33 research outputs found
Modeling Regulatory Networks to Understand Plant Development: Small Is Beautiful
- Publication venue
- 'American Society of Plant Biologists (ASPB)'
- Publication date
- Field of study
Sequential induction of auxin efflux and influx carriers regulates lateral root emergence
- Author
- Alistair M Middleton
- Andrew P French
- Anthony Bishopp
- Antoine Larrieu
- Benjamin Péret
- Darren M Wells
- Eric Kramer
- Eva Benkova
- Göran Sandberg
- Ilda Casimiro
- Ilkka Sairanen
- Ive De Smet
- Jiří Friml
- John R King
- Jürgen Kleine‐Vehn
- Karin Ljung
- Leah R Band
- Malamy JE
- Malcolm J Bennett
- Maria Njo
- Markus Owen
- Nathan Mellor
- Romain Mallet
- Silvana Porco
- Steffen Vanneste
- Tom Beeckman
- Tony Pridmore
- Publication venue
- Publication date
- 01/01/2013
- Field of study
Peer reviewe
Functional Morphometric Analysis of the Furcula in Mesozoic Birds
- Author
- A Grafen
- A Suh
- AH Turner
- AK Bell
- Alistair Robert Evans
- B Bruderer
- BC Livezey
- BW Tobalske
- BW Tobalske
- C Hui
- C Hui
- C Pennycuick
- C Pennycuick
- CJ Pennycuick
- D Hu
- D Lentink
- D Naish
- DA Burnham
- E Abouheif
- E Buffetaut
- E Buffetaut
- E Paradis
- ELR Simons
- ELR Simons
- Emily J. Rayfield
- F Rohlf
- F Zhang
- F Zhang
- F Zhang
- F Zhang
- FA Jenkins
- FK Barker
- G Mayr
- G Viscor
- GEJ Goslow
- GJ Dyke
- GJ Dyke
- GJ Dyke
- H Schmaljohann
- HL You
- HRL Lerner
- J Diniz-Filho
- J Felsenstein
- J Rayner
- JB Dunning
- JH Ostrom
- JH Ostrom
- JJ Baumel
- JK O'Connor
- JK O'Connor
- JK O'Connor
- JL Sanz
- JL Sanz
- JL Sanz
- JMV Rayner
- JMV Rayner
- JN Choiniere
- JP Bailey
- K Hornik
- KM Middleton
- L Harmon
- L Schmitz
- LJ Harmon
- LJ Revell
- LJ Revell
- LM Chiappe
- LM Chiappe
- LM Chiappe
- M Pagel
- M Ruta
- MB Habib
- MD Pagel
- ML Zelditch
- MSY Lee
- N MacLeod
- P Senter
- R Motani
- RL Nudds
- RL Nudds
- Roger A. Close
- S Hinic-Frlog
- S Hinic-Frlog
- S Kembel
- SB Hedges
- SJ Hackett
- SJ Nesbitt
- SL Brusatte
- SL Olson
- SM Gatesy
- SP Blomberg
- T Jombart
- T Jombart
- WP Maddison
- X Wang
- X Xu
- Z Zhou
- Z Zhou
- Z Zhou
- Z Zhou
- Z Zhou
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
The furcula displays enormous morphological and structural diversity. Acting as an important origin for flight muscles involved in the downstroke, the form of this element has been shown to vary with flight mode. This study seeks to clarify the strength of this form-function relationship through the use of eigenshape morphometric analysis coupled with recently developed phylogenetic comparative methods (PCMs), including phylogenetic Flexible Discriminant Analysis (pFDA). Additionally, the morphospace derived from the furculae of extant birds is used to shed light on possible flight adaptations of Mesozoic fossil taxa. While broad conclusions of earlier work are supported (U-shaped furculae are associated with soaring, strong anteroposterior curvature with wing-propelled diving), correlations between form and function do not appear to be so clear-cut, likely due to the significantly larger dataset and wider spectrum of flight modes sampled here. Interclavicular angle is an even more powerful discriminator of flight mode than curvature, and is positively correlated with body size. With the exception of the close relatives of modern birds, the ornithuromorphs, Mesozoic taxa tend to occupy unique regions of morphospace, and thus may have either evolved unfamiliar flight styles or have arrived at similar styles through divergent musculoskeletal configurations
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
- Author
- Abrams Simon
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A
- Ail Dhiraj
- Aldera Erin L
- Alegria Ana
- Alex Beatrice
- Angus Brian
- Armstrong Jane A
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G
