Genetik Programlama Yardimi İle Kı’nin Açik Formülasyonu

Konferans Bildirisi -- Teorik ve Uygulamalı Mekanik Türk Milli Komitesi, 2008Conference Paper -- Theoretical and Applied Mechanical Turkish National Committee, 2008Bu çalışmada, kırılma mekaniğinde açılma moduna (Kı) göre Gerilme Şiddet Çarpanı’nın (GŞÇ) formülasyonu için Genetik Programlama (GP) kullanılmıştır. GP için eğitim setleri ANSYS paket programı kullanılarak hazırlanmıştır. GP modellenmesi için gerekli tüm işlemler hazır paket program kullanılarak yapılmıştır. Kırılma Mekaniğinde yaygın olarak kullanılan üç değişik geometri için bir GŞÇ formülasyonu elde edilmiştir. Elde edilen bu açık formülasyonun sonuçlarının, ANSYS sonuçları ile oldukça uyumlu sonuçlar verdiği görülmüştür.In this study, Genetic Programming (GP) is used for the analysis and the formulation of the Stress Intensity Factor (SIF) for the opening mode (KI) of fracture mechanics. The training patterns for Genetic Programming are prepared using ANSYS. All necessary processes for Genetic Programming are conducted using ready package software. A SIF formulation for the three different geometries which are commonly used in fracture mechanics has been obtained. It is shown that the results of the explicit formulation are in good agreement with, ANSYS results

An unusual coexistence of Addison’s disease and phaeochromocytoma

No AbstractKeywords: Addison’s disease, phaeochromocytoma, glucocorticoids, chromaffin cell

The Classification of Obsessive–Compulsive and Related Disorders in the ICD-11

Background To present the rationale for the new Obsessive–Compulsive and Related Disorders (OCRD) grouping in the Mental and Behavioural Disorders chapter of the Eleventh Revision of the World Health Organization’s International Classification of Diseases and Related Health Problems (ICD-11), including the conceptualization and essential features of disorders in this grouping. Methods Review of the recommendations of the ICD-11 Working Group on the Classification for OCRD. These sought to maximize clinical utility, global applicability, and scientific validity. Results The rationale for the grouping is based on common clinical features of included disorders including repetitive unwanted thoughts and associated behaviours, and is supported by emerging evidence from imaging, neurochemical, and genetic studies. The proposed grouping includes obsessive–compulsive disorder, body dysmorphic disorder, hypochondriasis, olfactory reference disorder, and hoarding disorder. Body-focused repetitive behaviour disorders, including trichotillomania and excoriation disorder are also included. Tourette disorder, a neurological disorder in ICD-11, and personality disorder with anankastic features, a personality disorder in ICD-11, are recommended for cross-referencing. Limitations Alternative nosological conceptualizations have been described in the literature and have some merit and empirical basis. Further work is needed to determine whether the proposed ICD-11 OCRD grouping and diagnostic guidelines are mostly likely to achieve the goals of maximizing clinical utility and global applicability. Conclusion It is anticipated that creation of an OCRD grouping will contribute to accurate identification and appropriate treatment of affected patients as well as research efforts aimed at improving our understanding of the prevalence, assessment, and management of its constituent disorders

Dopamine-Secreting Giant Adrenal Ganglioneuroma: Clinical and Diffusion-Weighted Magnetic Resonance Imaging Findings

We report a case of a dopamine-secreting giant primary adrenal ganglioneuroma (GN) in a 29-year-old male patient. Although the patient was clinically silent, the 24-hour urine levels of dopamine, normetanephrine, homovanillic acid and vanillyl mandelic acid were elevated. Abdominal ultrasonography and magnetic resonance imaging showed a large solid tumor with calcifications and a slightly lobular edge on the left adrenal gland. A tumor, 13 × 23 × 25 cm in size, was completely resected without morbidity. A 2-year follow-up with computed tomography showed that the postoperative course of the patient was uneventful

A Performance Comparison According to Number of Wavelengths and Topologies on PCSA Reservation Mechanism for OBS

Abstract A performance comparison according to different number of wavelengths and topologies on OBS has been studied in this paper. Preemptive Channel Scheduling Algorithm (PCSA) has been used as reservation mechanism in OBS. In terms of performance criteria, loss rate in bytes, access delay and end-to-end delay are considered. A 2-state MMPP (Markov Modulated Poisson Process) traffic generator is used. Four different types of Mesh and Ring topologies are used. NS2 Network Simulation tool is used for our tests. In OBS algorithms, bursts are created using a hybrid model that takes into account both timeout and maximum length threshold mechanisms. In nodes, in order to satisfy QoS requirements, priority based queuing and Regulative Wavelength Grouping (RWG) are used. In priority based queuing, packets (bursts) are sent according to their priority order. In this study, the effects of generated traffic according to the topologies and the effects of increased number of wavelengths are shown by access delays. According to the simulation studies, the success of byte drop rate increases while the number of wavelengths increases. The results that obtained on mesh topologies are better than the results of ring topologies according to our simulation results

