A Multi Criteria Recommendation Engine Model for Cloud Renderfarm Services

Cloud services that provide a complete platform for rendering the animation files using the resources in the cloud are known as cloud renderfarm services. This work proposes a multi criteria recommendation engine model for recommending these Cloud renderfarm services to animators. The services are recommended based on the functional requirements of the animation file to be rendered like the rendering software, plug-in required etc and the non functional Quality of Service (QoS) requirements like render node cost, time taken to upload animation files etc. The proposed recommendation engine model uses a domain specific ontology of renderfarm services to identify the right services that could satisfy the functional requirements of the user and ranks the identified services using the popular Multi Criteria Decision Analysis method like Simple Additive Weighting (SAW). The ranked list of services is provided as recommended services to the animators in the ranking order. The Recommendation model was tested to rank and recommend the cloud renderfarm services in multi criteria requirements by assigning different QoS criteria weight for each scenario. The ranking based recommendations were generated for six different scenarios and the results were analyzed. The results show that the services recommended for each scenario were different and were highly dependent on the weights assigned to each criterion

A Framework for Securing Health Information Using Blockchain in Cloud Hosted Cyber Physical Systems

Electronic Health Records (EHRs) have undergone numerous technical improvements in recent years, including the incorporation of mobile devices with the cloud computing technologies to facilitate medical data exchanges between patients and the healthcare professionals. This cutting-edge architecture enables cyber physical systems housed in the cloud to provide healthcare services with minimal operational costs, high flexibility, security, and EHR accessibility. If patient health information is stored in the hospital database, there will always be a risk of intrusion, i.e., unauthorized file access and information modification by attackers. To address this concern, we propose a decentralized EHR system based on Blockchain technology. To facilitate secure EHR exchange across various patients and medical providers, we develop a reliable access control method based on smart contracts. We incorporate Cryptocurrency, specifically Ethereum, in the suggested system to protect sensitive health information from potential attackers. In our suggested approach, both physicians and patients are required to be authenticated. Patients can register, and a block with a unique hash value will be generated. Once the patient discusses the disease with the physician, the physician can check the patient's condition and offer drugs. For experimental findings, we employ the public Block chain Ganache and solidity remix-based smart contracts to protect privacy. Ethers are used as the crypto currencies

Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.info:eu-repo/semantics/publishedVersio

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity