Diseño de una estrategia pedagógica para mejorar las claves de búsqueda y selección de información con el motor de búsqueda Google en el área de informática con estudiantes del grado quinto del Colegio Rodolfo Llinas

En la actualidad vemos como las TIC (tecnologías de la información y comunicación) se muestran como una herramienta que mejora el aprendizaje del estudiante y los métodos de enseñanza por parte del docente. Estas tecnologías permiten a los docentes brindar nuevos objetivos de aprendizaje a sus estudiantes, para que sean ellos mismos quienes exploren y construyan a partir de una información que es cada vez más fácil de encontrar, información que puede ser aplicada para cualquier aspecto de la vida, ya sea académico o social. En este punto es donde hace su entrada la alfabetización digital identificada como la formación de conocimientos en el uso de las TIC. Esta, en la actualidad, es presentada desde dos amplias miradas, una como el manejo del dispositivo y la otra como la utilización que se le da a la información albergada en internet Teniendo en cuenta esto, es necesario hacer énfasis en la forma en que se busca y en la utilización que se le da a dicha información, ya que no todo lo que esta internet es confiable, además teniendo en cuenta que los jóvenes están totalmente permeados por el mundo de la web. Por esto es importante el desarrollo de una estrategia pedagógica mediatizada sobre la búsqueda y selección de información en internet, para enriquecer las habilidades de los estudiantes en la forma como usan, comprenden y crean información. Puesto que es necesario ser críticos y evaluadores de la información que es encontrada en internet y así poder utilizarla eficazmente para comunicarse, colaborar y resolver problemas. Para concluir, se lleva a cabo la estrategia pedagógica mediatizada “Diseño de una estrategia pedagógica para mejorar las claves de búsqueda y selección de información con el motor de búsqueda Google en el área de informática con estudiantes del grado quinto del Colegio Rodolfo Llinas” intentando reconocer las falencias en el tema de alfabetización digital y apostando a una mejoría de los procesos de búsqueda y selección de información en la web y a la utilización de alternativas innovadoras para educar

El sinsentido de la historia y la sociología del sentido: La concepción de historia en Max Weber

En este artículo se aborda la discusión sobre el papel de la historia en la teoría comprensiva de weber; por ello se parte del postulado de que el sentido en weber es un concepto que permite explorar cómo la historia les permite a los grupos sociales la construcción de significados y valoraciones en relación con su acción. Para abordar esta discusión se valoran y exploran los conceptos de tipo ideal y objetividad cognoscitiva, así como el papel del análisis de la burocracia y la imputación causal, con el fin de dar cuenta de cómo en el análisis de estos se pueden identificar las evidencias teóricas de dicho postulado.This article aims to address the discussion on the role of history on Weber’s comprehensive theory; it starts from a postulate according to which, sense, as per Weber, is a concept that let us explore how history allows the social groups to have the possibility to construct meaning and value in relation to their action. in order to address the discussion, cognitive and ideal concepts are valued and explored, as well as the role of the analysis of bureaucracy and casual imputation aimed at providing an account of how, by analyzing these concepts, it is possible to identify the theoretical evidence of the aforemen-tioned postulate.Universidad de Antioqui

Development and Validation of a Human Blood Acyl-Specific Lipidomic Profiling Method for Clinical Applications

Blood fatty acid levels have been used to determine dietary intakes of omega-3 highly unsaturated fatty acids, but also to examine the link between blood fatty acids, health and disease. However, these lipid analyses are gas chromatography-based and are dependent on derivatization of lipids to fatty acid methyl esters and do not provide information about the fatty acyl parent lipid species. The use of ultra high-performance liquid chromatography combined with tandem mass spectrometry (UHPLC-MS/MS) has the potential to do so. This thesis adapted a lipidomic approach to traditional blood fatty acid profiling to characterize lipids in their naturally-occurring state in human blood. Semi-quantitative methods using UHPLC-MS/MS were developed using a high-resolution Quadrupole-Orbitrap Hybrid Mass Spectrometer (Thermo Q-Exactive), and were validated for the determination of lipids in whole blood. Molecular species were confirmed for over 500 lipids, including phospholipids, sphingolipids, triacylglycerols, cholesteryl esters, free cholesterol and free fatty acids. Over 150 acyl-specific species were confirmed from all lipid classes. Following this, the method was used to validate dried blood spots for lipidomic profiling as this sampling technique offers several advantages, including minimally invasive sample collection, stability, and facilitated handling. Additionally, the UHPLC-MS/MS method was used to examine whole blood lipid remodeling that follows fish oil supplementation. Specifically, the blood lipidomic profiles of samples from a previous intervention trial comprising 20 participants that received eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) at 150 mg/d, 500 mg/d, and 1000 mg/d over a twelve-week period were determined. Notably, lipidomic profiling of whole blood suggests that three specific lipids (16:0/DHA phosphatidylcholine, 16:0/EPA phosphatidylcholine, and plasmenyl-phosphatidylethanolamine P-16:0/EPA) increase in a dose-dependent manner with increasing doses of EPA+DHA supplementation. Finally, lipidomic analyses of whole blood, plasma, and erythrocytes of individuals that consumed low, intermediate, and high amounts of EPA+DHA were performed. These results support previous observations on the rapid responsiveness of 16:0/DHA phosphatidylcholine and 16:0/EPA phosphatidylcholine to varying levels of EPA+DHA intake. The mechanisms through which lipid remodeling occurs remain to be elucidated. The work presented in this thesis provides the foundation for the use of acyl-specific complex lipids as biomarkers for omega-3 highly unsaturated fatty acid status and the lipidomic profiling method developed may be extrapolated for the characterization of acyl-specific lipids in other biological matrices

Fatty Acyl-Specific Macrolipidomics and Microlipidomics for Nutritional Research

The field of lipidomics can further our understanding of the biochemical processes of human health and disease. Generally, lipidomics methods utilize high-performance liquid chromatography (HPLC) for lipid separation, followed by detection using tandem mass spectrometry (MS/MS). The joint use of HPLC and MS/MS has increased dramatically over the past few years, and novel technologies continue to increase the versatility and practical usability of various lipidomics methods. However, a lack of harmonized language, nomenclature and standardized analytical strategies can result in lipid misannotations, improper analyte identifications, and incorrect quantitative results. In this thesis, the importance of adopting appropriate analytical strategies to answer research hypothesis(es) will be highlighted. Specifically, this entails a comparison between analytical platforms and four HPLC-MS/MS data acquisition strategies for untargeted/global lipidomic profiling of highly-abundant lipids including phospholipids, triacylglycerols and cholesteryl esters in human whole blood. In addition, the advantages of targeted analytical approaches for the measurement of specific lipid classes will be examined through the development of a tailored method for the determination of regioisomers of lysophosphatidic acid in plasma (mouse), the acyl species of triacylglycerols in cooking oil (sunflower), and the acyl species of phospholipids in brain tissue (mouse). Finally, comprehensive profiling of various lipid classes in whole blood using a novel retention time-based negative/positive ion mode switching method will be used to screen for potential blood biomarkers of omega-3 polyunsaturated fatty acid intake. This will include samples from a cross-sectional dietary assessment study in humans, and an acute/chronic docosahexaenoic acid supplementation study in rats. The methods presented in this thesis have the potential to be expanded for use in agriculture, nutrition, research and clinical settings

La lúdica como medio de prevención de la violencia escolar

La escuela como el segundo pilar de la educación de los estudiantes, está llamada a formar a sus educandos en principios y valores personales necesarios para la prevención de la violencia escolar. En el desarrollo de la propuesta “VIVO, CONVIVO Y APRENDO JUGANDO” se presenta la lúdica como la herramienta a través de la cual se pueden mejorar las relaciones interpersonales entre aquellos que interactúan en el aula. Esta puede ser implementada en las instituciones educativas, para la promoción de cambios generadores de nuevas actitudes y aprendizajes colectivos

Concentrations of docosahexaenoic acid are reduced in maternal liver, adipose, and heart in rats fed high-fat diets without docosahexaenoic acid throughout pregnancy

