Quasi-simultaneous Radio/X-Ray Observations of the Candidate Transitional Millisecond Pulsar 3FGL J1544.6-1125 during its Low-luminosity Accretion-disk State

3FGL J1544.6-1125 is a candidate transitional millisecond pulsar (tMSP). Similar to the well-established tMSPs - PSR J1023+0038, IGR J18245-2452, and XSS J12270-4859 -- 3FGL J1544.6-1125 shows $\gamma$-ray emission and discrete X-ray "low" and "high" modes during its low-luminosity accretion-disk state. Coordinated radio/X-ray observations of PSR J1023+0038 in its current low-luminosity accretion-disk state showed rapidly variable radio continuum emission-possibly originating from a compact, self-absorbed jet, the "propellering" of accretion material, and/or pulsar moding. 3FGL J1544.6-1125 is currently the only other (candidate) tMSP system in this state, and can be studied to see whether tMSPs are typically radio-loud compared to other neutron star binaries. In this work, we present a quasi-simultaneous Very Large Array and Swift radio/X-ray campaign on 3FGL J1544.6-1125. We detect 10 GHz radio emission varying in flux density from $47.7 \pm 6.0$ $\mu$Jy down to $\sim$15 $\mu$Jy (3$\sigma$ upper limit) at four epochs spanning three weeks. At the brightest epoch, the radio luminosity is $L_{5 GHz}$ $= (2.17 \pm 0.17) \times 10^{27}$ erg s$^{-1}$ for a quasi-simultaneous X-ray luminosity $L_{2-10 keV}$ $= (4.32 \pm 0.23) \times 10^{33}$ erg s$^{-1}$ (for an assumed distance of 3.8 kpc). These luminosities are close to those of PSR J1023+0038, and the results strengthen the case that 3FGL J1544.6-1125 is a tMSP showing similar phenomenology to PSR J1023+0038.Comment: Accepted for publication in the Astrophysical Journa

The Australian Reproductive Genetic Carrier Screening Project (Mackenzie's Mission): Design and Implementation

Published: 28 October 2022Reproductive genetic carrier screening (RGCS) provides people with information about their chance of having children with autosomal recessive or X-linked genetic conditions, enabling informed reproductive decision-making. RGCS is recommended to be offered to all couples during preconception or in early pregnancy. However, cost and a lack of awareness may prevent access. To address this, the Australian Government funded Mackenzie’s Mission—the Australian Reproductive Genetic Carrier Screening Project. Mackenzie’s Mission aims to assess the acceptability and feasibility of an easily accessible RGCS program, provided free of charge to the participant. In study Phase 1, implementation needs were mapped, and key study elements were developed. In Phase 2, RGCS is being offered by healthcare providers educated by the study team. Reproductive couples who provide consent are screened for over 1200 genes associated with >750 serious, childhood-onset genetic conditions. Those with an increased chance result are provided comprehensive genetic counseling support. Reproductive couples, recruiting healthcare providers, and study team members are also invited to complete surveys and/or interviews. In Phase 3, a mixed-methods analysis will be undertaken to assess the program outcomes, psychosocial implications and implementation considerations alongside an ongoing bioethical analysis and a health economic evaluation. Findings will inform the implementation of an ethically robust RGCS program.Alison D. Archibald ... Tristan Hardy ... et al. and The Mackenzie’s Mission Study Tea

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of them could not be assigned to a specific gene and initiate at unconventional regions, outside promoters or enhancers. Here, we probe these unassigned TSSs and show that, in all species studied, a significant fraction of CAGE peaks initiate at microsatellites, also called short tandem repeats (STRs). To confirm this transcription, we develop Cap Trap RNA-seq, a technology which combines cap trapping and long read MinION sequencing. We train sequence-based deep learning models able to predict CAGE signal at STRs with high accuracy. These models unveil the importance of STR surrounding sequences not only to distinguish STR classes, but also to predict the level of transcription initiation. Importantly, genetic variants linked to human diseases are preferentially found at STRs with high transcription initiation level, supporting the biological and clinical relevance of transcription initiation at STRs. Together, our results extend the repertoire of non-coding transcription associated with DNA tandem repeats and complexify STR polymorphism

Quasi-simultaneous Radio/X-Ray Observations of the Candidate Transitional Millisecond Pulsar 3FGL J1544.6-1125 during its Low-luminosity Accretion-disk State

3FGL J1544.6−1125 is a candidate transitional millisecond pulsar (tMSP). Similar to the well-established tMSPs—PSR J1023+0038, IGR J18245−2452, and XSS J12270−4859—3FGL J1544.6−1125 shows γ-ray emission and discrete X-ray "low" and "high" modes during its low-luminosity accretion-disk state. Coordinated radio/X-ray observations of PSR J1023+0038 in its current low-luminosity accretion-disk state showed rapidly variable radio continuum emission—possibly originating from a compact, self-absorbed jet, the "propellering" of accretion material, and/or pulsar moding. 3FGL J1544.6−1125 is currently the only other (candidate) tMSP system in this state, and can be studied to see whether tMSPs are typically radio-loud compared to other neutron star binaries. In this work, we present a quasi-simultaneous Very Large Array and Swift radio/X-ray campaign on 3FGL J1544.6−1125. We detect 10 GHz radio emission varying in flux density from 47.7 ± 6.0 μJy down to ≲15 μJy (3σ upper limit) at four epochs spanning three weeks. At the brightest epoch, the radio luminosity is L5 GHz = (2.17 ± 0.17) × 1027 erg s−1 for a quasi-simultaneous X-ray luminosity L2–10 keV = (4.32 ± 0.23) × 1033 erg s−1 (for an assumed distance of 3.8 kpc). These luminosities are close to those of PSR J1023+0038, and the results strengthen the case that 3FGL J1544.6−1125 is a tMSP showing similar phenomenology to PSR J1023+0038

Physical science in the time of Nero; being a translation of the Quaestiones naturales of Seneca,

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Quasi-simultaneous Radio/X-Ray Observations of the Candidate Transitional Millisecond Pulsar 3FGL J1544.6-1125 during its Low-luminosity Accretion-disk State

3FGL J1544.6−1125 is a candidate transitional millisecond pulsar (tMSP). Similar to the well-established tMSPs—PSR J1023+0038, IGR J18245−2452, and XSS J12270−4859—3FGL J1544.6−1125 shows γ-ray emission and discrete X-ray "low" and "high" modes during its low-luminosity accretion-disk state. Coordinated radio/X-ray observations of PSR J1023+0038 in its current low-luminosity accretion-disk state showed rapidly variable radio continuum emission—possibly originating from a compact, self-absorbed jet, the "propellering" of accretion material, and/or pulsar moding. 3FGL J1544.6−1125 is currently the only other (candidate) tMSP system in this state, and can be studied to see whether tMSPs are typically radio-loud compared to other neutron star binaries. In this work, we present a quasi-simultaneous Very Large Array and Swift radio/X-ray campaign on 3FGL J1544.6−1125. We detect 10 GHz radio emission varying in flux density from 47.7 ± 6.0 μJy down to ≲15 μJy (3σ upper limit) at four epochs spanning three weeks. At the brightest epoch, the radio luminosity is L5 GHz = (2.17 ± 0.17) × 1027 erg s−1 for a quasi-simultaneous X-ray luminosity L2–10 keV = (4.32 ± 0.23) × 1033 erg s−1 (for an assumed distance of 3.8 kpc). These luminosities are close to those of PSR J1023+0038, and the results strengthen the case that 3FGL J1544.6−1125 is a tMSP showing similar phenomenology to PSR J1023+0038