COVID-19 in adult acute myeloid leukemia patients: a long-term follow-up study from the European Hematology Association survey (EPICOVIDEHA)

Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients diagnosed with COVID-19 between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the preceding 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with better survival when AML treatment could be delayed (80%; P<0.001). Overall survival in patients with a diagnosis of COVID-19 between January 2020 and August 2020 was significantly lower than that in patients diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs. 60% vs. 61.9%, respectively; P=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible

Molecular taxonomic analysis of the plant associations of adult pollen beetles (Nitidulidae: Meligethinae), and the population structure of Brassicogethes aeneus

Pollen beetles (Nitidulidae: Meligethinae) are among the most abundant flower-visiting insects in Europe. While some species damage millions of hectares of crops annually, the biology of many species is little known. We assessed the utility of a 797 base pair fragment of the cytochrome oxidase 1 gene to resolve molecular operational taxonomic units (MOTUs) in 750 adult pollen beetles sampled from flowers of 63 plant species sampled across the UK and continental Europe. We used the same locus to analyse region-scale patterns in population structure and demography in an economically important pest, Brassicogethes aeneus. We identified 44 Meligethinae at ∼2% divergence, 35 of which contained published sequences. A few specimens could not be identified because the MOTUs containing them included published sequences for multiple Linnaean species, suggesting either retention of ancestral haplotype polymorphism or identification errors in published sequences. Over 90% of UK specimens were identifiable as B. aeneus. Plant associations of adult B. aeneus were found to be far wider taxonomically than for their larvae. UK B. aeneus populations showed contrasting affiliations between the north (most similar to Scandinavia and the Baltic) and south (most similar to western continental Europe), with strong signatures of population growth in the south

Taxonomy based on science is necessary for global conservation

Peer reviewe

Village des sciences Lifou 2023

International audienc

Raise public awareness on the importance of mangroves

International audienceImplement conservation strategies to ensure sustainable protection. Promote sustainable practices that depend on the mangroves. Identify the needs of mangrove stakeholders and guide them towards these needs

Versatile Access to N-Functionalized Iminosydnones by Carbonylimidazolium Activation

International audienceA new methodology for N-exocyclic functionalization of iminosydnones was developed involving the addition of a large variety of nucleophiles on carbonyl-imidazolium activated iminosydnones. This practical and highly versatile method pro-vided access to new classes of iminosydnones and opened a straight-forward synthetic route to prepare iminosydnone-based prodrugs

A practical synthesis of valuable strained 8-membered ring derivatives for click chemistry

International audienceA convenient and cost-effective synthetic access to cyclooctyne and trans-cyclooctene derivatives is described. A cyclopropanation step using copper powder in lieu of Rh₂(OAc)₄ as catalyst and a symmetric diazomalonate enabled to drastically reduce the overall cost of the synthesis. Further derivatizations allowed to characterize, for the first time, the structure of a BCN analogue by X-ray crystallography and obtain a library of derivatives potentially useful for applications in metal free click chemistry

EVOLUTION OF THE LAKES NETWORK OF CURUAI FLOODPLAIN BY CLASSIFICATION OF RADAR ALTIMETRY ECHOES

International audienc

Pyridine-based Strategy towards Nitrogen Isotope Exchange

Isotopic labeling is at the core of health and life science applications such as nuclear imaging, pharmacokinetics and bio-distribution studies and plays a central role in drug development. The rapid access to isotopically labeled organic molecules is a sine qua non condition to support these societally vital areas of research. Despite the relevance of pyridine as a biologically active scaffold, the nitrogen-13 labeling of this scaffold remains elusive and an almost prohibited challenge for radio-labelling (+ emitter, T1/2 9.97 min), despite its relevance in positron emission tomography. Based on a rationally driven approach, this study presents an innovative solution to access labeled pyridines by a nitrogen isotope exchange reaction based on a Zincke activation strategy. The technology conceptualizes a new opportunity in the field of nitrogen isotope labeling. 15N-labeling of pyridine and other heterocycles such as pyrimidines and isoquinolines was provided on a large set of derivatives including structurally elaborated pharmaceuticals. Using [13N]NH3 as the primary nitrogen-13 source, proof-of-concept was provided to achieve examples of 13N-labeling of pyridines. We believe this method will play a fundamental role for future developments of 13N-based PET radiotracers

Synthesis of Sydnonimines from Sydnones and their use for bioorthogonal release of isocyanates in cells

International audienceIn this article, we report the synthesis of sydnonimines fromsydnones and their use as dipoles for fast click-and-releasereactions. The process relies on nucleophilic aromaticsubstitution of aliphatic and aromatic amines with triflatedsydnones. This new methodology allowed the preparation offunctionalised sydnonimines probes otherwise difficult toprepare. Those probes were then used to release a drug and afluorescent aromatic isocyanate inside living cell