Brazilian undergraduate nursing students’ critical thinking need to be increased: a cross-sectional study

Objectives: To map Brazilian undergraduate nursing students’ critical thinking level and investigate the correlation between selected sociodemographic data and critical thinking domains. Methods: In this descriptive cross-sectional study, participants’ (N=89) critical thinking was assessed using the Health Science Reasoning Test. Correlation between critical thinking domains and sociodemographic data was assessed using the Pearson correlation coefficient. Results: The overall results showed a moderate level of participants’ critical thinking (mean = 70.7; standard deviation 5.7). A poor performance was identified in 5 of the 8 critical thinking domains. A significant positive correlation was found between education period and critical thinking (p<.001). Conclusions: Poor level in students critical thinking domains may lead to negative consequences for their learning outcomes. Further studies should be carried out to confirm our results, in addition to investigation of teaching methods that encourage and ensure the development of students’ critical thinking skills during nursing education.publishedVersio

O pensamento crítico dos estudantes de graduação em enfermagem brasileiros precisa ser ampliado: estudo transversal Es necesario aumentar el pensamiento crítico de los estudiantes brasileños de graduación en enfermería: estudio transversal

Objectives: to map Brazilian undergraduate nursing students’ critical thinking level and investigate the correlation between selected sociodemographic data and critical thinking domains. Methods: in this descriptive cross-sectional study, participants’ (N=89) critical thinking was assessed using the Health Science Reasoning Test. Correlation between critical thinking domains and sociodemographic data was assessed using the Pearson correlation coefficient. Results: the overall results showed a moderate level of participants’ critical thinking (mean = 70.7; standard deviation 5.7). A poor performance was identified in 5 of the 8 critical thinking domains. A significant positive correlation was found between education period and critical thinking (p<.001). Conclusions: poor level in students critical thinking domains may lead to negative consequences for their learning outcomes. Further studies should be carried out to confirm our results, in addition to investigation of teaching methods that encourage and ensure the development of students’ critical thinking skills during nursing education.publishedVersio

Genetic similarity between quince cultivars evaluated by AFLP markers

O objetivo deste trabalho foi determinar as relações genéticas de 21 cultivares de marmeleiro com base no marcador “amplified fragment length polymorphism” (AFLP), para melhoramento e conservação de recursos genéticos da espécie na região sul do Rio Grande do Sul. O DNA das cultivares foi extraído pelo método CTAB, e as reações de AFLP foram realizadas com os iniciadores EcoRI/MseI. Foram identificados dois grupos entre as 21 cultivares de marmeleiro, um com quatro e outro com sete cultivares geneticamente mais relacionadas. As cultivares de marmeleiro apresentam alta variabilidade genética, com máximo de 43% de similaridade.The objective of this work was to determine the genetic relationships of 21 quince cultivars based on the amplified fragment length polymorphism (AFLP) marker, for breeding and conservation of genetic resources of the specie in the south of the state of Rio Grande do Sul, Brazil. The DNA from the cultivars was extracted using the CTAB method, and the AFLP reactions were performed with the primers EcoRI/MseI. Two groups were identified among the 21 quince cultivars, one with four and the other with seven cultivars more genetically related. The quince cultivars show high genetic variability, with maximum of 43% similarity

Stormorken syndrome caused by a p.R304W STIM1 mutation: The first Italian patient and a review of the literature

Stormorken syndrome is a rare autosomal dominant disease that is characterized by a complex phenotype that includes tubular aggregate myopathy (TAM), bleeding diathesis, hyposplenism, mild hypocalcemia and additional features, such as miosis and a mild intellectual disability (dyslexia). Stormorken syndrome is caused by autosomal dominant mutations in the STIM1 gene, which encodes an endoplasmic reticulum Ca2+ sensor. Here, we describe the clinical and molecular aspects of a 21-year-old Italian female with Stormorken syndrome. The STIM1 gene sequence identified a c.910C T transition in a STIM1 allele (p.R304W). The p.R304W mutation is a common mutation that is responsible for Stormorken syndrome and is hypothesized to cause a gain of function action associated with a rise in Ca2+ levels. A review of published STIM1 mutations (n = 50) and reported Stormorken patients (n = 11) indicated a genotype-phenotype correlation with mutations in a coiled coil cytoplasmic domain associated with complete Stormorken syndrome, and other pathological variants outside this region were more often linked to an incomplete phenotype. Our study describes the first Italian patient with Stormorken syndrome, contributes to the genotype/phenotype correlation and highlights the possibility of directly investigating the p.R304W mutation in the presence of a typical phenotype

