Industry dynamics, technological regimes and the role of demand

In this paper, we propose an industrial dynamics model to analyze the interactions between the price-performance sensitivity of demand, the sources of innovation in a sector, and certain features of the corresponding pattern of industrial transformation. More precisely, we study market concentration in different technological regimes and demand conditions. The computational analysis of our model shows that market demand plays a key role in industrial dynamics. Thus, although for intermediate values of the price-performance sensitivity, our results show the well-known relationships in the literature between technological regimes and industry transformation, we find surprising outcomes when demand is strongly biased either towards price or performance. Hence, for different technological regimes, a high performance sensitivity of demand tends to concentrate the market. On the other hand, under conditions of high price sensitivity, the industry generally tends to atomize. That is to say, for extreme values of the price-performance sensitivity of demand, we find concentrated or atomized market structures no matter the technological regime we are in. These results highlight the importance of considering the role of demand in the analysis of industrial dynamics

Genomic adaptations to aquatic and aerial life in mayflies and the origin of insect wings

The evolution of winged insects revolutionized terrestrial ecosystems and led to the largest animal radiation on Earth. However, we still have an incomplete picture of the genomic changes that underlay this diversification. Mayflies, as one of the sister groups of all other winged insects, are key to understanding this radiation. Here, we describe the genome of the mayfly Cloeon dipterum and its gene expression throughout its aquatic and aerial life cycle and specific organs. We discover an expansion of odorant-binding-protein genes, some expressed specifically in breathing gills of aquatic nymphs, suggesting a novel sensory role for this organ. In contrast, flying adults use an enlarged opsin set in a sexually dimorphic manner, with some expressed only in males. Finally, we identify a set of wing-associated genes deeply conserved in the pterygote insects and find transcriptomic similarities between gills and wings, suggesting a common genetic program. Globally, this comprehensive genomic and transcriptomic study uncovers the genetic basis of key evolutionary adaptations in mayflies and winged insects

Radioterapia intraoperatoria en cáncer de mama precoz: análisis observacional frente a radioterapia externa

Introducción Una única dosis de radioterapia intraoperatoria (IORT) en cáncer de mama precoz (EBC) puede ser una opción frente a la radioterapia externa estándar (WBRT). Sin embargo, no existe consenso sobre su uso y resultados. Objetivo Analizar la morbilidad y resultados oncológicos de la IORT como monoterapia en el tratamiento del EBC. Métodos Se realiza un estudio analítico observacional unicéntrico, comparando una cohorte prospectiva IORT (2015-17) con una cohorte retrospectiva WBRT (2012-17). Los criterios de selección aplicados son: = 45 años de edad, carcinoma ductal infiltrante o variantes, tamaño tumoral radiológico = 3 cm, receptores estrogénicos positivos, HER2 negativo, cN0; criterios de exclusión: invasión linfovascular, multicentricidad/multifocalidad, mutaciones BRCA y tratamiento neoadyuvante. Se valoran características clínicas, tumorales, quirúrgicas, oncológicas y complicaciones. Resultados Se estudiaron 425 casos: 217 tratados con IORT y 208 con WBRT. La edad media en IORT y WBRT fue 67 ± 9, 5 y 64, 8 ± 9, 9 años, respectivamente (p = 0, 01). El riesgo ASA 3 en IORT fue 17, 7%, frente a 24 casos de WBRT (p = 0, 027). No hubo diferencias en resultados anatomopatológicos o estadificación. El seguimiento medio de IORT fue 24, 4 ± 8 meses, frente a 50, 5 ± 18 meses de WBRT (p < 0, 001). No se hallaron diferencias significativas en recidiva local, metástasis o mortalidad. Las complicaciones que precisaron reintervención u hospitalización resultaron equiparables. La radiodermitis precoz grave se presentó en tres casos IORT frente a 14 casos WBRT (p = 0, 01). Conclusiones La IORT como monoterapia en pacientes seleccionadas con EBC representa una opción alternativa frente a WBRT, especialmente en aquellas con edad avanzada y comorbilidades. Se asocia, además, con menos radiodermitis precoz grave. Introduction: In early breast cancer (EBC), a single dose of intraoperative radiotherapy (IORT) might be an option to standard whole breast radiotherapy (WBRT). However, there is no consensus about its use and clinical results. Aim: to analyse the morbidity and oncological outcomes of IORT as monotherapy in EBC. Methods: A single centre observational analytic study was performed. A prospective IORT cohort (2015-17) and a retrospective WBRT cohort (2012-17) were selected following the same criteria: = 45 y.o., invasive ductal carcinoma or variants, radiological tumour size = 3 cm, positive oestrogenic receptors, negative HER2, cN0; exclusion criteria: lymphovascular invasion, multicentricity/multifocality, BRCA mutation and neoadjuvant therapy. Clinical, histological, surgical, oncological characteristics and complications were collected. Results: A total of 425 cases were selected: 217 in IORT cohort and 208 in WBRT cohort. Average age in IORT and WBRT groups was 67±9.5 and 64.8 ± 9.9 y.o. respectively (p = 0.01). ASA 3 risk score patients were 17.7% in IORT and 24 cases in WBRT (p = 0.027). There were no differences in histological results or tumoral stage. Average follow up was 24.4 ± 8 months in IORT and 50.5 ± 18 months in WBRT (p < 0.001). No differences were detected in local recurrence, metastases or mortality. Complications that required reintervention or hospitalization were similar in both groups. A total of 3 and 14 cases developed early severe dermatitis in IORT and WBRT groups respectively (p = 0.01). Conclusion: IORT as monotherapy in selected patients with EBC stands for an alternative option versus WBRT. It seems especially useful in advanced-age patients with severe comorbidities. IORT associates lesser early severe dermatitis

