395 research outputs found
Lattice Kinetics of Diffusion-Limited Coalescence and Annihilation with Sources
We study the 1D kinetics of diffusion-limited coalescence and annihilation
with back reactions and different kinds of particle input. By considering the
changes in occupation and parity of a given interval, we derive sets of
hierarchical equations from which exact expressions for the lattice coverage
and the particle concentration can be obtained. We compare the mean-field
approximation and the continuum approximation to the exact solutions and we
discuss their regime of validity.Comment: 24 pages and 3 eps figures, Revtex, accepted for publication in J.
Phys.
Aliskiren, enalapril, or aliskiren and enalapril in heart failure
BACKGROUND
Among patients with chronic heart failure, angiotensin-converting–enzyme (ACE)
inhibitors reduce mortality and hospitalization, but the role of a renin inhibitor in
such patients is unknown. We compared the ACE inhibitor enalapril with the renin
inhibitor aliskiren (to test superiority or at least noninferiority) and with the combination
of the two treatments (to test superiority) in patients with heart failure
and a reduced ejection fraction.
METHODS
After a single-blind run-in period, we assigned patients, in a double-blind fashion,
to one of three groups: 2336 patients were assigned to receive enalapril at a dose
of 5 or 10 mg twice daily, 2340 to receive aliskiren at a dose of 300 mg once
daily, and 2340 to receive both treatments (combination therapy). The primary
composite outcome was death from cardiovascular causes or hospitalization for
heart failure.
RESULTS
After a median follow-up of 36.6 months, the primary outcome occurred in 770
patients (32.9%) in the combination-therapy group and in 808 (34.6%) in the
enalapril group (hazard ratio, 0.93; 95% confidence interval [CI], 0.85 to 1.03). The
primary outcome occurred in 791 patients (33.8%) in the aliskiren group (hazard
ratio vs. enalapril, 0.99; 95% CI, 0.90 to 1.10); the prespecified test for noninferiority
was not met. There was a higher risk of hypotensive symptoms in the combination-therapy
group than in the enalapril group (13.8% vs. 11.0%, P=0.005), as
well as higher risks of an elevated serum creatinine level (4.1% vs. 2.7%, P=0.009)
and an elevated potassium level (17.1% vs. 12.5%, P<0.001).
CONCLUSIONS
In patients with chronic heart failure, the addition of aliskiren to enalapril led to
more adverse events without an increase in benefit. Noninferiority was not shown
for aliskiren as compared with enalapri
Investigation of initiation of gigantic jets connecting thunderclouds to the ionosphere
The initiation of giant electrical discharges called as "gigantic jets"
connecting thunderclouds to the ionosphere is investigated by numerical
simulation method in this paper. Using similarity relations, the triggering
conditions of streamer formation in laboratory situations are extended to form
a criterion of initiation of gigantic jets. The energy source causing a
gigantic jet is considered due to the quasi-electrostatic field generated by
thunderclouds. The electron dynamics from ionization threshold to streamer
initiation are simulated by the Monte Carlo technique. It is found that
gigantic jets are initiated at a height of ~18-24 km. This is in agreement with
the observations. The method presented in this paper could be also applied to
the analysis of the initiation of other discharges such as blue jets and red
sprites.Comment: 12th International Congress on Plasma Physics, 25-29 October 2004,
Nice (France
First Results from Fermi GBM Earth Occultation Monitoring: Observations of Soft Gamma-Ray Sources Above 100 keV
The NaI and BGO detectors on the Gamma-ray Burst Monitor (GBM) on Fermi are
now being used for long-term monitoring of the hard X-ray/low energy gamma-ray
sky. Using the Earth occultation technique as demonstrated previously by the
BATSE instrument on the Compton Gamma-Ray Observatory, GBM can be used to
produce multiband light curves and spectra for known sources and transient
outbursts in the 8 keV to 1 MeV energy range with its NaI detectors and up to
40 MeV with its BGO detectors. Over 85% of the sky is viewed every orbit, and
the precession of the Fermi orbit allows the entire sky to be viewed every ~26
days with sensitivity exceeding that of BATSE at energies below ~25 keV and
above ~1.5 MeV. We briefly describe the technique and present preliminary
results using the NaI detectors after the first two years of observations at
energies above 100 keV. Eight sources are detected with a significance greater
than 7 sigma: the Crab, Cyg X-1, SWIFT J1753.5-0127, 1E 1740-29, Cen A, GRS
1915+105, and the transient sources XTE J1752-223 and GX 339-4. Two of the
sources, the Crab and Cyg X-1, have also been detected above 300 keV.Comment: 13 pages, 9 figures, submitted to Ap
Abiotic factors influencing biomass accumulation of green tide causing Ulva spp. on Pyropia culture rafts in the Yellow Sea, China
Annually recurrent green-tides in the Yellow Sea have been shown to result from direct disposal into the sea of fouling Ulva from Pyropia aquaculture. The role abiotic factors play in Ulva biomass accumulation on rafts was studied to find ways to mitigate this problem. Dissolved inorganic nitrogen (DIN) was very high at all sites, but the highest Ulva biomass was associated with the lowest DIN and anthropogenic N. Under luxuriant background nutrient conditions, variability in temperature and periods of emersion, rather than pH, light and salinity determined Ulva biomass. Two dominant species of Ulva displayed differing tolerances to temperature and desiccation which helped explain why Ulva prolifera dominates floating green-tides. Rather than trying to mitigate green tides only by reducing nutrient pollution, an earlier harvest of Pyropia in southern Jiangsu Province especially before temperatures increase greatly above 10 degrees C during April, could reduce the biomass of U. prolifera disposed from rafts. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved
Translated from Izvestiya An. Fizika atmosferi i Okeana
