Pustulosis exantemática generalizada aguda desencadenada por la vacunación con Pfizer-BioNTech frente a la COVID-19

Acute generalized exanthematous pustulosis (AGEP) is a type of uncommon skin lesion characterized by the rapid appearance of disseminated, sterile pustules over an erythematous skin background. This reaction is usually triggered by drugs, mainly antibiotics, although other causes are infections and vaccines. We report the case of a patient who developed AGEP after the administration of Pfizer-BioNTech vaccine against SARS-COV-2. To our knowledge, only six cases of AGEP due to SARS-COV-2 vaccine have been reported, and none with Pfizer-BioNTech vaccine.La pustulosis exantemática generalizada aguda (PEGA) es un tipo de lesión cutánea poco común caracterizada por la aparición rápida e insidiosa de numerosas pústulas estériles sobre un fondo eritematoso. Esta reacción normalmente es desencadenada por fármacos, principalmente antibióticos y más raramente por otros tipos de desencadenantes como infecciones o vacunas. Se presenta el caso de una paciente que desarrolló PEGA tras la administración de la vacuna de Pfizer-BioNTech frente al SARS-CoV-2. Según nuestro conocimiento solo hay seis casos descritos por la vacuna frente al SARS-CoV-2 y ninguno de ellos por la vacuna de Pfizer-BioNTech

Space and time in the tectonic evolution of the northwestern Iberian Massif: Implications for the Variscan belt.

Recent advances in geochemical studies of igneous rocks, isotopic age data for magmatism and metamorphism, quantitative pressure-temperature (P-T) estimates of metamorphic evolution, and structural geology in the northwestern Iberian Massif are integrated into a synthesis of the tectonic evolution that places the autochthonous and allochthonous terranes in the framework of Paleozoic plate tectonics. Because northwestern Iberia is free from strike-slip faults of continental scale, it is retrodeformable and preserves valuable information about the orthogonal component of convergence of Gondwana with Laurentia and/or Baltica, and the opening and closure of the Rheic Ocean. The evolution deduced for northwest Iberia is extended to the rest of the Variscan belt in an attempt to develop a three-dimensional interpretation that assigns great importance to the transcurrent components of convergence. Dominant Carboniferous dextral transpression following large Devonian and Early Carboniferous thrusting and recumbent folding is invoked to explain the complexity of the belt without requiring a large number of peri-Gondwanan terranes, and its ophiolites and highpressure allochthonous units are related to a single oceanic closure. Palinspastic reconstruction of the Variscan massifs and zones cannot be achieved without restoration of terrane transport along the colliding plate margins. A schematic reconstruction is proposed that involves postcollisional strike-slip displacement of ~3000 km between Laurussia and Gondwana during the Carboniferous

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Thrust geometry and the location of gneiss domes: implications of thermal models of the Central Iberian crustal domain during the Variscan

England and Thompson (1984) and Peacock (1989) developed a method to produce thermal models of the pressuretemperature-time (P-T-t) paths of regional metamorphism in thickened continental crust. Their models place the physical conditions undergone by rocks initially at different depths in a temporal frame and permit a better understanding of the orogenic processes involved. One common response to thickening that is observed in orogenic belts is the formation of gneiss domes (Whitney et al., 2004). Gneiss domes are an important feature of the Iberian crust affected by the Variscan orogeny and are abundant in the core of the Central Iberian arc (Martínez Catalán, 2011). Recent investigations (Rubio Pascua,l 2012) in the Central Iberian zone (CIZ) provide data that can be used to constrain thermal models and to evaluate the model response to changes in basic parameters and in the geometry of structural evolutionDepartment of Geosciences, Penn State, Estados UnidosInstituto Geológico y Minero de España, EspañaDepartamento de Geología, Universidad de Salamanca, EspañaUnidad de Salamanca, Instituto Geológico y Minero de España, EspañaDepartamento de Petrología y Geoquímica, Universidad Complutense de Madrid, EspañaInstituto de Geociencias, Consejo Superior de Investigaciones Científicas, EspañaInstituto de Geociencias, Universidad Complutense de Madrid, Españ

