Revealing the History of the Isthmus of Chignecto: Toward Truth and Reconciliation

Chignecto, the border region between Nova Scotia and New Brunswick, is a central region of Mi’kma’ki, linking the Atlantic seaboard to the Wulstuk, the St. John River region, the interior of the continent, and beyond. It was also the site of prosperous Acadian communities that became embroiled in colonial wars. In 2017, Parks Canada set out to create a new exhibit to tell the many stories of Chignecto, working in collaboration with Mi’kmaq community partners, and drawing upon Parks Canada’s new “Framework for History.” This exhibit’s collaborative research and development process provides an example of the challenges and the potential of such an approach to public history.Chignectou, la région frontalière entre la Nouvelle-Écosse et le Nouveau-Brunswick, est le territoire principal du Mi’kma’ki qui relie la côte atlantique à Wulstuk, à la région du fleuve Saint- Jean, à l’intérieur du continent et plus loin encore. Ce territoire est également le site des communautés acadiennes prospères qui ont été entrainées dans les guerres coloniales. En 2017, en collaboration avec les partenaires de la communauté mi’kmaque, Parcs Canada a entrepris la création d’une nouvelle exposition de nombreux récits de Chignectou, fondée sur le concept « Cadre de l’histoire et de la commémoration » de Parcs Canada. La recherche collaborative de l’exposition et son processus d’élaboration offrent un exemple des enjeux et des possibilités d’une telle approche de l’histoire publique

Disability and parenting : the experiences of four women with disability

Women with disability are said to experience double discrimination, and their role as mothers augments their experiences of disablement. This qualitative research explores the intertwining and complex factors that emerge from the narratives of four disabled mothers in a Maltese cultural context. Interviews were conducted with four mothers who have different impairments. The findings from the narratives are presented using a life course approach. In the analysis of the data, social factors were found to impinge on the experiences of mothers with disability to a greater extent than impairment-related factors. These social factors comprise the immediate support networks of each mother, as well as wider cultural factors pertaining to being a mother with disability in Malta. The responses of the four mothers to these factors the stigma and misconceptions about the inability of disabled women to be mothers while at the same time, particularly mothering.peer-reviewe

The World of Ancient Art

Book Review of The World of Ancient Art / John Boardman.--ISBN 0-500-23827-8. Reviewed by Anne Marie Lane

Galaxy Zoo : 3D – crowdsourced bar, spiral, and foreground star masks for MaNGA target galaxies

Funding: Funding for the Sloan Digital Sky Survey IV has been provided by the Alfred P. Sloan Foundation, the U.S. Department of Energy Office of Science, and the Participating Institutions. We gratefully acknowledge the National Science Foundation’s support of the Keck Northeast Astronomy Consortium’s REU program through grants AST-1005024 and AST-1950797, the KINSC (Koshland Integrated Natural Sciences Centre) at Haverford College for Summer Scholar funding, and the Ogden Trust, UK for support for summer undergraduate internships.The challenge of consistent identification of internal structure in galaxies – in particular disc galaxy components like spiral arms, bars, and bulges – has hindered our ability to study the physical impact of such structure across large samples. In this paper we present Galaxy Zoo: 3D (GZ:3D) a crowdsourcing project built on the Zooniverse platform that we used to create spatial pixel (spaxel) maps that identify galaxy centres, foreground stars, galactic bars, and spiral arms for 29 831 galaxies that were potential targets of the MaNGA survey (Mapping Nearby Galaxies at Apache Point Observatory, part of the fourth phase of the Sloan Digital Sky Surveys or SDSS-IV), including nearly all of the 10 010 galaxies ultimately observed. Our crowdsourced visual identification of asymmetric internal structures provides valuable insight on the evolutionary role of non-axisymmetric processes that is otherwise lost when MaNGA data cubes are azimuthally averaged. We present the publicly available GZ:3D catalogue alongside validation tests and example use cases. These data may in the future provide a useful training set for automated identification of spiral arm features. As an illustration, we use the spiral masks in a sample of 825 galaxies to measure the enhancement of star formation spatially linked to spiral arms, which we measure to be a factor of three over the background disc, and how this enhancement increases with radius.Publisher PDFPeer reviewe

Antiprotozoal Activities of Organic Extracts from French Marine Seaweeds

Marine macrophytes contain a variety of biologically active compounds, some reported to have antiprotozoal activity in vitro. As a part of a screening program to search for new natural antiprotozoals, we screened hydroalcoholic and ethyl acetate extracts of 20 species of seaweeds from three phyla (Rhodophyta, Heterokontophyta and Chlorophyta), sampled along the Normandy (France) coast. We tested them in vitro against the protozoa responsible for three major endemic parasitic diseases: Plasmodium falciparum, Leishmania donovani and Trypanosoma cruzi. The selectivity of the extracts was also evaluated by testing on a mammalian cell line (L6 cells). Ethyl acetate extracts were more active than hydroalcoholic ones. Activity against T. cruzi and L. donovani was non-existent to average, but almost half the extracts showed good activity against P. falciparum. The ethyl acetate extract of Mastocarpus stellatus showed the best antiplasmodial activity as well as the best selectivity index (IC50 = 2.8 μg/mL; SI > 30). Interestingly, a red algae species, which shares phylogenetic origins with P. falciparum, showed the best antiplasmodial activity. This study is the first to report comparative antiprotozoal activity of French marine algae. Some of the species studied here have not previously been biologically evaluated

Germline BAP1 Inactivation Is Preferentially Associated with Metastatic Ocular Melanoma and Cutaneous-Ocular Melanoma Families

Background: BAP1 has been shown to be a target of both somatic alteration in high-risk ocular melanomas (OM) and germline inactivation in a few individuals from cancer-prone families. These findings suggest that constitutional BAP1 changes may predispose individuals to metastatic OM and that familial permeation of deleterious alleles could delineate a new cancer syndrome. Design: To characterize BAP1’s contribution to melanoma risk, we sequenced BAP1 in a set of 100 patients with OM, including 50 metastatic OM cases and 50 matched non-metastatic OM controls, and 200 individuals with cutaneous melanoma (CM) including 7 CM patients from CM-OM families and 193 CM patients from CM-non-OM kindreds. Results: Germline BAP1 mutations were detected in 4/50 patients with metastatic OM and 0/50 cases of non-metastatic OM (8 % vs. 0%, p = 0.059). Since 2/4 of the BAP1 carriers reported a family history of CM, we analyzed 200 additional hereditary CM patients and found mutations in 2/7 CM probands from CM-OM families and 1/193 probands from CM-non-OM kindreds (29 % vs. 0.52%, p =.003). Germline mutations co-segregated with both CM and OM phenotypes and were associated with the presence of unique nevoid melanomas and highly atypical nevoid melanoma-like melanocytic proliferations (NEMMPs). Interestingly, 7/14 germline variants identified to date reside in C-terminus suggesting that the BRCA1 binding domain i