I have intention to get a mammogram: Stages of adoption for monitoring mammography in women of different social and cultural background

Objetivo: Describir el estadio de adopción en cuanto a la toma de decisión de hacerse controles regulares de cáncer de mama en mujeres de distinto origen sociocultural residentes en Barcelona en el año 2009. Métodos: Encuesta transversal realizada a una muestra de 960 mujeres de 45 a 69 años residentes en Barcelona en el año 2009 autóctonas e inmigrantes de países en vías de desarrollo. Se desarrolló un cuestionario telefónico. Las variables dependientes fueron los estadios de adopción en que se encontraban las mujeres según el Modelo Transteórico de las etapas de cambio: precontemplación, contemplación, acción, mantenimiento y recaída. Las variables independientes fueron: país de origen, clase social, edad, tiempo de estancia en el país de acogida, conocimiento del idioma, tener hijos, antecedentes familiares de cáncer y nivel de estudios. Se realizó un análisis descriptivo y se estimaron modelos de regresión de Poisson robusta para cada estadio con el fin de obtener las razones de prevalencia según las variables independientes y modelos multivariados para comparar los distintos estadios versus el de mantenimiento. Resultados: El 90% de las mujeres autóctonas se sitúan en el estadio de mantenimiento, 73% de las Latinoamericanas, 41% de las de Europa del Este, 47% de las chinas (47%), 58% de las filipinas, 70% de las magrebíes y 80% de las indopakistaníes. Conclusiones: Es necesario mejorar el conocimiento del cáncer de mama y su prevención trabajando conjuntamente con personas del propio colectivo sobretodo en el caso de las mujeres chinas, filipinas y de Europa del Este.Objective: To describe the stage of adoption in terms of decision making regular checkups for breast cancer in women of different sociocultural backgrounds living in Barcelona in 2009. Methods: A cross-sectional survey of a sample of 960 women aged 45 to 69 years living in Barcelona in 2009, native and immigrants from developing countries. We developed a telephone questionnaire. The dependent variables were the stages of adoption in which women were under the Transtheoretical Model: precontemplation, contemplation, action, maintenance and relapse. The independent variables were: Country of origin, social class, age, length of stay in the host country, language skills, have children, family history of cancer and educational level. We performed a descriptive analysis and regression models were estimated robust Poisson each stage in order to obtain the prevalence ratios as independent variables and multivariate models to compare the different stages versus maintenance. Results: Ninety percent of native women are in the maintenance stage, 73% of Latin American, 41% of Eastern Europe, 47% of Chinese (47%), 58% of the Philippines, 70% of Maghrebi and 80% of Pakistani-Indian. Conclusions: To improve knowledge of breast cancer and its prevention by working with people from the community itself especially in the case of Chinese women, Filipino and Eastern European women

A cloud-based integration platform for enterprise application integration: a model-driven engineering approach

This article addresses major information systems integration problems, approaches, technologies, and tools within the context of Model-Driven Software Engineering. The Guaraná integration platform is introduced as an innovative platform amongst state-of-the-art technologies available for enterprises to design and implement integration solutions. In this article, we present its domain-specific modeling language and its industrial cloud-based web development platform, which supports the design and implementation of integration solutions. A real-world case study is described and analyzed; then, we delve into its design and implementation, to finally disclose ten measures that empirically help estimating the amount of effort involved in the development of integration solutions.info:eu-repo/semantics/acceptedVersio

Cytogenetic effects of irradiation on somatic and germ cells

This paper summarizes the results obtained in two of the research projects carried out in our laboratory within the radiation protection programs of the Consejo de Seguridad Nuclear and the European Union. These two research lines are fundamentally interconnected, since the analysis of the cytogenetic effects of radiation on somatic cells studies the consequences of occupational or accidental exposure to radiation for the individual, especially from the point of view of developing some type of malignancy, while the studies carried out in germ cells evaluate the risk of exposure for future generations, through the transmission of chromosome abnormalities via affected spermatozoa. In both cases these studies, which were mainly carried out during the last six years, in addition to providing basic data for the assessment of the consequences of radiation exposure and defining the steps to be taken to prevent the transmission of chromosome anomalies to the offspring in cases of therapeutic exposure, have also been fundamental in developing more effective techniques for the evaluation of the cytogenetic consequences of exposure to radiation

Alpha-catenin-Dependent Recruitment of the Centrosomal Protein CAP350 to Adherens Junctions Allows Epithelial Cells to Acquire a Columnar Shape

