A full reconstruction of two galaxy clusters intra-cluster medium with strong gravitational lensing

Whilst X-rays and Sunyaev–Zel’dovich observations allow to study the properties of the intra-cluster medium (ICM) of galaxy clusters, their gravitational potential may be constrained using strong gravitational lensing. Although being physically related, these two components are often described with different physical models. Here, we present a unified technique to derive the ICM properties from strong lensing for clusters in hydrostatic equilibrium. In order to derive this model, we present a new universal and self-similar polytropic temperature profile, which we fit using the X-COP sample of clusters. We subsequently derive an analytical model for the electron density, which we apply to strong lensing clusters MACS J0242.5-2132 and MACS J0949.8+1708. We confront the inferred ICM reconstructions to XMM-Newton and ACT observations. We contrast our analytical electron density reconstructions with the best canonical β-model. The ICM reconstructions obtained prove to be compatible with observations. However they appear to be very sensitive to various dark matter halo parameters constrained through strong lensing (such as the core radius), and to the halo scale radius (fixed in the lensing optimizations). With respect to the important baryonic effects, we make the sensitivity on the scale radius of the reconstruction an asset, and use the inferred potential to constrain the dark matter density profile using ICM observations. The technique here developed should allow to take a new, and more holistic path to constrain the content of galaxy clusters

Joint HST, VLT/MUSE and XMM-Newton observations to constrain the mass distribution of the two strong lensing galaxy clusters: MACS J0242.5-2132 & MACS J0949.8+1708

We present the strong lensing analysis of two galaxy clusters: MACS J0242.5-2132 (MACS J0242, $z=0.313$) and MACS J0949.8+1708 (MACS J0949, $z=0.383$). Their total matter distributions are constrained thanks to the powerful combination of observations with the Hubble Space Telescope and the MUSE instrument. Using these observations, we precisely measure the redshift of six multiple image systems in MACS J0242, and two in MACS J0949. We also include four multiple image systems in the latter cluster identified in HST imaging without MUSE redshift measurements. For each cluster, our best-fit mass model consists of a single cluster-scale halo, and 57 (170) galaxy-scale halos for MACS J0242 (MACS J0949). Multiple images positions are predicted with a $rms$ 0.39 arcsec and 0.15 arcsec for MACS J0242 and MACS J0949 models respectively. From these mass models, we derive aperture masses of $M(R<$200 kpc$) = 1.67_{-0.05}^{+0.03}\times 10^{14} M_{\odot}$, and $M(R<$200 kpc$) = 2.00_{-0.20}^{+0.05}\times 10^{14} M_{\odot}$. Combining our analysis with X-ray observations from the XMM-Newton Observatory, we show that MACS J0242 appears to be a relatively relaxed cluster, while conversely, MACS J0949 shows a relaxing post-merger state. At 200 kpc, X-ray observations suggest the hot gas fraction to be respectively $f_g = 0.115^{+0.003}_{-0.004}$ and $0.053^{+0.007}_{-0.006}$ for MACS J0242 and MACS J0949. MACS J0242 being relaxed, its density profile is very well fitted by a NFW distribution, in agreement with X-ray observations. Finally, the strong lensing analysis of MACS J0949 suggests a flat dark matter density distribution in the core, between 10 and 100 kpc. This appears consistent with X-ray observations.Comment: 20 pages, 11 figures, published in MNRA

A full reconstruction of two galaxy clusters intra-cluster medium with strong gravitational lensing

Whilst X-rays and Sunyaev-Zel'dovich observations allow to study the properties of the intra-cluster medium (ICM) of galaxy clusters, their gravitational potential may be constrained using strong gravitational lensing. Although being physically related, these two components are often described with different physical models. Here, we present a unified technique to derive the ICM properties from strong lensing for clusters in hydrostatic equilibrium. In order to derive this model, we present a new universal and self-similar polytropic temperature profile, which we fit using the X-COP sample of clusters. We subsequently derive an analytical model for the electron density, which we apply to strong lensing clusters MACS J0242.5-2132 and MACS J0949.8+1708. We confront the inferred ICM reconstructions to XMM-Newton and ACT observations. We contrast our analytical electron density reconstructions with the best canonical $\beta$-model. The ICM reconstructions obtained prove to be compatible with observations. However they appear to be very sensitive to various dark matter halo parameters constrained through strong lensing (such as the core radius), and to the halo scale radius (fixed in the lensing optimisations). With respect to the important baryonic effects, we make the sensitivity on the scale radius of the reconstruction an asset, and use the inferred potential to constrain the dark matter density profile using ICM observations. The technique here developed should allow to take a new, and more holistic path to constrain the content of galaxy clusters.Comment: 26 pages, 21 figures, submitted to MNRA

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation

Genetic and developmental disorders of the oral mucosa : epidemiology; molecular mechanisms; diagnostic criteria; management

A large number of disorders may affect the oral cavity, including genetic diseases, infections, cancers, blood diseases, skin diseases, endocrine and metabolic disorders, autoimmune and rheumatologic diseases, local lesions, to name a few. Oral mucosa shows a considerable variation in its normal structure and a wide range of conditions may affect it. Such conditions are often harmless or minor and could be primary or secondary to systemic disease. Several of them are quite rare and, hence, the diagnosis is not easy. Clinically, lesions may appear as ulcers, discoloration of the oral mucosa and alterations in size and configuration of oral anatomy. Genetic disorders have specific manifestations and can be caused by a derangement of one or more components of the tissue. Many of them follow the skin or systemic signs of the underlying genetic disease, but in a few cases oral signs could be the first manifestation of the disorder. Among them genodermatoses are prominent. They are inherited disorders characterized by a multisystem involvement. This review describes chondro-ectodermal dysplasia, dyskeratosis congenita, Ehlers-Danlos syndrome, hereditary benign intraepithelial dyskeratosis, keratosis follicularis, lipoid proteinosis, multiple hamartoma syndrome, pachyonychia congenita, Peutz-Jeghers syndrome, tuberous sclerosis and white sponge nevus. Other genetic disorders not included in the genodermatosis group and reported in the present review are: acanthosis nigricans, angio-osteo-hypertrophic syndrome, encephalotrigeminal angiomatosis, familial adenomatous polyposis, focal dermal hypoplasia, focal palmoplantar and oral mucosa hyperkeratosis syndrome, gingival fibromatosis, Maffucci's syndrome, neurofibromatosis (type 1) and oro-facial-digital syndrome (type 1). Disorders during embryonic development might lead to a wide range of abnormalities in the oral cavity; some of them are quite common but of negligible concern, whereas others are rare but serious, affecting not only the oral mucosa, but also other structures of the oral cavity (ie palate, tongue and gingiva). Fordyce's granules, leukoedema, cysts of the oral mucosa in newborns, retrocuspid papilla, geographic tongue, fissured tongue, median rhomboid glossitis, hairy tongue, lingual varices and lingual thyroid nodule are described. This review may help dentists, dental hygienists, but also general internists and pediatricians to diagnose different disorders of the oral mucosa, to understand the pathogenesis and to schedule a treatment plan