Generalized S-space-forms with two structure vector fields

We introduce and study generalized S-space-forms with two structure vector fields. We also present several examples of these manifolds such as certain hypersurfaces of Sasakianspace-forms, principal toroidal bundles and warped products. Moreover, we investigate generalized S-space-forms endowed with an additional structure and we obtain some obstructions for them to be S-manifolds.Plan Andaluz de Investigación (Junta de Andalucía)Ministerio de Educación y CienciaFondo Europeo de Desarrollo Regiona

Establishment and characterization of an iPSC line (UCLi023-A) derived from a Late-Onset Retinal Degeneration patient carrying a founder mutation in C1QTNF5

Late-Onset Retinal Degeneration (L-ORD) is a rare autosomal dominant macular disease, with most cases being caused by a founder mutation in C1QTNF5. Initial symptoms, which generally occur during or after the sixth decade, include abnormal dark adaptation and changes in peripheral vision. Over time, the build-up of sub-retinal pigment epithelium (RPE) deposits leads to macular atrophy and bilateral central vision loss1. Here, we describe the generation of a human induced pluripotent stem cell (iPSC) line from dermal fibroblasts of a 61-year-old L-ORD Caucasian male patient carrying the founder mutation (c.489C>G, p.Ser163Arg), using episomal reprogramming

Gender, albuminuria and chronic kidney disease progression in treated diabetic kidney disease

Background: Women are reported to have a lower incidence of renal replacement therapy, despite a higher prevalence of chronic kidney disease (CKD). Aim: To analyze diabetic kidney disease (DKD) progression in men and women. Methods: Prospective cohort: n = 261, 35% women, new consecutive nephrology DKD referrals. Results: Women smoked less and better complied with the dietary phosphate and sodium restrictions. Despite a less frequent nephrology referral, women had lower baseline albuminuria. Over a 30 + - 10-month follow-up, albuminuria decreased in women and the estimated glomerular filtration rate (eGFR) loss was slower than in men. However, the percentage of rapid progressors was similar in both sexes. The best multivariate model predicting rapid progression in men (area under curve (AUC) = 0.92) and women differed. Albuminuria and fractional excretion of phosphate (FEphosphate) were part of the men multivariable model, but not of women. The AUC for the prediction of rapid progression by albuminuria was higher in men than in women, and the albuminuria cut-off points also differed. In women, there was a higher percentage of rapid progressors who had baseline physiological albuminuria. Conclusions: Female DKD differs from male DKD: albuminuria was milder and better responsive to therapy, the loss of eGFR was slower and the predictors of rapid progression differed from men: albuminuria was a better predictor in men than in women. Lifestyle factors may contribute to the differencesThis work and the APC was funded by FIS grant numbers CP14/00133, PI16/02057, PI18/01366, PI19/00588, PI19/00815, DTS18/00032, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN AC18/00071, National Institute of Health (2R01AI063331), ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Sociedad Española de Nefrología, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM, Miguel Servet MS14/00133 to M.D.S.-N. and A.B.S. and Cátedra Mundipharma UAM. IIS-Fundacion Jimenez Diaz Biobank, part of the Spanish Biobanks Platform (PT17/0015/0006)

Andalusian program for early detection of diabetic retinopathy: implementation and 15-year follow-up of a population-based screening program in Andalusia, Southern Spain

Introduction Diabetic retinopathy (DR) is a preventable cause of vision loss and blindness worldwide. We aim at analyzing the impact of a population-based screening program of DR using retinal photography with remote reading in terms of population coverage, diagnosis of asymptomatic DR and impact on visual disability, in the region of Andalusia, Spain, in the period 2005-2019. Research design and methods Descriptive study. Sociodemographic and clinical features included in the Andalusian program for early detection of diabetic retinopathy (APDR) were analyzed. Population coverage, annual incidence of DR, and DR severity gradation were analyzed. Estimated data on prevalence and incidence of legal blindness due to DR were included. Results 407 762 patients with at least one successful DR examination during the study period were included. Most of the performed retinographies (784 584, 84.3%) were 'non-pathological.' Asymptomatic DR was detected in 52 748 (5.9%) retinographies, most of them (94.2%) being classified as 'mild to moderate non-proliferative DR.' DR was detected in 44 815 patients, while sight-threatening DR (STDR) in 6256 patients; cumulative incidence of DR was 11.0% and STDR was 1.5%, as DR and STDR was detected in 44 815 and 6256 patients, respectively. Annual incidence risk per patient recruitment year progressively decreased from 22.0% by January 2005 to 3.2% by June 2019. Conclusions Implementation of a long-term population-based screening program for early detection of DR is technically feasible and clinically viable. Thus, after 15 years of existence, the program has enabled the screening of the vast majority of the target population allowing the optimization of healthcare resources and the identification of asymptomatic DR

Ruralidad Urbana de la Ciudad de Villa María, Córdoba.: Hacia una planificación saludable, inclusiva y sustentable

