INTEGRAL broadband spectroscopy of Vela X-1

The wind-accreting X-ray binary pulsar and cyclotron line source Vela X-1 has been observed extensively during INTEGRAL Core Program observations of the Vela region in June-July and November-December 2003. In the latter set of observations the source showed intense flaring -- see also Staubert et al. (2004), these proceedings. We present early results on time averaged and time resolved spectra, of both epochs of observations. A cyclotron line feature at ~53 keV is clearly detected in the INTEGRAL spectra and its broad shape is resolved in SPI spectra. The remaining issues in the calibration of the instruments do not allow to resolve the question of the disputed line feature at 20-25 keV. During the first main flare the average luminosity increases by a factor of \~10, but the spectral shape remains very similar, except for a moderate softening.Comment: Accepted for proceedings of 5th INTEGRAL Worksho

EIS/Hinode observations of Doppler flow seen through the 40 arcsec wide slit

The Extreme ultraviolet Imaging Spectrometer (EIS) on board Hinode is the first solar telescope to obtain wide slit spectral images that can be used for detecting Doppler flows in transition region and coronal lines on the Sun and to relate them to their surrounding small scale dynamics. We select EIS lines covering the temperature range 6x10^4 K to 2x10^6 K that give spectrally pure images of the Sun with the 40 arcsec slit. In these images Doppler shifts are seen as horizontal brightenings. Inside the image it is difficult to distinguish shifts from horizontal structures but emission beyond the image edge can be unambiguously identified as a line shift in several lines separated from others on their blue or red side by more than the width of the spectrometer slit (40 pixels). In the blue wing of He II, we find a large number of events with properties (size and lifetime) similar to the well-studied explosive events seen in the ultraviolet spectral range. Comparison with X-Ray Telescope (XRT) images shows many Doppler shift events at the footpoints of small X-ray loops. The most spectacular event observed showed a strong blue shift in transition region and lower corona lines from a small X-ray spot that lasted less than 7 min. The emission appears to be near a cool coronal loop connecting an X-ray bright point to an adjacent region of quiet Sun. The width of the emission implies a line-of-sight velocity of 220 km/s. In addition, we show an example of an Fe XV shift with a velocity about 120 km/s, coming from what looks like a narrow loop leg connecting a small X-ray brightening to a larger region of X-ray emission.Comment: 12 pages, 8 figures, to be published in Solar Physic

Luspatercept improves hemoglobin levels and blood transfusion requirements in a study of patients with b-thalassemia

b-thalassemia is a hereditary disorder with limited approved treatment options; patients experience anemia and its complications, including iron overload. The study aim was to determine whether luspatercept could improve anemia and disease complications in patients with b-thalassemia. This open-label, nonrandomized, uncontrolled study consisted of a 24-week dose-finding and expansion stage (initial stage) and a 5-year extension stage, currently ongoing. Sixty-four patients were enrolled; 33 were non\u2013transfusion dependent (mean hemoglobin, <10.0 g/dL; <4 red blood cell [RBC] units transfused per 8 weeks), and 31 were transfusion dependent (\u20214 RBC units per 8 weeks). Patients received 0.2 to 1.25 mg/kg luspatercept subcutaneously every 21 days for \u20215 cycles (dose-finding stage) and 0.8 to 1.25 mg/kg (expansion cohort and 5-year extension). The primary end point was erythroid response, defined as hemoglobin increase of \u20211.5 g/dL from baseline for \u202114 consecutive days (without RBC transfusions) for non\u2013transfusion-dependent patients or RBC transfusion burden reduction \u202120% over a 12-week period vs the 12 weeks before treatment for transfusion-dependent patients. Eighteen non\u2013transfusion-dependent patients (58%) receiving higher dose levels of luspatercept (0.6-1.25 mg/kg) achieved mean hemoglobin increase \u20211.5 g/dL over \u202114 days vs baseline. Twenty-six (81%) transfusion-dependent patients achieved \u202120% reduction in RBC transfusion burden. The most common grade 1 to 2 adverse events were bone pain, headache, and myalgia. As of the cutoff, 33 patients remain on study. In this study, a high percentage of b-thalassemia patients receiving luspatercept had hemoglobin or transfusion burden improvements. These findings support a randomized clinical trial to assess efficacy and safety. This study was registered at www.clinicaltrials.gov as #NCT01749540 and #NCT02268409

