Real and Virtual Classrooms Can Trigger the Same Levels of Stuttering Severity Ratings and Anxiety in School-Age Children and Adolescents who Stutter

Purpose: Many school-age children and adolescents who stutter experience the fear of public speaking. Treatment implications include the need to address this problem. However, it is not always possible to train repeatedly in front of a real audience. The present study aimed to assess the relevance of using a virtual classroom in clinical practice with school-age children and adolescents who stutter. Methods: Ten children and adolescents who stutter (aged 9 to 17 years old) had to speak in three different situations: in front of a real audience, in front of a virtual class and in an empty virtual apartment using a head-mounted display. We aimed to assess whether the self-rated levels of anxiety while speaking in front of a virtual audience reflect the levels of anxiety reported while speaking in front of a live audience, and if the stuttering level while speaking to a virtual class reflects the stuttering level while speaking in real conditions. Results: Results show that the real audience creates higher anticipatory anxiety than the virtual class. However, both the self-reported anxiety levels and the stuttering severity ratings when talking in front of a virtual class did not differ from those observed when talking to a real audience, and were significantly higher than when talking in an empty virtual apartment. Conclusion: Our results support the feasibility and relevance of using a virtual classroom to expose school-age children and adolescents who stutter to a feared situation during cognitive behavioral therapy targeting the fear of public speaking.Peer reviewe

Recrutement des poissons dans le fjord du Saguenay

La faune ichtyologique du fjord du Saguenay est composée de plus de 60 espèces de poissons marins, diadromes et dulcicoles dont plusieurs font l’objet d’une pêche récréative comme l’éperlan arc-en-ciel anadrome (Osmerus mordax), le sébaste (Sebastes spp.), la morue franche (Gadus morhua), la morue ogac (Gadus ogac) et le flétan du Groenland (Reinhardtius hippoglossoides). On ignore si le recrutement des poissons marins exploités par la pêche récréative dans le Saguenay dépend de la production des stocks locaux ou des échanges avec les populations de l’estuaire du Saint-Laurent. Nous avons donc étudié la distribution spatio-temporelle de l’ichtyoplancton dans le fjord du Saguenay afin d’identifier les zones de production, de rétention et d’advection larvaires dans le but d’y préciser les mécanismes de recrutement des stocks de poissons. L’ichtyoplancton a été échantillonné à 21 stations sur le fjord du Saguenay à six occasions, de mai à octobre 2004, et à cinq occasions, de juin à septembre 2005. Les résultats montrent que le recrutement du capelan et de l’éperlan arc‑en‑ciel anadrome repose sur la production et la rétention des larves dans le fjord du Saguenay. Cependant, le recrutement des sébastes et des morues dépendrait de l’immigration de juvéniles en provenance de l’estuaire du Saint-Laurent. Ces résultats sont supportés par une revue des résultats des études antérieures sur les poissons du fjord du Saguenay. L’étude des mécanismes de recrutement des stocks de poissons du fjord du Saguenay favorise l’exploitation durable de ces ressources halieutiques conformément à la mission de Pêches et Océans Canada et dans le respect du programme de conservation du parc marin du Saguenay‑Saint-Laurent.In the Saguenay Fjord, the fish community is composed of more than 60 marine, diadromous and freshwater species, including many species exploited by the winter sport fishery such as the rainbow smelt (Osmerus mordax), redfish (Sebastes spp.), Atlantic cod (Gadus morhua), Greenland cod (Gadus ogac), and Greenland halibut (Reinhardtius hippoglossoides). We do not know if the recruitment of the fish species exploited by the winter sport fishery depends on the local production of recruits in the Saguenay Fjord or on exchanges with the St. Lawrence Estuary populations. Hence, we measured the spatio-temporal distribution of ichthyoplankton in the Fjord to identify zones of larval production, retention or advection, in order to investigate the recruitment mechanisms of these stocks. We sampled ichthyoplankton at 21 stations on six occasions, from May to October 2004, and on five occasions, from June to September 2005. Results indicated that the recruitment of capelin (Mallotus villosus) and of the anadromous rainbow smelt (Osmerus mordax) relied on the local production and retention of larvae within the Fjord. However, the recruitment of redfish (Sebastes spp.) and cods (Gadus spp.) depended on the immigration of juveniles from the St. Lawrence Estuary. Our results are corroborated by a review of previous studies of these fish populations. Studying the recruitment mechanisms of fish populations in the Saguenay Fjord supports a sustainable exploitation of these locally important fisheries resources, in accordance with the mission of Fisheries and Oceans Canada and consistent with the conservation program of the Saguenay St. Lawrence Marine Park

