Interventions for improving recovery from work

ObjectivesThis is a protocol for a Cochrane Review (intervention). The objectives are as follows:To compare the effectiveness of different individual interventions in recovery from work.info:eu-repo/semantics/publishedVersio

The Wintertime Southern Hemisphere Split Jet: Structure, Variability, and Evolution

A persistent feature of the Southern Hemisphere upper-level time-mean flow is the presence of a split jet across the South Pacific east of Australia during the austral winter. The split jet is composed of the subtropical jet (STJ) on its equatorward branch and the polar front jet (PFJ) on its poleward branch. The NCEP-NCAR reanalysis is used to investigate the structure and evolution of the split jet. Results show that the presence/absence of the PFJ determines the degree of split flow, given that the STJ is a quasi-steady feature. A split-flow index (SFI) is developed to quantify the variability of the split jet, in which negative values represent strong split flow and positive values nonsplit flow. Correlations with teleconnection indices are investigated, with the SFI positively correlated to the Southern Oscillation index and negatively correlated to the Antarctic oscillation. The SFI is used to construct composites of heights, temperature, and wind for split-flow and non-split-flow days. The composites reveal that relatively cold conditions occur in the South Pacific in association with non-split-flow regimes, and split-flow regimes occur when relatively warm conditions prevail. In the latter situation cold air bottled up over Antarctica helps to augment the background tropospheric thickness gradient between Antarctica and the lower latitudes with a resulting increase in the thermal wind and the PFJ. It is surmised that frequent cold surges out of Antarctica moving into the South Pacific are associated with non-split-flow regimes. In this context, the variability of the split jet responds to large-scale baroclinic processes and is further modulated by synoptic-scale disturbances

Transanal total mesorectal excision with triangle rules: a road map to prevent injuries

[Extract] Transanal total mesorectal excision (TaTME) is presented as a promising new surgical technique for the approach to the distal rectum, providing the ability to perform a highquality resection, with technical advantages over the laparoscopic approach. However, the new surgical anatomy of the TaTME resection complicates surgical understanding and increases the risks of inadvertent injuries to important anatomic structures...info:eu-repo/semantics/publishedVersio

Compact Size Triple Notched-bands UWB Antenna with Sharp Band-Rejection Characteristics at WiMAX and WLAN Bands

In this paper, a compact triple band-notched Ultra Wideband (UWB) antenna with sharp band-elimination features and controlled notched bandwidths is proposed and discussed. The design is made up of a rectangular-shaped   patch UWB planar monopole antenna with double collections of band-notched configurations. The band-notched configurations are involved to produce the desired lower and upper stop bands with good frequency selectivity and suitable stop bandwidths. The first notch is realized by using a C-shaped slot etched in the radiating patch in order to eliminate the interference at the WiMAX (3.4 - 3.8 GHz) applications. The second and the third notches are realized together by using a pair of U-shaped resonators that are located beside the feed line in both sides to eliminate the interference with the lower WLAN (5.15–5.35 GHz) and the higher WLAN (5.725–5.825GHz) bands.  Additionally, the bandwidths of the lower and upper stop bands can be control separately by changing the parameters of the band-notched configurations. Furthermore, the suggested triple notched bands UWB antenna is optimized, fabricated, and measured for verification purposes. The measured results are close to the simulated ones

A Formal Study of the Privacy Concerns in Biometric-Based Remote Authentication Schemes

With their increasing popularity in cryptosystems, biometrics have attracted more and more attention from the information security community. However, how to handle the relevant privacy concerns remains to be troublesome. In this paper, we propose a novel security model to formalize the privacy concerns in biometric-based remote authentication schemes. Our security model covers a number of practical privacy concerns such as identity privacy and transaction anonymity, which have not been formally considered in the literature. In addition, we propose a general biometric-based remote authentication scheme and prove its security in our security model

Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-jB signaling and IL-8 expression

Medulloblastoma (MB) is the most common malignant brain tumor of childhood. The transcription factor NF-κB is overexpressed in human MB and is a critical factor for MB tumor growth. NF-κB is known to regulate the expression of interleukin-8 (IL-8), the chemokine that enhances cancer cell growth and resistance to chemotherapy. We have recently shown that thymoquinone (TQ) suppresses growth of hepatocellular carcinoma cells in part by inhibiting NF-κB signaling. Here we sought to extend these studies in MB cells and show that TQ suppresses growth of MB cells in a dose- and time-dependent manner, causes G2M cell cycle arrest, and induces apoptosis. TQ significantly increased generation of reactive oxygen species (ROS), while pretreatment of MB cells with the ROS scavenger N-acetylcysteine (NAC) abrogated TQ-induced cell death and apoptosis, suggesting that TQ-induced cell death and apoptosis are oxidative stress-mediated. TQ inhibitory effects were associated with inhibition of NF-κB and altered expression of its downstream effectors IL-8 and its receptors, the anti-apoptotic Bcl-2, Bcl-xL, X-IAP, and FLIP, as well as the pro-apoptotic TRAIL-R1, caspase-8, caspase-9, Bcl-xS, and cytochrome c. TQ-triggered apoptosis was substantiated by up-regulation of the executioner caspase-3 and caspase-7, as well as cleavage of the death substrate poly(ADP-ribose)polymerase. Interestingly, pretreatment of MB cells with NAC or the pan-caspase inhibitor zVAD-fmk abrogated TQ-induced apoptosis, loss of cyclin B1 and NF-κB activity, suggesting that these TQ-mediated effects are oxidative stress- and caspase-dependent. These findings reveal that TQ induces both extrinsic and intrinsic pathways of apoptosis in MB cells, and suggest its potential usefulness in the treatment of MB

Será que a soja aumenta as contagens sanguíneas em síndrome mielodisplásica?

Myelodysplastic syndromes (MDS) are a group of clonal stem cell diseases characterized by ineffective hematopoiesis, bone marrow hyperproliferation, cytopenias in peripheral blood and risk of transformation into acute leukemia. We decided to investigate the effects of a soy concentrate on MDS patients based on the follow-up results of a 61 year-old Japanese female patient who was diagnosed with MDS and refractory cytopenia with multilineage dysplasia in 2003 (hemoglobin = 11g/dL; white blood cells count = 2,500/uL and platelets = 25,000/uL; marrow with mild dysplasia and normal karyotype; paroxysmal nocturnal hemoglobinuria was excluded). She started using soy as a dietary supplementation in May 2004 and presented a gradual increment in blood counts, achieving normalization approximately eight months afterwards. Among the soy components, the main compounds with anti-carcinogenic activity are the isoflavones (genistein and daidzein). Based on these lines of evidence, we proposed to administer daily a standard soy concentrate to 14 MDS out-patients for a minimum period of three months and maximum of 12 months, in an attempt to evaluate prospectively the possible increase in hemoglobin, neutrophils and platelet counts. A historical control group was used to compare results. The use of a soy concentrate in a standardized manner was associated with an increase in neutrophil and/or platelet counts in some cases, but spontaneous increments were also observed in historical controls. This preliminary study does not allow establishing a relation between soy supplementation and blood cell count increase.As síndromes mielodisplásicas (SMD) são um grupo das doenças clonais de células-tronco caracterizado por hematopoese ineficaz, hiperproliferação de medula óssea, citopenias no sangue periférico e risco de transformação para leucemia aguda. Decidimos investigar os efeitos de um concentrado de soja em pacientes com SMD com base no fato de termos o seguimento de uma paciente japonesa, de 61 anos de idade, que foi diagnosticada em 2003 com SMD, citopenia refratária com displasia subtipo multilinhagens (hemoglobina = 11 g/dL; contagem de glóbulos brancos = 2.500/uL e plaquetas = 25.000/uL; medula com displasia leve e cariótipo normal; hemoglobinúria paroxística excluída), e que começou a usar a soja como suplemento alimentar em maio de 2004, apresentando gradual aumento da contagem das células sanguíneas, atingindo a normalização cerca de oito meses depois. Entre os componentes da soja, os principais compostos com propriedades anticarcinogênese são as isoflavonas (Ge nisteína e daidzeína). Com base nessas linhas de evidência, foi proposto oferecer diariamente um concentrado de soja padrão, por um período mínimo de três meses e máximo de doze meses, a 14 pacientes ambulatoriais, na tentativa de avaliar, prospectivamente, o possível aumento de hemoglobina, neutrófilos e plaquetas. Um grupo controle histórico foi utilizado para comparar os resultados. O uso de um concentrado de soja de forma padronizada foi associado ao aumento na contagem de neutrófilos e/ou de plaquetas em alguns casos, mas aumentos espontâneos também foram observados em controles históricos. Este estudo preliminar não permite estabelecer relação entre o uso de soja e o aumento na contagem sanguínea.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Hematologia e HemoterapiaEmpresa Brasileira de Pesquisa Agropecuária Centro Nacional de Pesquisa de SojaInstituto FleuryUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Departamento de MedicinaUNIFESP, EPM, Hematologia e HemoterapiaUNIFESP, EPM, Depto. de MedicinaSciEL

Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible.

To uncover the circuit-level alterations that underlie atypical sensory processing associated with autism, we adopted a symptom-to-circuit approach in the Fmr1-knockout (Fmr1-/-) mouse model of Fragile X syndrome. Using a go/no-go task and in vivo two-photon calcium imaging, we find that impaired visual discrimination in Fmr1-/- mice correlates with marked deficits in orientation tuning of principal neurons and with a decrease in the activity of parvalbumin interneurons in primary visual cortex. Restoring visually evoked activity in parvalbumin cells in Fmr1-/- mice with a chemogenetic strategy using designer receptors exclusively activated by designer drugs was sufficient to rescue their behavioral performance. Strikingly, human subjects with Fragile X syndrome exhibit impairments in visual discrimination similar to those in Fmr1-/- mice. These results suggest that manipulating inhibition may help sensory processing in Fragile X syndrome

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far

Computationally efficient 3D analytical magnet loss prediction in surface mounted permanent magnet machines

This study proposes a computationally efficient analytical method, for accurate prediction of three-dimensional (3D) eddy current loss in the rotor magnets of surface mounted permanent magnet (SPM) machines considering slotting effect. Subdomain model incorporating stator tooth tips is employed to generate the information on radial and tangential time-derivatives of 2D magnetic field (eddy current sources) within the magnet. The distribution of the eddy current sources in 3D is established for the magnets by applying the eddy current boundary conditions and the Coulomb gauge imposed on the current vector potential. The 3D eddy current distributions in magnets are derived analytically by employing the method of variable separation and the total eddy current loss in the magnets are subsequently established. The method is validated by 3D time-stepped finite element analysis for 18-slot, 8-pole and 12-slot, 8-pole permanent magnet machines. The eddy current loss variations in the rotor magnets with axial and circumferential number of segmentations are studied. The reduction of magnet eddy current loss is investigated with respect to harmonic wavelength of the source components to suggest a suitable segmentation for the rotor magnets in SPM machines