Utopia competition: A new approach to the micro-foundations of sustainability transitions

We present a new evolutionary political economy approach to the study of transition dynamics based on a co-evolutionary model of differential citizen contributions to competing &#039;utopias&#039;-market fundamentalism, socialism, and environmentalism. We model sustainability transitions as an outcome of &#039;utopia competition&#039; in which environmentalism manages to coexist with the market, while socialism vanishes. Our simulation-based framework suggests that the individual economic contributions of citizens to the battle of ideas-both the distribution within a utopia, and the interaction between different utopias-are crucial but much overlooked micro-factors in explaining the dynamics of sustainability transitions

Absorptive capacity of demand in sports innovation

We propose a stylized and tractable Neo-Schumpeterian model of sectorial transformations in which demand side knowledge constraints inhibit innovation diffusion and industrial change, causing structural instability. Evolutionary competition in the model implies that innovation can overshoot the absorptive capacity of demand, leading to a slowdown in sectorial dynamism and even to structural collapse. Closed-form analytical results prove the existence of a unique stationary state in the dynamic model that is (globally) asymptotically stable. We show how the dynamic paths and the stationary rest-point depend on the trade-off between innovation and demand absorptive capacity parameters. To illustrate the plausibility and relevance of our results, we examine the Australian windsurfing industry in which diminished demand absorptive capacity (in the terms of the model) was a factor underlying sectoral collapse. We discuss how development of absorptive capacity of demand presents a collective action problem for an industry sector, and the role of demand side factors as constraints in industry and innovation policy

A robust (re-)annotation approach to generate unbiased mapping references for RNA-seq-based analyses of differential expression across closely related species

Correlation plots for DESeq2 using direct counts. Relation between length differences and the log2-fold change. Comparisons between D. mauritiana and D. melanogaster are shown on the left side, comparisons between D. mauritiana and D. simulans are shown on the right side. On the first row, the published annotations are used as mapping references; on the second row, the directly re-annotated references are used as mapping references and on the third row, the reciprocally re-annotated references are used. Dots represent genes with length difference > 49 bp in these annotations. Genes significantly differentially expressed in the presented analysis (padj < 0.05) are shown in red. A negative log2-fold change indicates higher expression in D. mauritiana. A positive length difference indicates that the ortholog of D. mauritiana is longer. The p-value and rho of the Spearman’s rank correlation are indicated on the upper right side of the plots. (PDF 3164 kb

The economics of utopia: a co-evolutionary model of ideas, citizenship and socio-political change

We propose a new history-friendly approach to evolutionary socio-economic dynamics based around competition between five &#039;utopias&#039; as central ideas about which to order society: capitalism, socialism, civil liberty, nature, and nationalism. In our model, citizens contribute economic resources to support their preferred utopia, and societal dynamics are explained as a co-evolutionary process between these competing utopias. We apply the model to analyze certain aspects of socio-economic and political change in the US from the 1960s-present. We carry out a history-friendly analysis inspired by such episodes as the outbreak of civil movements in the 1970s, the rise of neo-liberalism in the 1980s, and the channels through which America has engendered an &#039;age of fracture&#039;. Further applications for empirical and theoretical research are suggested