Dispersion-shifted all-solid high index-contrast microstructured optical fiber for nonlinear applications at 1.55µm

We report the fabrication of an all-solid highly nonlinear microstructured optical fiber. The structured preform was made by glass extrusion using two types of commercial lead silicate glasses that provide high index-contrast. Effectively single-moded guidance was observed in the fiber at 1.55µm. The effective nonlinearity and the propagation loss at this wavelength were measured to be 120W/km respectively at 1.55µm. These predictions are consistent with the experimentally determined dispersion of +12.5ps/nm/km at 1.55µm. Tunable and efficient four-wave-mixing based wavelength conversion was demonstrated at wavelengths around 1.55µm using a 1.5m length of the fiber

Multichannel wavelength conversion of 40 Gbit/s NRZ DPSK signals in a highly nonlinear dispersion flattened lead silicate fibre

We experimentally demonstrate the wavelength conversion of three wavelength multiplexed 40 Gbit/s Differential Phase Shift Keyed (DPSK) signals in a 2.2m length of highly nonlinear, dispersion tailored W-type lead-silicate optical fibre

Examining hope as a transdiagnostic mechanism of change across anxiety disorders and CBT treatment protocols.

Hope is a trait that represents the capacity to identify strategies or pathways to achieve goals and the motivation or agency to effectively pursue those pathways. Hope has been demonstrated to be a robust source of resilience to anxiety and stress and there is limited evidence that, as has been suggested for decades, hope may function as a core process or transdiagnostic mechanism of change in psychotherapy. The current study examined the role of hope in predicting recovery in a clinical trial in which 223 individuals with 1 of 4 anxiety disorders were randomized to transdiagnostic cognitive behavior therapy (CBT), disorder-specific CBT, or a waitlist controlled condition. Effect size results indicated moderate to large intraindividual increases in hope, that changes in hope were consistent across the five CBT treatment protocols, that changes in hope were significantly greater in CBT relative to waitlist, and that changes in hope began early in treatment. Results of growth curve analyses indicated that CBT was a robust predictor of trajectories of change in hope compared to waitlist, and that changes in hope predicted changes in both self-reported and clinician-rated anxiety. Finally, a statistically significant indirect effect was found indicating that the effects of treatment on changes in anxiety were mediated by treatment effects on hope. Together, these results suggest that hope may be a promising transdiagnostic mechanism of change that is relevant across anxiety disorders and treatment protocols.R01 MH090053 - NIMH NIH HHSAccepted manuscrip

Dementia cafes : recommendations from interviews with informal carers

Purpose Dementia cafés (also known as Alzheimer’s or memory cafés) have been running in the UK since 2000. The purpose of this paper is to report on the recommendations from recent research that interviewed family carers on their experiences of using the cafés. Design/methodology/approach The research was carried out in cafés in and around London, and focussed on informal, unpaid carers’ experiences of using them. In total, 11 carers from five different dementia cafés were interviewed, using semi-structured questionnaires. The results were thematically analysed. Findings The findings showed that carers had an overwhelming appreciation of the cafés and what they offered, but several of the findings led to the recommendations about the recruitment and training of café co-ordinators; how cafés present themselves and their services and how they can offer dedicated support to informal carers. Originality/value These recommendations will be of use to café organisers and commissioners, especially considering the dearth of information currently available in this area. </jats:sec

Experiences of older people dying in nursing homes : a narrative systematic review of qualitative studies

Objectives To identify and synthesise qualitative research from 2001 investigating older people's (65+ years) experiences of dying in nursing and care homes. Methods and outcomes Eight electronic databases (AMED, ASSIA, CINAHL Plus, Embase, HMIC, Medline, PsychINFO and Scopus) from 2001 to July 2017 were searched. Studies were included if they were qualitative, primary research and described the experiences of dying in nursing or care homes from the perspectives of the older people themselves, their families or staff. Study quality assessment was undertaken to systematically assess methodological quality, but no studies were excluded as a result. Results 1305 articles were identified. Nine met the inclusion criteria. North American studies dominated. Most used a mixture of observations and interviews. All the included studies highlighted the physical discomfort of dying, with many older people experiencing potentially avoidable symptoms if care were to be improved. Negative psychosocial experiences such as loneliness and depression were also often described in addition to limited support with spiritual needs. Conclusions More qualitative research giving a holistic understanding of older people’s experiences of dying in residential care homes is needed. Undertaking research on this topic is challenging and requires great sensitivity, but the dearth of qualitative research from the perspectives of those most closely involved in older people’s deaths hampers service improvement

