851 research outputs found
Desperately Seeking Chiral Fermions
Chiral fermions can (presumably) be constructed by introducing two
regulators, one for the gauge fields (e.g. a lattice), and another for the
fermion functional integrals in a fixed (regulated) gauge field. This talk
discusses cutoff effects arising from the regulator of the fermions.Comment: 4 pages, contribution to Lattice '95 Postscript at
http://www-theory.fnal.gov/people/ask/TeX/lat95/chiral.p
Continuum Gauge Fields from Lattice Gauge Fields
On the lattice some of the salient features of pure gauge theories and of
gauge theories with fermions in complex representations of the gauge group seem
to be lost. These features can be recovered by considering part of the theory
in the continuum. The prerequisite for that is the construction of continuum
gauge fields from lattice gauge fields. Such a construction, which is gauge
covariant and complies with geometrical constructions of the topological charge
on the lattice, is given in this paper. The procedure is explicitly carried out
in the theory in two dimensions, where it leads to simple results.Comment: 16 pages, HLRZ 92-3
Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed
BACKGROUND: Potent anthrax toxin neutralizing human monoclonal antibodies were generated from peripheral blood lymphocytes obtained from Anthrax Vaccine Adsorbed (AVA) immune donors. The anti-anthrax toxin human monoclonal antibodies were evaluated for neutralization of anthrax lethal toxin in vivo in the Fisher 344 rat bolus toxin challenge model. METHODS: Human peripheral blood lymphocytes from AVA immunized donors were engrafted into severe combined immunodeficient (SCID) mice. Vaccination with anthrax protective antigen and lethal factor produced a significant increase in antigen specific human IgG in the mouse serum. The antibody producing lymphocytes were immortalized by hybridoma formation. The genes encoding the protective antibodies were rescued and stable cell lines expressing full-length human immunoglobulin were established. The antibodies were characterized by; (1) surface plasmon resonance; (2) inhibition of toxin in an in vitro mouse macrophage cell line protection assay and (3) in vivo in a Fischer 344 bolus lethal toxin challenge model. RESULTS: The range of antibodies generated were diverse with evidence of extensive hyper mutation, and all were of very high affinity for PA83~1 Ă 10(-10-11)M. Moreover all the antibodies were potent inhibitors of anthrax lethal toxin in vitro. A single IV dose of AVP-21D9 or AVP-22G12 was found to confer full protection with as little as 0.5Ă (AVP-21D9) and 1Ă (AVP-22G12) molar equivalence relative to the anthrax toxin in the rat challenge prophylaxis model. CONCLUSION: Here we describe a powerful technology to capture the recall antibody response to AVA vaccination and provide detailed molecular characterization of the protective human monoclonal antibodies. AVP-21D9, AVP-22G12 and AVP-1C6 protect rats from anthrax lethal toxin at low dose. Aglycosylated versions of the most potent antibodies are also protective in vivo, suggesting that lethal toxin neutralization is not Fc effector mediated. The protective effect of AVP-21D9 persists for at least one week in rats. These potent fully human anti-PA toxin-neutralizing antibodies are attractive candidates for prophylaxis and/or treatment against Anthrax Class A bioterrorism toxins
Few-body decay and recombination in nuclear astrophysics
Three-body continuum problems are investigated for light nuclei of
astrophysical relevance. We focus on three-body decays of resonances or
recombination via resonances or the continuum background. The concepts of
widths, decay mechanisms and dynamic evolution are discussed. We also discuss
results for the triple decay in connection with resonances and
density and temperature dependence rates of recombination into light nuclei
from -particles and neutrons.Comment: 9 pages, 8 figures. Proceedings of the 21st European Few Body
Conference held in Salamanca (Spain) in August-September 201
OperA/ALIVE/OperettA
Comprehensive models for organizations must, on the one hand, be able to specify global goals and requirements but, on the other hand, cannot assume that particular actors will always act according to the needs and expectations of the system design. Concepts as organizational rules (Zambonelli 2002), norms and institutions (Dignum and Dignum 2001; Esteva et al. 2002), and social structures (Parunak and Odell 2002) arise from the idea that the effective engineering of organizations needs high-level, actor-independent concepts and abstractions that explicitly define the organization in which agents live (Zambonelli 2002).Peer ReviewedPostprint (author's final draft
Aharonov-Casher effect for spin one particles in a noncommutative space
In this work the Aharonov-Casher (AC) phase is calculated for spin one
particles in a noncommutative space. The AC phase has previously been
calculated from the Dirac equation in a noncommutative space using a gauge-like
technique [17]. In the spin-one, we use kemmer equation to calculate the phase
in a similar manner. It is shown that the holonomy receives non-trivial
kinematical corrections. By comparing the new result with the already known
spin 1/2 case, one may conjecture a generalized formula for the corrections to
holonomy for higher spins.Comment: 9 page
Prevalence of iron deficiency anaemia and risk factors in 1,010 adolescent girls from rural Maharashtra, India: a cross-sectional survey
Objective: Iron deficiency anaemia (IDA) is the most common nutritional disorder observed in adolescent girls in India. Our aim was to investigate the prevalence and risk factors associated with IDA in rural Maharashtra, India to address current evidence gaps.
