First records of Buchonomyia thienemanni Fittkau (Diptera: Chironomidae) from the Czech Republic

Buchonomyia thienemanni Fittkau is recorded from the Czech Republic for the first time based on specimens collected in samples from a section of the River Dyje in Podyjí National Park (Moravia) and the Litavka River in the Brdy Mountains (Bohemia)

Could the Last Interglacial Constrain Projections of Future Antarctic Ice Mass Loss and Sea‐Level Rise?

Previous studies have interpreted Last Interglacial (LIG; ∼129–116 ka) sea-level estimates in multiple different ways to calibrate projections of future Antarctic ice-sheet (AIS) mass loss and associated sea-level rise. This study systematically explores the extent to which LIG constraints could inform future Antarctic contributions to sea-level rise. We develop a Gaussian process emulator of an ice-sheet model to produce continuous probabilistic projections of Antarctic sea-level contributions over the LIG and a future high-emissions scenario. We use a Bayesian approach conditioning emulator projections on a set of LIG constraints to find associated likelihoods of model parameterizations. LIG estimates inform both the probability of past and future ice-sheet instabilities and projections of future sea-level rise through 2150. Although best-available LIG estimates do not meaningfully constrain Antarctic mass loss projections or physical processes until 2060, they become increasingly informative over the next 130 years. Uncertainties of up to 50 cm remain in future projections even if LIG Antarctic mass loss is precisely known (±5 cm), indicating that there is a limit to how informative the LIG could be for ice-sheet model future projections. The efficacy of LIG constraints on Antarctic mass loss also depends on assumptions about the Greenland ice sheet and LIG sea-level chronology. However, improved field measurements and understanding of LIG sea levels still have potential to improve future sea-level projections, highlighting the importance of continued observational efforts

A Neuroeconomics Approach to Inferring Utility Functions in Sensorimotor Control

Making choices is a fundamental aspect of human life. For over a century experimental economists have characterized the decisions people make based on the concept of a utility function. This function increases with increasing desirability of the outcome, and people are assumed to make decisions so as to maximize utility. When utility depends on several variables, indifference curves arise that represent outcomes with identical utility that are therefore equally desirable. Whereas in economics utility is studied in terms of goods and services, the sensorimotor system may also have utility functions defining the desirability of various outcomes. Here, we investigate the indifference curves when subjects experience forces of varying magnitude and duration. Using a two-alternative forced-choice paradigm, in which subjects chose between different magnitude–duration profiles, we inferred the indifference curves and the utility function. Such a utility function defines, for example, whether subjects prefer to lift a 4-kg weight for 30 s or a 1-kg weight for a minute. The measured utility function depends nonlinearly on the force magnitude and duration and was remarkably conserved across subjects. This suggests that the utility function, a central concept in economics, may be applicable to the study of sensorimotor control

Could the Last Interglacial Constrain Projections of Future Antartic Ice Mass Loss and Sea-Level Rise?

Previous studies have interpreted Last Interglacial (LIG; ∼129–116 ka) sea‐level estimates in multiple different ways to calibrate projections of future Antarctic ice‐sheet (AIS) mass loss and associated sea‐level rise. This study systematically explores the extent to which LIG constraints could inform future Antarctic contributions to sea‐level rise. We develop a Gaussian process emulator of an ice‐sheet model to produce continuous probabilistic projections of Antarctic sea‐level contributions over the LIG and a future high‐emissions scenario. We use a Bayesian approach conditioning emulator projections on a set of LIG constraints to find associated likelihoods of model parameterizations. LIG estimates inform both the probability of past and future ice‐sheet instabilities and projections of future sea‐level rise through 2150. Although best‐available LIG estimates do not meaningfully constrain Antarctic mass loss projections or physical processes until 2060, they become increasingly informative over the next 130 years. Uncertainties of up to 50 cm remain in future projections even if LIG Antarctic mass loss is precisely known (±5 cm), indicating that there is a limit to how informative the LIG could be for ice‐sheet model future projections. The efficacy of LIG constraints on Antarctic mass loss also depends on assumptions about the Greenland ice sheet and LIG sea‐level chronology. However, improved field measurements and understanding of LIG sea levels still have potential to improve future sea‐level projections, highlighting the importance of continued observational efforts

Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study.