Relationship between p53 and p27 expression following HER2 signaling

HER2, frequently associated with low p27 expression in breast tumors, when activated has been found to upmodulate p53 in tumor cells. The aim of this work was to investigate the role of p53 in the connection between HER2 and p27. Fifty-two breast tumor specimens, characterized for p53 mutations, were analyzed immunohistochemically (IHC) for HER2, p53 and p27 expression. p27, inversely associated with HER2, was found in 29% of tumors with IHC-negative mutated p53 versus 93% of tumors with accumulation of p53 protein and 59% with wild-type p53 (p=0.001), indicating a direct association between p53 and p27 expression. HER2-overexpressing cell lines carrying wild-type or null p53 protein, and treated with heregulin beta1 (HRG), were analyzed for expression and subcellular localization of p53 and p27. In HER2-overexpressing cells stimulated with HRG, p27 protein expression increased in parallel with p53 with no corresponding increase in p27 transcript. No p27 increase was observed in p53-null cells. Transfection with wild-type p53 restored p27 upmodulation in HRG-stimulated cells, indicating a crucial role of p53 in determining p27 upmodulation following HER2 activation. Together, our data demonstrate the crucial role of p53 in determining p27 upmodulation following HER2 activation. This could have implications in the response to Transtuzumab therapy

Dynamical Evidence of a Spiral Arm-driving Planet in the MWC 758 Protoplanetary Disk

More than a dozen young stars host spiral arms in their surrounding protoplanetary disks. The excitation mechanisms of such arms are under debate. The two leading hypotheses—companion-disk interaction and gravitational instability (GI)—predict distinct motion for spirals. By imaging the MWC 758 spiral arm system at two epochs spanning ∼5 yr using the SPHERE instrument on the Very Large Telescope, we test the two hypotheses for the first time. We find that the pattern speeds of the spirals are not consistent with the GI origin. Our measurements further evince the existence of a faint "missing planet" driving the disk arms. The average spiral pattern speed is 0°22 ± 0°03 yr[SUP]-1[/SUP], pointing to a driver at ${172}_{-14}^{+18}$ au around a 1.9 M[SUB]☉[/SUB] central star if it is on a circular orbit. In addition, we witness time-varying shadowing effects on a global scale that are likely originating from an inner disk

Ongoing flyby in the young multiple system UX Tauri

We present observations of the young multiple system UX Tauri to look for circumstellar disks and for signs of dynamical interactions. We obtained SPHERE/IRDIS deep differential polarization images in the J and H bands. We also used ALMA archival CO data. Large extended spirals are well detected in scattered light coming out of the disk of UX Tau A. The southern spiral forms a bridge between UX Tau A and C. These spirals, including the bridge connecting the two stars, all have a CO (3-2) counterpart seen by ALMA. The disk of UX Tau C is detected in scattered light. It is much smaller than the disk of UX Tau A and has a major axis along a different position angle, suggesting a misalignment. We performed PHANTOM SPH hydrodynamical models to interpret the data. The scattered light spirals, CO emission spirals and velocity patterns of the rotating disks, and the compactness of the disk of UX Tau C all point to a scenario in which UX Tau A has been perturbed very recently (∼1000 years) by the close passage of UX Tau C. Movies associated to Fig. 3 are available at http://https://www.aanda.orgPeer reviewe

