NAUTILUS Navigator: Búsqueda Interactiva de Soluciones en Optimización Multiobjetivo sin Trade-offs

En este trabajo, se propone un método interactivo de ayuda a la decisión para resolver problemas de optimización multiobjetivo: NAUTILUS Navigator. En este método, el decisor explora libremente el espacio de objetivos hasta que encuentra la solución eficiente que mejor se ajusta a sus preferencias. El proceso de búsqueda consiste en navegar, en tiempo real, por el conjunto de soluciones hasta converger en la solución preferida, partiendo de una solución "mala"(en el sentido de que alcanza valores no deseables para las funciones objetivo). La información preferencial que proporciona el decisor consiste en valores de aspiración para cada función objetivo, así como cotas que no desearía sobrepasar.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Rasch Analysis of the Q-CHAT in Colombian Toddlers with Autism Spectrum Disorder

[EN]The objective of this study was the validation of the Colombian version of The Quantitative Checklist for Autism in Toddlers (Q-CHAT) by means of the Rasch Rating Scale Model. The Q-CHAT was applied to parents of 100 typically developing toddlers and 40 toddlers and preschoolers with Autism Spectrum Disorder (ASD). The Q-CHAT scores showed some limitations. The questionnaire did not meet the condition of unidimensionality. Two dimensions were detected. The first dimension, with 13 items and 4 response categories (13i-4c), showed good psychometric properties: the items fit the Rasch Rating Scale model, the reliability of persons and items was appropriate, and scores adequately discriminate between children with and without ASD. The second dimension is a measure of traits that are usually associated with ASD, but that have shown validity problems. Thus, it is proposed that dimension 1 of the Q-CHAT (13i-4c) be used as the screening tool for ASD in Colombia

Implementación de Twitter en la docencia universitaria

Twitter es una de las redes sociales más utilizadas en España; la que ha gozado de mayor crecimiento de usuarios debido a su fácil funcionamiento, su adaptación a las tecnologías móviles y su rejuvenecimiento. Muchos adolescentes han pasado de Tuenti a Twitter, sin detenerse en Facebook, la red social más utilizada en la actualidad. Por tanto, la importancia de esta red de microblogging recae en que no sólo se ha convertido en un canal de información y comunicación, sino en un gran apoyo a la docencia. En primer lugar hay que destacar el apoyo a la información que ofrece en los más variados eventos académicos, a los que enriquece con testimonios, ejemplos, infografías, etc. Por otra parte, los asistentes pasan de ser meros espectadores a ser los protagonistas y encargados de retransmitir todo lo que ocurre durante la jornada añaden nuevas informaciones, complementan la comunicación, e incorporan juicios de valor, algunos de ellos muy interesantes para las futuras ediciones. Por último, hay que destacar su importancia para la difusión. Por operar Twitter a nivel mundial, las simples publicaciones pueden llegar a miles y millones de personas, que pueden seguir, incluso en tiempo real, todo lo que acontece en la sesión. También, puede servir de referente en un futuro ya que, mediante búsquedas, se podría recuperar y volver a ver y revisar lo que sucedió dentro de la red social. En esta comunicación analizaremos los datos obtenidos en el curso Community Manager. El profesional del social media, recientemente celebrado en la Facultad de Comunicación y Documentación de la Universidad de Granada. Estos datos reflejan el grado de participación de los asistentes, protagonistas de la difusión del evento a través de Twitter. Para medir la influencia de la comunicación y el alcance de dicha actividad en esta red de microblogging se han analizado una serie de parámetros para ver, para demostrar que Twitter no sólo es una red social sino una herramienta adecuada de apoyo docente.Twitter is one of the most popular social networks in Spain, has increased user growth due to its easy operation, its adaptation to mobile technologies and its rejuvenation. Many teenagers have passed from Tuenti to Twitter without stopping at Facebook, the most commonlysocial network used today. Therefore, the importance of this network of microblogging doesn`t go to in fact to having become a channel of information and communication and to be a great teaching support. First we must mention the backing information provided in the most varied academic events, which enriches with testimonies, illustrations, infographics, etc. Moreover, participants move from being mere spectators to become actors and managers of relaying everything that happens during the conference, they add new information, they complement communication and they incorporate value judgments, some of them very interesting for future editions. Finally, we must highlight its importance for diffusion. Twitter operates globally, simple publications can reach thousands and millions persons who can follow, even in real time, all that happens in the session. Also, it can serve as a reference in the future because, by searching, it could be recovered and to re-watch and to review what happened within the social network. In this paper we will analyze the data obtained in the course Community Manager. The social media's professional, celebrated at the Faculty of Communication and Information at the University of Granada last March. These data reflect the degree of participation of the attendees, players in the marketing of the event via Twitter. For measuring the influence of communication and the extent of that activity in this network microblogging it has been used several parameters for analysing, for showing that Twitter is not just a social network it is also a suitable tool for teaching support