The final publication is available at Elsevier via https://dx.doi.org/10.1016/j.plefa.2018.10.003 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/Fetal accretion for DHA is high during late pregnancy due to the brain growth spurt. Prior evidence suggests that DHA is mobilized from maternal liver and adipose to meet fetal accretion and physiological requirements. However, changes in the DHA levels of various maternal tissues throughout pregnancy and into lactation of mothers on diets with and without dietary DHA, and with a background dietary fatty acid profile that resembles human intake has not been examined. Sprague Dawley rats were fed a total western diet with (TWD + ) or without DHA (TWD-) along with a commercial rodent chow control (Chow) throughout pregnancy and postpartum. The fatty acid compositions of adipose, brain, heart, liver, erythrocytes, and plasma were determined before pregnancy, at 15 and 20 days of pregnancy, and 7 days postpartum. The placenta, fetuses, and pups were also examined when available. Maternal DHA concentrations were increased in plasma at 20 days pregnancy in all the diets with TWD + > Chow > TWD-. Maternal DHA concentrations in the TWD- group were lower in adipose throughout pregnancy as compared with the other diets. At postpartum, DHA concentrations decreased below baseline levels in the heart of the TWD- and Chow dams and the liver of the TWD- dams. Whole body DHA concentrations of the fetuses did not differ but there was evidence of decreased DHA in the whole body and tissues of the TWD- and Chow 7d old pups. In conclusion, it appears that in this rodent model of pregnancy, maternal adaptations were made to meet fetal DHA requirements, but they may compromise maternal DHA status and the ability to deliver DHA during lactation.Natural Sciences and Engineering Research Council of Canada [327149-2013]Canada Research Chairs program as a Chair in Nutritional Lipidomics [950-228125

Facial Thermal and Blood Perfusion Patterns of Human Emotions: Proof-of-Concept

In this work, a preliminary study of proof-of-concept was conducted to evaluate the performance of the thermographic and blood perfusion data when emotions of positive and negative valence are applied, where the blood perfusion data are obtained from the thermographic data. The images were obtained for baseline, positive, and negative valence according to the protocol of the Geneva Affective Picture Database. Absolute and percentage differences of average values of the data between the valences and the baseline were calculated for different regions of interest (forehead, periorbital eyes, cheeks, nose and upper lips). For negative valence, a decrease in temperature and blood perfusion was observed in the regions of interest, and the effect was greater on the left side than on the right side. In positive valence, the temperature and blood perfusion increased in some cases, showing a complex pattern. The temperature and perfusion of the nose was reduced for both valences, which is indicative of the arousal dimension. The blood perfusion images were found to be greater contrast; the percentage differences in the blood perfusion images are greater than those obtained in thermographic images. Moreover, the blood perfusion images, and vasomotor answer are consistent, therefore, they can be a better biomarker than thermographic analysis in identifying emotions.Comment: 22 pages, 9 figure

Experiencias narrativas de niños desplazados : sanación y reconocimiento de sí

Licenciado (a) en Educación Básica con Énfasis en Humanidades y Lengua CastellanaPregrad

Intraoral EBV-positive sporadic Burkitt lymphoma in an elderly patient with bilateral presentation

Sporadic Burkitt lymphoma (SBL) is a variant of Burkitt lymphoma that occurs worldwide, affecting mainly children and young adults. Association with Epstein-Barr virus (EBV) can be identified in approximately 20-30% of cases. Herein we described a case of a 63-year-old male presenting intraoral bilateral mandibular swelling, subjacent to fixed dental prosthesis, with one month of duration. Incisional biopsies were performed, and after two days, the patient was hospitalized due to malaise and breathing difficulty, and died after a week when an abdominal tumor was detected. The mandibular biopsies revealed a diffuse proliferation of medium-sized monomorphic atypical lymphoid cells exhibiting numerous mitoses and areas of “starry-sky” pattern. The tumor showed immunohistochemical positivity for CD20, CD10, Bcl-6, and Ki-67 (≈ 100%); it was negative for CD3, Bcl-2, Vs38c, and MUM-1. Positivity for EBV was found by in situ hybridization. The final diagnosis was intraoral SBL positive for EBV. Clinical, morphological and molecular criteria are necessary for the correct diagnosis of aggressive B-cell neoplasms positive for EBV in elderly patients