yr−1 in comoving units at the 90% confidence level, an improvement of nearly 2 orders of magnitude over previous upper limits

Does the El Niño-Southern Oscillation Affect the Combined Impact of the Atlantic Multidecadal Oscillation and Pacific Decadal Oscillation on the Precipitation and Surface Air Temperature Variability over South America?

Previous studies have shown that the Atlantic Multidecadal Oscillation (AMO) and Pacific Decadal Oscillation (PDO) have combined effects on the precipitation (PRP) variability over South America. The combined impacts have been assessed considering four mean states as the averages of the variable anomalies during sub-periods overlapping time intervals of the PDO and AMO phases. Since these sub-periods include years under El Niño-Southern Oscillation (ENSO) extremes, the extent to which these years’ occurrence affects the averaged anomaly patterns during different mean states is investigated. The analyses are done for the PRP and surface air temperature (SAT) during the austral winter (June to August) and summer (December to February) of the 1901–2014 period using a composite technique. The nonlinear ENSO response in each mean state for a variable corresponds to the sum of the anomaly composites of the El Niño and La Niña events. In each mean state, the nonlinear PRP and SAT anomalies are not negligible and show similar patterns of the corresponding mean state, with larger magnitudes. For both seasons and all mean states, these similarities are more pronounced for SAT than for PRP. Thus, the ENSO variability affects the mean state’s PRP and SAT anomaly patterns in different ways. As far as we know, analyses of the nonlinear ENSO response of the South American climate during distinct mean states were not performed before. Our results also indicate that the ENSO variability should be considered in the studies of the low-frequency modes and their effects on the mean state over South America. The results presented could be relevant for climate monitoring and modeling studies.Incluye referencias bibliográfica

Evaluation of extreme precipitation climate indices and their projected changes for Brazil: From CMIP3 to CMIP6

Extreme events usually cause numerous economic and social losses, especially in vulnerable countries, such as Brazil. Understanding whether the evolution of Earth System Models (ESMs) from Coupled Model Intercomparison Project (CMIP) improves the representation of extreme events and investigating their future change is fundamental because device policies of adaptation and mitigation to climate change generally consider the results of the most recent generation of ESMs. This study analyzes the performance of a subset of 40 ESMs from CMIP3, CMIP5, and CMIP6 in simulating eight extreme precipitation climate indices over Brazil during 1981–2000 and also estimates their projected changes for the middle (2046–2065) and far future (2081–2 100) under the worst-case scenario for each CMIP generation. Results reveal that CDD are the most challenging precipitation index to be simulated, while the best ones were PRCPTOT and R20mm. The model performance shows that CMIP3 has the best skill for Northeast Brazil, CMIP5 for Center-West, and CMIP6 for North, Southeast and South regions. Thus, at least for Brazil, the evolution of the ESMs from CMIP did not reflect a substantial improvement in the representation of precipitation climate extremes over all Brazilian regions. In addition, all the models across CMIP generations have difficulty in simulating the observed trends. This indicate that improvements are still needed in CMIP models. Despite the relative low performance in the historical climate, the climate projections indicate a consensus signal among most of precipitation climate extremes and CMIP generations, which increase its reliability. Overall, the extreme precipitation events are projected to be more severe, frequent, and long-lasting in all Brazilian regions, with the more pronounce changes expected in heavy rainfall and severe droughts in the central northern portion of Brazil and in the southern sectorIncluye referencias bibliográfica

Nonstationary extreme precipitation in Brazil

This study provides the first estimates of the frequency distribution of observational and future maximum daily precipitation considering nonstationarity for the entire Brazilian territory. We assess observational data from 1980 to 2015 and projected data from 2020 to 2099 for two climate change scenarios and four downscaled climate models. We modelled extreme precipitation according to the extreme values theory and calculated the precipitation intensity associated with the return periods of 5, 10, 25, 50, and 100 years in nonstationary conditions. The results indicate that nonstationarity is identified in 17.5% of the study area during 1980–2015. The analysis of future climate projections indicated an increase in the return levels of extreme precipitation compared to the historical period in at least 90% of the national territory. It shows that engineering design must urgently consider the nonstationarity of extreme precipitation under the risk of increasingly unsafe infrastructure.Incluye referencias bibliográficas

Climate extremes and their impacts on agriculture across the Eastern Corn Belt Region of the U.S.

The Eastern Corn Belt Region (ECBR) is an important agricultural sector for the U.S. This study analyzes the climate extremes over the contemporary (1980–2018) and future (2036–2099) periods over the ECBR. We evaluated the performance of 32 downscaled models from the U.S. Global Change Research Program's Localized Constructed Analogs (LOCA) of the Coupled Model Intercomparison Project (CMIP5) to simulate extreme temperature and precipitation indices. The LOCA downscaled models were evaluated for the recent past against the National Aeronautics and Space Administration (NASA)-supported gridded observational dataset DAYMET. Results reveal key trends throughout the region that are consistent with previous studies, including significant increases in extreme minimum temperatures, reduction of cold nights, increase of warm nights, and decreases in diurnal temperature ranges. Much of the region demonstrates extreme warming trends in the coldest night of the year (more than 5 °C) and an increase in the heaviest precipitation events over 1980–2018. An optimal model ensemble (OME) was constructed using a Kling-Gupta Efficiency and Bhattacharyya coefficient evaluation to construct a comprehensive ranking procedure. Having outperformed a standard multi-model ensemble approach, the OME was used to evaluate the future changes of extreme climate indices under RCP4.5 and RCP8.5 scenarios. Though the OME showed consistently strong warming throughout the ECBR, variability among the optimal models and across watersheds is quite significant, especially for precipitation indices. Thus, constraining the uncertainty in future climate models, specifically as it relates to agriculture decisions that support climate-resilience, remains a challenge.Inlcuye referencias bibliográficas

Daily dataset of precipitation and temperature in the Department of Cauca, Colombia

This study used the geostatistical Kriging methodology to reduce the spatial scale of a host of daily meteorological variables in the Department of Cauca (Colombia), namely, total precipitation and maximum, minimum, and average temperature. The objective was to supply a high-resolution database from 01/01/2015 to 31/12/2021 in order to support the climate component in a project led by the National Institute of Health (INS) named “Spatial Stratification of dengue based on the identification of risk factors: a pilot study in the Department of Cauca”. The scaling process was applied to available databases from satellite information and reanalysis sources, specifically, CHIRPS (Climate Hazards Group InfraRed Precipitation with Station Data), ERA5-Land (European Centre for Medium-Range Weather Forecasts), and MSWX (Multi-Source Weather). The 0.1° resolution offered by both the MSWX and ERA5-Land databases and the 0.05° resolution found in CHIRPS, was successfully reduced to a scale of 0.01° across all variables. Statistical metrics such as Root Mean Squared Error (RMSE), Mean Absolute Error (MAE), Person Correlation Coefficient (r), and Mean Bias Error (MBE) were used to select the database that best estimated each variable. As a result, it was determined that the scaled ERA5-Land database yielded the best performance for precipitation and minimum daily temperature. On the other hand, the scaled MSWX database showed the best behavior for the other two variables of maximum temperature and daily average temperature. Additionally, using the scaled meteorological databases improved the performance of the regression models implemented by the INS for constructing a dengue early warning system