Abstract-An efficient technique for solving an inverse problem of remote sensing of atmospheric ozone at millimeter radio waves is described. The technique is based on an iteration scheme in which Tikhonov's method in the form of the principle of generalized residual is used at each step. A significant advantage of the method lies in the association of the regularization parameter and in the degree of smoothness of the solution with the total effective error. To increase the accuracy of the inverse-problem solution, a difference version of the technique is used. For this version of the technique based on data of thermal radio radiation of ozone molecules, the relative spectral behavior of brightness temperatures, but not their absolute values, are significant. Results of a numerical experiment modeling of ground-based atmospheric ozone observations within the spectral band centered at 142.2 GHz are given. Actual parameters, such as noise, operating frequencies, and spectra! resolution of the ozonometric instruments at the Lebedev Institute of Physics arc considered in computations. Results of the application of this technique to ozone observational data obtained in early 1996 over the Moscow region are given. The proposed method extends a class of problems, related to ecology and atmospheric physics, solvable with millimeter-wave-radiophysics methods
Nearfield Summary and Statistical Analysis of the Second AIAA Sonic Boom Prediction Workshop
A summary is provided for the Second AIAA Sonic Boom Workshop held 8-9 January 2017 in conjunction with AIAA SciTech 2017. The workshop used three required models of increasing complexity: an axisymmetric body, a wing body, and a complete configuration with flow-through nacelle. An optional complete configuration with propulsion boundary conditions is also provided. These models are designed with similar nearfield signatures to isolate geometry and shock/expansion interaction effects. Eleven international participant groups submitted nearfield signatures with forces, pitching moment, and iterative convergence norms. Statistics and grid convergence of these nearfield signatures are presented. These submissions are propagated to the ground, and noise levels are computed. This allows the grid convergence and the statistical distribution of a noise level to be computed. While progress is documented since the first workshop, improvement to the analysis methods for a possible subsequent workshop are provided. The complete configuration with flow-through nacelle showed the most dramatic improvement between the two workshops. The current workshop cases are more relevant to vehicles with lower loudness and have the potential for lower annoyance than the first workshop cases. The models for this workshop with quieter ground noise levels than the first workshop exposed weaknesses in analysis, particularly in convective discretization
Detecting planetary geochemical cycles on exoplanets: Atmospheric signatures and the case of SO2
We study the spectrum of a planetary atmosphere to derive detectable features
in low resolution of different global geochemical cycles on exoplanets - using
the sulphur cycle as our example. We derive low resolution detectable features
for first generation space- and ground- based telescopes as a first step in
comparative planetology. We assume that the surfaces and atmospheres of
terrestrial exoplanets (Earth-like and super-Earths) will most often be
dominated by a specific geochemical cycle. Here we concentrate on the sulphur
cycle driven by outgassing of SO2 and H2S followed by their transformation to
other sulphur-bearing species which is clearly distinguishable from the carbon
cycle which is driven by outgassing of CO2. Due to increased volcanism, the
sulphur cycle is potentially the dominant global geochemical cycle on dry
super-Earths with active tectonics. We calculate planetary emission, reflection
and transmission spectrum from 0.4 to 40 micrometer with high and low
resolution to assess detectable features using current and Archean Earth models
with varying SO2 and H2S concentrations to explore reducing and oxidizing
habitable environments on rocky planets. We find specific spectral signatures
that are observable with low resolution in a planetary atmosphere with high SO2
and H2S concentration. Therefore first generation space and ground based
telescopes can test our understanding of geochemical cycles on rocky planets
and potentially distinguish planetary environments dominated by the carbon and
sulphur cycle.Comment: 9 pages, 6 figures, ApJ accepted - detailed discussion adde
A Multi-Fidelity Prediction of Aerodynamic and Sonic Boom Characteristics of the JAXA Wing Body
This paper presents a detailed comparison between the linear panel solver PANAIR A502 and the in-house Navier–Stokes solver UNS3D for a supersonic low-boom geometry. The high-fidelity flow solver was used to predict both the inviscid and laminar flow about the aircraft geometry. The JAXA wing body was selected as the supersonic low-boom geometry for this study. A comparison of the undertrack near-field pressure signatures showed good agreement between the three levels of model fidelity along the first 0.8L of the signature. Large oscillations in the PANAIR results were observed. The PANAIR discrepancies were traced back to violations of the underlying assumptions within PANAIR: (1) small perturbation velocities and (2) no regions of transonic flow. These violations were due to large changes in surface curvature resulting in a strong expansion wave. While investigating the PANAIR discrepancy, measures of the fundamental assumptions of the Prandtl-Glauert equation used by PANAIR were quantified and used to assess the applicability of PANAIR to a given problem. Further comparison of surface temperatures predicted between the inviscid and laminar solutions was made. It was found that the recovery temperatures predicted by the inviscid solution were 5% less than those predicted by the laminar solution in likely candidate regions for distributed adaptivity. A surface deformation was added to the forward portion of the geometry to asses the viability of a future optimization study in this region. In this study, it was found that the near-field and ground signatures predicted by PANAIR and the UNS3D solutions responded in similar manners to the deformation
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