A rootless suture and the loss of the roots of a mountain chain: The Variscan belt of NW Iberia

Ophiolites of different Paleozoic ages occur in North-West (NW) Iberia in a rootless suture representing the remnants of the Rheic Ocean. Associated allochthonous terranes in the hanging- and foot-walls of the suture derive from the former margins, whereas the relative autochthon corresponds to the Paleozoic passive margin of northern Gondwana. The Paleozoic tectonic evolution of this part of the circum-Atlantic region is deduced from the stratigraphical, petrological, structural and metamorphic evolution of the different units and their ages. The tectonic reconstruction covers from Cambro-Ordovician continental rifting and the opening of the Rheic Ocean to its Middle to Upper Devonian closure. Then, the Variscan Laurussia–Gondwana convergence and collision is briefly described, from its onset to the late stages of collapse associated with the demise of the orogenic roots. [RÉSUMÉ] Une suture sans racines et la perte des racines d’une chaîne montagneuse : la chaîne varisque du Nord-Ouest de l’Ibérie. Des ophiolites d’âges différents affleurent dans le Nord-Ouest de l’Ibérie dans une suture sans racines, témoin de l’océan Rhéïque. Les terrains allochtones sur et sous la suture dérivent de ses deux marges, tandis que l’autochtone relatif appartient à la marge passive du Nord de Gondwana. On peut déduire l’évolution des plaques dans cette partie de la région circum-Atlantique à partir des données stratigraphiques, pétrologiques, structurales, métamorphiques et géochronologiques. Cette évolution inclut le développement d’un rift continental et l’ouverture de l’océan Rhéïque pendant le Cambro-Ordovicien ainsi que sa fermeture au Dévonien moyen à supérieur. On décrit aussi l’évolution de la convergence et collision varisque entre Laurussia et Gondwana, du début jusqu’aux derniers stades d’un effondrement associé à la perte des racines orogéniques

Owning a Pet Is Associated with Changes in the Composition of Gut Microbiota and Could Influence the Risk of Metabolic Disorders in Humans

Pet ownership positively influences clinical outcomes in cardiovascular prevention. Additionally, cardiovascular disease (CVD) has been previously linked to microbiota dysbiosis. We evaluated the influence of owning a pet and its relationship with the intestinal microbiota. We analyzed the gut microbiota from 162 coronary patients from the CORDIOPREV study (NCT00924937) according to whether they owned pets (n = 83) or not (n = 79). The pet-owner group was further divided according to whether they owned dogs only (n = 28) or not (n = 55). A 7-item pet-owners test score was used. Patients who owned pets had less risk of metabolic syndrome (MetS) (OR = 0.462) and obesity (OR = 0.519) and were younger (p < 0.001) than patients who did not own pets. Additionally, patients who owned dogs had less risk of MetS (OR = 0.378) and obesity (OR = 0.418) and were younger (p < 0.001) than patients who did not own pets. A preponderance of the genera Serratia and Coprococcus was found in the group of owners, while the genera Ruminococcus, an unknown genus of Enterobacteriaceae and Anaerotruncus were preponderant in the group of non-owners. In patients who owned dogs, Methanobrevibacter and two more genera, Coprococcus and Oscillospira, were more common. Our study suggests that the prevalence of MetS and obesity in CVD patients is lower in pet owners, and that pet ownership could be a protective factor against MetS through the shaping of the gut microbiota. Thus, owning a pet could be considered as a protective factor against cardiometabolic diseases

Hace tiempo. Un viaje paleontológico ilustrado por Colombia

En un viaje nuestro cuerpo se mueve de un lugar a otro, nuestra imaginación se despierta al conocer espacios nuevos y nuestra vida cambia con cada experiencia del recorrido. Hay viajes cortos, largos, en carro, en avión, al mar, a la montaña, y hay viajes que inician con un libro. Aquí te proponemos hacer un viaje con las maletas repletas de atención y curiosidad por las imágenes y letras en cada página. Tus ojos, oídos e imaginación serán las alas que te llevarán a descubrir formas, paisajes y seres vivos que vivieron en Colombia alguna vez.Bogotá, D. C

