Beneficios de la implementación de la administración de categorías de aseo y hogar para el supermercado Belalcazar en Yumbo

El presente trabajo de grado se enfoca en el diseño de un plan para la compañía “Supermercados Belalcazar”, ubicada en la ciudad de Yumbo, departamento del Valle de Cauca. El supermercado con 1600 metros cuadrados de área de ventas en el primer piso y 400 metros cuadrados en el segundo nivel dedicado a concesionarios, es un supermercado independiente, situado en el municipio de Yumbo a 10 minutos del norte de la ciudad de Cali. A medida que la empresa ha ido creciendo tanto en volumen de ventas como capacidad instalada, se han ido redistribuyendo funciones asignando tareas especificas al personal administrativo, mejorando departamentos como son: personal, tesorería, auditoria, costos, que considero que son de suma importancia para optimizar los recursos de la empresa generando mayores controles y por ende un crecimiento en los niveles de la organización. La estrategia de excelente calidad, precio por ajustado al mercado, proveedores de alta tecnología y distribución en 2 puntos de venta, nos ayuda a evolucionar y a ser optimistas en el aprovisionamiento en el mercado Toda esta propuesta de valor que ayudara a su directivos a evaluar el desempeño de las categorías que en estos momentos se manejan dentro del almacén, así nos concentraremos en la categoría aseo-hogar ya que es una de las categorías que más le brindan rentabilidad a la compañía. Este proyecto está dirigido a profesionales de administración de empresas y de mercadeo, así como a las demás personas interesadas en conocer acerca del manejo de las categorías dentro de un supermercado, y su positiva gestión al momento de captar clientes, y fidelizar un mercado existente. El mercado de la compañía es muy amplio abarca todo el municipio de Yumbo con un total de 680.000.000 habitantes aproximadamente1, con los estratos económicos desde el 1 al 3. Las fincas de recreo ubicadas en el corregimiento de La Cumbre, Dapa, Vijes, Vitaco, Pavas, estas últimas le proporcionan un gran ingreso de clientes en los fines de semana. La metodología de la investigación es de tipo descriptivo y analítico ya que se utilizan fuentes primarias y secundarias en el análisis y recolección de la información. Como fuente primaria se realizaron entrevistas con los diferentes ejecutivos de la empresa, y fuentes secundarias todos los documentos facilitados por la directiva y guardados con gran recelo. En el siguiente cuadro se presentara un resumen de las ventas obtenidas en el año 2007, comparado con el año 2008, cuando se comenzó a utilizar la implementación por categorías en el supermercado, se tomaron los dos años completos ya que se quería encontrar una diferencia en un periodo de doce meses. Esto para que sus directivas direccionen la importancia de no solo seguir con los proyectos establecidos, sino de implementar las diferentes categorías relacionadas en el lmacén. ________________________________ 1 Alcaldía de Yumbo, censo del año 2007Trabajo de grado (Administrador de Empresas)-- Universidad Autónoma de Occidente, 2010PregradoAdministrador(a) de Empresa

Acute and Preventive Treatment of COVID-19-Related Headache: A Series of 100 Patients

To describe the need and effectiveness of acute and preventive medications in a series of 100 consecutive patients referred due to COVID-19-related headaches. Patients were aged 48.0 (standard deviation (SD): 12.4), 84% were female, and 56% had a prior history of headache. The most common headache phenotype was holocranial (63%), frontal (48%), pressing (75%), of moderate intensity (7 out of 10), and accompanied by photophobia (58%). Acute medication was required by 93%, with paracetamol (46%) being the most frequently used drug, followed by ibuprofen (44%). The drugs with the highest proportion of a 2 h pain-freedom response were dexketoprofen (58.8%), triptans (57.7%), and ibuprofen (54.3%). Preventive treatment was required by 75% of patients. The most frequently used drugs were amitriptyline (66%), anesthetic blockades (18%), and onabotulinumtoxinA (11%). The drugs with the highest 50% responder rate were amitriptyline (45.5%), mirtazapine (50%), and anesthetic blockades (38.9%). The highest 75% responder rate was experienced following onabotulinumtoxinA (18.2%). In conclusion, most patients required acute medication, with triptans and non-steroidal anti-inflammatory drugs achieving the best responses. Three-quarters of patients required preventive medication. The most frequently used drug was amitriptyline, which obtained the best results. In some treatment-resistant patients, anesthetic blockades and onabotulinumtoxinA were also beneficial.Grant GRS 2284/A/2020 - Gerencia Regional de Salud Cy

Treatment of primary nummular headache: a series of 183 patients from the NUMITOR study

