Doença poliquística renal autossómica dominante : clínica, genética e epidemiologia

Tese de doutoramento, Medicina (Nefrologia), Universidade de Lisboa, Faculdade de Medicina, 2009Resumos em inglês e em português disponíveis no document

Jan Dejnozka, “The Concept of Relevance and the Logic Diagram Tradition”, Create Space Independent Publishing Platform, 2012

Jan Dejnozka, The Concept of Relevance and the Logic Diagram Tradition, Create Space Independent Publishing Platform, 2012, 170 pp., ISBN-10 1475071094, ISBN-13 978-1475071092

Trace Elements as Contaminants and Nutrients

Knowledge about trace elements has evolved remarkably in recent decades, both in terms of their metabolism and their functions. Acting mainly as cofactors of enzymatic systems, several trace elements play an essential role in numerous physiological processes in the human organism, from cell metabolism to the immune response and gene expression, among others. On the other hand, it is also well known that excessive exposure to trace elements can be highly harmful and even fatal.info:eu-repo/semantics/publishedVersio

Trace elements in ambient air at Porto metropolitan area: checking for compliance with new European Union (EU) air quality standards

Because of the scientific evidence showing that arsenic (As), cadmium (Cd), and nickel (Ni) are human genotoxic carcinogens, the European Union (EU) recently set target values for metal concentration in ambient air (As: 6 ng/m3, Cd: 5 ng/m3, Ni: 20 ng/m3). The aim of our study was to determine the concentration levels of these trace elements in Porto Metropolitan Area (PMA) in order to assess whether compliance was occurring with these new EU air quality standards. Fine (PM2.5) and inhalable (PM10) air particles were collected from October 2011 to July 2012 at two different (urban and suburban) locations in PMA. Samples were analyzed for trace elements content by inductively coupled plasma–mass spectrometry (ICP-MS). The study focused on determination of differences in trace elements concentration between the two sites, and between PM2.5 and PM10, in order to gather information regarding emission sources. Except for chromium (Cr), the concentration of all trace elements was higher at the urban site. However, results for As, Cd, Ni, and lead (Pb) were well below the EU limit/target values (As: 1.49 ± 0.71 ng/m3; Cd: 1.67 ± 0.92 ng/m3; Ni: 3.43 ± 3.23 ng/m3; Pb: 17.1 ± 10.1 ng/m3) in the worst-case scenario. Arsenic, Cd, Ni, Pb, antimony (Sb), selenium (Se), vanadium (V), and zinc (Zn) were predominantly associated to PM2.5, indicating that anthropogenic sources such as industry and road traffic are the main source of these elements. High enrichment factors (EF > 100) were obtained for As, Cd, Pb, Sb, Se, and Zn, further confirming their anthropogenic origin

Measuring Mental Health Literacy of Teacher: A Pilot Study

Almeida A, Pinheiro P, Okan O, Pereira A, Mesquita E. Measuring Mental Health Literacy of Teacher: A Pilot Study. International Journal of Case Studies. 2017;5(12):35-40

Trace elements in medicinal plants traditionally used in the treatment of diabetes—do they have a role in the claimed therapeutic effect?

Medicinal plants are often used in the treatment of diabetes mellitus, although knowledge about their mode of action and the substances responsible for their antidiabetic potential is limited. It is well known that some trace elements play a role in glucose metabolism and insulin action. Thus, a particular trace elements profile could be associated with the antidiabetic properties observed for some medicinal plants. Methods: Infusions (n = 102) prepared from commercial herbal products (n = 34) containing medicinal plants indicated for the treatment of diabetes (n = 16 different plant species) and infusions (n = 60) prepared from commercial herbal products (n = 20) containing medicinal plants without such an indication (n = 7 different plant species) were analyzed by ICP-MS for their trace elements content. In both groups, results varied significantly between different medicinal plants and also between different origins (brands) of the same medicinal plant. Significant differences (p < 0.05) between the two groups were found for nine elements, including four trace elements related to glucose metabolism (Mn, B, V, and Se), but with lower median contents in the group of medicinal plants for diabetes. Except for some particular species (e.g., Myrtilli folium) in which the trace element Mn may play a role in its antidiabetic effect, globally, a direct association between the claimed antidiabetic properties and a specific trace element profile of the studied medicinal plants was not evident.info:eu-repo/semantics/publishedVersio

Metals transfer from tobacco to cigarette smoke: Evidences in smokers’ lung tissue

Tobacco use kills millions of people every year around the world. The current level of 11 metals in tobacco was determined and their transfer rate to cigarette smoke was calculated as the difference between the total metal content in cigarettes and the amount present in its ashes. The metals content was also determined in the lung tissue of smokers and non-smokers in order to evaluate the marks that smoking leaves in this tissue. Metals content in tobacco ranged from less than 1μg/g (Co, Cd, Pb, As and Tl) to several hundreds of μg/g (Al, Mn and Ba). The highest transfer rate from tobacco to cigarette smoke was found for Tl (85-92%) and Cd (81-90%), followed by Pb (46-60%) and As (33-44%). Significantly higher levels of As, Cd and Pb were found in the lung tissue of smokers compared to non-smokers, showing that smoking results in an increase of these metals in the lungs and that they contribute to the carcinogenic potential of cigarette smoke. This study presents important data on current metals content in tobacco and its transference to cigarette smoke and provides evidence of their accumulation in smokers' lung tissue.info:eu-repo/semantics/publishedVersio

Expressão interartística na performance pianística

Mestrado em Ensino de músicaO presente trabalho descreve a implementação de uma série de workshops para alunos de piano do Curso Básico. Nas diferentes sessões de experimentação criativa, os alunos foram convidados a participar em jogos dramáticos e a articular diversas formas de expressão artística, tais como o movimento e a expressão dramática. A aplicação das competências adquiridas à performance ao piano possibilitou o desenvolvimento de ferramentas criativas para o estudo e a análise do repertório pianístico, bem como para a improvisação.The present work describes the implementation of a series of workshops for piano students of beginner levels. In the different sessions of creative experimentation, the students were invited to take part in drama games and to articulate various forms of artistic expression, such as movement and creative drama. The application of the acquired skills to piano performance enabled the development of creative tools for study and analysis of the piano repertoire and also for improvisation

intervenções especializadas de enfermagem

O presente Relatório de Estágio, inserido no Curso de Mestrado de Enfermagem em Pessoa em Situação Crítica, visa descrever as aprendizagens e as competências adquiridas e desenvolvidas durante o período de estágio em Unidade de Cuidados Intensivos e Serviço de Urgência no âmbito da prestação de cuidados à pessoa em situação crítica e família. Pretende, ainda, enfatizar o trajeto percorrido com recurso a uma análise construtiva e a uma reflexão crítica das referidas competências alcançadas, tendo por base os conceitos fundamentais do modelo de aquisição de competências de Benner (2001) e o seu referencial teórico pelo qual se regeu o exercício clínico. O recente avanço tecnológico veio criar novos desafios e horizontes e cabe aos enfermeiros articularem-se com os novos recursos, incorporando-os em abordagens humanas com vista à melhoria da qualidade dos cuidados de enfermagem e obtenção de ganhos em saúde. A “Abordagem e Monitorização da Via Aérea na Pessoa em Situação Crítica submetida a Ventilação Mecânica Invasiva” surge como uma temática de predileção e lança um estímulo sobre os enfermeiros, pelo que foi intencional explorar a atual evidência científica e desenvolver uma aprendizagem que conduzisse a novos conhecimentos e competências tendo como desígnio a manutenção e recuperação das funções vitais da pessoa em situação crítica. A monitorização e melhoria da qualidade dos cuidados de enfermagem com vista à segurança do doente requer que o enfermeiro possua premeditação clínica, a identificação precoce de situações potencialmente perigosas e desenvolva o conhecimento clínico. Assim, com base nestas premissas, a monitorização da pessoa em situação crítica submetida a ventilação mecânica invasiva assenta em enfermeiros experientes, possuidores de um vasto conhecimento, capazes de reconhecer e intervir oportunamente em situações críticas e em implementar ações para prevenir a sua recorrência (Benner, Kyriakidis, & Stannard, 2011).This Internship Report, integrated on Master's Degree in Nursing of Patients in Critical Condition, aims to describe the learning process and skills acquired and developed during the internship of Intensive Care Unit and Emergency department, provisioning care to the patients in critical conditions and their families. Additionally, emphasizing the rout that was taken with the objective of creating a constructive analysis and critical observations within the acquired competences, having as a baseline the concepts and fundamentals from Benner’s (2001) model of skill acquisition and her theoretical referential to which she grounded his professional endeavours. Technological advances have created new challenges and expanded our horizons, it is the nurse’s duty to express himself/herself with those new resources, incorporating them into their human approach, improving their quality in nurse care and obtaining gains in health in regards to their patients. The “Approach and Monitoring Airway in Person in Critical Situation subjected to Invasive Mechanical Ventilation” shows itself as a predilectic theme, engaging the stimuli of nurses, intentionally occurring as scientifically evidence to explore and to further develop skills, serving as a guide to new wisdoms and competences, being the main objective to maintain and recover vital functions from a person in critical condition. Monitoring and enhancing the quality of nursing care requires clinical premonition from the nurse. Knowing how to identify potential dangerous situations precociously and having clinical knowledge is a precious skill. Having that as a premise, monitoring a person in critical condition, subjected to invasive mechanical ventilation, requires experienced nurses, with vast knowledge, able to recognize and intervene in critical situations while trying to prevent any recurrence (Benner Kyriakidis, & Stannard, 2011)