- Atkinson Dougal
- Bach Benjamin
- Baillie J Kenneth
- Baillie J Kenneth
- Bakshi Siddharth
- Barclay Wendy S
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin W A
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J
- Clark Tom
- Clarke Emily A
- Clohisey Sara
- Cole Sarah
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S
- Cooper Louise
- Cosgrove Catherine
- Cox Helen
- Cupitt Jason
- Cutino-moguel Maria-teresa
- Dalton Jo
- Dark Paul
- Davis Christopher
- Dawson Chris
- De Silva Thushan
- De Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Doce Carracedo Alejandra
- Docherty Annemarie B
- Docherty Annemarie B
- Donnison Phil
- Donohue Chloe
- Douthwaite Sam
- Drake Thomas M
- Drake Thomas M
- Dunn Chris
- Dunning Jake
- Durand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Eunice Zhang J
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J
- Fairfield Cameron J
- Fegan Christopher
- Filipe Ana Da Silva
- Finch Lorna
- Finn Adam
- Fisher Lewis W S
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garg Sanjeev
- Girvan Michelle
- Gkrania-klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Green Christopher A
- Greenhalf William
- Greenhalf William
- Griffiths Fiona
- Gunning Philip
- Gupta Rishi K
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E
- Hardy Elaine
- Harrison Ewen M
- Harrison Ewen M
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B
- Hendry Ross
- Hiscox Julian A
- Ho Antonia
- Ho Antonia Ying Wai
- Hobrok Maria
- Hodgson Luke
- Holmes Anthony
- Horby Peter W
- Hormis Anil
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L
- Jones Christopher B
- Jones Trevor R
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kiy Robyn T
- Klenerman Paul
- Knight Stephen R
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-langham Lara
- Law Andrew
- Law Andrew
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A
- Lyons Ruth
- Lyttle Mark
- Maclean Alan
- Macmahon Michael
- Macnaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Matthew Ridley P
- Maziere Nicole
- Mccafferty Sarah
- Mccullough Katherine
- Mcdonald Sara
- Mcdonald Sarah
- Mcevoy Laurence
- Mcewen Ruth
- Mclauchlan John
- Mclean Kenneth A
- Meda Manjula
- Mentzer Alexander J
- Merson Laura
- Metelmann Soeren
- Meynert Alison M
- Miah Nahida S
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moore Elinoor
- Moore Shona C
- Moore Shona C
- Moore Shona C
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Norman Lisa
- Noursadeghi Mahdad
- Oosthuyzen Wilna
- Oosthuyzen Wilna
- Openshaw Peter J M
- Openshaw Peter J M
- Ostermann Marlies
- Otahal Igor
- O’shea Matthew K
- Pais Mark
- Palmarini Massimo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Brij
- Pattison Natalie
- Paxton William A
- Penrice-randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Pollakis Georgios
- Pooni Jagtur Singh
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Relph Katharine A
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L
- Roger Thompson A A
- Rose Alistair
- Rousseau Guy
- Russell Clark D
- Russell Clark D
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-shimizu Vanessa
- Saviciute Egle
- Scott Janet T
- Scott-brown James
- Semple Malcolm G
- Semple Malcolm G
- Shah Aarti
- Shankar-hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A
- Shaw Victoria
- Shaw Victoria E
- Shawcross Anna
- Shears Rebecca K
- Sigfrid Louise
- Siggins Matthew K
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S
- Subudhi Pradeep
- Summers Charlotte
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Tanianis-hughes Jolanta
- Tatham Kate
- Tedder Richard S
- Thomas Jo
- Thomas Jordan
- Thompson Chris
- Thompson Robert
- Thomson Emma C
- Thwaites Ryan S
- Thwaites Ryan S
- Tridente Ascanio
- Trochu Erwan
- Tupper-carey Darell
- Turtle Lance
- Turtle Lance C W