Producción CientíficaNummular headache (NH) is a primary headache characterized by superficial coin-shaped pain. NUMITOR (NCT 05475769) is an observational study evaluating the responder rate of preventive drugs in NH patients. The treatment response was assessed between weeks 8 and 12 compared with the baseline. Patients were included between February 2002 and October 2022. Demographic and clinical variables were assessed; treatment response was estimated by 50%, 30%, and 75% responder rates and treatment discontinuation due to inadequate tolerability. A total of 183 out of 282 patients fulfilled eligibility criteria and completed the study. Patients were aged 49.5 (standard deviation (SD): 16.8) years, and 60.7% were female. NH phenotype was a parietal circular pain of four centimeters’ diameter, moderate intensity, and oppressive quality. At baseline, patients had 25 (interquartile range) pain days per month. Preventive treatment was used by 114 (62.3%) patients. The highest 50% and 75% responder rates corresponded to onabotulinumtoxinA (62.5%, 47.5%), followed by gabapentin (43.7%, 35.2%). Oral preventive drugs were not tolerated by 12.9–25%. The present study provides class IV evidence of the effectiveness of oral preventive drugs and onabotulinumtoxinA in the treatment of primary NH. OnabotulinumtoxinA was the most effective and best-tolerated drug, positioning it as first-line treatment of NH.Junta de Castilla y León, Gerencia Regional de Salud (SACYL) - (grant GRS 2416/A/21

Basophil-lineage commitment in acute promyelocytic leukemia predicts for severe bleeding after starting therapy

Severe hemorrhagic events occur in a significant fraction of acute promyelocytic leukemia patients, either at presentation and/or early after starting therapy, leading to treatment failure and early deaths. However, identification of independent predictors for high-risk of severe bleeding at diagnosis, remains a challenge. Here, we investigated the immunophenotype of bone marrow leukemic cells from 109 newly diagnosed acute promyelocytic leukemia patients, particularly focusing on the identification of basophil-related features, and their potential association with severe bleeding episodes and patient overall survival. From all phenotypes investigated on leukemic cells, expression of the CD203c and/or CD22 basophil-associated markers showed the strongest association with the occurrence and severity of bleeding (p ≤ 0.007); moreover, aberrant expression of CD7, coexpression of CD34+/CD7+ and lack of CD71 was also more frequently found among patients with (mild and severe) bleeding at baseline and/or after starting treatment (p ≤ 0.009). Multivariate analysis showed that CD203c expression (hazard ratio: 26.4; p = 0.003) and older age (hazard ratio: 5.4; p = 0.03) were the best independent predictors for cumulative incidence of severe bleeding after starting therapy. In addition, CD203c expression on leukemic cells (hazard ratio: 4.4; p = 0.01), low fibrinogen levels (hazard ratio: 8.8; p = 0.001), older age (hazard ratio: 9.0; p = 0.002), and high leukocyte count (hazard ratio: 5.6; p = 0.02) were the most informative independent predictors for overall survival. In summary, our results show that the presence of basophil-associated phenotypic characteristics on leukemic cells from acute promyelocytic leukemia patients at diagnosis is a powerful independent predictor for severe bleeding and overall survival, which might contribute in the future to (early) risk-adapted therapy decisions.This work was supported by the Fundación Científica de la Asociación Española Contra el Cáncer (AECC, Madrid, Spain) and the Fundación Rafael del Pino (Madrid, Spain) and both CIBERONC (CB16/12/00400, CB16/12/00233, CB16/12/00480) and grant PI16/00787 from Instituto de Salud Carlos III (Ministerio de Economía y Competitividad, Madrid, Spain)

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Spread of a SARS-CoV-2 variant through Europe in the summer of 2020

[EN] Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3,4,5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes.S

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Complicaciones cardiológicas del Covid-19: estudio observacional descriptivo retrospectivo

INTRODUCCIÓN: ElCOVID-19 se ha convertido en una relevante crisis sanitaria. Se asocia a patologías principalmente del tracto respiratorio tales como el Síndrome Respiratorio Agudo Grave(SARS) y el Síndrome Respiratorio de oriente Medio(MERS), por ello durante este año ha sido el centro de atención debido la morbimortalidad que ha supuesto esta pandemia. ElCOVID-19presenta repercusión a nivel respiratorio, aunque otros tejidos como el miocardio entre otros muchos órganos se muestran afectados. Se relaciona también con afectación sistémica y cardiovascular. OBJETIVOS:Analizar la incidencia de complicaciones cardiológicas en pacientes con COVID-19y su influencia en la mortalidad. METODOLOGÍA: Estudio observacional, descriptivo y retrospectivo de los pacientes ingresados en la Unidad de Cuidados Intensivos tras desarrollar la enfermedad por COVID-19entre el 15 de abril al 15 agosto de 2020.RESULTADOS:Se estudiaron un total de 63 pacientes. Respeto a las comorbilidades un 54% padecía HTA, un 40% dislipemia y un 19% antecedentes cardiológicos. El 69%desarrollaron complicaciones, siendo las más frecuentes shock séptico e insuficiencia cardiaca. La mortalidad se estimó en un 44,4% de los pacientes, siendo un 75% hombres frente a un 25% de mujeres. CONCLUSIONES: Existe una fuerte correlación entre las comorbilidades y el desarrollo de la enfermedad por COVID-19y su peor pronóstico. La lesión cardíaca es una afección común entre los pacientes hospitalizados con COVID-19y se asocia con un mayor riesgo de mortalidad intrahospitalaria.Grado en Enfermerí