De Jules et Jim au Vel’ d’Hiv

Dans son roman intitulé On ne peut plus dormir tranquille quand on a une fois ouvert les yeux, Robert Bober s’inspire de sa propre histoire et relate bon nombre de faits qui ont réellement eu lieu, à commencer par le tournage en 1961 du film de François Truffaut Jules et Jim. C’est à partir de ce film – et de nombreuses autres références cinématographiques, de Max Ophuls aux Marx Brothers – que le narrateur, d’origine juive polonaise, va retrouver l’histoire de sa famille mais aussi celle d’une ville, Paris, de la Commune de 1871 à la rafle du Vélodrome d’Hiver en 1942.In his novel On ne peut plus dormir tranquille quand on a une fois ouvert les yeux Robert Bober draws his inspiration from his own life and tells a good number of events which have really taken place. Starting with the shooting, in 1961, of François Truffaut Jules et Jim. From this movie, as well as from many other film references – from Max Ophuls to the Marx Brothers – the narrator of Jewish-Polish origin rediscovers the history of his own family together with that of Paris, from the 1971 Commune to the 1942 round-up of Jews in the Vélodrome d’Hiver

Macromodeling of high-speed interconnects by positive interpolation of vertical segments

State-of-the-art interconnect design is very challenging. Designers are facing ever more stringent design specifications expressed in terms of bandwidth, speed, crosstalk, signal attenuation, etc. that dictate the need for powerful modeling tools. It is of a paramount importance that these tools are able to very accurately incorporate all substrate loss mechanisms and the finite conductivity and shape of the metallic interconnects. From this perspective, macromodels describing all high-frequency behavior are extremely useful to analyze the signal integrity (SI) behavior of the interconnects. Often, interconnect structures are characterized by using their cross-sectional geometry in a two-dimensional (2-D) electromagnetic (EM) simulation, leading up to a corresponding transmission line model [1]. An accurate description of the interconnects is then provided in terms of their per unit of length (p.u.1.) resistance (R), inductance (L), conductance (G) and capacitance (C) parameters, yielding so-called RLGC(f) models. Here, f denotes the frequency, as such indicating the frequency-dependent character of the p.u.l. parameters. For a comprehensive overview of such modeling methods, the reader is encouraged to consult [1] and the references therein. For on-chip lines that are electrically very short, sometimes, the p.u.l. resistance R and capacitance C are dominant (RC regime). In the present paper, however, all four p.u.l. parameters are considered, making the approach more general and also valid at very high frequencies. Thereto, a very accurate 2-D EM modeling procedure, making use of a Dirichlet-to-Neumann (DtN) boundary operator, is used as a starting point [2]. This metho

Siglec receptors impact mammalian lifespan by modulating oxidative stress.

Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number of genes encoding the immunomodulatory CD33-related sialic acid-binding immunoglobulin-like receptors (CD33rSiglecs) and maximum lifespan in mammals. In keeping with this, we show that mice lacking Siglec-E, the main member of the CD33rSiglec family, exhibit reduced survival. Removal of Siglec-E causes the development of exaggerated signs of aging at the molecular, structural, and cognitive level. We found that accelerated aging was related both to an unbalanced ROS metabolism, and to a secondary impairment in detoxification of reactive molecules, ultimately leading to increased damage to cellular DNA, proteins, and lipids. Taken together, our data suggest that CD33rSiglecs co-evolved in mammals to achieve a better management of oxidative stress during inflammation, which in turn reduces molecular damage and extends lifespan

Stepwise investigation of the influences of steric groups versus counter ions to target Cu/Dy complexes

From an investigation of varying the steric bulk of a flexible ligand, we have produced a family of structures using similar reaction conditions. Even small changes from a hydrogen atom to a methyl to an ethyl group on the ligand influences the structural outcome, which can also be steered by the nature of the metal source. We employed Schiff base ligands by combining o-vanillin and three different 2-amino-1,3-propandiol units, leading to H3L1 (R=hydrogen), H3L2 (R=methyl) and H3L3 (R=ethyl). The differing nuclearities of the three clusters, 1 to 3, originate mainly from the steric influence, while this effect is not seen in complex 4 to 6, where the general butterfly motif is maintained. We present here the synthesis, crystal structures and magnetic properties of six new CuII-LnIII complexes, providing valuable insight into future synthetic directions. The topological part includes a table of all CuII-DyIII complexes with nuclearities higher than four and their topological motif. The investigation of the magnetic behaviors reveal that all six complexes show frequency dependent signals in the out-of phase ac susceptibility, which is indicative for SMM behavior

Risk indicators for oral ulcers among people living with HIV during the first wave of the pandemic: A cross-sectional study

Background: Little is currently known about HIV-related parameters that may increase the risk for oral ulcers during the COVID-19 pandemic. This study aimed to overcome this gap in research by assessing the associations between HIV viral load, antiretroviral adherence profile, co-morbidity status, SARS-CoV-2 infection and oral ulcers among people living with HIV (PLHIV). Methods: This was a secondary analysis of data generated from 21,206 to 18 years and above, recruited from 152 countries through an online survey between July and December 2020. Data were extracted for 874 people who reported living with HIV. The dependent variable was reporting having oral ulcer. The independent variables were the viral load, adherence to antiretroviral treatment and a history of SARS-CoV-2 infection. The confounding variables were age at last birthday and sex at birth. A multivariable logistic regression analysis was conducted to determine the associations between the dependent and independent variables after adjusting for the confounding variables. Results: Of the 874 participants, 99 (11.3%) reported having oral ulcers during the first wave of the COVID-19 pandemic. The odds of PLHIV having oral ulcers during the first wave of the COVID-19 pandemic was significantly higher for people who did not know their viral load than those who had undetectable viral load (AOR: 2.036; 95% CI: 1.204–3.443; p = 0.008); and people who did not adhere to the use of antiretroviral treatment than those who adhered (AOR: 4.113; 95% CI: 2.567–6.589; p < 0.001). Also, PLHIV who had SARS-CoV-2 infection had significantly higher odds of having oral ulcers than those who did not have the infection (AOR: 14.556; 95% CI: 4.500-47.078; p < 0.001). PLHIV who had co-morbidities had non-significantly higher odds of having oral ulcers than those without co-morbidities (AOR: 1.170; 95% CI: 0.656–2.085; p = 0.595). Conclusion: Oral ulcers may be an indicator of poor adherence to antiretroviral therapy and unsuppressed viral load among PLHIV. It may also be an indicator of SARS-CoV-2 infection and a signal to take prompt and critical care of affected individuals because of the risk for severe COVID-19 for these individuals.publishedVersio

Cultural corridors: An analysis of persistence in impacts on local development — A neo-Weberian perspective on South-East Europe

Culture matters for economic development. This postulate has been a main conceptual concern for “old” institutional economics (OIE) and has lately also been tested through neoclassically inspired econometric techniques. This conceptual foundation has been confirmed in several quantitative studies on developed countries, in particular cases from the USA, Germany, and Italy. In less developed regions with a wealth of cultural heritage, particularly in South-East Europe, this postulate is still an underexplored issue from the perspective of advanced econometric approaches. Our goal is to examine the impact of the so-called South-East European cultural corridors on welfare — and especially on total employment — at the local or regional level. Accounting for gross value added and sectoral specialization, we examine the effect of such corridors by considering the distance to a cultural corridor: namely, the East Trans-Balkan Road (crossing Romania, Bulgaria, and Greece) as an explanatory factor for regional development, particularly employment. Using the European University Institute (EUI) European Regional Dataset (ERD), as well as the geo-data from the Cultural Corridors of the South-East Europe website, we estimate a regression model using a 2SLS instrumental variable (IV) approach, with a pooled dataset at the NUTS 3 level (Eurostat) from 1980 to 2011. We then triangulate the results by using the distance to the cultural corridor concerned as a treatment effect in a propensity-score-matching and difference-in-differences exploratory analysis. The findings confirm the importance of distance to the cultural corridor under investigation as a strong predictor for local socio-economic development. The results further suggest that the slow evolution of culture over time is likely to lead to the gradual emergence of new geographical cultural centers and a new cultural path-dependence build-up of persistence chains

Integrated Mapping of Yaws and Trachoma in the Five Northern-Most Provinces of Vanuatu.

Yaws and trachoma are targeted for eradication and elimination as public health problems. In trachoma-endemic populations mass administration of azithromycin can simultaneously treat yaws. We conducted a population-based prevalence survey in the five northernmost provinces of Vanuatu, where trachoma and yaws are suspected to be co-endemic. Clinical signs of trachoma were evaluated using the WHO simplified grading system, and skin examination with a serological rapid diagnostic test used to identify yaws. We enrolled 1004 households in 59 villages over 16 islands, and examined 3650 individuals of all ages for trachoma. The overall adjusted prevalence of trachomatous inflammation-follicular (TF) in 1-9 year-olds was 12.0% (95% Confidence Interval: 8.1-16.7%), and the overall adjusted prevalence of TT in those aged 15 years and greater was 0.04% (95% CI 0-0.14%). In multivariate analysis, the odds of children having TF was 2.6 (95% CI = 1.5-4.4) times higher in households with unimproved latrines, and independently associated with the number of children in the household (OR 1.3, 95% CI = 1.0-1.6 for each additional child). We examined the skin of 821 children aged 5-14 years. Two children had yaws, giving an estimated prevalence of active yaws in those aged 5-14 years of 0.2% (95% CI = 0.03-0.9%). Mass treatment with azithromycin is recommended in these provinces. Given the apparent low burden of yaws, integration of yaws and trachoma control programmes is likely to be useful and cost-effective to national programmes

Mindfulness-based interventions for people diagnosed with a current episode of an anxiety or depressive disorder: a meta-analysis of randomised controlled trials

Objective Mindfulness-based interventions (MBIs) can reduce risk of depressive relapse for people with a history of recurrent depression who are currently well. However, the cognitive, affective and motivational features of depression and anxiety might render MBIs ineffective for people experiencing current symptoms. This paper presents a meta-analysis of randomised controlled trials (RCTs) of MBIs where participants met diagnostic criteria for a current episode of an anxiety or depressive disorder. Method Post-intervention between-group Hedges g effect sizes were calculated using a random effects model. Moderator analyses of primary diagnosis, intervention type and control condition were conducted and publication bias was assessed. Results Twelve studies met inclusion criteria (n = 578). There were significant post-intervention between-group benefits of MBIs relative to control conditions on primary symptom severity (Hedges g = −0.59, 95% CI = −0.12 to −1.06). Effects were demonstrated for depressive symptom severity (Hedges g = −0.73, 95% CI = −0.09 to −1.36), but not for anxiety symptom severity (Hedges g = −0.55, 95% CI = 0.09 to −1.18), for RCTs with an inactive control (Hedges g = −1.03, 95% CI = −0.40 to −1.66), but not where there was an active control (Hedges g = 0.03, 95% CI = 0.54 to −0.48) and effects were found for MBCT (Hedges g = −0.39, 95% CI = −0.15 to −0.63) but not for MBSR (Hedges g = −0.75, 95% CI = 0.31 to −1.81). Conclusions This is the first meta-analysis of RCTs of MBIs where all studies included only participants who were diagnosed with a current episode of a depressive or anxiety disorder. Effects of MBIs on primary symptom severity were found for people with a current depressive disorder and it is recommended that MBIs might be considered as an intervention for this population