Obscuring clouds playing hide-and-seek in the Active Nucleus H0557-385

This paper reports on two XMM-Newton observations of the Seyfert 1 Galaxy H0557-385 obtained in 2006, which show the source at an historical low flux state, more than a factor of 10 lower than a previous XMM-Newton look in 2002. The low flux spectrum presents a strong Fe Kalpha line associated to a Compton reflection continuum. An additional spectral line around 6.6 keV is required to fit Kalpha emission from Fe XXV. The spectral curvature below 6 keV implies obscuration by neutral gas with a column density of 8*10^{23}cm^{-2} partially covering the primary emission, which still contributes for a few percent of the soft X-ray emission. Absorption by ionised material on the line of sight is required to fit the deep trough below 1 keV. The comparison of the two spectral states shows that the flux transition is to be ascribed entirely to intervening line-of-sight clouds with high column density.Comment: 5 pages, accepted for publication on MNRAS Letter

Increasing powers to reject licences to sell alcohol: Impacts on availability, sales and behavioural outcomes from a novel natural experiment evaluation.

Excessive alcohol consumption leads to negative health and social impacts at individual and population levels. Interventions that aim to limit the density of alcohol retail premises (including cumulative impact policies (CIPs)) have been associated with decreases in alcohol-related crime and alcohol-related hospital admissions. We evaluated the quantitative impact of introducing a new alcohol licensing policy that included a comprehensive Cumulative Impact Policy (CIP) enforced in seven Cumulative Impact Zones (CIZs) in one English Local Authority in 2013. We used time series analysis to assess immediate and longer term impacts on licensing decisions and intermediate outcomes, including spatial and temporal alcohol availability, crime, alcohol-related ambulance call-outs and on-licence alcohol retail sales across the Local Authority and in CIZs and non-CIZs during the period 2008 to 2016. We found no impact on licence application rates but post-intervention applications involved fewer trading hours. Application approvals declined initially but not over the longer term. Longer term, small reductions in units of alcohol sold in bars (-2060, 95% confidence interval (CI) = -3033, -1087) were observed in areas with more intensive licensing policies ('Cumulative Impact Zones' (CIZs)). Significant initial declines in overall crime rates (CIZs = -12.2%, 95% CI = -18.0%, -6.1%; non-CIZs = -8.0%, 95% CI = -14.0%, -1.6%) were only partially reversed by small, longer term increases. Ambulance callout rates did not change significantly. The intervention was partially successful but a more intensive and sustained implementation may be necessary for longer term benefits

XMM-Newton and Suzaku analysis of the Fe K complex in the Seyfert 1 galaxy Mrk 509

We report on partially overlapping XMM-Newton (~260 ks) and Suzaku (~100 ks) observations of the iron K band in the nearby, bright Seyfert 1 galaxy Mrk 509. The source shows a resolved neutral Fe K line, most probably produced in the outer part of the accretion disc. Moreover, the source shows further emission blue-ward of the 6.4 keV line due to ionized material. This emission is well reproduced by a broad line produced in the accretion disc, while it cannot be easily described by scattering or emission from photo-ionized gas at rest. The summed spectrum of all XMM-Newton observations shows the presence of a narrow absorption line at 7.3 keV produced by highly ionized outflowing material. A spectral variability study of the XMM-Newton data shows an indication for an excess of variability at 6.6-6.7 keV. These variations may be produced in the red wing of the broad ionized line or by variation of a further absorption structure. The Suzaku data indicate that the neutral Fe Kalpha line intensity is consistent with being constant on long timescales (of a few years) and they also confirm as most likely the interpretation of the excess blueshifted emission in terms of a broad ionized Fe line. The average Suzaku spectrum differs from the XMM-Newton one for the disappearance of the 7.3 keV absorption line and around 6.7 keV, where the XMM-Newton data alone suggested variability.Comment: MNRAS in pres

Spinocerebellar ataxia 27B: episodic symptoms and acetazolamide response in 34 patients

Ashton C et al report a retrospective multi-centre cohort of 34 patients from Canada, France, Austria and Australia with spinocerebellar ataxia 27B, describing the common feature of episodic ataxia and other episodic features, as well as the inefficacy of acetazolamide in these patients

Risk Factors for Malaria Infection and Seropositivity in the Elimination Area of Grand'Anse, Haiti: A Case-Control Study among Febrile Individuals Seeking Treatment at Public Health Facilities.