Sociodemographic profile, diagnoses and nursing care in post-COVID-19 patients in a Brazilian university hospital

ABSTRACT Objectives: to analyze the sociodemographic profile, diagnoses and nursing care of post-COVID-19 patients admitted to a university hospital in southern Brazil. Methods: a retrospective cohort study. The sample consisted of 1,467 medical records, from January 2020 to January 2021. Results: from the analyzed medical records, the most prevalent profiles, respectively, included: males (52.9%); white (81.1%); with Impaired Physiological Balance Syndrome* Nursing Diagnosis (77.3%); nursing care implementing aerosol precautions (94.5%); implementing droplet precautions (93.4%); checking vital signs (91.9%); applying standard disinfectant to equipment and surfaces (89.6%). Conclusions: the analysis of the sociodemographic profile, diagnoses and nursing care of patients in this study may contribute to implementing the Nursing Process in the coronavirus pandemic context

COVID-19-associated Guillain-Barré syndrome in the early pandemic experience in Lombardia (Italy)

Objective To estimate the incidence and describe clinical characteristics and outcome of GBS in COVID-19 patients (COVID19-GBS) in one of the most hit regions during the frst pandemic wave, Lombardia. Methods Adult patients admitted to 20 Neurological Units between 1/3–30/4/2020 with COVID19-GBS were included as part of a multi-center study organized by the Italian society of Hospital Neuroscience (SNO). Results Thirty-eight COVID19-GBS patients had a mean age of 60.7 years and male frequency of 86.8%. CSF albuminocytological dissociation was detected in 71.4%, and PCR for SARS-CoV-2 was negative in 19 tested patients. Based on neurophysiology, 81.8% of patients had a diagnosis of AIDP, 12.1% of AMSAN, and 6.1% of AMAN. The course was favorable in 76.3% of patients, stable in 10.5%, while 13.2% worsened, of which 3 died. The estimated occurrence rate in Lombardia ranges from 0.5 to 0.05 GBS cases per 1000 COVID-19 infections depending on whether you consider positive cases or estimated seropositive cases. When we compared GBS cases with the pre-pandemic period, we found a reduction of cases from 165 to 135 cases in the 2-month study period in Lombardia. Conclusions We detected an increased incidence of GBS in COVID-19 patients which can refect a higher risk of GBS in COVID-19 patients and a reduction of GBS events during the pandemic period possibly due to a lower spread of more common respiratory infectious diseases determined by an increased use of preventive measures

Prevalência de pacientes com Insuficiência Renal Crônica em hemodiálise no município de Mafra-SC

O corrente artigo, quantitativo, retrospectivo, analítico e descritivo, analisa dados sobre o perfil epidemiológico dos pacientes com DRC (Doença Renal Crônica) e relaciona-os aos dados da literatura brasileira. Foram analisadas a prevalência, o perfil sociodemográfico, as etiologias do doente renal crônico, a sobrevida global e a taxa de mortalidade desses pacientes, no período de julho de 2020 a julho de 2021. Foram incluídos na pesquisa todos os pacientes em procedimento hemodialítico devido DRC que foram atendidos na região de Mafra-SC e excluídos aqueles pacientes que apresentaram IRA, perfazendo um total de 101 pacientes adultos analisados. A prevalência desses pacientes foi de 291,3 por milhão da população (pmp), média de idade foi de 54,98 anos, 42,57% tinham idade superior a 60 anos, 54% eram homens, e 93% tinham baixa escolaridade. A taxa de mortalidade bruta desse período foi de 72,3 pacientes pmp, sobrevida global foi de 74,26% neste período de um ano. O acesso mais utilizado para hemodiálise foi a fistula artério-venosa em 71% dos pacientes. A pesquisa demonstrou características peculiares dos pacientes atendidos no centro de hemodiálise em Mafra e as correlacionou aos dados verificados nos bancos de dados brasileiros sobre o mesmo tema. O centro em comento conta com uma prevalência de 0,03%, sendo esta a metade da prevalência nacional (0,06%). A Hipertensão é uma das principais etiologias, seguida por diabetes mellitus. Ao tornar disponível o perfil sociodemográfico dos pacientes com doença renal crônica (se já citado aqui deve ser DRC), possibilita-se que a comunidade local seja beneficiada e que evitem o desenvolvimento dessa doença renal crônica