Brain network activity associated with altered motor control in individuals with chronic pain is not well understood. Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a debilitating condition in which previous studies have revealed altered resting pelvic floor muscle activity in men with CP/CPPS compared to healthy controls. We hypothesized that the brain networks controlling pelvic floor muscles would also show altered resting state function in men with CP/CPPS. Here we describe the results of the first test of this hypothesis focusing on the motor cortical regions, termed pelvic-motor, that can directly activate pelvic floor muscles. A group of men with CP/CPPS (N = 28), as well as group of age-matched healthy male controls (N = 27), had resting state functional magnetic resonance imaging scans as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network study. Brain maps of the functional connectivity of pelvic-motor were compared between groups. A significant group difference was observed in the functional connectivity between pelvic-motor and the right posterior insula. The effect size of this group difference was among the largest effect sizes in functional connectivity between all pairs of 165 anatomically-defined subregions of the brain. Interestingly, many of the atlas region pairs with large effect sizes also involved other subregions of the insular cortices. We conclude that functional connectivity between motor cortex and the posterior insula may be among the most important markers of altered brain function in men with CP/CPPS, and may represent changes in the integration of viscerosensory and motor processing

New Directions in Conservation for the National Wildlife Refuge System

The National Wildlife Refuge System Improvement Act of 1997 includes the nation’s broadest statutory commitment to ecosystem protection: to “ensure that the biological integrity, diversity, and environmental health of the system are maintained.” The act also directs the US Fish and Wildlife Service (FWS) to expand the scope of conservation monitoring, assessment, and management beyond refuge boundaries to encompass surrounding landscapes. The act thus gives the FWS a leadership role in developing research and management partnerships with other agencies, organizations, and neighboring landowners. Increasing research capacity and scientific expertise, and strengthening institutional resolve to limit activities that impede the attainment of this directive, are challenges for the FWS. Success requires reexamination of existing priorities, refocused training, the acquisition of new funding and technical expertise, and creative application of those new skills to meet the law’s broad mandat

How Could Minority and Women's Rights be Protected in a United Ireland?

This is a report of a seminar held at Ulster University by the Equality Coalition and Transitional Justice Institute, supported by the Gender, Justice and Security Hub

Thermoregulatory ability and mechanism do not differ consistently between neotropical and temperate butterflies

Climate change is a major threat to species worldwide, yet it remains uncertain whether tropical or temperate species are more vulnerable to changing temperatures. To further our understanding of this, we used a standardised field protocol to (1) study the buffering ability (ability to regulate body temperature relative to surrounding air temperature) of neotropical (Panama) and temperate (the United Kingdom, Czech Republic and Austria) butterflies at the assemblage and family level, (2) determine if any differences in buffering ability were driven by morphological characteristics and (3) used ecologically relevant temperature measurements to investigate how butterflies use microclimates and behaviour to thermoregulate. We hypothesised that temperate butterflies would be better at buffering than neotropical butterflies as temperate species naturally experience a wider range of temperatures than their tropical counterparts. Contrary to our hypothesis, at the assemblage level, neotropical species (especially Nymphalidae) were better at buffering than temperate species, driven primarily by neotropical individuals cooling themselves more at higher air temperatures. Morphology was the main driver of differences in buffering ability between neotropical and temperate species as opposed to the thermal environment butterflies experienced. Temperate butterflies used postural thermoregulation to raise their body temperature more than neotropical butterflies, probably as an adaptation to temperate climates, but the selection of microclimates did not differ between regions. Our findings demonstrate that butterfly species have unique thermoregulatory strategies driven by behaviour and morphology, and that neotropical species are not likely to be more inherently vulnerable to warming than temperate species

Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise

Background: Inbred individuals reared in controlled environments display considerable variance in many complex traits but the underlying cause of this intangible variation has been an enigma. Here we show that two modifiers of epigenetic gene silencing play a critical role in the process.Results: Inbred mice heterozygous for a null mutation in DNA methyltransferase 3a (Dnmt3a) or tripartite motif protein 28 (Trim28) show greater coefficients of variance in body weight than their wild-type littermates. Trim28 mutants additionally develop metabolic syndrome and abnormal behavior with incomplete penetrance. Genome-wide gene expression analyses identified 284 significantly dysregulated genes in Trim28 heterozygote mutants compared to wild-type mice, with Mas1, which encodes a G-protein coupled receptor implicated in lipid metabolism, showing the greatest average change in expression (7.8-fold higher in mutants). This gene also showed highly variable expression between mutant individuals.Conclusions: These studies provide a molecular explanation of developmental noise in whole organisms and suggest that faithful epigenetic control of transcription is central to suppressing deleterious levels of phenotypic variation. These findings have broad implications for understanding the mechanisms underlying sporadic and complex disease in humans