394 research outputs found
Single photon quantum non-demolition in the presence of inhomogeneous broadening
Electromagnetically induced transparency (EIT) has been often proposed for
generating nonlinear optical effects at the single photon level; in particular,
as a means to effect a quantum non-demolition measurement of a single photon
field. Previous treatments have usually considered homogeneously broadened
samples, but realisations in any medium will have to contend with inhomogeneous
broadening. Here we reappraise an earlier scheme [Munro \textit{et al.} Phys.
Rev. A \textbf{71}, 033819 (2005)] with respect to inhomogeneities and show an
alternative mode of operation that is preferred in an inhomogeneous
environment. We further show the implications of these results on a potential
implementation in diamond containing nitrogen-vacancy colour centres. Our
modelling shows that single mode waveguide structures of length in single-crystal diamond containing a dilute ensemble of NV
of only 200 centres are sufficient for quantum non-demolition measurements
using EIT-based weak nonlinear interactions.Comment: 21 pages, 9 figures (some in colour) at low resolution for arXiv
purpose
A Cultural Comparison of the ''Dark Constellations'' in the Milky Way
Cultures around the world find meaning in the groupings of stars and features in the Milky Way. The striking appearance of our Galaxy in the night sky serves as a reference to traditional knowledge, encoding science and culture to a memory space, becoming part of their overarching cosmologies. This paper examines traditional views of the Milky Way from cultures around the world, primarily in the Southern Hemisphere. These views comprise dark constellations: familiar shapes made up of the dark dust lanes in the Milky Way, rather than the bright stars. Some of the better-known examples include the celestial emu from Aboriginal traditions of Australia, and the llama in Inca traditions of the Andes. We conduct a comparative analysis of cultural perceptions of âdark constellationsâ in the Milky Way, examining common cultural themes and meanings at the crossroads of Indigenous Knowledge and Western science with applications to topics ranging from Indigenous Studies to psychology.Fil: Gullberg, Steven R.. Oklahoma State University; Estados UnidosFil: Hamacher, Duane. University of Melbourne; AustraliaFil: Lopez, Alejandro Martin. Universidad de Buenos Aires. Facultad de FilosofĂa y Letras. Instituto de Ciencias AntropolĂłgicas. SecciĂłn de EtnologĂa y EtnografĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Mejuto, Javier. Universidad Nacional AutĂłnoma de Honduras; HondurasFil: Munro, Andrew M.. University of Oklahoma; Estados UnidosFil: Orchiston, Wayne. University of Southern Queensland; Australia. National Astronomical Research Institute of Thailand; Tailandi
Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin
This work was funded by the Neonatal Unit Endowment Fund, Aberdeen Maternity Hospital. RH is funded by a career researcher fellowship from NHS Research Scotland. SG was funded by the MRC Flagship PhD programme. We are grateful for the support of Dr Phil Cash and Aberdeen Proteomics, at University of Aberdeen, in completing this project. Supplementary information accompanies this paper at https://doi.org/10.1038/s41598-018-24811-3.Peer reviewedPublisher PD
The effect of distance on reaction time in aiming movements
Target distance affects movement duration in aiming tasks but its effect on reaction time (RT) is poorly documented. RT is a function of both preparation and initiation. Experiment 1 pre-cued movement (allowing advanced preparation) and found no influence of distance on RT. Thus, target distance does not affect initiation time. Experiment 2 removed pre-cue information and found that preparing a movement of increased distance lengthens RT. Experiment 3 explored movements to targets of cued size at non-cued distances and found size altered peak speed and movement duration but RT was influenced by distance alone. Thus, amplitude influences preparation time (for reasons other than altered duration) but not initiation time. We hypothesise that the RT distance effect might be due to the increased number of possible trajectories associated with further targets: a hypothesis that can be tested in future experiments
Are quasars accreting at super-Eddington rates?
