New insights about the Upper Jurassic – Lower Cretaceous sedimentary successions from Asturias (NW Iberian Peninsula)

Detailed mapping of the Jurassic to pre-Albian deposits of central and eastern Asturias (NW of the Iberian Peninsula) has enabled several Upper Jurassic and Lower Cretaceous outcrops, previously assigned to other ages, to be identified. Where possible, these outcrops have been correlated with the well-known sequences outcropping on the Asturian coast. A new Jurassic unit, the Miyares Formation, has been defined, which consists of a Lower conglomerate Unit, a Middle Unit composed mainly of oolitic limestones and an Upper Unit comprising bioclastic and marly limestones with a rich fauna of larger foraminifera. The Lower Unit is interpreted as having been deposited in a fan delta, the Middle Unit represents a shallow marine high-energy environment, and the Upper Unit was deposited on a restricted shallow marine platform. The shallow-water foraminiferal assemblage from the Upper Unit is attributed to the Tithonian and the oldest Cretaceous rocks are Barremian; there is therefore a stratigraphic gap recorded in the study area, which might correspond to the latest Jurassic to Early Cretaceous p. p. timespan.Una cartografía geológica detallada de los depósitos jurásicos y cretácicos pre-albienses ha permitido identificar varios afloramientos del Jurásico Superior y del Cretácico Inferior, asignados previamente a otras edades. Donde ha sido posible, estos afloramientos han sido correlacionados con las sucesiones bien conocidas que afloran en la costa asturiana. Se ha definido una nueva unidad, la Formación Miyares, formada por una Unidad Inferior conglomerática, una Unidad Media mayoritariamente de calizas oolíticas y una Unidad Superior de calizas bioclásticas y margosas con abundantes macroforaminíferos. La Unidad Inferior se interpreta como depósitos de fan delta, la Unidad Media representa un ambiente marino somero de alta energía, y la Unidad Superior fue depositada en una plataforma marina somera restringida. El conjunto de foraminíferos de agua somera de la Unidad Superior se atribuye al Titoniense y las rocas más antiguas del Cretácico son del Barremiense; existe por lo tanto, en el área de estudio, una laguna estratigráfica que abarca la parte terminal del Jurásico y una parte del Cretácico Inferior

Non‐Toxic Glycosylated Gold Nanoparticle‐Amphotericin B Conjugates Reduce Biofilms and Intracellular Burden of Fungi and Parasites

Infections by intracellular pathogens cause significant morbidity and mortality due to lack of efficient drug delivery. Amphotericin B, currently used to treat leish maniasis and cryptococcosis, is very toxic and cannot eradicate intracellular Cryptococcus neoformans (C. neoformans). Glycosylated gold nanoparticles are water dispersible and biocompatible with very little toxici ty. While amphotericin B is insoluble in water at neutral pH, conjugates of amphotericin B and ultra-small gold nanoparticles (AuNP) are better dispersible in water. Amphotericin B conjugated glycosylated gold nanoparticles (AmpoB@AuNP) are more efficacious in treating both extracellular and intracellular forms of Leishmania mexicana (L. mexicana) than amphotericin B alone. In addition, AmpoB@AuNP are effective in reducing C. neoformans biofilms by 80% and intracellular C. neoformans burden by >90%. Furthermore, AmpoB@AuNP are not haemolytic at 50 mu g mL(-1) and are significantly less toxic to murine macrophages than amphotericin B. Ultra-small AuNPs are attractive delivery agents to treat intracellular infections and AmpoB@AuNP may be useful for treating C. neoformans infections in immunocompromised patients

Revisión bioestratigráfica de las pizarras del Ordovícico Medio en el noroeste de España (zonas Cantábrica, Asturoccidental-leonesa y Centroibérica septentrional)

A complete review of more than one hundred Middle Ordovician fossil localities, distributed within the north western part of the Hesperian Massif, shows that the sedimentation of the dark shales (Luarca Fo rmation and equivalents) that overlie Arenig quartzites with Cruziana (the 'Armorican Quartzite' facies) was not as uniform as it has been supposed for the whole NW Spain. These shales were mainly deposited during the Oretanian in the West Asturian-Leonese Zone and in nort h e rn Central-Iberian Zone (Domain of the Ollo de Sapo Antiform). In these zones, the top of the unit is close to the Oretanian/Dobrotivian boundary, without any fossils with proved Dobrotivian age. In the Cantabrian Zone, clay sedimentation started in the latest Oretanian and continued during the Dobrotivian. Several local or regional stratigraphic gaps are proposed and characterized for the whole study area. In addition, the most recent paleog e ographical reconstructions proposed are discussed, in accordance with new paleoecological and paleobiog e ographical data. These data indicate that sedimentation took place in open shelf areas, relative ly deeper than in the southern Central Iberian shelf, and with trough areas where some mesopelagic elements are recorded. We identified a total of 97 different fossil taxa (67 from Oretanian rocks and 45 from Dobrotivian rocks), remarkable among which are the first known appearance of certain trilobites and ostracodes, the latest record of other taxa, and also the presence of some taxa in common with Avalonia and Baltica, that were previously unknown from any area of SW Europe