The island of Hispaniola aims to eliminate malaria by 2025; however, there are limited data to describe epidemiologic risk factors for malaria in this setting. A prospective case-control study was conducted at four health facilities in southwest Haiti, aiming to describe factors influencing the risk of current and past malaria infection. Cases were defined as individuals attending facilities with current or recent fever and positive malaria rapid diagnostic test (RDT), while controls were those with current or recent fever and RDT negative. Serological markers of recent and cumulative exposure to Plasmodium were assessed using the multiplex bead assay from dried blood spots and used for alternate case definitions. Kuldorff's spatial scan statistic was used to identify local clusters of infection or exposure. Logistic regression models were used to assess potential risk factors for RDT positivity and recent exposure markers, including age-group, gender, and recruiting health facility as group-matching variables. A total of 192 cases (RDT positive) and 915 controls (RDT negative) were recruited. Consistent spatial clusters were identified for all three infection and exposure metrics, indicating temporal stability of malaria transmission at these sites. Risk factors included remoteness from health facilities and household construction, furthermore, insecticide-treated net ownership or use was associated with reduced odds of RDT positivity. These findings indicate the malaria risk in Grand'Anse is driven primarily by location. Travel, occupation, and other behavioral factors were not associated with malaria. These data can support the National Malaria Program to refine and target their intervention approaches, and to move toward elimination

Examining the Auroral Ionosphere in Three Dimensions Using Reconstructed 2D Maps of Auroral Data to Drive the 3D GEMINI Model

We use the Geospace Environment Model of Ion-Neutral Interactions (GEMINI) to create three-dimensional, time-dependent simulations of auroral ionospheric parameters in the localized, several 100 km region surrounding auroral arcs observed during a winter 2017 sounding rocket campaign, resolving three-dimensional features of fine-scale (km) flow structures in the vicinity of an auroral arc. The three-dimensional calculations of GEMINI allow (with sufficient driving data) auroral current closure to be investigated without idealizing assumptions of sheet-like structures or height integrated ionospheres. Datamaps for two nearly sheet-like arcs are reconstructed from replications of the Isinglass sounding rocket campaign data, and combined with camera-based particle inversions into a set of driving inputs to run the 3D time-dependent model. Comparisons of model results to radar density profiles and to in situ magnetometry observations are presented. Slices of volumetric current, flow, and conductance structures from model outputs are used to interpret closure currents in an auroral arc region, and are compared to original in situ measurements for verification. The predominant source of return current region field aligned current closure for these slow time variation events is seen to be from the conductance gradients, including the Hall. The importance of the versus terms in the determination of the current structure provides a more complicated picture than a previous GEMINI study, which relied predominantly on the divergence of the electric field to determine current structure. Sensitivity of data-driven model results to details of replication and reconstruction processes are discussed, with improvements outlined for future work

Radio and X-ray emission from disc winds in radio-quiet quasars

It has been proposed that the radio spectra of radio-quiet quasars is produced by free-free emission in the optically thin part of an accretion disc wind. An important observational constraint on this model is the observed X-ray luminosity. We investigate this constraint using a sample of PG radio-quiet quasars for which XMM-Newton EPIC spectra are available. Comparing the predicted and measured luminosities for 0.5, 2 and 5 keV, we conclude that all of the studied PG quasars require a large hydrogen column density absorber, requiring these quasars to be close to or Compton-thick. Such a large column density can be directly excluded for PG 0050+124, for which a high-resolution RGS spectrum exists. Further constraint on the column density for a further 19 out of the 21 studied PG quasars comes from the EPIC spectrum characteristics such as hard X-ray power-law photon index and the equivalent width of the Fe Kalpha line; and the small equivalent width of the C IV absorber present in UV spectra. For 2 sources: PG 1001+054 and PG 1411+442 we cannot exclude that they are indeed Compton-thick, and the radio and X-ray luminosity are due to a wind originating close to the super-massive black hole. We conclude that for 20 out of 22 PG quasars studied free-free emission from a wind emanating from the accretion disc cannot mutually explain the observed radio and X-ray luminosity.Comment: Accepted for publication in MNRAS, 10 pages, 5 figure

