Ficha de Observação/Avaliação Motora: Ficha para verificação da qualidade de jogo dos alunos do 3º ciclo do Ensino Básico, nos Jogos Desportivos Colectivos

The present work consisted on the design of a motor performance observational sheet that could also be used for motor evaluation. For this purpose, we analyzed the common characteristics of group sports, with the intention of obtaining a distinction between the two final levels (good or weak). We also used all the basic theoretical assumptions inherent to the construction of motor performance tests, as well as the programme for Physical Education proposed by the Education Ministry for the school year of 2004/2005. This work has emerging relevance mainly due to the lack of observational instruments on the motor performance, domain of group sports with territorial invasion. We therefore, attempted to create an observational sheet as valid, objective and reliable as possible, in order to evaluate students of the third grade of basic education. This assessment was made independently of student age or gender so that the success criterion could be adapted to the abilities that are expected to be present in these students. Prior to the use of this observational sheet, the proper application conditions should be present, as well as its application protocol should be of the subject’s knowledge. When used along with video aid this sheet becomes an extraordinarily simple and fast instrument to work with, being also wide enough to include several types of group sports

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Avaliação/Classificação da Disciplina “Seminário”: Métodos e Técnicas de Avaliação, estudo realizado no curso de Desporto da Universidade de Trás-os-Montes e Alto Douro

The central theme of this study is to verify what sort of evaluation the orientactors teachers of the physical education and sport’s of monographs of the University of Trás-os-Montes e Alto Douro base their judgement when evaluating (trainee) students of this institution for the subject of seminar. To obtain the information, an anonymous and confidential questionnaire was made for the project. The results were statistically treated by descriptive statistics analyse and content analyse. The obtained results certified that there are orientactors which realise a normative evaluation among the students who have been orientated by them (66,7%), but on the other hand very few orientactors compare the results of their students with the others orientactors students (72,2%). In relation to the criterion of evaluation, all the orientactors (100%) compare the results obtain by their students with criterions established at the beginning of their work. The mystic evaluation (normative and criterion) is realizes by 61,1% of the orientactors. Most of these orientactors (72,2%) realise sumative evaluation, while only 16,7% of the orientactors realise a somative evaluation. Finally 66,7% of the orientactors believe that all the teaching courses should give higher value to the formation in the area of evaluation. Of this percentage, 25% of the orientactors believe that there are no subjects that actually teach how to evaluate

Peripheral T-cell Lymphoma In Hiv-positive Patients.

Two cases of peripheral T-cell lymphomas in HIV-positive patients are reported: one case of T-pleomorphic small cell non-Hodgkin lymphoma in a 27 year-old bisexual male, and one case of a T-pleomorphic medium and large cell non-Hodgkin lymphoma in a 27 year-old female, whose husband was drug addicted. Both cases were studied on a morphological and immunohistological basis.111342742

Association Between Human Leukocyte Antigens And Graft-versus-host Disease Occurrence After Allogenic Hematopoietic Stem Cell Transplantation [associação Entre Antígenos Leucocitários Humanos E A Ocorrência Da Doença Do Enxerto Contra O Hospedeiro Após O Transplante Alogênico Decélulas-tronco Hematopoiéticas]