Valid practice of personal and electronic notification in civil matters

La notificación personal es uno de los institutos jurídicos vitales del derecho procesal. Constituye el acto de enteramiento al convocado en un determinado juicio, materializa el derecho fundamental al proceso debido y el de contradicción y defensa. A consecuencia de la implementación de las TIC’S el sistema judicial colombiano, coexisten en la actualidad dos regímenes de notificación personal, uno de carácter presencial o físico y otro electrónico o digital. Cada modalidad de notificación cuenta con unos requisitos esenciales que resultan distintos para cada régimen. En la ejecución de este acto procesal se han confundido y mezclado los presupuestos de uno y otro, lo que ha conllevado a practicarse y avalarse notificaciones hibridas que legalmente no están permitidas. Este estudio explica las diferencias entre uno y otro régimen, lo que permite clarificar el trámite individual y plantear soluciones que ayudarán al lector a comprender y hacer un uso adecuado de esta institución procesal, a partir del análisis normativo y jurisprudencial.Universidad Libre Seccional Socorro -- Facultad de derecho, ciencias políticas y sociales -- Especialización en derecho procesalPersonal service is one of the vital legal institutes of procedural law. It constitutes the act of informing the summoned in a certain trial, materializes the fundamental right to due process and that of contradiction and defense. As a result of the implementation of ICTs in the Colombian judicial system, there are currently two personal notification mechanisms, one face-to-face or physical and the other electronic or digital. Each type of notification has essential requirements that are different for each regime. In the execution of this procedural act, the budgets of one and the other have been confused and mixed, which has led to the practice and endorsement of hybrid notifications that are not legally allowed. This study explains the differences between one and the other regime, which allows clarifying the individual procedure and proposing solutions that help the reader to understand and make proper use of this procedural institution, based on normative and jurisprudential analysis

https://doi.org/10.1016/j.chemosphere.2023.140364

The fate of the antibiotic sulfamethoxazole in amended soils remains unclear, moreover in basic soils. This work aimed to assess the adsorption, leaching, and biodegradation of sulfamethoxazole in unamended and biochar from holm oak pruning (BC)- and green compost from urban pruning (CG)-amended basic soil. Adsorption properties of the organic amendments and soil were determined by adsorption isotherms of sulfamethoxazole. The leachability of this antibiotic from unamended (Soil) and BC- (Soil + BC) and GC- (Soil + GC) amended soil was determined by leaching columns using water as solvent up to 250 mL. Finally, Soil, Soil + BC, and Soil + GC were spiked with sulfamethoxazole and incubated for 42 days. The degradation rate and microbial activity were periodically monitored. Adsorption isotherms showed poor adsorption of sulfamethoxazole in unamended basic soil. BC and CG showed good adsorption capacity. Soil + BC and Soil + GC increased the sulfamethoxazole adsorption capacity of the soil. The low sulfamethoxazole adsorption of Soil produced quick and intense sulfamethoxazole leaching. Soil + BC reduced the sulfamethoxazole leaching, unlike to Soil + GC which enhanced it concerning Soil. The pH of adsorption isotherms and leachates indicate that the anion of sulfamethoxazole was the major specie in unamended and amended soil. CG enhanced the microbial activity of the soil and promoted the degradability of sulfamethoxazole. In contrast, the high adsorption and low biostimulation effect of BC in soil reduced the degradation of sulfamethoxazole. The half-life of sulfamethoxazole was 2.6, 6.9, and 11.9 days for Soil + GC, Soil, and Soil + BC, respectively. This work shows the benefits and risks of two organic amendments, BC and GC, for the environmental fate of sulfamethoxazole. The different nature of the organic carbon of the amendments was responsible for the different effects on the soilPDC 2021-120744-I0

El AMD3100 (plerixafor) puede mejorar la movilización de células hematopoyéticaspara hacer trasplantes autólogos : Informe de un caso.

La quimioterapia a dosis alta rescatada con trasplante de células hematopoyéticas autólogas se ha convertido en el tratamiento de elección en los pacientes con mieloma múltiple menores de 65 años de edad. El éxito del autotrasplante depende de la infusión de un número suficiente de células CD34+. Algunos pacientes no movilizan adecuadamente células CD34 de la médula ósea a la sangre periférica para hacer los trasplantes, principalmente aquellos quienes han recibido quimioterapia previa. En estos casos, además de los agentes movilizantes habituales como el G-CSF, la adición de plerixafor incrementa la colección de células CD34+. Se presenta el caso de un paciente con mieloma múltiple quien había sido sometido a un trasplante de células hematopoyéticas autólogas y que, al intentar un segundo trasplante, no movilizó adecuadamente células CD34 al usar filgrastim. La adición de plerixafor permitió hacer adecuadamente la movilización de las células hematopoyética y trasplantar al paciente. No existen en la literatura nacional publicaciones sobre este tema

As Percepções dos Residentes Sobre os Impactos do Turismo como Preditor de Participação Social

Residents' perception of the impacts of tourism is a relevant issue in academic studies through both qualitative and quantitative approaches. This study was conducted in the metropolitan area of Puerto Vallarta, Jalisco and Bahía de Banderas, Nayarit, where tourism is the predominant activity. With a survey raised to the population, it was developed a “Structural Equations Model” (SEM) which determine that the impacts of tourism explain in an adequate way the perception of the local population, as it is based on academic literature, with the contribution in this work, that the perception is a predictor of the interest to solve their problems of the community. For the case study, although there are differences in the integration of impacts as perception, there is no significant statistical difference in the perception as a predictor of the interest in participating in the two analyzed populations. Keywords: Tourism; Perception; Local Residents; Tourism Impacts.La percepción de la población local sobre los impactos del turismo es un tema relevante en los estudios académicos a través de abordajes cualitativos y cuantitativos. Este estudio se realizó en la zona metropolitana de Puerto Vallarta, Jalisco y Bahía de Banderas, Nayarit, donde el turismo es la actividad preponderante. Con una encuesta levantada a la población, se desarrolló un “Modelo de Ecuaciones Estructurales” (SEM) el cual determinan que los impactos del turismo explican de forma adecuada la percepción de la población local, como esta fundamentado en la literatura académica, con la aportación en este trabajo, que la percepción es un predictor del interés por resolver sus problemas de la comunidad. Para el caso de estudio, aunque existen diferencias en la integración de los impactos como percepción, no hay diferencia estadística significativa en la percepción como predictor del interés por participar en las dos poblaciones analizadas. Palabras claves: Turismo; Percepción; Población Local; Impactos del Turismo.A percepção da população local sobre os impactos do turismo é um tema relevante nos estudos acadêmicos através de abordagens qualitativas e quantitativas. Este estudo foi realizado na área metropolitana de Puerto Vallarta, Jalisco e Bahía de Banderas, Nayarit, onde o turismo é a atividade predominante. Com um levantamento da população, foi desenvolvido um "Modelo de Equação Estrutural" (SEM), que determinou que os impactos do turismo explicam adequadamente a percepção da população local, pois se baseia na literatura acadêmica, com a contribuição deste trabalho, essa percepção é um preditor de interesse na solução de seus problemas da comunidade. Para o estudo de caso, embora haja diferenças na integração dos impactos como percepção, não há diferença estatística significativa na percepção como preditor de interesse em participar das duas populações analisadas. Palavras-chave: Turismo; Percepção; População Local; Impactos do Turismo

MYC as therapeutic target in leukemia and lymphoma

MYC is a transcription factor that is involved in the expression of many genes. Deregulated MYC is found in about half of human tumors, being more prevalent in hematological neoplasms. Deregulation mechanisms include chromosomal translocation (particularly in lymphoma), amplification, and hyperactivation of MYC transcription. Here we review MYC involvement in the major types of leukemia and lymphoma. MYC rearrangements appear in all Burkitt lymphomas and are common in other lymphoma types, whereas in acute lymphoblastic leukemia, acute myeloid leukemia, lymphoproliferative, and myeloproferative diseases, they are less frequent. However, MYC overexpression is present in all types of hematological malignancies and often correlates with a worse prognosis. Data in leukemia-derived cells and in animal models of lymphomagenesis and leukemogenesis suggest that MYC would be a good therapeutic target. Several MYC-directed therapies have been assayed in preclinical settings and even in clinical trials. First, peptides and small molecules that interrupt the MYC–MAX interaction impair MYC-mediated tumorogenesis in several mouse models of solid tumors, although not yet in lymphoma and leukemia models. Second, there are a number of small molecules inhibiting the interaction of MYC–MAX heterodimers with DNA, still in the preclinical research phase. Third, inhibitors of MYC expression via the inhibition of BRD4 (a reader of acetylated histones) have been shown to control the growth of MYC-transformed leukemia and lymphoma cells and are being used in clinic trials. Finally, we review a number of promising MYC-mediated synthetic lethal approaches that are under study and have been tested in hematopoietic neoplasms

Effectiveness of a Tai-Chi Training and Detraining on Functional Capacity, Symptomatology and Psychological Outcomes in Women with Fibromyalgia

Background. The purpose was to analyze the effects of Tai-Chi training in women with fibromyalgia (FM). Methods. Thirty-two women with FM (mean age, 51.4 ± 6.8 years) attended to Tai-Chi intervention 3 sessions weekly for 28 weeks. The outcome measures were: tenderness, body composition, functional capacity and psychological outcomes (Fibromyalgia impact questionnaire (FIQ), Short Form Health Survey 36 (SF-36)). Results. Patients showed improvements on pain threshold, total number of tender points and algometer score (all P < 0.001). The intervention was effective on 6-min walk (P = 0.006), back scratch (P = 0.002), handgrip strength (P = 0.006), chair stand, chair sit & reach, 8 feet up & go and blind flamingo tests (all P < 0.001). Tai-Chi group improved the FIQ total score (P < 0.001) and six subscales: stiffness (P = 0.005), pain, fatigue, morning tiredness, anxiety, and depression (all P < 0.001). The intervention was also effective in six SF-36 subscales: bodily pain (P = 0.003), vitality (P = 0.018), physical functioning, physical role, general health, and mental health (all P < 0.001). Conclusions. A 28-week Tai-Chi intervention showed improvements on pain, functional capacity, symptomatology and psychological outcomes in female FM patients