The INTEGRAL/IBIS AGN catalogue I: X-ray absorption properties versus optical classification

In this work we present the most comprehensive INTEGRAL AGN sample which lists 272 objects. Here we mainly use this sample to study the absorption properties of active galaxies, to probe new AGN classes and to test the AGN unification scheme. We find that half (48%) of the sample is absorbed while the fraction of Compton thick AGN is small (~7%). In line with our previous analysis, we have however shown that when the bias towards heavily absorbed objects which are lost if weak and at large distance is removed, as it is possible in the local Universe, the above fractions increase to become 80% and 17%. We also find that absorption is a function of source luminosity, which implies some evolution in the obscuration properties of AGN. Few peculiar classes, so far poorly studied in the hard X-ray band, have been detected and studied for the first time such as 5 XBONG, 5 type 2 QSOs and 11 LINERs. In terms of optical classification, our sample contains 57% of type 1 and 43% of type 2 AGN; this subdivision is similar to that found in X-rays if unabsorbed versus absorbed objects are considered, suggesting that the match between optical and X-ray classification is overall good. Only a small percentage of sources (12%) does not fulfill the expectation of the unified theory as we find 22 type 1 AGN which are absorbed and 10 type 2 AGN which are unabsorbed. Studying in depth these outliers we found that most of the absorbed type 1 AGN have X-ray spectra characterized by either complex or warm/ionized absorption more likely due to ionized gas located in an accretion disk wind or in the biconical structure associated to the central nucleus, therefore unrelated to the toroidal structure. Among 10 type 2 AGN which resulted to be unabsorbed, at most 3-4% is still eligible to be classified as a "true" type 2 AGN.Comment: 21 pages, 6 figures, 5 tables. Accepted for publication on MNRAS. arXiv admin note: text overlap with arXiv:0709.2077 by other author

COVID-19 risk-mitigation in reopening mass events: population-based observational study for the UK Events Research Programme in Liverpool City Region

OBJECTIVES: To understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission risks, perceived risks and the feasibility of risk mitigations from experimental mass cultural events before coronavirus disease 2019 (COVID-19) restrictions were lifted. DESIGN: Prospective, population-wide observational study. SETTING: Four events (two nightclubs, an outdoor music festival and a business conference) open to Liverpool City Region UK residents, requiring a negative lateral flow test (LFT) within the 36 h before the event, but not requiring social distancing or face-coverings. PARTICIPANTS: A total of 12,256 individuals attending one or more events between 28 April and 2 May 2021. MAIN OUTCOME MEASURES: SARS-CoV-2 infections detected using audience self-swabbed (5-7 days post-event) polymerase chain reaction (PCR) tests, with viral genomic analysis of cases, plus linked National Health Service COVID-19 testing data. Audience experiences were gathered via questionnaires, focus groups and social media. Indoor CO2 concentrations were monitored. RESULTS: A total of 12 PCR-positive cases (likely 4 index, 8 primary or secondary), 10 from the nightclubs. Two further cases had positive LFTs but no PCR. A total of 11,896 (97.1%) participants with scanned tickets were matched to a negative pre-event LFT: 4972 (40.6%) returned a PCR within a week. CO2 concentrations showed areas for improving ventilation at the nightclubs. Population infection rates were low, yet with a concurrent outbreak of >50 linked cases around a local swimming pool without equivalent risk mitigations. Audience anxiety was low and enjoyment high. CONCLUSIONS: We observed minor SARS-CoV-2 transmission and low perceived risks around events when prevalence was low and risk mitigations prominent. Partnership between audiences, event organisers and public health services, supported by information systems with real-time linked data, can improve health security for mass cultural events