SPI observations of the diffuse 60Fe emission in the Galaxy

Gamma-ray line emission from radioactive decay of 60Fe provides constraints on nucleosynthesis in massive stars and supernovae. The spectrometer SPI on board INTEGRAL has accumulated nearly three years of data on gamma-ray emission from the Galactic plane. We have analyzed these data with suitable instrumental-background models and sky distributions to produce high-resolution spectra of Galactic emission. We detect the gamma-ray lines from 60Fe decay at 1173 and 1333 keV, obtaining an improvement over our earlier measurement of both lines with now 4.9 sigma significance for the combination of the two lines. The average flux per line is (4.4 \pm 0.9) \times 10^{-5} ph cm^{-2} s^{-1} rad^{-1} for the inner Galaxy region. Deriving the Galactic 26Al gamma-ray line flux with using the same set of observations and analysis method, we determine the flux ratio of 60Fe/26Al gamma-rays as 0.148 \pm 0.06. The current theoretical predictions are still consistent with our result.Comment: 10 pages, 7 figures, 2 tables, A&A in pres

Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study

Objectives To validate the clinical efficacy and practical feasibility of massively parallel maternal plasma DNA sequencing to screen for fetal trisomy 21 among high risk pregnancies clinically indicated for amniocentesis or chorionic villus sampling

Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts

Aims: Fibroblast growth factor 21 (FGF21) is a hepatic metabolic regulator with pleotropic actions. Its plasma concentrations are increased in obesity and diabetes; states associated with an increased incidence of cardiovascular disease. We therefore investigated the direct effect of FGF21 on cardio-protection in obese and lean hearts in response to ischemia. Methods and Results: FGF21, FGF21-receptor 1 (FGFR1) and beta-Klotho (βKlotho) were expressed in rodent, human hearts and primary rat cardiomyocytes. Cardiac FGF21 was expressed and secreted (real time RT-PCR/western blot and ELISA) in an autocrine-paracrine manner, in response to obesity and hypoxia, involving FGFR1-βKlotho components. Cardiac-FGF21 expression and secretion were increased in response to global ischemia. In contrast βKlotho was reduced in obese hearts. In isolated adult rat cardiomyocytes, FGF21 activated PI3K/Akt (phosphatidylinositol 3-kinase/Akt), ERK1/2(extracellular signal-regulated kinase) and AMPK (AMP-activated protein kinase) pathways. In Langendorff perfused rat [adult male wild-type wistar] hearts, FGF21 administration induced significant cardio-protection and restoration of function following global ischemia. Inhibition of PI3K/Akt, AMPK, ERK1/2 and ROR-α (retinoic-acid receptor alpha) pathway led to significant decrease of FGF21 induced cardio-protection and restoration of cardiac function in response to global ischemia. More importantly, this cardio-protective response induced by FGF21 was reduced in obesity, although the cardiac expression profiles and circulating FGF21 levels were increased. Conclusion: In an ex vivo Langendorff system, we show that FGF21 induced cardiac protection and restoration of cardiac function involving autocrine-paracrine pathways, with reduced effect in obesity. Collectively, our findings provide novel insights into FGF21-induced cardiac effects in obesity and ischemia

Infrastructure for Detector Research and Development towards the International Linear Collider

The EUDET-project was launched to create an infrastructure for developing and testing new and advanced detector technologies to be used at a future linear collider. The aim was to make possible experimentation and analysis of data for institutes, which otherwise could not be realized due to lack of resources. The infrastructure comprised an analysis and software network, and instrumentation infrastructures for tracking detectors as well as for calorimetry.Comment: 54 pages, 48 picture

A geostationary thermal infrared sensor to monitor the lowermost troposphere: O₃ and CO retrieval studies

This paper describes the capabilities of a nadir thermal infrared (TIR) sensor proposed for deployment onboard a geostationary platform to monitor ozone (O3) and carbon monoxide (CO) for air quality (AQ) purposes. To assess the capabilities of this sensor we perform idealized retrieval studies considering typical atmospheric profiles of O3 and CO over Europe with different instrument configuration (signal to noise ratio, SNR, and spectral sampling interval, SSI) using the KOPRA forward model and the KOPRA-fit retrieval scheme. We then select a configuration, referred to as GEO-TIR, optimized for providing information in the lowermost troposphere (LmT; 0–3 km in height). For the GEO-TIR configuration we obtain ~1.5 degrees of freedom for O3 and ~2 for CO at altitudes between 0 and 15 km. The error budget of GEO-TIR, calculated using the principal contributions to the error (namely, temperature, measurement error, smoothing error) shows that information in the LmT can be achieved by GEO-TIR. We also retrieve analogous profiles from another geostationary infrared instrument with SNR and SSI similar to the Meteosat Third Generation Infrared Sounder (MTG-IRS) which is dedicated to numerical weather prediction, referred to as GEO-TIR2. We quantify the added value of GEO-TIR over GEO-TIR2 for a realistic atmosphere, simulated using the chemistry transport model MOCAGE (MOd`ele de Chimie Atmospherique `a Grande Echelle). Results show that GEO-TIR is able to capture well the spatial and temporal variability in the LmT for both O3 and CO. These results also provide evidence of the significant added value in the LmT of GEO-TIR compared to GEO-TIR2 by showing GEO-TIR is closer to MOCAGE than GEO-TIR2 for various statistical parameters (correlation, bias, standard deviation)