A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis

The ERAP1 gene encodes an aminopeptidase involved in antigen processing. A functional polymorphism in the gene (rs30187, Arg528Lys) associates with susceptibility to ankylosying spondylitis (AS), whereas a SNP in the interacting ERAP2 gene increases susceptibility to another inflammatory autoimmune disorder, Crohn's disease (CD). We analysed rs30187 in 572 Italian patients with CD and in 517 subjects suffering from multiple sclerosis (MS); for each cohort, an independent sex- and age-matched control group was genotyped. The frequency of the 528Arg allele was significantly higher in both disease cohorts compared to the respective control population (for CD, OR = 1.20 95%CI: 1.01–1.43, p = 0.036; for RRMS, OR = 1.26; 95%CI: 1.04–1.51, p = 0.01). Meta-analysis with the Wellcome Trust Cases Control Consortium GWAS data confirmed the association with MS (pmeta = 0.005), but not with CD. In AS, the rs30187 variant has a predisposing effect only in an HLA-B27 allelic background. It remains to be evaluated whether interaction between ERAP1 and distinct HLA class I alleles also affects the predisposition to MS, and explains the failure to provide definitive evidence for a role of rs30187 in CD. Results herein support the emerging concept that a subset of master-regulatory genes underlay the pathogenesis of autoimmunity

VizieR Online Data Catalog: Superluminous supernovae in faint galaxies (McCrum+, 2015)

From the period starting February 25th 2010 and ending July 9th 2011, 249 hostless transients or "orphans" were discovered in the PS1 Medium Deep fields. AN orphan is defined as an object that is >3.4" away from the centre of a catalogued galaxy or point source brighter than approximately 23.5m (in any of the gP1 rP1 iP1 filters that the transient was detected in). The PS1 observations are obtained through a set of five broadband filters, which we have designated as gP1, rP1, iP1, zP1, and yP1. Although the filter system for PS1 has much in common with that used in previous surveys, such as SDSS (Abazajian et al., 2009ApJS..182..543A), there are important differences. The gP1 filter extends 20nm redward of gSDSS, paying the price of 5577Å emission for greater sensitivity and lower systematics for photometric redshifts, and the zP1 filter is cut off at 930nm, giving it a different response than the detector response which defined zSDSS. SDSS has no corresponding yP1 filter. Further information on the passband shapes is described in Stubbs et al. (2010ApJS..191..376S). The PS1 photometric system and its response is covered in detailed in Tonry et al. (2012ApJ...750...99T, Cat. J/ApJ/750/99). Photometry is in the "natural" PS1 system, m=-2.5log(flux)+m', with a single zeropoint adjustment m' made in each band to conform to the AB magnitude scale. (8 data files). <P /

VizieR Online Data Catalog: SN PS1-11ap light curves (McCrum+, 2014)

The PS1 system is a high-etendue wide-field imaging system, designed for dedicated survey observations. The system is installed on the peak of Haleakala on the island of Maui in the Hawaiian island chain. The telescope has a 1.8m diameter primary mirror, and the gigapixel camera (GPC1) located at the f/4.4 Cassegrain focus consists of sixty 4800x4800-pixel detectors (pixel scale 0.258-arcsec) giving a field of view of 3.3° diameter. The PS1 observations are obtained through a set of five broad-band filters, which are designated as gP1, rP1, iP1, zP1 and yP1. The PS1 photometric system and its response are covered in detail in Tonry et al. (2012ApJ...750...99T, Cat. J/ApJ/750/99). (1 data file)