The influence of physical performance on technical and tactical outcomes in the UEFA Champions League

Background: To clarify does physical performance affect success in highest-level soccer, the purpose of the present study was to identify differences in technical-tactical performance (TP) between teams covering high and low run- ning performance (RP) during the UEFA Champions League (UCL) matches. Methods: The RP and TP data were collected from UCL group stage matches in the 2020/21 season. RP variables included total distance covered (TD), high intensity running (HIR), total distance when in ball possession (TDB), and high intensity running when in ball possession (HIRB). TP variables included goal chances, shots, shots on target, passes, accurate passes, key passes, key passes accurate, crosses, crosses accurate, counter attacks, counter attacks with a shot, high pressing, high pressing successful, low pressing, low pressing successful, tackles, tackles successful, entrances to the opponent’s box, total actions, and successful actions. K-means cluster analysis method was used to classify teams covering (i) low and high TD, (ii) low and high HIR, (iii) low and high TDB, (iv) low and high and HIRB. Linear mixed models were used to identify differences in teams’ TP according to their RP. Pearson’s correlations were used to establish direct association between team TP and RP. Results: Similar TP were observed whether teams covering high or low TD/HIR. Teams covering greater TDB/HIRB had more goal chances, shots, shots on target, passes, accurate passes, key passes, accurate key passes, crosses, successful high pressing, entrances to the opponent’s box, total actions, and successful actions were observed (all moderate to very large effect sizes. Significant association between specific TP variables and TDB/HIRB were evidenced (Pearson’s r = 0.35–0.96, all p < 0.05). Conclusion: Covering greater TDB and HIRB may allow more frequent execution of fundamental TP which are con- sidered essential for match success, indicating that RP when team has ball in possession is important determinant of success in highest-level soccer. This study shows that physical performance affect success in highest-level soccer. Keywords: Football, Running performance, Technical-tactical performance, Success, Linear mixed model *

KIT is required for hepatic function during mouse post-natal development

<p>Abstract</p> <p>Background</p> <p>The <it>Kit </it>gene encodes a receptor tyrosine kinase involved in various biological processes including melanogenesis, hematopoiesis and gametogenesis in mice and human. A large number of <it>Kit </it>mutants has been described so far showing the pleiotropic phenotypes associated with partial loss-of-function of the gene. Hypomorphic mutations can induce a light coat color phenotype while complete lack of KIT function interferes with embryogenesis. Interestingly several intermediate hypomorphic mutations induced in addition growth retardation and post-natal mortality.</p> <p>Results</p> <p>In this report we investigated the post-natal role of <it>Kit </it>by using a panel of chemically-induced hypomorphic mutations recently isolated in the mouse. We found that, in addition to the classical phenotypes, mutations of <it>Kit </it>induced juvenile steatosis, associated with the downregulation of the three genes, <it>VldlR</it>, <it>Lpin1 </it>and <it>Lpl</it>, controlling lipid metabolism in the post-natal liver. Hence, <it>Kit </it>loss-of-functions mimicked the inactivation of genes controlling the hepatic metabolism of triglycerides, the major source of energy from maternal milk, leading to growth and viability defects during neonatal development.</p> <p>Conclusion</p> <p>This is a first report involving KIT in the control of lipid metabolism in neonates and opening new perspectives for understanding juvenile steatosis. Moreover, it reinforces the role of Kit during development of the liver and underscores the caution that should be exerted in using KIT inhibitors during anti-cancer treatment.</p

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Утилизация дренажных вод на полигоне твердых бытовых отходов в связи с выводом его из эксплуатации (г. Томск)

Объектом исследования является полигон твердых бытовых отходов г. Томска. Цель работы – обоснование инженерных мероприятий по устранению очага загрязнения подземных вод в составе комплекса работ по рекультивации участка размещения полигона твёрдых бытовых отходов. Данные о геологическом строении и гидрогеологических условиях участка получены из технического отчета по инженерно-геологическим изысканиям "Рекультивация (восстановление) нарушенных земель занятых отходами на полигоне размещения отходов" выполненных ООО "Группа 72". В процессе выполнения работы были получены оценки расхода, которые могут быть использованы в качестве исходных данных для проектирования эффективной работы дренажной системы.The object of the study is a solid waste landfill in Tomsk. The purpose of the work is the justification of engineering measures to eliminate the source of groundwater pollution as part of a complex of works for reclamation of the landfill site for solid household waste. Data on the geological structure and hydrogeological conditions of the site were obtained from the technical report on engineering and geological surveys "Reclamation (restoration) of disturbed lands occupied by waste at the landfill site" performed by "Group 72". In the course of the work, flow estimates were obtained that can be used as input data for designing the effective operation of the drainage system

Magnetic, transport and high-pressure properties of a W7Re13B superconducting compound

In this report we present experimental and theoretical investigations of the properties of the recently discovered W7Re13B superconductor. This compound is synthesized by means of inductive melting and contains a pure phase with a sharp superconducting transition at T-c = 7.22 K. The superconductor exhibits type-II behaviour with reversible magnetic properties in a large part of the H-T diagram. The irreversibility line with the irreversibility field mu H-0(irr)(0) equal to 2 T is well separated from the upper critical field. The values of lower mu H-0(c1)(0) and upper mu H-0(c2)(0) critical fields are equal to 8.8 mT and 11.8 T, respectively. These values correspond to penetration depth lambda, coherence length xi and Ginzburg-Landau coefficient kappa equal to 2675 angstrom, 52 angstrom and 51, respectively. The critical current density J(c) is low and equal to 4.9 kA cm(-2) at zero magnetic field and at 2 K. The effect of pressure on superconducting properties is almost negligible, probably due to the low compressibility of this compound. The pressure coefficient dT(c)/dP is negative and equal to -0.037 K GPa(-1). The XPS spectrum and numerical calculations confirm that the main contributions to the density of states at the Fermi level come from W(5d) and Re(5d) states

Superconducting properties of W7Re13B compound

We present both experimental and theoretical investigations of the magnetic properties and electronic structure of the recently discovered superconductor W7Re13B. We determine the lower and the upper critical fields H-c1(0) = 8.77 mT and H-c2(0) = 11.8 T, which correspond to a penetration depth lambda = 2675 angstrom and to a coherence length xi = 52 angstrom. The Ginzburg-Landau parameter, kappa is equal to 51. The effect of pressure on W7Re13B is negligible. This can be attributed to small changes in the density of states under pressure, or alternatively, to a low compressibility of this hard compound. (C) 2007 Elsevier B.V. All rights reserved

Serum Leptin Is a Biomarker of Malnutrition in Decompensated Cirrhosis.

Malnutrition is a leading cause of morbidity and mortality in cirrhosis. There is no consensus as to the optimal approach for identifying malnutrition in end-stage liver disease. The aim of this study was to measure biochemical, serologic, hormonal, radiographic, and anthropometric features in a cohort of hospitalized cirrhotic patients to characterize biomarkers for identification of malnutrition.In this prospective observational cohort study, 52 hospitalized cirrhotic patients were classified as malnourished (42.3%) or nourished (57.7%) based on mid-arm muscle circumference < 23 cm and dominant handgrip strength < 30 kg. Anthropometric measurements were obtained. Appetite was assessed using the Simplified Nutrition Appetite Questionnaire (SNAQ) score. Fasting levels of serum adipokines, cytokines, and hormones were determined using Luminex assays. Logistic regression analysis was used to determine features independently associated with malnutrition.Subjects with and without malnutrition differed in several key features of metabolic phenotype including wet and dry BMI, skeletal muscle index, visceral fat index and HOMA-IR. Serum leptin levels were lower and INR was higher in malnourished subjects. Serum leptin was significantly correlated with HOMA-IR, wet and dry BMI, mid-arm muscle circumference, skeletal muscle index, and visceral fat index. Logistic regression analysis revealed that INR and log-transformed leptin were independently associated with malnutrition.Low serum leptin and elevated INR are associated with malnutrition in hospitalized patients with end-stage liver disease