Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study

Chiu, Rossa W K; Akolekar, Ranjit; Zheng, Yama W L; Leung, Tak Y; Sun, Hao; Chan, K C Allen; Lun, Fiona M F; Go, Attie T J I; Lau, Elizabeth T; To, William W K; Leung, Wing C; Tang, Rebecca Y K; Au-Yeung, Sidney K C; Lam, Helena; Kung, Yu Y; Zhang, Xiuqing; van Vugt, John M G; Minekawa, Ryoko; Tang, Mary H Y; Wang, Jun; Oudejans, Cees B M; Lau, Tze K; Nicolaides, Kypros H; Lo, Y M Dennis

Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study

Authors: Rossa W K Chiu
Ranjit Akolekar
Yama W L Zheng
Tak Y Leung
Hao Sun
K C Allen Chan
Fiona M F Lun
Attie T J I Go
Elizabeth T Lau
William W K To
Wing C Leung
Rebecca Y K Tang
Sidney K C Au-Yeung
Helena Lam
Yu Y Kung
Xiuqing Zhang
John M G van Vugt
Ryoko Minekawa
Mary H Y Tang
Jun Wang
Cees B M Oudejans
Tze K Lau
Kypros H Nicolaides
Y M Dennis Lo
Publication date: 1 January 2008
Publisher: BMJ Publishing Group Ltd.
Doi

Abstract

Objectives To validate the clinical efficacy and practical feasibility of massively parallel maternal plasma DNA sequencing to screen for fetal trisomy 21 among high risk pregnancies clinically indicated for amniocentesis or chorionic villus sampling