A model to estimate the lifetime health outcomes of patients with Type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68)

<i>Aims/hypothesis</i> The aim of this study was to develop a simulation model for Type 2 diabetes that can be used to estimate the likely occurrence of major diabetes-related complications over a lifetime, in order to calculate health economic outcomes such as quality-adjusted life expectancy. <i>Methods</i> Equations for forecasting the occurrence of seven diabetes-related complications and death were estimated using data on 3642 patients from the United Kingdom Prospective Diabetes Study (UKPDS). After examining the internal validity, the UKPDS Outcomes Model was used to simulate the mean difference in expected quality-adjusted life years between the UKPDS regimens of intensive and conventional blood glucose control. <i>Results</i> The models forecasts fell within the 95% confidence interval for the occurrence of observed events during the UKPDS follow-up period. When the model was used to simulate event history over patients lifetimes, those treated with a regimen of conventional glucose control could expect 16.35 undiscounted quality-adjusted life years, and those receiving treatment with intensive glucose control could expect 16.62 quality-adjusted life years, a difference of 0.27 (95% CI: –0.48 to 1.03). <i>Conclusions/interpretations</i> The UKPDS Outcomes Model is able to simulate event histories that closely match observed outcomes in the UKPDS and that can be extrapolated over patients lifetimes. Its validity in estimating outcomes in other groups of patients, however, remains to be evaluated. The model allows simulation of a range of long-term outcomes, which should assist in informing future economic evaluations of interventions in Type 2 diabetes

Infant and child oral health risk status correlated to behavioral habits of parents or caregivers: a survey in central Italy

Aim: The aim of this survey was to evaluate the knowledge and awareness of parents and caregivers about potential oral health risk factors for their children in their first months of life (3–30 months). Materials and Methods: The participation to the survey was proposed to all parents or caregivers of children attending the public consulting service in Latina for mandatory vaccinations during the period of June to August 2014. A self-administered questionnaire was completed to obtain information regarding demographic variables, infant feeding practice, maternal oral health during and after pregnancy, children’s oral hygiene habits and risk behaviors (e.g., sharing cutlery, tasting of baby food, nightly using of baby bottles with sugared beverages, or sugared pacifier), and knowledge about caries and its transmission. The analysis of the data was performed using SPSS 14.0 for Windows (SPSS Inc., Chicago, IL, USA). The variance analysis and chi-square test were used to investigate the relationship between the variables. Results: Overall, the parents of 304 children consented to fill the questionnaire. Data analysis showed that about 50% of respondents considered dental caries an infectious disease, however, 53.6% was not aware of the potential vertical transmissibility of cariogenic bacteria through contaminated saliva. It is a common trend in the early stages of weaning to taste the baby food (53%) and sharing cutlery (38.5%). With regard to children oral health care, parents reported no toothbrushing for 53.1% of the children in their first 3 years of life. The relationship between the two variables concerning caries transmissibility and tools sharing carried out on through Pearson chi-square test identified P = 0.32. Conclusions: From this survey, the need for parental oral health promoting program emerged to control children oral health risk status

American terror:from Oklahoma City to 9/11 and after

Throughout American history, both terrorism and extremism have been constructed, evoked or ignored strategically by the state, media and public at different points, in order to disown and demonize political movements whenever their ideologies and objectives become problematic or inconvenient – because they overlap with, and thus compromise, the legitimacy of the dominant ideology and democratic credentials of the state, because they conflict with the dominant ideology or hegemonic order, because they offend the general (voting) public, or because they expose the fallacies of national unity and bi-polar opposition in the face of foreign enemies or international conflicts, such as the war on terror. This chapter looks at how domestic extreme right terrorism has been constructed, represented, evoked or ignored in the American political imagination in the post-civil rights era, with a particular focus on its changing status following the Oklahoma City bombing and 9/11

The Ideological Mapping of American Legislatures

The development and elaboration of the spatial theory of voting has contributed greatly to the study of legislative decision making and elections. Statistical models that estimate the spatial locations of individual legislators have been a key contributor to this success (Poole and Rosenthal 1997; Clinton, Jackman and Rivers 2004). In addition to applications to the U.S. Congress, spatial models have been estimated for the Supreme Court, U.S. presidents, a large number of non-U.S. legislatures, and supra- national organizations. But, unfortunately, a potentially fruitful laboratory for testing spatial theories of policymaking and elections, the American states, has remained relatively unexploited. Two problems have limited the empirical application of spatial theory to the states. The first is that state legislative roll call data has not yet been systematically collected for all states over time. Second, because ideal point models are based on latent scales, comparisons of ideal points across states or chambers within a state are difficult. This paper reports substantial progress on both fronts. First, we have obtained the roll call voting data for all state legislatures from the mid-1990s onward. Second, we exploit a recurring survey of state legislative candidates to enable comparisons across time, chambers, and states as well as with the U.S. Congress. The resulting mapping of America's state legislatures has tremendous potential to address numerous questions not only about state politics and policymaking, but legislative politics in general.

American Culture: A Sociological Perspectives

The culture of the United States of America is primarily of Western origin but is influenced by a multicultural ethos that includes African, Native American, Asian, Pacific Island, and Latin American people and their cultures. American culture encompasses the customs and traditions of the United States. The United States is sometimes described as a "melting pot" in which different cultures have contributed their own distinct "flavors" to American culture. The United States of America is a North American nation that is the world\u27s most dominant economic and military power. Likewise, its cultural imprint spans the world, led in large part by its popular culture expressed in music, movies and television. The culture of the United States of America is primarily of Western culture (European) origin and form but is influenced by a multicultural ethos that includes African, Native American, Asian, Polynesian, and Latin American people and their cultures. The American way of life or simply the American way is the unique lifestyle of the people of the United States of America. It refers to a nationalist ethos that adheres to the principle of life, liberty and the pursuit of happiness

Intellectual Life in Jefferson\u27s Virginia, 1790-1830

https://trace.tennessee.edu/utk_early-american/1003/thumbnail.jp

Intellectual Life in the Colonial South, 1585-1763 (Volume 2 of 3)

https://trace.tennessee.edu/utk_early-american/1015/thumbnail.jp