In a previous paper, Collin & Hur\'e (2001), using a sample of Active
Galactic Nuclei (AGN) where the mass has been determined by reverberation
studies (Kaspi et al. 2000), have shown that if the optical luminosity is
emitted by a steady accretion disc, about half of the objects are accreting
close to or higher than the Eddington rate. We conclude here that this result
is unavoidable, unless the masses are strongly underestimated by reverberation
studies, which does not seem to be the case. There are three issues to the
problem: 1. Accretion proceeds at Eddington or super-Eddington rates through
thick discs. Several consequences follow: an anti-correlation between the line
widths of the lines and the Eddington ratios, and a decrease of the Eddington
ratio with an increasing black hole mass. Extrapolated to all quasars, these
results imply that the amount of mass locked in massive black holes should be
larger than presently thought. 2. The optical luminosity is not produced
directly by the gravitational release of energy, and super-Eddington rates are
not required. The optical luminosity has to be emitted by a dense and thick
medium located at large distances from the center (10 to
gravitational radii). It can be due to reprocessing of the X-ray photons from
the central source in a geometrically thin warped disc, or in dense "blobs"
forming a geometrically thick system, which can be a part of the accretion flow
or the basis of an outflow. 3. Accretion discs are completely "non standard".
Presently neither the predictions of models nor the observed spectral
distributions are sufficient to help choosing between these solutions.Comment: 16 pages, 11 figures, accepted in A&
Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast
ABSTRACT: Cancer/testis (CT) genes represent a unique class of genes, which are expressed by germ cells, normally silenced in somatic cells, but activated in various cancers. CT proteins can elicit spontaneous immune responses in cancer patients and this feature makes them attractive targets for immunotherapy-based approaches. We have previously reported that CTs are relatively commonly expressed in estrogen receptor (ER) negative, high risk carcinomas. In this study, we examined the expression of selected CT genes in ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and benign proliferative lesions of the breast. ER negative DCIS were found to be associated with significant CT gene expression together with HER2 positivity and a marked stromal immune respons
Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex
DGCR8 is the RNA-binding partner of the nuclease Drosha. Their complex (the âMicroprocessorâ) is essential for processing of long, primary microRNAs (pri-miRNAs) in the nucleus. Binding of heme to DGCR8 is essential for pri-miRNA processing. On the basis of the split Soret ultravioletâvisible (UVâvis) spectrum of ferric DGCR8, bis-thiolate sulfur (cysteinate, Cysâ) heme iron coordination of DGCR8 heme iron was proposed. We have characterized DGCR8 heme ligation using the Î276 DGCR8 variant and combined electron paramagnetic resonance (EPR), magnetic circular dichroism (MCD), electron nuclear double resonance, resonance Raman, and electronic absorption spectroscopy. These studies indicate DGCR8 bis-Cys heme iron ligation, with conversion from bis-thiolate (Cysâ/Cysâ) axial coordination in ferric DGCR8 to bis-thiol (CysH/CysH) coordination in ferrous DGCR8. Pri-miRNA binding does not perturb ferric DGCR8âs optical spectrum, consistent with the axial ligand environment being separated from the substrate-binding site. UVâvis absorption spectra of the FeII and FeIIâCO forms indicate discrete species exhibiting peaks with absorption coefficients substantially larger than those for ferric DGCR8 and that previously reported for a ferrous form of DGCR8. Electronânuclear double resonance spectroscopy data exclude histidine or water as axial ligands for ferric DGCR8 and favor bis-thiolate coordination in this form. UVâvis MCD and near-infrared MCD provide data consistent with this conclusion. UVâvis MCD data for ferrous DGCR8 reveal features consistent with bis-thiol heme iron coordination, and resonance Raman data for the ferrousâCO form are consistent with a thiol ligand trans to the CO. These studies support retention of DGCR8 cysteine coordination upon reduction, a conclusion distinct from those of previous studies of a different ferrous DGCR8 isoform
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