Oxygen concentration in the water column over a Posidonia oceanica meadow in Cabrera Archipelago Marine-Terrestrial National Park between October 2019 – October 2021

[Description of methods used for collection/generation of data] For the study, environmental data were measured by sensors located in both the water column and the benthic compartment (at 4 m and 8 m, respectively). Temperature, salinity and dissolved oxygen (DO) from the water column were measured from October 2019 to October 2021 by a sensor attached to the mooring line. Data were recorded with a CT SBE37 (Conductivity, Temperature) sensor (SBE37SMP-ODO-RS232, Sea-Bird Scientific©) coupled with an SBE 63 (Sea-Bird Scientific©) dissolved oxygen (DO) sensor with accuracies of ± 0.002 °C for temperature, ± 0.002 mS cm-1 for conductivity and ± 2 % for DO. Measurements were taken with a resolution of 0.0001 ºC for temperature, 0.0001 mS cm−-1 for conductivity and 0.2 µmol kg-1 for DO. Multiparametric Hydrolab HL4 probes (OTT HydroMet) were deployed during 8 different periods covering all seasons following the procedure by Hendriks et al. (2021). Accuracy for the multiparametric probe sensors is ± 0.10 ºC for temperature and ± 0.5 % of reading + 0.001 mS cm−1 for conductivity, with resolutions of 0.01 ºC and 0.001 mS cm-−1, respectively. The DO sensor presents an accuracy of ± 0.1 mg L−1 for values lower than 8 mg L−1, and ± 0.2 mg L−1 for values higher than 8 mg L−1, and a resolution of 0.01 mg L−1. Two benthic chambers were installed during May and July 2021 using a design previously described in Barrón et al. (2006). MiniDOT sensors (PME, Inc. ©) were used for temperature and DO measurements every 15 minutes, with accuracies of ± 0.1 ºC and ± 5 %, respectively. DO sensor data were validated against water samples analysed with the Winkler method.. Three chamber replicates were installed during each deployment. Wind speed (m s−1) values at Cabrera NP Station were obtained from data provided by the Organismo Autónomo de Parques Nacionales (OAPN, Spain). For the benthic chambers, night respiration was estimated from changes in DO between one hour after sunset and one hour before sunrise. The same procedure was followed for the calculation of the net community production (NCP) during daylight hours, and the two values were summed for GPP. NCP was used along with the total meadow area coverage and residence time of water in Sta. María Bay to determine the total O2 exported by the meadow to the water column. For the metabolic rate calculation, only oxygen data from the first 24 hours were used.[Methods for processing the data] Seasonal variations in the metabolic rates were analysed with a one-way ANOVA test using the Statistics and Machine Learning ToolboxTM in Matlab® (https://mathworks.com). For this purpose, daily metabolic rates from water column sensors and multiparametric sensors were grouped by season . The same statistical analysis was performed to analyse disparities between sensors. Since benthic chamber data were only available for one day in May and one day in July, differences between deployments were tested using a Student t-test.readme provides background information for csv datafiles. Csv datafiles are processed data of oxygen concentrations used as input for the model, with a frequency of 10 minutes for hydrolab (HL) measurements and hourly for the CT measurements, and a frequency of 15 minutes for MiniDot measurements.Spanish Ministry of Science (SumaEco, RTI2018–095441-B-C21), the Government of the Balearic Islands through la Consellería d'Innovació, Recerca i Turisme (Projecte de recerca científica i tecnològica SEPPO, PRD2018/18), the Posi-COIN Project from the 2018 BBVA Foundation “Ayudas a equipos de investigación científica” call. STARTER research project funded by the 2021 call of the Càtedra de la Mar, Iberostar Foundation. This work is a contribution to CSIC's Thematic Interdisciplinary Platform PTI OCEANS+. The present research was carried out within the framework of the activities of the Spanish Government through the "Maria de Maeztu Centre of Excellence" accreditation to IMEDEA (CSIC-UIB) (CEX2021-001198).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001198).Peer reviewe

Introducing Hyaluronic Acid into Supramolecular Polymers and Hydrogels

[Abstract] The use of supramolecular polymers to construct functional biomaterials is gaining more attention due to the tunable dynamic behavior and fibrous structures of supramolecular polymers, which resemble those found in natural systems, such as the extracellular matrix. Nevertheless, to obtain a biomaterial capable of mimicking native systems, complex biomolecules should be incorporated, as they allow one to achieve essential biological processes. In this study, supramolecular polymers based on water-soluble benzene-1,3,5-tricarboxamides (BTAs) were assembled in the presence of hyaluronic acid (HA) both in solution and hydrogel states. The coassembly of BTAs bearing tetra(ethylene glycol) at the periphery (BTA-OEG4) and HA at different ratios showed strong interactions between the two components that led to the formation of short fibers and heterogeneous hydrogels. BTAs were further covalently linked to HA (HA-BTA), resulting in a polymer that was unable to assemble into fibers or form hydrogels due to the high hydrophilicity of HA. However, coassembly of HA-BTA with BTA-OEG4 resulted in the formation of long fibers, similar to those formed by BTA-OEG4 alone, and hydrogels were produced with tunable stiffness ranging from 250 to 700 Pa, which is 10-fold higher than that of hydrogels assembled with only BTA-OEG4. Further coassembly of BTA-OEG4 fibers with other polysaccharides showed that except for dextran, all polysaccharides studied interacted with BTA-OEG4 fibers. The possibility of incorporating polysaccharides into BTA-based materials paves the way for the creation of dynamic complex biomaterials.The authors acknowledge the ICMS Animation Studio for providing the artwork. S.V.-A. and G.M. acknowledge the funding received by Gravitation Program “Materials Driven Regeneration,” funded by the Netherlands Organization for Scientific Research (024.003.013). J.M. acknowledges a Marie Skłodowska-Curie postdoctoral fellowship (794016) for financial support. G.M. acknowledges the funding received by the Swiss National Science Foundation (SNSF “Early PostDoc Mobility” P2EZP2-178435). R.C. acknowledges TA Instruments for providing the DHR-3 rheometer under the Young Distinguished Rheologist Award instrument grant. S.S. and E.W.M acknowledge the European Research Council (H2020-EU.1.1., SYNMAT project, ID 788618).Netherlands Organisation for Scientific Research; 024.003.013Swiss National Science Foundation; P2EZP2-17843

Por la Ciudad de Tudela, y su Diputación de el Campo de Traselpuente, querellantes en su causa criminal. Contra Don Joseph Serrano Ichaso Alcalde que fue de dicha Ciudad, el año 1720. acusado. sobre Aver puesto en libertad dicho Acusado à tres presos de orden de la Diputación, y expedido de propia authoridad un vando en materia de govierno de dicha Ciudad

Texto firmado por José Ignacio de Colmenares y AramburuSe ha respetado la puntuación originalPrecede a tít.: Muy Ilustre SeñorTexto fechado en Pamplona, 5 mayo 1724Sign.: [ ]2, B-L2Port. con orla tip. y grab. xil. al comienzo del texto representando a la Virge

Uso problemático de redes sociales virtuales y miedo a quedar afuera (FoMO)

El uso problemático de Internet, y en particular de las redessociales virtuales (RSV), ha reactivado las discusiones sobre elmiedo a quedar afuera (Fear of missing out, FoMO), como unaemoción negativa que está incrementándose por asociación aluso de las tecnologías de información y comunicación (TIC). Conun total de 273 adultos, de 25 a 65 años de edad (M=42.18,D.s.=11.74), de ambos sexos y usuarios de al menos una RSV,se realizó un estudio descriptivo-correlacional que –coninstrumentos locales– indagó las variables uso problemático deRSV y FoMO, además de adicción a internet, ansiedadtecnológica, adicción al teléfono móvil y búsqueda de novedades.Asimismo se determinaron horas de uso no instrumental de TIC ycantidad de perfiles en RSV (intensidad de uso)

SAVASA project @ TRECVid 2013: semantic indexing and interactive surveillance event detection

In this paper we describe our participation in the semantic indexing (SIN) and interactive surveillance event detection (SED) tasks at TRECVid 2013 [11]. Our work was motivated by the goals of the EU SAVASA project (Standards-based Approach to Video Archive Search and Analysis) which supports search over multiple video archives. Our aims were: to assess a standard object detection methodology (SIN); evaluate contrasting runs in automatic event detection (SED) and deploy a distributed, cloud-based search interface for the interactive component of the SED task. Results from the SIN task, underlying retrospective classifiers for the surveillance event detection and a discussion of the contrasting aims of the SAVASA user interface compared with the TRECVid task requirements are presented