CONTEXT AND OBJECTIVE: Graft-versus-host disease (GVHD) is one of the complications following allogenic stem cell transplantation. This study investigated an association between human leukocyte antigen (HLA) and the occurrence of acute and chronic GVHD in patients who had received stem cell transplantations from HLA-identical siblings. DESIGN AND SETTING: Retrospective study at Hematology and Hemotherapy Center, Universidade Estadual de Campinas (Unicamp). METHODS: The participants were 176 patients whose first transplant was between 1997 and 2009. HLA genotyping was performed serologically and using the polymerase chain reaction with specific primer sequence. RESULTS: Acute GVHD was positively associated with HLA-A10 (P = 0.0007), HLA-A26 (P = 0.002), B55 (P = 0.001), DRB1 *15 (P = 0.0211) and DQB1 *05 (P = 0.038), while HLA-B16 (P = 0.0333) was more frequent in patients without acute GVHD. Chronic GVHD was positively associated with HLA-A9 (P = 0.01) and A23 (P = 0.0292) and negatively with HLA-A2 (P = 0.0031) and B53 (P = 0.0116). HLA-B35 (P = 0.0373), B49 (P = 0.0155) and B55 (P = 0.0024) were higher in patients with acute GVHD grade 3 or above, than in other patients. In patients with extensive chronic GVHD, HLA-A9 (P = 0.0004), A24 (P = 0.0059) and A26 (P = 0.0411) were higher than in other patients, while HLA-A2 was lower (P = 0.0097). CONCLUSION:This study suggests that HLA can influence the incidence and severity of acute and chronic GVHD. However, a study with a better design and more patients will be needed to confirm these results.1304219224Dickinson, A.M., Charron, D., Non-HLA immunogeneticsin hematopoietic stem cell transplantation (2005) Curr Opin Immunol, 17 (5), pp. 517-525Charron, D., Immunogenetics today: HLA, MHC and much more (2005) Curr Opin Immunol, 17 (5), pp. 493-497Mohyeddin Bonab, M., Alimoghaddam, K., Vatandoust, S., Are HLA antigens a risk factor for acute GVHD in thalassemic patients receiving HLA-identical stem cell transplantation? (2004) Transplant Proc, 36 (10), pp. 3190-3193Battiwalla, M., Hahn, T., Radovic, M., Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence (2006) Blood, 107 (5), pp. 1970-1973Storb, R., Prentice, R.L., Hansen, J.A., Thomas, E.D., Association between HLA-B antigens and acute graft-versus-host disease (1983) Lancet, 2 (8354), pp. 816-819Clark, R.E., Hermans, J., Madrigal, A., HLA-A3 increases and HLA-DR1 decreases the risk of acute graft-versus-host disease after HLA-matched sibling bone marrow transplantation for chronic myelogenous leukaemia (2001) BrJ Haematol, 114 (1), pp. 36-41Weisdorf, D., Hakke, R., Blazar, B., Risk factors for acute graft-versus-host disease in histocompatible donor bone marrow transplantation (1991) Transplantation, 51 (6), pp. 1197-1203Bross, D.S., Tutschka, P.J., Farmer, E.R., Predictive factors for acute graft-versus-host disease in patients transplanted with HLA-identical bone marrow (1984) Blood, 63 (6), pp. 1265-1270Remberger, M., Persson, U., Hauzenberger, D., Ringdén, O., An association between human leucocyte antigen alleles and acute and chronic graft-versus-host disease after allogeneic haematopoietic stem cell transplantation (2002) Br J Haematol, 119 (3), pp. 751-759Ghavamzadeh, A., Alimoghaddam, K., Behrouzan, O., HLA and risk of acute graft versus host disease in allogenic bone marrow transplantation from an HLA-identical sibling (2002) Arch Irn Med, 5 (1), pp. 16-20. , http://www.ams.ac.ir/AIM/0251/aim025116.htm, Available from, Accessed in 2011 (Nov 22)Adams, K.M., Holmberg, L.A., Leisenring, W., Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation (2004) Blood, 104 (6), pp. 1894-1897Stern, M., Passweg, J., Tiercy, J.M., Human leukocyte antigen DR15 is associated with reduced relapse rate and improved survival after human leukocyte antigen-identical sibling hematopoietic stem cell transplantation (2006) Biol Blood Marrow Transplant, 12 (11), pp. 1169-1175Petersdorf, E.W., Malkki, M., Genetics of risk factors for graft-versus-host disease (2006) Semin Hematol, 43 (1), pp. 11-23Glucksberg, H., Storb, R., Fefer, A., Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors (1974) Transplantation, 18 (4), pp. 295-304Atkinson, K., Horowitz, M.M., Gale, R.P., Consensus among bone marrow transplanters for diagnosis, grading and treatment of chronic graft-versus-host disease (1989) Bone Marrow Transplant, 4 (3), pp. 247-254. , Committee of the International Bone Marrow Transplant RegistryVisentainer, J.E., Lieber, S.R., Persoli, L.B., Serum cytokine levels and acute graft-versus-host disease after HLA-identical hematopoietic stem cell transplantation (2003) Exp Hematol, 31 (11), pp. 1044-1050Vigorito, A.C., Azevedo, W.M., Marques, J.F., A randomised, prospective comparison of allogeneic bone marrow and peripheral blood progenitor cell transplantation in the treatment of haematological malignancies (1998) Bone Marrow Transplant, 22 (12), pp. 1145-1151Lin, M.T., Storer, B., Martin, P.J., Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation (2003) N Engl J Med, 349 (23), pp. 2201-2210Laguila Visentainer, J.E., Lieber, S.R., Lopes Persoli, L.B., Relationship between cytokine gene polymorphisms and graft-versus-host disease after allogeneic stem cell transplantation in a Brazilian population (2005) Cytokine, 32 (3-4), pp. 171-177Hsu, K.C., Keever-Taylor, C.A., Wilton, A., Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes (2005) Blood, 105 (12), pp. 4878-4884Viel, D.O., Tsuneto, L.T., Sossai, C.R., IL2 andTNFA gene polymorphisms and the risk of graft-versus-host disease after allogeneic haematopoietic stem cell transplantation (2007) Scand J Immunol, 66 (6), pp. 703-710Azarpira, N., Ramzi, M., Aghdaie, M.H., Darai, M., Geramizadeh, B., Interleukin-10 gene polymorphism in bone marrow transplant recipients (2008) Exp Clin Transplant, 6 (1), pp. 74-79Schellekens, J., Rozemuller, E.H., Petersen, E.J., Activating KIRs exert a crucial role on relapse and overall survival after HLA-identical sibling transplantation (2008) Mol Immunol, 45 (8), pp. 2255-2261Visentainer, J.E.L., Sell, A.M., Franceschi, D.A., Lieber, S.R., Souza, C.A., Importância de polimorfismos de genes reguladores de citocinas em transplantes de células progenitoras hematopoiéticas [Importance of regulatory cytokine gene polymorphisms in hematopoietic stem cell transplantation] (2008) RBCF Rev Bras Ciênc Farm (Impr), 44 (4), pp. 739-74