Inflammatory Markers and Aortic Aneurysms: Exploring the Role of Hs-CRP and MHR in Ascending Aortic Aneurysm Development

Diyar Köprülü,1 Mohamed Omar Hassan,2 Hüsnü Atmaca,3 Sezgin Albayrak,1 Esra Işcanlı4 1Department of Cardiology, Ordu State Hospital, Ordu, Turkey; 2Department of Cardiology, Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia; 3Department of Cardiology, Samsun Gazi State Hospital, Samsun, Turkey; 4Department of Radiology, Ankara Bilkent Sehir Hospital, Ankara, TurkeyCorrespondence: Diyar Köprülü, Email [email protected]: Aortic aneurysms, particularly those affecting the ascending aorta, pose significant health risks due to their potential to cause life-threatening complications such as rupture and dissection. While the etiology of ascending aortic aneurysms has traditionally been associated with non-inflammatory processes, emerging evidence suggests a potential role of inflammation in their development.Methods: This study investigates the relationship between inflammatory markers and ascending aortic aneurysms, focusing on high-sensitivity C-reactive protein (hs-CRP) and the monocyte-to-HDL ratio (MHR). A total of 135 patients with ascending aortic aneurysms and 40 control subjects underwent comprehensive evaluations, including echocardiography, computed tomography imaging, and serum biomarker measurements.Results: The results indicate significantly elevated levels of hs-CRP and MHR in patients with ascending aortic aneurysms compared to the control group, suggesting a potential inflammatory component in the pathogenesis of these aneurysms. However, the precise mechanisms underlying this association remain to be elucidated.Conclusion: Despite limitations such as the cross-sectional study design and relatively small sample size, this study provides valuable insights into the potential involvement of inflammation in ascending aortic aneurysms. Further research, including longitudinal studies and histopathological analysis of aortic tissue, is warranted to confirm these findings and explore the utility of inflammatory markers as diagnostic and prognostic indicators in this patient population.Keywords: ascending aortic aneurysm, inflammation, hs-CRP, monocyte-to-HDL rati

Dobrava Hantavirus Infection Complicated by Panhypopituitarism, Istanbul, Turkey, 2010

We identified Dobrava-Belgrade virus infection in Turkey (from a strain related to hantavirus strains from nearby countries) in a patient who had severe symptoms leading to panhypopituitarism, but no known risk for hantavirus. Our findings emphasize the need for increased awareness of hantaviruses in the region and assessment of symptomatic persons without known risk factors for infection

A Jurisprudential Analysis of Government Intervention and Prenatal Drug Abuse

This article takes a different approach in considering the problem of prenatal drug abuse. After briefly discussing government intervention and constitutional issues, this article will consider the concept of duty and correlative rights. This discussion of duty and correlative rights suggests that the government can take measures to curb prenatal drug use without recognizing fetal rights. The article concludes with a discussion of the utility of criminal legislation as compared to public health legislation that treats drug addiction as a disease requiring treatment. As formulated, the proposal for public health legislation is not based on any concept of fetal rights. Instead, it is based on the recognition of societal interests, as well as the woman’s needs

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer

Background Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours. The over-expression of these proteins and their known functions in malignant neoplasms has led to the development of HDAC inhibitors (HDI) as new anti-neoplastic drugs. However, little is known about HDAC expression in renal cell cancer. Methods We investigated the expression of HDAC 1, 2 and 3 in 106 renal cell carcinomas and corresponding normal renal tissue by immunohistochemistry on tissue micro arrays and correlated expression data with clinico-pathological parameters including patient survival. Results Almost 60% of renal cell carcinomas expressed the HDAC isoforms 1 and 2. In contrast, HDAC 3 was only detected in 13% of all renal tumours, with particular low expression rates in the clear cell subtype. HDAC 3 was significantly higher expressed in pT1/2 tumours in comparison to pT3/4 tumours. Expression of class I HDAC isoforms correlated with each other and with the proliferative activity of the tumours. We found no prognostic value of the expression of any of the HDAC isoforms in this tumour entity. Conclusion Class I HDAC isoforms 1 and 2 are highly expressed in renal cell cancer, while HDAC 3 shows low, histology dependent expression rates. These unexpected differences in the expression patterns suggests alternative regulatory mechanisms of class I HDACs in renal cell cancer and should be taken into account when trials with isoform selective HDI are being planned. Whether HDAC expression in renal cancers is predictive of responsiveness for HDI will have to be tested in further studies