Integral Care for Elderly Patients: Ethical and Legal Issues

Las estructuras sanitarias, ante una población cada vez más envejecida, tienen serios problemas para adaptarse a las necesidades de este colectivo. Asistencia sanitaria, asistencia social, respeto a la dignidad y mecanismos de protección jurídica específica han de combinarse para lograr una atención de calidad que responda, con sentido integral, a las necesidades de los pacientes mayores. Se hace necesaria la aplicación de fórmulas de bioderecho, inspiradas en principios de ética cívica y sustentadas por la ciencia médica, que eviten la discriminación en razón de la edad, permitan respetar la dignidad de la persona mayor y procuren a este colectivo una atención integral centrada en la persona y en las circunstancias que lo rodean, promoviendo la participación del paciente mayor en la toma de decisiones en dignidad y con el trato y cuidados adecuados.Healthcare structures are increasingly under pressure to adapt to the needs of an aging population. Healthcare, social assistance, respect, dignity and mechanisms of specific legal protection must be combined to achieve quality care which responds to the needs of older patients. The application of bio-law formulas, inspired by principles of civic ethics and supported by medical science is required to avoid age discrimination and to ensure respect and dignity for the elderly, providing them with comprehensive personal attention and patient participation in the decision making process surrounding their treatment and careAgencia de Ciencia y Tecnología de la Región de Murcia 19486/PI/1

Towards a New Use of Health Data

Las TIC han entrado con fuerza en los últimos años en el ámbito de la salud, tanto en la prestación de los servicios sanitarios como en su gestión. Dentro de estos está cobrando un papel absolutamente primordial la información sanitaria y los datos de salud; hasta el punto de que no es aventurado decir que la información sanitaria se va a convertir en el eje del sistema. A lo anterior hay que sumar una nueva regulación a nivel europeo en materia de protección de datos personales (Reglamento UE 2016/679). Partiendo de este marco, el presente artículo analiza las posibilidades de tratamiento y uso que la nueva normativa europea en protección de datos personales nos permite respecto de los datos de salud, en particular, la posibilidad de utilización con fines no directamente relacionados con la prestación de la asistencia sanitariaIn recent years ICTs have strongly influenced not only the provision of Health Services but also Health Service management. Consequently, the role of health information, as well as that of health data, is becoming increasingly essential to the extent that it could become the axis of the system in the near future. Additionally, the new regulation on personal data protection at a European level (EU Regulation 2016/679) must be taken into consideration. Taking this legal framework as a starting point, the present paper analyses the possibilities of the processing of health data permitted by legal norms, paying special attention to the possibility of its use for purposes not directly related to the provision of healthcareFundación SENECA de la Región de Murcia (España) 19486/PI/1

Primer curso de Bioderecho y los Comités de Ética en Investigación “Cuestiones fundamentales desde el Derecho, la Ética y la Ciencia"

Contenido resumen del primer curso de Bioderecho y los Comités de Ética en Investigación “Cuestiones fundamentales desde el Derecho, la Ética y la Ciencia”. Organizado por el Comité de Ética en Investigación del Centro Universitario de la Costa. Celebradas el 23 y 24 de octubre de 2014 en Puerto Vallarta, México

COVID-19 outbreaks in a transmission control scenario: challenges posed by social and leisure activities, and for workers in vulnerable conditions, Spain, early summer 2020

Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends’ gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings. Control measures were accordingly applied

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Cross-disease Meta-analysis of Genome-wide Association Studies for Systemic Sclerosis and Rheumatoid Arthritis Reveals IRF4 as a New Common Susceptibility Locus

Objectives: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that share clinical and immunological characteristics. To date, several shared SSc- RA loci have been identified independently. In this study, we aimed to systematically search for new common SSc-RA loci through an inter-disease meta-GWAS strategy. Methods: We performed a meta-analysis combining GWAS datasets of SSc and RA using a strategy that allowed identification of loci with both same-direction and opposingdirection allelic effects. The top single-nucleotide polymorphisms (SNPs) were followed-up in independent SSc and RA case-control cohorts. This allowed us to increase the sample size to a total of 8,830 SSc patients, 16,870 RA patients and 43,393 controls. Results: The cross-disease meta-analysis of the GWAS datasets identified several loci with nominal association signals (P-value < 5 x 10-6), which also showed evidence of association in the disease-specific GWAS scan. These loci included several genomic regions not previously reported as shared loci, besides risk factors associated with both diseases in previous studies. The follow-up of the putatively new SSc-RA loci identified IRF4 as a shared risk factor for these two diseases (Pcombined = 3.29 x 10-12). In addition, the analysis of the biological relevance of the known SSc-RA shared loci pointed to the type I interferon and the interleukin 12 signaling pathways as the main common etiopathogenic factors. Conclusions: Our study has identified a novel shared locus, IRF4, for SSc and RA and highlighted the usefulness of cross-disease GWAS meta-analysis in the identification of common risk loci

¿Hacia una limitación de la capacidad de obrar de los menores de edad?

1. Notas acerca de la capacidad de obrar de los menores de edad en Derecho español En España, la legislación reconoce desde hace décadas una cierta capacidad de obrar a los menores atendiendo a su edad y grado de madurez, especialmente en los ámbitos personal y familiar. Ya desde mediados del siglo pasado, se abandonó la idea presente en la doctrina desde la Codificación de que el menor era un incapaz hasta la mayoría de edad. El artículo 162.2.1º Código civil (en adelante, CC) excluye de la..

El término en la eficacia y cumplimiento de las obligaciones / Belén Andreu Martínez ; dirigida por Antonio Reverte Navarro, Isabel González Pacanowska.

Tesis-Universidad de Murcia.Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. T.M. 2373

Documento de conclusiones: Jornada ensayos clínicos y su nueva normativa

Recopilación y resumen de la Jornad