Revealing asymmetrical dust distribution in the inner regions of HD 141569

Context. The combination of high-contrast imaging with spectroscopy and polarimetry offers a pathway to studying the grain distribution and properties of debris disks in exquisite detail. Here, we focus on the case of a gas-rich debris disk around HD 141569A, which features a multiple-ring morphology first identified with SPHERE in the near-infrared. Aims. We obtained polarimetric differential imaging with SPHERE in the H-band to compare the scattering properties of the innermost ring at 44 au with former observations in total intensity with the same instrument. In polarimetric imaging, we observed that the intensity of the ring peaks in the south-east, mostly in the forward direction, whereas in total intensity imaging, the ring is detected only at the south. This noticeable characteristic suggests a non-uniform dust density in the ring. With these two sets of images, we aim to study the distribution of the dust to solve for the actual dust distribution. Methods. We implemented a density function varying azimuthally along the ring and generated synthetic images both in polarimetry and in total intensity, which are then compared to the actual data. The search for the best-fit model was performed both with a grid-based and an MCMC approach. Using the outcome of this modelization, we further measured the polarized scattering phase function for the observed scattering angle between 33° and 147° as well as the spectral reflectance of the southern part of the ring between 0.98 and 2.1 μm. We tentatively derived the grain properties by comparing these quantities with MCFOST models and assuming Mie scattering. Results. We find that the dust density peaks in the south-west at an azimuthal angle of 220°∼238° with a rather broad width of 61°∼127°. The difference in the intensity distributions observed in polarimetry and total intensity is the result of this particular morphology. Although there are still uncertainties that remain in the determination of the anisotropic scattering factor, the implementation of an azimuthal density variation to fit the data proved to be robust. Upon elaborating on the origin of this dust density distribution, we conclude that it could be the result of a massive collision when we account for the effect of the high gas mass that is present in the system on the dynamics of grains. In terms of grain composition, our preliminary interpretation indicates a mixture of porous sub-micron sized astro-silicate and carbonaceous grains. Conclusions. The SPHERE observations have allowed, for the first time, for meaningful constraints to be placed on the dust distribution beyond the standard picture of a uniform ring-like debris disk. However, future studies with a multiwavelength approach and additional detailed modeling would be required to better characterize the grain properties in the HD 141569 system. © G. Singh et al. 2021

Searching for the near-infrared counterpart of Proxima c using multi-epoch high-contrast SPHERE data at VLT★

Context. Proxima Centauri is the closest star to the Sun and it is known to host an Earth-like planet in its habitable zone; very recently a second candidate planet was proposed based on radial velocities. At quadrature, the expected projected separation of this new candidate is larger than 1 arcsec, making it a potentially interesting target for direct imaging. Aims: While identification of the optical counterpart of this planet is expected to be very difficult, successful identification would allow for a detailed characterization of the closest planetary system. Methods: We searched for a counterpart in SPHERE images acquired over four years through the SHINE survey. In order to account for the expected large orbital motion of the planet, we used a method that assumes the circular orbit obtained from radial velocities and exploits the sequence of observations acquired close to quadrature in the orbit. We checked this with a more general approach that considers Keplerian motion, called K-stacker. Results: We did not obtain a clear detection. The best candidate has signal-to-noise ratio (S/N) = 6.1 in the combined image. A statistical test suggests that the probability that this detection is due to random fluctuation of noise is Conclusions: On the other hand, if confirmed, this would be the first observation in imaging of a planet discovered from radial velocities and the second planet (after Fomalhaut b) of reflecting circumplanetary material. Further confirmation observations should be done as soon as possible. The reduced images are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/cat/J/A+A/638/A120 Based on data collected at the European Southern Observatory, Chile (ESO Programs 095.D-0309, 096.C-0241, 096.D-0252, 097.C-0865, 198.C-D0209, 099.D-0098, 099.C-0127

Au-delà du cabinet : Evaluer le bégaiement dans différents contextes et évaluer la qualité de vie

Le bégaiement est un trouble complexe dont les manifestations varient d’une situation à l’autre. Les patients peuvent témoigner d’une bonne gestion de leur parole au quotidien, mais évoquer des difficultés marquées dans certaines situations comme le fait de devoir s’adresser à un étranger ou prendre la parole devant un groupe. Par conséquent, lors de l’évaluation, un recueil de parole dans le cadre sécurisant du cabinet de logopédie ne permet pas toujours de révéler les principales difficultés rencontrées par les personnes qui bégaient. En outre, plusieurs études ont révélé un impact négatif du bégaiement sur la qualité de vie, qui n’est pas forcément lié à la sévérité objective du bégaiement. Cet exposé présente d’une part la réalité virtuelle comme un outil permettant d’évaluer la prise de parole dans différentes situations et d’autre part des données préliminaires sur la validation en français du questionnaire OASES, un outil d’évaluation de la qualité de vie chez la personne qui bégaie