La Extensión Universitaria como una herramienta para la apropiación social del conocimiento

La Universidad Tecnológica de Pereira (UTP), a través de la Vicerrectoría de Investigaciones Innovación y Extensión, busca promover la extensión universitaria como una estrategia que permite el intercambio, la aplicación y la integración del conocimiento científico, tecnológico, artístico y cultural; al igual que la vinculación con la realidad social, cultural, económica y productiva de la región y del país, al darle valor a las capacidades institucionales y al generar una articulación e integración entre la docencia y la investigación, la cual permita la identificación de problemáticas y la propuesta de alternativas de solución; además de las oportunidades en el sector externo para realizar intervenciones y alianzas que conduzcan a fortalecer y aportar al desarrollo económico, cultural y el bienestar de la comunidad en general. En este sentido, para el año 2019 se ofertó, a los miembros de la comunidad universitaria, la «Convocatoria interna para la financiación de proyectos de extensión social, cultural y artístico» cuya ejecución se realizaría en el año 2020 y cuyo objetivo era fomentar el desarrollo de proyectos de carácter social, cultural, artístico, los cuales permitieran la solución y transformación de problemáticas que involucrarán o beneficiarán sectores de diferentes comunidadesApropiación social del conocimientoCONTENIDO Población beneficiada ...............................................................................................54 Conclusiones..............................................................................................................54 Fotografías..................................................................................................................55 Bibliografía .................................................................................................................58 Capítulo cuatro Generación de Apropiación Social del Conocimiento en Temas de Procesamiento, Bioconservación y Nutrición, a los Productores del Mercado Agroecológico de la Universidad Tecnológica de Pereira Alimentos para la Vida...................................................................................................................................63 Resumen .....................................................................................................................64 Abstract.......................................................................................................................65 Introducción...............................................................................................................65 Objetivos.....................................................................................................................66 Objetivo general.........................................................................................................66 Objetivos específicos.................................................................................................66 Metodología ..............................................................................................................67 Resultados...................................................................................................................68 Población beneficiada ...............................................................................................70 Conclusiones..............................................................................................................71 Bibliografía .................................................................................................................71 Fotografías..................................................................................................................74 Capítulo cinco Cursos de refuerzo basados en aprendizaje activo, social y cultural, para afrontar el contexto de la enseñanza en ingeniería desde una visión interdisciplinaria............................................................................................................79 Resumen .....................................................................................................................79 Abstract ......................................................................................................................80 Introducción...............................................................................................................81 Objetivos.....................................................................................................................84 Objetivo general.........................................................................................................84 Objetivos específicos.................................................................................................84 Metodología ...............................................................................................................85 Resultados...................................................................................................................88 Población beneficiada ...............................................................................................89 Conclusiones..............................................................................................................89 Bibliografía .................................................................................................................90 Capítulo seis Laboratorios andantes: Fotografía estenopeica como interfaz cultural de la memoria colectiva..........................................................................................................95 Resumen .....................................................................................................................95 Abstract ......................................................................................................................96 Introducción...............................................................................................................97 Objetivos.................................................................................................................. 101 Objetivo general...................................................................................................... 101 Objetivos específicos.............................................................................................. 101 Metodología ........................................................................................................... 101 Resultados................................................................................................................ 105 Conclusiones........................................................................................................... 108 Bibliografía .............................................................................................................. 109 Capítulo siete Divulgación académica y cultural de los productos turísticos y rol del arenero artesanal en el turismo de la Virginia, Risaralda.................................................. 113 Resumen .................................................................................................................. 113 Abstract ................................................................................................................... 114 Introducción............................................................................................................ 114 Objetivos.................................................................................................................. 116 Objetivo general...................................................................................................... 116 Objetivos específicos.............................................................................................. 116 Metodología ............................................................................................................ 117 Resultados................................................................................................................ 117 Población beneficiada ............................................................................................ 119 Conclusiones........................................................................................................... 120 Bibliografía .............................................................................................................. 120 Capítulo ocho Proyecto de actualización en cirugía general........................................................ 125 Resumen .................................................................................................................. 125 Abstract.................................................................................................................... 