Epithelial morphogenesis involves a dramatic reorganisation of the microtubule cytoskeleton. How this complex process is controlled at the molecular level is still largely unknown. Here, we report that the centrosomal microtubule (MT)-binding protein CAP350 localises at adherens junctions in epithelial cells. By two-hybrid screening, we identified a direct interaction of CAP350 with the adhesion protein α-catenin that was further confirmed by co-immunoprecipitation experiments. Block of epithelial cadherin (E-cadherin)-mediated cell-cell adhesion or α-catenin depletion prevented CAP350 localisation at cell-cell junctions. Knocking down junction-located CAP350 inhibited the establishment of an apico-basal array of microtubules and impaired the acquisition of columnar shape in Madin-Darby canine kidney II (MDCKII) cells grown as polarised epithelia. Furthermore, MDCKII cystogenesis was also defective in junctional CAP350-depleted cells. CAP350-depleted MDCKII cysts were smaller and contained either multiple lumens or no lumen. Membrane polarity was not affected, but cortical microtubule bundles did not properly form. Our results indicate that CAP350 may act as an adaptor between adherens junctions and microtubules, thus regulating epithelial differentiation and contributing to the definition of cell architecture. We also uncover a central role of α-catenin in global cytoskeleton remodelling, in which it acts not only on actin but also on MT reorganisation during epithelial morphogenesis.This work was supported by Ministerio de Economia y Competitividad, Spain (BFU2012-36717 and CSD2009-00016 to RMR and BFU2011-22916 to JRM) and by Junta de Andalucia (CVI-7256 and CTS-2071), and by a funding GenHomme Network 02490-6088 to Hybrigenics and the Institut Curie. MA and AZ were supported by MEC–FPI Grants.Peer Reviewe

A cloud-based integration platform for enterprise application integration: A Model-Driven Engineering approach

This article addresses major information systems integration problems, approaches, technologies, and tools within the context of Model-Driven Software Engineering. The Guaraná integration platform is introduced as an innovative platform amongst state-of-the-art technologies available for enterprises to design and implement integration solutions. In this article, we present its domain-specificmodeling language and its industrial cloud-based web development platform, which supports the design and implementation of integration solutions. A real-world case study is described and analyzed; then, we delve into its design and implementation, to finally disclose ten measures that empirically help estimating the amount of effort involved in the development of integration solutions

Gestión de las diferencias culturales y apoyo social como predictores de la satisfacción familiar de las parejas mixtas

La presente investigación tiene como finalidad comprobar si las estrategias de gestión de las diferencias culturales que valorizan la doble cultura y el apoyo social, entre otros factores psicosociales, predicen la satisfacción familiar de las parejas mixtas o interculturales. Parejas que arrojan una tasa de divorcio doble comparación con las parejas españolas (Domínguez, 2014). Método: Se realiza un diseño no experimental de tipo transversal con 146 parejas mixtas (146 extranjeros y 146 españoles) residentes en España seleccionados con la técnica snow ball. Las variables predictoras de la satisfacción familiar son el apoyo social, la discriminación percibida y 4 estrategias para la gestión de las diferencias culturales en distintos ámbitos familiares. Resultados: En el caso de los españoles, el apoyo de la pareja (β=.443; p<.01), la utilización de una estrategia que valoriza la doble cultura (β=.415; p<.01), la capacidad de asimilar la cultura de su pareja extranjera (β=.309; p<.01), unido a la baja discriminación percibida (β= -.235; p<.01), predicen su satisfacción familiar (R2=.774). Para los extranjeros, las variables predictoras de su satisfacción familiar son las estrategias que valorizan la doble cultura -ampliación de las posibilidades- (β=.262; p<.01), el apoyo de la pareja (β=.184; p<.01), apoyo familiar (β=.203; p<.01) y la baja discriminación (β= -.205; p<.05). Estas variables explican el 71,4% de la varianza (R2=.714). Existe un efecto de moderación entre la estrategia que valoriza la doble cultura con la diferencia religiosa. En este sentido los miembros de las parejas con diferencias religiosas mejorarán considerablemente su satisfacción familiar si utilizan masivamente las estrategias que valorizan la doble cultura (Effect= .79; p<.001). Conclusiones: Los resultados pueden abrir nuevas líneas de investigación y de intervención orientadas a mejorar la estabilidad de las parejas mixtas con el objetivo de reducir el número de divorcios.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases

Background: Summer and spring eruptions on the elbows are a variant of polymorphous light eruption described on clinical and histopathological grounds; however, to our knowledge, they have not been confirmed by photobiological studies. Objective: Based on photobiological studies, this study aimed to demonstrate the involvement of ultraviolet-A (UVA) radiation in this variant of polymorphous light eruption occurring exclusively on the elbows. Methods: A series of five patients with polymorphous light eruption lesions on the elbows were included in our study. All patients underwent phototesting and photoprovocation of the skin lesions after exposure to a UVA light source [Philips UVA HPA lamp (400 W)]. All patients underwent punch biopsy and histopathological and immunohistochemical studies with anti-CD123. Results: In all the cases, UVA irradiation caused the appearance of skin lesions on the elbows with characteristic polymorphous light eruption. Histological data showed edema in the superficial dermis and a perivascular lymphocytic infiltrate compatible with polymorphous light eruption. Immunohistochemical staining for CD1-23 showed negative results. Conclusions: For the first time, photobiological photoprovocation studies demonstrated that repeated exposure to UVA radiation leads to the generation of skin lesions on the elbows, which are clinically and histologically consistent with summer and spring eruptions, confirming that elbow rash is a variant of polymorphous light eruptio