Interdisciplinary and interinstitutional work contributes to territorial construction, consolidating bases and spaces for the integral development of the territory. This proposal sought to analyze the process of creating Municipal Ordinance N° 7.209 in the city of Villa María, Córdoba. A research group began to work on the delimitation of the peri-urban area of ​​the city as the local government was modifying the municipal zoning ordinance. This inter-institutional work gave up the opportunity to use the academic study as a scientific basis for the review of municipal ordinances that regulated land use planning. Survey forms and participating activities were carried out to learn about the status and demands of this peri-urban area. The research defined the environmental baseline, considering the results from participating activities, and the projection of local government. It was made towards a healthy, inclusive, and sustainable city. Municipal Ordinance No. 7,209 was passed unanimously at the end of 2017 and established the new zoning plan, the creation of a urban-rural technical unit and its role.El trabajo interdisciplinario e interinstitucional aporta a la construcción territorial consolidando bases y espacios para el desarrollo integral del territorio. Esta propuesta buscó analizar el proceso de creación de la Ordenanza Municipal N°7.209 de la ciudad de Villa María, Córdoba. Un grupo de investigación comenzó a trabajar en la delimitación del periurbano de la ciudad y simultáneamente desde la gestión local se modificó la ordenanza municipal de zonificación. Este trabajo interinstitucional surgió con el objetivo de que el estudio académico sirva de base científica para la revisión de las ordenanzas municipales que regulaban el ordenamiento territorial. Se realizaron actividades de relevamiento y talleres participativos a fin de conocer el estado y las demandas de ese periurbano. La investigación definió la línea de base ambiental sobre la cual se consensuaron las posiciones resultantes de los talleres y la proyección de la gestión municipal hacia una ciudad saludable, inclusiva y sustentable. La Ordenanza Municipal N° 7.209 fue sancionada por unanimidad a fines del año 2017 y en ella se aprueba el nuevo plano de zonificación, se crea la unidad ejecutora técnica de ruralidad urbana y se establecen sus funciones

El iPad en la Educación científica de estudiantes de Secundaria y Bachillerato

The new technologies have penetrated deeply into Education. We have analyzed the perception of students and teachers on the use of tablets as teaching sciences tools, in a Secondary and High School where each student is provided with an iPad. Both students and teachers consider that the highest performance of the iPad is achieved in subjects related to life sciences. However, most teachers recognize that they do not take advantage of all the iPad resources. We discuss why technology does not guarantee an improvement in the quality of scientific education without an adequate training of teachers and some didactic strategies to implement its suitable use in the classrooms

Urban Rurality of the City of Villa María, Córdoba: Towards a healthy, inclusive, and sustainable planning

El trabajo interdisciplinario e interinstitucional aporta a la construcción territorial consolidando bases y espacios para el desarrollo integral del territorio. Esta propuesta buscó analizar el proceso de creación de la Ordenanza Municipal N°7.209 de la ciudad de Villa María, Córdoba. Un grupo de investigación comenzó a trabajar en la delimitación del periurbano de la ciudad y simultáneamente desde la gestión local se modificó la ordenanza municipal de zonificación. Este trabajo interinstitucional surgió con el objetivo de que el estudio académico sirva de base científica para la revisión de las ordenanzas municipales que regulaban el ordenamiento territorial. Se realizaron actividades de relevamiento y talleres participativos a fin de conocer el estado y las demandas de ese periurbano. La investigación definió la línea de base ambiental sobre la cual se consensuaron las posiciones resultantes de los talleres y la proyección de la gestión municipal hacia una ciudad saludable, inclusiva y sustentable. La Ordenanza Municipal N° 7.209 fue sancionada por unanimidad a fines del año 2017 y en ella se aprueba el nuevo plano de zonificación, se crea la unidad ejecutora técnica de ruralidad urbana y se establecen sus funciones.Interdisciplinary and interinstitutional work contributes to territorial construction, consolidating bases and spaces for the integral development of the territory. This proposal sought to analyze the process of creating Municipal Ordinance N° 7.209 in the city of Villa María, Córdoba. A research group began to work on the delimitation of the peri-urban area of the city as the local government was modifying the municipal zoning ordinance. This inter-institutional work gave up the opportunity to use the academic study as a scientific basis for the review of municipal ordinances that regulated land use planning. Survey forms and participating activities were carried out to learn about the status and demands of this peri-urban area. The research defined the environmental baseline, considering the results from participating activities, and the projection of local government. It was made towards a healthy, inclusive, and sustainable city. Municipal Ordinance No. 7,209 was passed unanimously at the end of 2017 and established the new zoning plan, the creation of a urban-rural technical unit and its role.Fil: Guzmán, Leticia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; ArgentinaFil: Carriazo, Silvia R.. Municipalidad de Villa María (Córdoba).; ArgentinaFil: Suarez, Valeria. Municipalidad de Villa María (Córdoba).; ArgentinaFil: Castoldi, Leonardo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; ArgentinaFil: Mizdraje, Dafne Aylén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentin

Lagrangian translators under mean curvature flow

We provide a new construction of Lagrangian surfaces in C2 in terms of two planar curves. When we take such curves as appropriate solutions of the curve shortening problem, including self-shrinking and self-expanding curves or spirals, we will obtain translating solitons which generalize the Joyce, Lee and Tsui ones in dimension two D. Joyce, Y.-I. Lee, and M.-P. Tsui. Self-similar solutions and translating solitons for Lagrangian mean curvature flow. J. Differential Geom. 84 (2010), no. 1, 127-161. Finally, we characterize locally all examples in terms of an analytical condition on the Hermitian product of the position vector of the immersion and the translating vector that allows us separation of variables. As a consequence we get the classification of the Hamiltonian stationary Lagrangian translating solitons for Lagrangian mean curvature flow in complex Euclidean plane. This work is based in I. Castro and A. M. Lerma. Translating solitons for Lagrangian mean curvature flow in complex Euclidean plane. Internat. J. Math. 23 (2012), no. 10, 1250101-1-1250101-16.Ministerio de Economía y CompetitividadFondo Europeo de Desarrollo RegionalJunta de Andalucí

The role of bioimpedance analysis in overweight and obese patients with acute heart failure: a pilot study.

AIMS Residual congestion at the time of hospital discharge is an important readmission risk factor, and its detection with physical examination and usual diagnostic techniques have strong limitations in overweight and obese patients. New tools like bioelectrical impedance analysis (BIA) could help to determine when euvolaemia is reached. The aim of this study was to investigate the usefulness of BIA in management of heart failure (HF) in overweight and obese patients. METHODS AND RESULTS Our study is a single-centre, single-blind, randomized controlled trial that included 48 overweight and obese patients admitted for acute HF. The study population was randomized into two arms: BIA-guided group and standard care. Serum electrolytes, kidney function, and natriuretic peptides were followed up during their hospital stay and at 90 days after discharge. The primary endpoint was development of severe acute kidney injury (AKI) defined as an increase in serum creatinine by >0.5 mg/dL during hospitalization, and the main secondary endpoint was the reduction of N-terminal pro-brain natriuretic peptide (NT-proBNP) levels during hospitalization and within 90 days after discharge. The BIA-guided group showed a remarkable lower incidence of severe AKI, although no significant differences were found (41.4% vs. 16.7%; P = 0.057). The proportion of patients who achieved levels of NT-proBNP < 1000 pg/mL at 90 days was significantly higher in the BIA-guided group than in the standard group (58.8% vs. 25%; P = 0.049). No differences were observed in the incidence of adverse outcomes at 90 days. CONCLUSIONS Among overweight and obese patients with HF, BIA reduces NT-proBNP levels at 90 days compared with standard care. In addition, there is a trend towards lower incidence of AKI in the BIA-guided group. Although more studies are required, BIA could be a useful tool in decompensated HF management in overweight and obese patients.This research received no external funding.S

Epigenetic modifiers as potential therapeutic targets in diabetic kidney disease

Diabetic kidney disease is one of the fastest growing causes of death worldwide. Epigenetic regulators control gene expression and are potential therapeutic targets. There is functional interventional evidence for a role of DNA methylation and the histone post-translational modifications—histone methylation, acetylation and crotonylation—in the pathogenesis of kidney disease, including diabetic kidney disease. Readers of epigenetic marks, such as bromodomain and extra terminal (BET) proteins, are also therapeutic targets. Thus, the BD2 selective BET inhibitor apabetalone was the first epigenetic regulator to undergo phase-3 clinical trials in diabetic kidney disease with an endpoint of kidney function. The direct therapeutic modulation of epigenetic features is possible through pharmacological modulators of the specific enzymes involved and through the therapeutic use of the required substrates. Of further interest is the characterization of potential indirect effects of nephroprotective drugs on epigenetic regulation. Thus, SGLT2 inhibitors increase the circulating and tissue levels of β-hydroxybutyrate, a molecule that generates a specific histone modification, β-hydroxybutyrylation, which has been associated with the beneficial health effects of fasting. To what extent this impact on epigenetic regulation may underlie or contribute to the so-far unclear molecular mechanisms of cardio-and nephroprotection offered by SGLT2 inhibitors merits further in-depth studies.This research was funded by FIS/FEDER funds (PI15/00298, CP14/00133, PI16/01900, PI18/01386, PI18/0133, PI19/00588, PI19/00815, DTS18/00032, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN AC18/00071), ISCIII-RETIC REDinREN RD016/0009), Sociedad Española de Nefrología, FRIAT, Comunidad de Madrid en Biomedicina B2017/BMD- 3686 CIFRA2-CM. Salary support: ISCIII Miguel Servet to ABS and MDS-N, ISCIII Sara Borrell to JM-MM, REDinREN RD016/0009 to MF-B, and MICIU to JG-M