126 Introducción............................................................................................................ 127 Objetivos.................................................................................................................. 127 Objetivo general...................................................................................................... 127 Objetivos específicos.............................................................................................. 128 Metodología ............................................................................................................ 128 Resultados................................................................................................................ 128 Población beneficiada ............................................................................................ 140 Conclusiones........................................................................................................... 141 Bibliografía .............................................................................................................. 141 Capítulo nueve Implementación de metodologías de enseñanza/aprendizaje en niños de tercera infancia y adolescentes a través de conceptos y proyectos de la aeronáutica (Aerokid)....................................................................................................................... 145 Resumen .................................................................................................................. 145 Abstract.................................................................................................................... 146 Introducción............................................................................................................ 147 Objetivos.................................................................................................................. 148 Objetivo general...................................................................................................... 148 Objetivos específicos.............................................................................................. 148 Metodología ............................................................................................................ 148 Resultados................................................................................................................ 158 Población beneficiada ............................................................................................ 158 Conclusiones........................................................................................................... 158 Bibliografía .............................................................................................................. 159 Capítulo diez “Contagio: Cursos de Extensión de Educadores Noveles para Población Migrante”...................................................................................................................... 163 Resumen .................................................................................................................. 163 Abstract.................................................................................................................... 164 Introducción............................................................................................................ 165 Objetivos.................................................................................................................. 166 Objetivo general...................................................................................................... 166 Objetivos específicos.............................................................................................. 166 Metodología ............................................................................................................ 167 Población beneficiada ............................................................................................ 169 Evento de cierre, 19 de noviembre: Narrativas migratorias: experiencias de viaje............................................................................................... 170 Medios de difusión................................................................................................ .171 Datos sobre la inscripción de los cursillistas....................................................... 171 Sobre la migración.................................................................................................. 173 Conclusiones........................................................................................................... 173 Bibliografía .............................................................................................................. 177 Capítulo once Los mercados agroecológicos en Pereira, Dosquebradas y Santa Rosa: una expresión de dinámicas sociales y economías posibles....................................... 181 Resumen .................................................................................................................. 181 Abstract.................................................................................................................... 182 Introducción............................................................................................................ 183 Objetivos.................................................................................................................. 185 Objetivo general...................................................................................................... 185 Objetivos específicos.............................................................................................. 185 Metodología ............................................................................................................ 185 Resultados................................................................................................................ 187 Población beneficiada ............................................................................................ 196 Conclusiones........................................................................................................... 198 Bibliografía .............................................................................................................. 200 Capítulo doce Identificación e implementación de medidas integrales basadas en minería de datos para la disminución de la deserción al interior de la facultad de ingenierías de la Universidad Tecnológica de Pereira ......................................... 205 Resumen .................................................................................................................. 205 Abstract.................................................................................................................... 206 Introducción............................................................................................................ 206 Objetivos ................................................................................................................. 208 Objetivo general...................................................................................................... 208 Objetivos específicos.............................................................................................. 208 Metodología ............................................................................................................ 208 Resultados................................................................................................................ 209 Resultados preliminares......................................................................................... 225 Población beneficiada ........................................................................................... 226 Conclusiones........................................................................................................... 226 Bibliografía .............................................................................................................. 22

Variscan Metamorphism

Various segments of Variscan crust are currently exposed in Iberia in response to successive tectonic events during the Variscan orogeny itself and subsequent extensional and compressive events during the Alpine cycle, all accompanied by surface erosion, and collectively contributing to their exhumation. We review the main characteristics and geodynamic contexts of the metamorphic complexes developed in Iberia during the Variscan cycle, which include: (i) LP-HT complexes associated to the Cambrian-Early Ordovician rift stage; (ii) HP-LT complexes associated to subduction; and (iii) syn-to-post-collisional, MP and LP/HT complexes from the hinterland to the foreland fold-and thrust belts. All the above contexts are illustrated with case studies. Finally, a review of Variscan metamorphism in the Pyrenees and Catalan Coastal Ranges, located far away from the Rheic suture is also presented