Intervención arqueológica de urgencia en la calle Concepción nº 13 de Córdoba. Restos de pintura mural hallados en un edificio altoimperial próximo al foro colonial

In this archaelogical action it has to be emphasized the discovery in situ of some roman wal coverings decorated with paintings. The preserved paintings imitate the marble walls of luxurious houses, fitting into the "First pompeian style", where architectural simulation is reduced to representation of a building of the high imperial period, and it's situated nearby the Porta Principal Sinistra (The main left gate) in the west side of the roman wal, nowadays known as Puerta de Gallegos.De esta actuación arqueológica cabe destacar el descubrimiento in situ de unos paramentos romanos con decoración parietal pintada. Estas pinturas imitan las paredes marmóreas de lujosas casas, encuadrándose en el "Primer estilo pompeyano" donde la simulación arquitectónica se reduce a representar altos zócalos. Los paramentos decoraban las estancias de un edificio de cronología alto-imperial, ubicado en las inmediaciones de la Porta Principal Sinistra en el lienzo oeste de la muralla romana, actual Puerta de Gallegos

La necrópolis de la Avenida del Aeropuerto de Córdoba

Este trabajo ofrece los resultados obtenidos en la excavación arqueológica realizada en 1995 de la necrópolis andalusí de la Avenida del Aeropuerto en Córdoba. Ha sido estudiada una necrópolis urbana, con diversas fases de ocupación y más de 200 tumbas, de gran interés para el conocimiento de la organización espacial de los cementerios de la Córdoba califal.This work presents the results from the archaeoligcal excavation made in 1995 in the Andalusian necropole of Avenida del Aeropuerto, Córdoba. It has been studied an urban cemetery with several phases of occupation and more than two hundred graves, with high interest for the knowledge of spatial structure of graveyards in caliphal Córdob

Hallazgo de una nueva columna miliaria perteneciente a la Via Augusta

By means of this article we let you know about the discovery of a new milliary column which belonged to the Roman Via Augusta. It has been found in the environs of La Torrecilla industrial area close to Córdoba. Its chronology based upon epigraphic analysis allow us to date it in the early years of Nero mandate.Mediante este artículo damos a conocer una nueva columna miliaria correspondiente a la Via Augusta y hallada en las inmediaciones del Polígono Industrial de La Torrecilla. Su cronología, basada en el análisis epigráfico, nos permite adjudicarla al emperador Nerón, en los primeros años de su mandato

New data on the royal Convento of Saint Paulo of Cordoba: the water supply and study of the foundations of its Church

En una reciente actuación arqueológica en el Real Convento de San Pablo de Córdoba hemos podido documentar, de una parte, la cimentación del muro de la fachada principal de la iglesia y, de otra, una importante canalización de agua dulce que abastecía a los dominicos. El monasterio de San Pablo se ubicó en terrenos donados por Fernando III en 1241, concediéndoles el rey un tercio del agua que corría bajo el lienzo este de la muralla de la Villa (antigua Medina).Through a recent archaeological survey at the Royal Monastery of San Pablo in Cordova, we have been able to study the foundations of the wall in the church façade and a freshwater piping system that supplied the dominican friars. The monastery was built on grounds donated by Ferdinand III in 1241, and the king gave the friars access to one third of the water that ran under the east stretch of the wall around the Villa (the old Medina)

Investigating potential inhibitory effect of Uncaria tomentosa (Cat's Claw) against the main protease 3CL pro of SARS-CoV-2 by molecular modeling

COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2. Presently, there is no effective treatment for COVID-19. As part of the worldwide efforts to find efficient therapies and preventions, it has been reported the crystalline structure of the SARS-CoV-2 main protease M pro (also called 3CL pro) bound to a synthetic inhibitor, which represents a major druggable target. The druggability of M pro could be used for discovering drugs to treat COVID-19. A multilevel computational study was carried out to evaluate the potential antiviral properties of the components of the medicinal herb Uncaria tomentosa (Cat's claw), focusing on the inhibition of M pro. The in silico approach starts with protein-ligand docking of 26 Cat's claw key components, followed by ligand pathway calculations, molecular dynamics simulations, and MM-GBSA calculation of the free energy of binding for the best docked candidates. The structural bioinformatics approaches led to identification of three bioactive compounds of Uncaria tomentosa (speciophylline, cadambine, and proanthocyanidin B2) with potential therapeutic effects by strong interaction with 3CL pro. Additionally, in silico drug-likeness indices for these components were calculated and showed good predicted therapeutic profiles of these phytochemicals. Our findings suggest the potential effectiveness of Cat's claw as complementary and/or alternative medicine for COVID-19 treatment

Los aportes de aerosoles afectan las propiedades ópticas de la materia orgánica disuelta en las aguas costeras del Mediterráneo Noroccidental

Aeolian inputs of organic and inorganic nutrients to the ocean are important as they can enhance biological production in surface waters, especially in oligotrophic areas like the Mediterranean. The Mediterranean littoral is particularly exposed to both anthropogenic and Saharan aerosol depositions on a more or less regular basis. During the last few decades experimental studies have been devoted to examining the effect of inorganic nutrient inputs from dust on microbial activity. In this study, we performed experiments at two different locations of the NW Mediterranean, where we evaluated the changes in the quality and quantity of dissolved organic matter due to atmospheric inputs of different origin (Saharan and anthropogenic) and its subsequent transformations mediated by microbial activities. In both experiments the humic-like and protein-like substances, and the fluorescence quantum yield increased after addition. In general, these changes in the quality of dissolved organic matter did not significantly affect the prokaryotes. The recalcitrant character of the fluorescent dissolved organic matter (FDOM) associated with aerosols was confirmed, as we found negligible utilization of chromophoric compounds over the experimental period. We framed these experiments within a two-year time series data set of atmospheric deposition and coastal surface water analyses. These observations showed that both Saharan and anthropogenic inputs induced changes in the quality of organic matter, increasing the proportion of FDOM substances. This increase was larger during Saharan dust events than in the absence of Saharan influence.Los aportes atmosféricos de nutrientes orgánicos e inorgánicos al océano son importantes ya que pueden aumentar la producción biológica en aguas superficiales, especialmente en las zonas oligotróficas como el Mediterráneo. El litoral del Mediterráneo está particularmente expuesto a aportes de origen antropogénico y a deposiciones de polvo sahariano de forma más o menos regular. Durante las últimas décadas los estudios experimentales se han dedicado, sobre todo, a examinar el efecto de la entrada de nutrientes inorgánicos atmosféricos sobre la actividad microbiana. En este estudio, se realizaron experimentos con comunidades microbianas procedentes de dos zonas del Mediterráneo noroccidental. Se evaluaron los cambios en la calidad y cantidad de la materia orgánica disuelta debido a aportes atmosféricos de distinto origen y sus posteriores transformaciones mediadas por actividades microbianas. En ambos experimentos las sustancias orgánicas fluorescentes y el rendimiento cuántico de fluorescencia aumentaron después de la adición de material atmosférico. En general, estos cambios en la calidad de la materia orgánica no afectaron significativamente a los organismos procariotas. El carácter recalcitrante de la materia orgánica disuelta fluorescente (FDOM) contenida en los aerosoles se confirmó ya que la utilización de compuestos cromóforos durante el período experimental fue insignificante. Los resultados obtenidos se contextualizan en relación con una serie temporal de dos años de datos adquiridos de deposición atmosférica y análisis de agua superficial costera. La variabilidad temporal de estas dos variables mostró que tanto los aportes saharianos como antropogénicos provocaron cambios en la calidad de la materia orgánica disuelta en aguas superficiales, incrementando la fracción fluorescente. Éste aumento resultó ser mayor durante eventos de polvo sahariano que en ausencia de ellos

Danio Rerio as Model Organism for Adenoviral Vector Evaluation

Viral vector use is wide-spread in the field of gene therapy, with new clinical trials starting every year for different human pathologies and a growing number of agents being approved by regulatory agencies. However, preclinical testing is long and expensive, especially during the early stages of development. Nowadays, the model organism par excellence is the mouse (Mus musculus), and there are few investigations in which alternative models are used. Here, we assess the possibility of using zebrafish (Danio rerio) as an in vivo model for adenoviral vectors. We describe how E1/E3-deleted adenoviral vectors achieve efficient transduction when they are administered to zebrafish embryos via intracranial injection. In addition, helper-dependent (high-capacity) adenoviral vectors allow sustained transgene expression in this organism. Taking into account the wide repertoire of genetically modified zebrafish lines, the ethical aspects, and the affordability of this model, we conclude that zebrafish could be an efficient alternative for the early-stage preclinical evaluation of adenoviral vectorsThis research was funded by Xunta de Galicia, Local Government, grant number ED431C 2018/28, and Gobierno de Navarra, Local Government, grant numbers 0011-1383-2018-000011 PT038 and 0011-1383-2019-000006 PT013 (XANTOGEN)S

The association between muscle dysmorphia and eating disorder symptomatology: A systematic review and meta-analysis

Background and aims: Research shows inconsistent findings about the link between muscle dysmorphia (MD) and eating disorder (ED) symptomatology. The aim of this study is to synthesize the scientific evidence available on this topic, the researchers conducted a systematic review and meta-analysis. Methods: The literature search enabled us to identify 39 published articles, which provided 36 independent estimations of the correlation between the two variables. Results: Our analysis found a positive association between MD and ED symptoms (r+ = .36; 95% CI = 0.30, 0.41). Moderator analyses showed that the type of sample and the tools for assessing MD and ED were statistically associated with the MD–ED effect sizes. The methodological quality of the studies exhibited a positive, statistically significant association with the MD–ED effect sizes. Conclusions: Higher levels of MD were related to greater ED symptomatology, but several study characteristics may moderate the association between the two variables. In this study, we discuss limitations and implications for clinical practice and future research

Differences in maternal and neonatal cardiometabolic markers and placenta status by foetal sex. The GESTAFIT project

Aims: To explore the differences in some maternal-neonatal metabolic markers and placenta status by foetal sex. Methods: One hundred thirty-nine Caucasian pregnant women from the GESTAFIT project and their new-borns were included in the present cross-sectional study. Serum cardiometabolic markers (i.e. lipid and glycaemic profile and uric acid) were analysed at late pregnancy and at birth. In placenta, telomeres length, proportion of deleted mitochondrial-DNA and mitochondrial-DNA density, some minerals and interleukin 8, epidermal growth factor, fibroblast growth factor-2 and vascular endothelial growth factor were measured. The study was run between November 2015 and April 2018. Results: Mothers carrying a male showed higher serum triglycerides than mothers carrying a female at late pregnancy (p < .05). Serum total and low-density lipoprotein cholesterol were greater in males’ umbilical cord blood artery compared to females’ new-borns (both, p < .05). Mothers of males and male new-borns presented higher uric acid than mothers of females and female new-borns at birth (p < .05). Female’s placentas presented greater placental-newborn weight ratio, manganese content and fibroblast growth factor-2 (all, p ⩽ .05), and evidence of statistical significance in telomeres length, which were 17% longer (p = .076). Conclusion: Our findings show weak differences in some cardiometabolic and placental status markers by foetal sex. Notwithstanding, we observed a slightly more proatherogenic profile in both, mothers carrying males’ foetuses and male new-borns. We also found lower serum uric acid and better placenta status in mothers carrying a female. These findings indicate that foetal sex might need to be considered for a more personalized follow-up of pregnancies.Regional Ministry of Health, Junta de Andalucia PI-0395-2016University of GranadaJunta de AndaluciaEuropean Commission SOMM17/6107/UGRPlan Propio de Investigacion 2016, Excellence actions (Units of Excellence: Unit of Excellence in Exercise and Health

Los docentes como mediadores activos en la adaptación del alumnado al contexto universitario

Entendemos la mediación como una forma de resolver conflictos con la ayuda de una tercera persona imparcial, el mediador. El mediador no es juez, no impone soluciones ni opina sobre quién tiene la verdad, lo que busca es satisfacer las necesidades de las partes en conflicto, regulando el proceso de comunicación y conduciéndolo hacia una posible solución. En ocasiones ejercemos como mediadores al tiempo que realizamos nuestras funciones como docentes y tutores en el proceso de aprendizaje, pero no siempre somos conscientes de todo lo que esta labor implica. La experiencia vivida en la Facultad de Educación nos ha permitido reflexionar acerca de lo que ha supuesto para los diferentes agentes implicados y de las competencias que se han tenido que poner en juego para abordar de forma adecuada una situación excepcional. La investigación se ha realizado por el equipo que constituye la red: la Mediadora de la Facultad, docentes con un perfil de una actitud flexible y un grupo de alumnas de diferentes cursos. El proceso nos ha derivado hacia la búsqueda de delimitación de funciones, estrategias de gestión y propuestas de actuación en pro de la optimización del proceso mediador que propicie la adaptación al entorno universitario