COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Cooperation INRA-JNICT. Secteur Productions Animales. Resumes des interventions. Tableaux synoptiques des cooperations. Liste des participants.

*INRA, Station d'Hydrobiologie, Saint Pee sur Nivelle (FRA) Diffusion du document : INRA, Station d'Hydrobiologie, Saint Pee sur Nivelle (FRA)National audienc

Minéralogie, pétrographie et géochimie des laves spilitiques et des filons basiques associés du massif des Ecrins-Pelvoux (Alpes françaises occidentales)

Les laves spilitiques triasiques et les filons basiques du massif des Ecrins-Pelvoux sont étudiées sous l'aspect minéralogique , géochimiques. Les relations entre le volcanisme effusif triasique et l'ensemble dolérito-spilitique intrusif sont étudiées.Pas de résum

Origin and 10Be surface exposure dating of a coarse debris accumulation in the Hrubý Jeseník Mountains, Central Europe

International audienceCoarse debris accumulations cover large areas in high latitude and mountain environments, but their age and origin remain mostly unknown. Here we reassess the morphology of a prominent coarse debris accumulation in the Sudetes Mountain range in central Europe and constrain its timing with 10Be surface exposure data. Our observations indicate that the landform in the south-eastern slope of the Suť ridge appears consistent with the morphology of a block slope. The oldest minimum age of 150.1 ± 4.8 ka obtained for the tor at the upper limit of the block slope indicates the disintegration of the ridge and surface lowering under periglacial conditions prior to the last glacial-interglacial cycle. Four exposure ages retrieved for block samples range from 84.3 ± 3.8 to 26.8 ± 2.6 ka, providing evidence for block emplacement during the last cold period. The exposure ages extend existing chronological dataset for peri/glacial landforms in the Sudetes and constrain the timing of cold environments in the area prior the Last Glacial Maximum. The ages are also consistent with surface exposure data reported for block fields and block slopes in Western Europe and confirm the formation of similar landforms over the last glacial period in the Sudetes

Dissolved and Particulate Beryllium Isotopes in the Pearl River Estuary:Their Geochemical Behavior in Estuarine Water and PotentialContributions From Anthropogenic Sources

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Towards successful cleaning of chert samples for improved 10Be and 26Al measurements

International audienceIn situ-produced cosmogenic Be-10 and Al-26 measurements are widely applied in geomorphological studies and in archaeology and paleoanthropology as a chronologic tool applicable to the past 5 Ma. While most of these measurements are made from concentrates of quartz, a ubiquitous and resistant mineral, it is of great interest to extend this method to other silicates and particularly to the amorphous silicates whose purification may not be as straightforward. This paper presents a cleaning procedure that has been applied on ten samples of various siliceous rocks (chert, granite and quartzolite). The aim is to monitor the Be-10, Al-27 and Al-26 concentration evolution as a function of cleaning steps. While this protocol appears suitable for Be-10, when measuring Al-26 careful attention should be paid to Al-27, whose concentration should be measured regularly to ensure that a constant value is achieved and most important, allowing measuring Al-26/Al-27 by AMS

Steady erosion rates in the Himalayas through late Cenozoic climatic changes

International audienceSediment accumulation rates and thermal trackers suggest a substantial and global increase in erosion rates over the last few million years. That increase is commonly associated with the impact of the Northern Hemisphere glaciation, but methodological biases have led researchers to debate this hypothesis. Here, we test whether Himalayan erosion rates increased by measuring beryllium 10 (10Be) in the sediment of the Bengal Bay seabed. Sediment originated from rocks that produced 10Be under the impact of cosmic rays during erosion near surface. Thus, the 10Be concentrations tell erosion rates. The 10Be concentration of the Bengal Bay sediment depends on the contributions of the Ganga and Brahmaputra Rivers. Their sediments have distinct 10Be concentrations because of distinct elevations and erosion in their drainage basins. Variable contributions could thus complicate erosion rate calculation. We traced these contributions by a provenance study using the Sr and Nd isotopic sediment compositions. Within uncertainties of ±30%, our reconstructed past erosion rates show no long-term increase for the last six million years. This stability suggests that climatic changes during the late Cenozoic have an undetectable impact on the erosion patterns in the Himalayas, at least on the ten-thousand to million-year timescales accounted for by our dataset

Sediment sources and transport by the Kahiltna Glacier and other catchments along the south side of the Alaska Range, Alaska

International audienceErosion related to glacial activity produces enormous amounts of sediment. However, sediment mobilization in glacial systems is extremely complex. Sediment is derived from headwalls, slopes along the margins of glaciers, and basal erosion; however, the rates and relative contributions of each are unknown. To test and quantify conceptual models for sediment generation and transport in a simple valley glacier system, we collected samples for 10 Be analysis from the Kahiltna Glacier, which flows off Denali, the tallest mountain in North America. We collected angular quartz clasts on bedrock ledges from a high mountainside above the equilibrium line altitude (ELA), amalgamated clast samples from medial moraines, and sand samples from the river below the glacier. We also collected sand from nine other rivers along the south flank of the Alaska Range. In the upper catchment of the Kahiltna drainage system, toppling, rockfall, and slab collapse are significant erosional processes. Erosion rates of hundreds of millimeters per thousand years were calculated from 10 Be concentrations. The 10 Be concentrations in amalgamated samples from medial moraines showed concentrations much lower than those measured from the high mountainside, a result of the incorporation of thick, and effectively unexposed, blocks into the moraine, as well as the incorporation of material from lower-elevation nearby slopes above the moraines. The 10 Be sediment samples from downstream of the Kahiltna Glacier terminus showed decreasing concentrations with increasing distance from the moraine, indicating the incorporation of material that was less exposed to cosmic rays, most likely from the glacier base as well as from slopes downstream of the glacier. Taken together, 10 Be concentrations in various samples from the Kahiltna drainage system indicated erosion rates of hundreds of millimeters per thousand years, which is typical of tectonically active terrains. We also measured 10 Be concentrations from river sediment samples collected from across the south flank of the Alaska Range. Calculation of basinwide weighted erosion rates that incorporated hypsometric curves produced unrealistically high erosion rates, which indicates that the major source of sediment was not exposed to cosmic rays and was primarily derived from the base of glaciers. Moreover, the apparently high erosion rates suggest that parts of each drainage system are not in erosional steady state with respect to cosmogenic isotope accumulation