Study Design: Cross sectional survey
Methods: The study recruited 13 to 17 year old adolescent girls living in 34 villages of Osmanabad district. Data were collected on individual health, dietary, sociodemographic factors, and anthropometric measurements were taken. Haemoglobin (Hb) levels were measured using Sahliâs hemometer. Logistic and linear regressions were used to identify risk factors associated with IDA and Hb level respectively.
Results: Among 1,010 adolescent girls (response rate 97.5%), the mean Hb was 10.1 g/dl (standard deviation=1.3), and 87% had anaemia (Hb<12 g/dl). The prevalence of mild (11.0-11.9 g/dl), moderate (8.0-10.9 g/dl) and severe (Hb†7.9 g/dl) anaemia was 17%, 65% and 5% respectively. Anaemia likelihood increased significantly with age (odds ratio (OR): 1.41 per year, 95% confidence interval (CI): 1.17 to 1.70). Factors associated with decreased anaemia risk were mid upper arm circumference (MUAC) â„22 cm (OR: 0.51, 95% CI: 0.31 to 0.82), â„3 days/week consumption of fruit (OR: 0.35, 95% CI: 0.23 to 0.54) or rice (OR: 0.39, 95% CI: 0.17 to 0.91), and incomplete schooling (OR: 0.47, 95% CI: 0.24 to 0.91). In the final model lower age, MUAC and fruit consumption were significantly associated with Hb level.
Conclusion: Anaemia prevalence was extremely high among adolescent girls in rural areas of Maharashtra. Whilst we identified risk factors that could be used for targeting interventions, there is urgent need of comprehensive preventative interventions for the whole adolescent girl population
Molecular analysis of the distribution and phylogeny of the soxB gene among sulfur-oxidizing bacteria - evolution of the Sox sulfur-oxidizing enzyme system
The soxB gene encodes the SoxB component of the periplasmic thiosulfate-oxidizing Sox enzyme complex, which has been proposed to be widespread among the various phylogenetic groups of sulfur-oxidizing bacteria (SOB) that convert thiosulfate to sulfate with and without the formation of sulfur globules as intermediate. Indeed, the comprehensive genetic and genomic analyses presented in the present study identified the soxB gene in 121 phylogenetically and physiologically divergent SOB, including several species for which thiosulfate utilization has not been reported yet. In first support of the previously postulated general involvement of components of the Sox enzyme complex in the thiosulfate oxidation process of sulfur-storing SOB, the soxB gene was detected in all investigated photo- and chemotrophic species that form sulfur globules during thiosulfate oxidation (Chromatiaceae, Chlorobiaceae, Ectothiorhodospiraceae, Thiothrix, Beggiatoa, Thiobacillus, invertebrate symbionts and free-living relatives). The SoxB phylogeny reflected the major 16S rRNA gene-based phylogenetic lineages of the investigated SOB, although topological discrepancies indicated several events of lateral soxB gene transfer among the SOB, e.g. its independent acquisition by the anaerobic anoxygenic phototrophic lineages from different chemotrophic donor lineages. A putative scenario for the proteobacterial origin and evolution of the Sox enzyme system in SOB is presented considering the phylogenetic, genomic (sox gene cluster composition) and geochemical data
The anomaly line bundle of the self-dual field theory
In this work, we determine explicitly the anomaly line bundle of the abelian
self-dual field theory over the space of metrics modulo diffeomorphisms,
including its torsion part. Inspired by the work of Belov and Moore, we propose
a non-covariant action principle for a pair of Euclidean self-dual fields on a
generic oriented Riemannian manifold. The corresponding path integral allows to
study the global properties of the partition function over the space of metrics
modulo diffeomorphisms. We show that the anomaly bundle for a pair of self-dual
fields differs from the determinant bundle of the Dirac operator coupled to
chiral spinors by a flat bundle that is not trivial if the underlying manifold
has middle-degree cohomology, and whose holonomies are determined explicitly.
We briefly sketch the relevance of this result for the computation of the
global gravitational anomaly of the self-dual field theory, that will appear in
another paper.Comment: 41 pages. v2: A few typos corrected. Version accepted for publication
in CM
Supersymmetry in noncommutative superspaces
Non commutative superspaces can be introduced as the Moyal-Weyl quantization
of a Poisson bracket for classical superfields. Different deformations are
studied corresponding to constant background fields in string theory.
Supersymmetric and non supersymmetric deformations can be defined, depending on
the differential operators used to define the Poisson bracket. Some examples of
deformed, 4 dimensional lagrangians are given. For extended superspace (N>1),
some new deformations can be defined, with no analogue in the N=1 case.Comment: 23 pages, AMS-LaTeX. Misprints corrected, references adde
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