- Twagira Mary
- Ustianowski Andrew
- Vallotton Nick
- Van Tonder Libby
- Vincent-smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/04/2022
- Field of study
Abstract Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]).</jats:p
Implementation of corticosteroids in treating COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK:prospective observational cohort study
- Author
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A
- Ail Dhiraj
- Aldera Erin L
- Alegria Ana
- Alex Beatrice
- Allen Sam
- Andrikopoulos Petros
- Angus Brian
- Armstrong Jane A
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G
- Atkinson Dougal
- Bach Benjamin
- Baillie J Kenneth
- Baillie J Kenneth
- Bakshi Siddharth
- Barclay Wendy S
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-Long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin WA
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J
- Clark Richard
- Clark Tom
- Clarke Emily A
- Clohisey Sara
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S
- Cooper Louise
- Cosgrove Catherine
- Coutts Audrey
- Cox Helen
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- da Silva Filipe Ana
- Dalton Jo
- Dark Paul
- Davis Christopher
- Dawson Chris
- de Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Doce Carracedo Alejandra
- Docherty Annemarie B
- Docherty Annemarie B
- Donegan Cara
- Donegan Cara
- Donelly Lorna
- Donnison Phil
- Donohue Chloe
- dos Santos Correia Gon alo
- Douthwaite Sam
- Drake Thomas M
- Drake Thomas M
- Drummond Andrew
- Dumas Marc-Emmanuel
- Dunn Chris
- Dunning Jake
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J
- Fairfield Cameron J
- Fawkes Angie
- Fegan Chrisopher
- Finch Lorna
- Finn Adam
- Fisher Lewis WS
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garg Sanjeev
- Gilchrist Tammy
- Girvan Michelle
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Green Christopher A
- Greenhalf William
- Griffin Julian
- Griffiths Fiona
- Gunning Philip
- Gupta Rishi K
- Hafezi Katarzyna
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E
- Hardy Elaine
- Harrison Ewen M
- Harrison Ewen M
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B
- Hendry Ross
- Hiscox Julian A
- Ho Antonia
- Ho Antonia YW
- Hobrok Maria
- Hodgson Luke
- Holmes Anthony
- Horby Peter W
- Hormis Anil
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L
- Jones Christopher B
- Jones Trevor R
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Say
- King Katharine
- Kiy Robyn T
- Klenerman Paul
- Knight Stephen R
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Law Andrew
- Lee James
- Leeming Gary
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lewis Matthew
- Liggi Sonia
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A
- Lyttle Mark
- MacGillivray Louise
- Maclean Alan
- MacMahon Michael
- MacNaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E
- McEvoy Laurence
- McEwen Ruth
- McLauchlan John
- Mclean Kenneth A
- Meda Manjula
- Mentzer Alexander J
- Merson Laura
- Metelmann Soeren
- Meynert Alison M
- Miah Nahida S
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moonesinghe S Ramani
- Moore Elinoor
- Moore Shona C
- Moore Shona C
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulholland Rachel H
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Nguyen-Van-Tam Jonathan S
- Norman Lisa
- Norris Lillian
- Noursadeghi Mahdad
- Närhi Fiina
- O'Shea Matthew K
- Olanipekun Michael
- Oosthuyzen Wilna
- Openshaw Peter JM
- Openshaw Peter JM
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Pais Mark
- Palmarini Massimo
- Palmieri Carlo
- Palmieri Carlo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Brij
- Pattison Natalie
- Paxton William A
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollakis Georgios
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P Matthew
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L
- Rose Alistair
- Rousseau Guy
- Ruge Bobby
- Russell Clark D
- Russell Clark D
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-Shimizu Vanessa
- Sands Caroline
- Sarah Sarah
- Saviciute Egle
- Schmid Matthias
- Scott Janet T
- Scott-Brown James
- Semple Malcolm G
- Semple Malcolm G
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A
- Shaw Catherine A
- Shaw Victoria
- Shaw Victoria E
- Shawcross Anna
- Shears Rebecca K
- Shenkin Susan D
- Sigfrid Louise
- Singh Pooni Jagtur
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spencer Rebecca G
- Spencer Rebecca G
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S
- Subudhi Pradeep
- Summers Charlotte
- Swann Olivia V
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Takats Zoltan
- Takis Panteleimon
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tedder Richard S
- Thomas Jo
- Thomas Jordan
- Thompson AA Roger
- Thompson Chris
- Thompson Robert
- Thomson Emma C
- Thwaites Ryan S
- Tridente Ascanio
- Trochu Erwan
- Tupper-Carey Darell
- Turtle Lance
- Turtle Lance CW
- Twagira Mary
- Vallotton Nick
- van Tonder Libby
- Vancheeswaran Rama
- Vincent-Smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Zhang J Eunice
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
BACKGROUND: Dexamethasone was the first intervention proven to reduce mortality in patients with COVID-19 being treated in hospital. We aimed to evaluate the adoption of corticosteroids in the treatment of COVID-19 in the UK after the RECOVERY trial publication on June 16, 2020, and to identify discrepancies in care. METHODS: We did an audit of clinical implementation of corticosteroids in a prospective, observational, cohort study in 237 UK acute care hospitals between March 16, 2020, and April 14, 2021, restricted to patients aged 18 years or older with proven or high likelihood of COVID-19, who received supplementary oxygen. The primary outcome was administration of dexamethasone, prednisolone, hydrocortisone, or methylprednisolone. This study is registered with ISRCTN, ISRCTN66726260. FINDINGS: Between June 17, 2020, and April 14, 2021, 47 795 (75·2%) of 63 525 of patients on supplementary oxygen received corticosteroids, higher among patients requiring critical care than in those who received ward care (11 185 [86·6%] of 12 909 vs 36 415 [72·4%] of 50 278). Patients 50 years or older were significantly less likely to receive corticosteroids than those younger than 50 years (adjusted odds ratio 0·79 [95% CI 0·70–0·89], p=0·0001, for 70–79 years; 0·52 [0·46–0·58], p80 years), independent of patient demographics and illness severity. 84 (54·2%) of 155 pregnant women received corticosteroids. Rates of corticosteroid administration increased from 27·5% in the week before June 16, 2020, to 75–80% in January, 2021. INTERPRETATION: Implementation of corticosteroids into clinical practice in the UK for patients with COVID-19 has been successful, but not universal. Patients older than 70 years, independent of illness severity, chronic neurological disease, and dementia, were less likely to receive corticosteroids than those who were younger, as were pregnant women. This could reflect appropriate clinical decision making, but the possibility of inequitable access to life-saving care should be considered. FUNDING: UK National Institute for Health Research and UK Medical Research Council
Constraints on cosmic strings using data from the first Advanced LIGO observing run
- Author
- Abbott B.P.
- Abbott R.
- Abbott T.D.
- Acernese F.
- Ackley K.
- Adams C.
- Adams T.
- Addesso P.
- Adhikari R.X.
- Adya V.B.
- Affeldt C.
- Afrough M.
- Agarwal B.
- Agathos M.
- Agatsuma K.
- Aggarwal N.
- Aguiar O.D.
- Aiello L.
- Ain A.
- Ajith P.
- Allen B.
- Allen G.
- Allocca A.