Human growth hormone (GH1) gene polymorphism map in a normal-statured adult population

OBJECTIVE: GH1 gene presents a complex map of single nucleotide polymorphisms (SNPs) in the entire promoter, coding and noncoding regions. The aim of the study was to establish the complete map of GH1 gene SNPs in our control normal population and to analyse its association with adult height. DESIGN, SUBJECTS AND MEASUREMENTS: A systematic GH1 gene analysis was designed in a control population of 307 adults of both sexes with height normally distributed within normal range for the same population: −2 standard deviation scores (SDS) to +2 SDS. An analysis was performed on individual and combined genotype associations with adult height. RESULTS: Twenty-five SNPs presented a frequency over 1%: 11 in the promoter (P1 to P11), three in the 5′UTR region (P12 to P14), one in exon 1 (P15), three in intron 1 (P16 to P18), two in intron 2 (P19 and P20), two in exon 4 (P21 and P22) and three in intron 4 (P23 to P25). Twenty-nine additional changes with frequencies under 1% were found in 29 subjects. P8, P19, P20 and P25 had not been previously described. P6, P12, P17 and P25 accounted for 6·2% of the variation in adult height (P = 0·0007) in this population with genotypes A/G at P6, G/G at P6 and A/G at P12 decreasing height SDS (−0·063 ± 0·031, −0·693 ± 0·350 and −0·489 ± 0·265, Mean ± SE) and genotypes A/T at P17 and T/G at P25 increasing height SDS (+1·094 ± 0·456 and +1·184 ± 0·432). CONCLUSIONS: This study established the GH1 gene sequence variation map in a normal adult height control population confirming the high density of SNPs in a relatively small gene. Our study shows that the more frequent SNPs did not significantly contribute to height determination, while only one promoter and two intronic SNPs contributed significantly to it. Studies in larger populations will have to confirm the associations and in vitro functional studies will elucidate the mechanisms involved. Systematic GH1 gene analysis in patients with growth delay and suspected GH deficiency/insufficiency will clarify whether different SNP frequencies and/or the presence of different sequence changes may be associated with phenotypes in them

Comparative trial between the use of amoxicillin and amoxicillin clavulanate in the removal of third molars

Objectives: The purpose of this study was to compare the use of amoxicillin (1g) vs amoxicillin and clavulanate (875/125mg) after extraction of retained third molars for prevention of infectious complications. Study Design: The study involved 546 patients attending for removal a retained third molar and divided in to two groups: Group 1 - amoxicillin and clavunate (875/125mg) group (n=257) and Group 2 - amoxicillin (1g) group (n=289). All patients were recalled for investigating the possibility of infection, presence of diarrhea and further analgesic intake. Results: From a total of 546 patients, the frequency of infection was 1.4%, without no statistically differences be - tween the two groups. Group 1 showed statistically higher presence of patients with gastrointestinal complications ( p>0.05). In 546 patients, 2.7% of patients reported severe pain that would not relieve with medication. Conclusions: The results of our study show that the use of amoxicillin (1g) and amoxicillin and clavunate (875/125mg) is similar efficacious in preventing infection after retained third molar extraction but amoxicillin and clavunate (875/125mg) produces more gastrointestinal discomfort

Tengo intención de hacerme una mamografía: estadios de adopción para realizar control mamográfico en mujeres de distinto origen cultural y social

Objetivo: Describir el estadio de adopción en cuanto a la toma de decisión de hacerse controles regulares de cáncer de mama en mujeres de distinto origen sociocultural residentes en Barcelona en el año 2009. Métodos: Encuesta transversal realizada a una muestra de 960 mujeres de 45 a 69 años residentes en Barcelona en el año 2009 autóctonas e inmigrantes de países en vías de desarrollo. Se desarrolló un cuestionario telefónico. Las variables dependientes fueron los estadios de adopción en que se encontraban las mujeres según el Modelo Transteórico de las etapas de cambio: precontemplación, contemplación, acción, mantenimiento y recaída. Las variables independientes fueron: país de origen, clase social, edad, tiempo de estancia en el país de acogida, conocimiento del idioma, tener hijos, antecedentes familiares de cáncer y nivel de estudios. Se realizó un análisis descriptivo y se estimaron modelos de regresión de Poisson robusta para cada estadio con el fin de obtener las razones de prevalencia según las variables independientes y modelos multivariados para comparar los distintos estadios versus el de mantenimiento. Resultados: El 90% de las mujeres autóctonas se sitúan en el estadio de mantenimiento, 73% de las Latinoamericanas, 41% de las de Europa del Este, 47% de las chinas (47%), 58% de las filipinas, 70% de las magrebíes y 80% de las indopakistaníes. Conclusiones: Es necesario mejorar el conocimiento del cáncer de mama y su prevención trabajando conjuntamente con personas del propio colectivo sobretodo en el caso de las mujeres chinas, filipinas y de Europa del Este