The Culture Boundary: How Awareness Informs Teaching Practice

In this paper I discuss the value of exploring student culture through ongoing reflective processes for effective and responsible language teaching. I reflect on my own experience of teaching in a foreign language context for the first time, and discuss how developing cultural awareness helped me move from a place of frustration to understanding, and how a change in attitude and teaching approach impacted my relationships and significantly improved the quality of teaching and learning in my classroom. Using Pat Moran’s ‘Cultural Knowings’ framework as a guide, I reflect on my personal transformation while working in South Korea and report on my experience of moving through the stages of learning about the culture of my students (knowing about), investigating the reasons behind their cultural practices (knowing why), exploring my own beliefs (knowing oneself), and applying it all to make informed decisions about my teaching approach (knowing how). This case study highlights the importance of considering culture in foreign language pedagogy and demonstrates how the ‘Cultural Knowings’ framework can be used as a tool for teachers seeking to find balance and harmony in a foreign teaching context, or for teacher training in general

Factors associated with self-care activities among adults in the United Kingdom: a systematic review

Background: The Government has promoted self-care. Our aim was to review evidence about who uses self-tests and other self-care activities (over-the-counter medicine, private sector,complementary and alternative medicine (CAM), home blood pressure monitors). Methods: During April 2007, relevant bibliographic databases (Medline, Embase, Cumulative Index to Nursing and Allied Health Literature, Applied Social Sciences Index and Abstracts, PsycINFO,British Nursing Index, Allied and Complementary Medicine Database, Sociological Abstracts, International Bibliography of the Social Sciences, Arthritis and Complementary Medicine Database, Complementary and Alternative Medicine and Pain Database) were searched, and potentially relevant studies were reviewed against eligibility criteria. Studies were included if they were published during the last 15 years and identified factors, reasons or characteristics associated with a relevant activity among UK adults. Two independent reviewers used proformas to assess the quality of eligible studies. Results: 206 potentially relevant papers were identified, 157 were excluded, and 49 papers related to 46 studies were included: 37 studies were, or used data from questionnaire surveys, 36 had quality scores of five or more out of 10, and 27 were about CAM. Available evidence suggests that users of CAM and over-the-counter medicine are female, middle-aged, affluent and/or educated with some measure of poor health, and that people who use the private sector are affluent and/or educated. Conclusion: People who engage in these activities are likely to be affluent. Targeted promotion may, therefore, be needed to ensure that use is equitable. People who use some activities also appear to have poorer measures of health than non-users or people attending conventional services. It is, therefore, also important to ensure that self-care is not used as a second choice for people who have not had their needs met by conventional service

The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation

Background: The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic nature, the protein is rather stable. We studied the thermal denaturation of full-length RIα and a truncated RIα(92-381) that contains the tandem cyclic nucleotide binding (CNB) domains A and B. Methodology/Principal Findings: As revealed by circular dichroism (CD) and differential scanning calorimetry, both RIα proteins contain significant residual structure in the heat-denatured state. As evidenced by CD, the predominantly α-helical spectrum at 25°C with double negative peaks at 209 and 222 nm changes to a spectrum with a single negative peak at 212-216 nm, characteristic of β-structure. A similar α→β transition occurs at higher temperature in the presence of cAMP. Thioflavin T fluorescence and atomic force microscopy studies support the notion that the structural transition is associated with cross-β-intermolecular aggregation and formation of non-fibrillar oligomers. Conclusions/Significance: Thermal denaturation of RIα leads to partial loss of native packing with exposure of aggregation-prone motifs, such as the B' helices in the phosphate-binding cassettes of both CNB domains. The topology of the β-sandwiches in these domains favors inter-molecular β-aggregation, which is suppressed in the ligand-bound states of RIα under physiological conditions. Moreover, our results reveal that the CNB domains persist as structural cores through heat-denaturation. © 2011 Dao et al