- Altin P.A.
- Amato A.
- Ananyeva A.
- Anderson S.B.
- Anderson W.G.
- Antier S.
- Appert S.
- Arai K.
- Araya M.C.
- Areeda J.S.
- Arnaud N.
- Arun K.G.
- Ascenzi S.
- Ashton G.
- Ast M.
- Aston S.M.
- Astone P.
- Aufmuth P.
- Aulbert C.
- AultONeal K.
- Avila-Alvarez A.
- Babak S.
- Bacon P.
- Bader M.K.M.
- Bae S.
- Baker P.T.
- Baldaccini F.
- Ballardin G.
- Ballmer S.W.
- Banagiri S.
- Barayoga J.C.
- Barclay S.E.
- Barish B.C.
- Barker D.
- Barone F.
- Barr B.
- Barsotti L.
- Barsuglia M.
- Barta D.
- Bartlett J.
- Bartos I.
- Bassiri R.
- Basti A.
- Batch J.C.
- Baune C.
- Bawaj M.
- Bazzan M.
- Beer C.
- Bejger M.
- Belahcene I.
- Bell A.S.
- Berger B.K.
- Bergmann G.
- Berry C.P.L.
- Bersanetti D.
- Bertolini A.
- Betzwieser J.
- Bhagwat S.
- Bhandare R.
- Bilenko I.A.
- Billingsley G.
- Billman C.R.
- Birch J.
- Birney R.
- Birnholtz O.
- Biscans S.
- Bisht A.
- Bitossi M.
- Biwer C.
- Bizouard M.A.
- Blackburn J.K.
- Blackman J.
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- Publication venue
- Publication date
- 01/01/2018
- Field of study
Cosmic strings are topological defects which can be formed in grand unified theory scale phase transitions in the early universe. They are also predicted to form in the context of string theory. The main mechanism for a network of Nambu-Goto cosmic strings to lose energy is through the production of loops and the subsequent emission of gravitational waves, thus offering an experimental signature for the existence of cosmic strings. Here we report on the analysis conducted to specifically search for gravitational-wave bursts from cosmic string loops in the data of Advanced LIGO 2015-2016 observing run (O1). No evidence of such signals was found in the data, and as a result we set upper limits on the cosmic string parameters for three recent loop distribution models. In this paper, we initially derive constraints on the string tension Gμ and the intercommutation probability, using not only the burst analysis performed on the O1 data set but also results from the previously published LIGO stochastic O1 analysis, pulsar timing arrays, cosmic microwave background and big-bang nucleosynthesis experiments. We show that these data sets are complementary in that they probe gravitational waves produced by cosmic string loops during very different epochs. Finally, we show that the data sets exclude large parts of the parameter space of the three loop distribution models we consider
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
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- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
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- Zanolin M.
- Zeeshan M.
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- Zendri J. -P.
- Zevin Michael
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
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- Berger Beverly
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- Chalathadka Subrahmanya Shreevathsa
- Chan M.
- Chandra K.
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- Charlton E. L.
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- Chassande-Mottin Eric
- Chatterjee Chayan
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- Chen A.
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- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain A.
- Ajith Parameswaran
- Akutsu Tomotada
- Albanesi S.
- Alfaidi R. A.
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Amato Alex
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Arnaud Nicolas
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- Arène M.
- Asada Hideki
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
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- Aubin Florian
- Babak Stanislav
- Badaracco Francesca
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- Baka T.
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- Ballardin G.
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- Yang Yang
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- Yeh S. -W.
- Yelikar A. B.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yoshioka T.
- Yu Hang
- Yu Haocun
- Yuzurihara H.
- Zadrożny A.
- Zahoor Jan Aasim
- Zanolin M.
- Zeidler Simon
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhan M.
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- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
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- Zhao C.
- Zhao G.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
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- Andrés-Carcasona Marc
- Anglin J.
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
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- Zhu Zong-Hong
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- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM