Localización gráfica de los expedientes patrimoniales de Vitoria en el AHPA

Direcciones de correo electrónico de las autoras: [email protected] ; [email protected][ES] Georreferenciación de proyectos de edificios históricos conservados en el Archivo Municipal Pilar Aróstegui y comprendidos entre los siglos XVII y XIX de la ciudad de Vitoria-Gasteiz (Álava). Mediante un sistema de SIG, Manifold, y utilizando un plano de la ciudad de Vitoria (escala 1/5000) acompañado de ortofotos (sistema ETRS89 y resolución de pixel de 25x25cm) se puede consultar toda la información existente de cada uno de los proyectos.[EUS] Vitoria-Gasteizen (Araba), XVII eta XIX bitarteko mendeetan, Pilar Aróstegui Udal Artxiboan gordetzen diren eraikin historikoen proiektuen Georrektifikazioa. GIS sistema baten bidez egina, "Manifold" izenekoa. Gasteizko planoa (1/5000 eskalan) eta ortofoto bat konbinatuz (ETRS89 sisteman eta 25x25cm-ko resoluzioarekin), ikus daiteke proyectu bakoitzaren informazio guztia

Imaginarios colectivos y representaciones sociales en la forma de habitar los espacios urbanos. Barrios Pardo Rubio y Rincón de Suba

En este artículo se plantea la relación existente entre los imaginarios colectivos, las representaciones sociales, el lenguaje y el espacio urbano, partiendo de este último como el escenario en el que por excelencia el hombre construye las relaciones sociales que dan como fruto la cultura. Igualmente, presenta los imaginarios y las representaciones como manifestaciones de las mentalidades y las ideologías. Pone en escena los barrios Pardo Rubio y Rincón de Suba para evidenciar en ellos las diversas expresiones, que como representación de los imaginarios de sus respectivos contenidos sociales construyen sus costumbres, sus hábitos y su historia.AbstractThis article is about the existent relationships among the collective imaginaries, the social representations, the language and the urban space. As the scenario in which man par excellence builds the social relationships that give origin to culture. Equally, it presents the imaginaries and the representations like manifestations of the mentalities and the ideologies. It puts in scene the Pardo Rubio neighborhoods and Rincón de Suba to evidence in them the diverse expressions that as representation of the imaginaries of their respective social milieus build their customs, their habits and their history.</p

Elaboración del modelo hidrogeológico conceptual de la Mina de Sal de Zipaquirá, correspondiente al Título Minero HIQO-03.

171 páginas : ilustraciones color, mapas, fotografías,tablas.El trabajo permite analizar la problemática con enfoque más detallado, es así, que COLSALMINAS LTDA se propuso realizar un modelo hidrogeológico conceptual del área de concesión HIQO-03. Se ha tomado como metodología guía el Programa de Exploración de Aguas Subterraneas, propuesto por el Instituto Colombiano de Geología y Minería en el año 2004, INGEOMINAS, actualmente llamado Servicio Geológico Colombiano, SGC. El presente documento constituye un informe final del desarrollo de la metodología en cuestión para la consecución de los objetivos propuestos.Bibliografía: páginas 143-146.PregradoIngeniero Geólog

Isolation of Aspergillus spp. from the respiratory tract in critically ill patients: risk factors, clinical presentation and outcome

INTRODUCTION: Our aims were to assess risk factors, clinical features, management and outcomes in critically ill patients in whom Aspergillus spp. were isolated from respiratory secretions, using a database from a study designed to assess fungal infections. METHODS: A multicentre prospective study was conducted over a 9-month period in 73 intensive care units (ICUs) and included patients with an ICU stay longer than 7 days. Tracheal aspirate and urine samples, and oropharyngeal and gastric swabs were collected and cultured each week. On admission to the ICU and at the initiation of antifungal therapy, the severity of illness was evaluated using the Acute Physiology and Chronic Health Evaluation II score. Retrospectively, isolation of Aspergillus spp. was considered to reflect colonization if the patient did not fulfil criteria for pneumonia, and infection if the patient met criteria for pulmonary infection and if the clinician in charge considered the isolation to be clinically valuable. Risk factors, antifungal use and duration of therapy were noted. RESULTS: Out of a total of 1756 patients, Aspergillus spp. were recovered in 36. Treatment with steroids (odds ratio = 4.5) and chronic obstructive pulmonary disease (odds ratio = 2.9) were significantly associated with Aspergillus spp. isolation in multivariate analysis. In 14 patients isolation of Aspergillus spp. was interpreted as colonization, in 20 it was interpreted as invasive aspergillosis, and two cases were not classified. The mortality rates were 50% in the colonization group and 80% in the invasive infection group. Autopsy was performed in five patients with clinically suspected infection and confirmed the diagnosis in all of these cases. CONCLUSION: In critically ill patients, treatment should be considered if features of pulmonary infection are present and Aspergillus spp. are isolated from respiratory secretions

Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions

The transcriptional response driven by Hypoxia-inducible factor (HIF) is central to the adaptation to oxygen restriction. Despite recent characterization of genome-wide HIF DNA binding locations and hypoxia-regulated transcripts in different cell types, the molecular bases of HIF target selection remain unresolved. Herein, we combined multi-level experimental data and computational predictions to identify sequence motifs that may contribute to HIF target selectivity. We obtained a core set of bona fide HIF binding regions by integrating multiple HIF1 DNA binding and hypoxia expression profiling datasets. This core set exhibits evolutionarily conserved binding regions and is enriched in functional responses to hypoxia. Computational prediction of enriched transcription factor binding sites identified sequence motifs corresponding to several stress-responsive transcription factors, such as activator protein 1 (AP1), cAMP response element-binding (CREB), or CCAAT-enhancer binding protein (CEBP). Experimental validations on HIF-regulated promoters suggest a functional role of the identified motifs in modulating HIF-mediated transcription. Accordingly, transcriptional targets of these factors are over-represented in a sorted list of hypoxia-regulated genes. Altogether, our results implicate cooperativity among stress-responsive transcription factors in fine-tuning the HIF transcriptional responseThis work was supported by Ministerio de Ciencia e Innovación (Spanish Ministry of Science and Innovation, MICINN) [grant number SAF2008-03147 to L. del P.], Comunidad Autónoma de Madrid [grant number S-SAL-0311_2006 to L. del P.] and the 7th Research Framework Programme of the European Union [grant number METOXIA project ref. HEALTH-F2-2009-222741] to L. del P. D.V. was a recipient of PhD funding from the Spanish Ministry of Science and Innovation [FPU programme] and the European Molecular Biology Organization [Short-Term Fellowships

Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1

When oxygen becomes limiting, cells reduce mitochondrial respiration and increase ATP production through anaerobic fermentation of glucose. The Hypoxia Inducible Factors (HIFs) play a key role in this metabolic shift by regulating the transcription of key enzymes of glucose metabolism. Here we show that oxygen regulates the expression of the muscle glycogen synthase (GYS1). Hypoxic GYS1 induction requires HIF activity and a Hypoxia Response Element within its promoter. GYS1 gene induction correlated with a significant increase in glycogen synthase activity and glycogen accumulation in cells exposed to hypoxia. Significantly, knockdown of either HIF1α or GYS1 attenuated hypoxia-induced glycogen accumulation, while GYS1 overexpression was sufficient to mimic this effect. Altogether, these results indicate that GYS1 regulation by HIF plays a central role in the hypoxic accumulation of glycogen. Importantly, we found that hypoxia also upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2) and 1,4-α glucan branching enzyme (GBE1), two enzymes involved in the biosynthesis of glycogen. Therefore, hypoxia regulates almost all the enzymes involved in glycogen metabolism in a coordinated fashion, leading to its accumulation. Finally, we demonstrated that abrogation of glycogen synthesis, by knock-down of GYS1 expression, impairs hypoxic preconditioning, suggesting a physiological role for the glycogen accumulated during chronic hypoxia. In summary, our results uncover a novel effect of hypoxia on glucose metabolism, further supporting the central importance of metabolic reprogramming in the cellular adaptation to hypoxia

El microsite bibliográfico como recurso didáctico de las Humanidades Digitales. Proyecto de innovación docente en Historia del Arte. "Revistas de vanguardia: humanidades digitales y recursos bibliográficos"

“El microsite bibliográfico como recurso didáctico de las Humanidades Digitales" (Ref. 079) es un Proyecto de innovación docente en Historia del Arte desarrollado en el marco de las clases prácticas de la asignatura "Arte de las vanguardias", con la participación de los grupos A1 y A2 de 3º del Grado en Historia del Arte, durante el curso 2021-2022. El propósito ha sido producir un microsite en el que se estudia un conjunto de 17 revistas de vanguardia conservadas en la red de bibliotecas de la UCM. Ahí reside el doble objetivo del proyecto: incentivar la práctica lectora por parte del/la estudiante y poner en valor la riqueza del patrimonio bibliográfico complutense. Por otra parte, se ha querido iniciar a las/los estudiantes en el análisis complejo y crítico de las revistas de arte, como agentes en la configuración de la modernidad y sus imaginarios, atendiendo también a marcos de trabajo e investigación como los Periodical Studies y las Humanidades Digitales, esto es más allá de la lectura parcial de las revistas como mero elemento secundario en la construcción de los relatos de la historia del arte. El proyecto de innovación docente, así como el trabajo desarollado por las/los estudiantes, ha constituido una experiencia formativa colaborativa, que se ha llevado a cabo en conjunto con la Biblioteca de la Facultad de Geografía e Historia, el Servicio de Edición Digital y Web de la UCM y el área de Proyectos Digitales y el Departamento de Colecciones del Museo Reina Sofía. Por su parte, el conjunto de estudiantes se ha dividido en grupos de trabajo de 2-4 personas. Cada grupo se ha ocupado de una revista, creando recursos originales, pero también estableciendo conexiones con otros ya existentes y que posibilitan al usuario profundizar en el conocimiento de la revista en cuestión

Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction

The transcriptional response driven by Hypoxia-inducible factor (HIF) is central to the adaptation to oxygen restriction. Hence, the complete identification of HIF targets is essential for understanding the cellular responses to hypoxia. Herein we describe a computational strategy based on the combination of phylogenetic footprinting and transcription profiling meta-analysis for the identification of HIF-target genes. Comparison of the resulting candidates with published HIF1a genome-wide chromatin immunoprecipitation indicates a high sensitivity (78%) and specificity (97.8%). To validate our strategy, we performed HIF1a chromatin immunoprecipitation on a set of putative targets. Our results confirm the robustness of the computational strategy in predicting HIF-binding sites and reveal several novel HIF targets, including RE1-silencing transcription factor co-repressor (RCOR2). In addition, mapping of described polymorphisms to the predicted HIF-binding sites identified several single-nucleotide polymorphisms (SNPs) that could alter HIF binding. As a proof of principle, we demonstrate that SNP rs17004038, mapping to a functional hypoxia response element in the macrophage migration inhibitory factor (MIF) locus, prevents induction of this gene by hypoxia. Altogether, our results show that the proposed strategy is a powerful tool for the identification of HIF direct targets that expands our knowledge of the cellular adaptation to hypoxia and provides cues on the inter-individual variation in this response