Caipira sweet orange + Rangpur lime: a somatic hybrid with potential for use as rootstock in the Brazilian citrus industry

Protoplast culture following polyethylene glycol-induced fusion resulted in the regeneration of somatic hybrid plants between Caipira sweet orange (Citrus sinensis L. Osbeck) and Rangpur lime (C. limonia L. Osbeck). The plants were confirmed as somatic hybrids by leaf morphology, chromosome number and RAPD profile. All regenerated plants were tetraploid (2n = 4x = 36), with intermediate leaf morphology and complementary RAPD banding profile of both parents. This combination may be useful as a rootstock for the citrus industry in Southeastern Brazil since this somatic hybrid could combine the drought tolerance and vigor of Rangpur lime with the blight tolerance of Caipira sweet orange.<br>Híbridos somáticos de laranja doce (Citrus sinensis L. Osbeck) e limão Cravo (C. limonia L. Osbeck) foram regenerados após a fusão (polietileno glicol) e cultura de protoplastos. Os híbridos somáticos foram confirmados pela análise da morfologia das folhas, determinação do número de cromossomos e marcadores moleculares (RAPD). Todas as plantas analisadas revelaram-se tetraplóides (2n = 4x = 36), possuíam folhas de morfologia intermediária e uma combinação do padrão de bandas de RAPD de ambos os parentais. Esta combinação pode se tornar útil como porta-enxerto para a Região Sudeste da indústria citrícola brasileira. Este híbrido somático potencialmente combinará as características de tolerância à seca e o vigor do limão Cravo com a tolerância ao declínio da laranja Caipira