Global school relationships. School linking and future challenges

The process of School Linking has attained a raised profile in UK Development Education circles in recent years. This paper reviews recent literature ans issues. It set out to answer these research questions: What is the interest in North-South School Links for people in the North and the South and what are possible contradictions? How in the School Linking process currently evaluated? Arising from these research questions, the concluding section seeks to identify the challenges for further Links and potential research topics in the field. (DIPF/Orig.)Schulpartnerschaftsarbeit zwischen Nord und Süd hat in den letzten Jahren im Kontext des Globalen Lernens in Großbritannien an Profil gewonnen. In diesem Beitrag wird ein Überblick über die aktuelle Diskussion gegeben. Zudem werden Forschungsfragen thematisiert: Was sind Interessen und Ziele in der Schulpartnerschaftsarbeit und was sind mögliche Widersprüche dieser Arbeit? Wie wird diese Arbeit evaluiert? Anschließend werden die zukünftigen Herausforderungen dieser Arbeit benannt. (DIPF/Orig.

LIPID FORCE FIELD PARAMETERIZATION FOR IMPROVED MODELING OF ION-LIPID INTERACTIONS AND ETHER LIPIDS, AND EVALUATION OF THE EFFECTS OF LONG-RANGE LENNARD-JONES INTERACTIONS ON ALKANES

Chemical specificity of lipid models used in molecular dynamics simulations is essential to accurately represent the complexity and diversity of biological membranes. This dissertation discusses contributions to the CHARMM36 (C36) family of lipid force fields, including a revised model for the glycerol-ether linkage found in plasmalogens and archaeal membranes; interaction parameters between ions and lipid oxygens; and evaluation of the effects of long-range Lennard-Jones parameters on alkanes. Long-range Lennard-Jones interactions have a significant impact on structural and thermodynamic properties of systems with nonpolar regions such as membranes. Effects of these interactions on properties of alkanes are investigated. Implementation of the Lennard-Jones particle-mesh Ewald (LJ-PME) method with the C36 additive and Drude polarizable force fields improves agreement with experiment for thermodynamic and kinetic properties of alkanes, with Drude outperforming the additive FF for nearly all quantities. Trends in the temperature dependence of the density and isothermal compressibility are also improved. Phospholipids containing an ether linkage between the glycerol backbone and hydrophobic tails are prevalent in human red blood cells and nerve tissue. Ab initio results are used to revise linear ether parameters and develop new parameters for the glycerol-ether linkage in lipids. The new force field, called C36e, more accurately represents the dihedral potential energy landscape and improves solution properties of linear ethers. C36e allows more water to penetrate an ether-linked lipid bilayer, increasing the surface area per lipid compared to simulations carried out with the original C36 parameters and improving structural properties. In addition to modulating membrane structure, lipid-ion interactions influence protein-ligand binding and conformations of membrane-bound proteins. Interaction parameters are introduced describing Be2+ affinity for binding sites on lipids. Experimental binding affinities reveal that Be2+ strongly binds to phosphoryl groups. Revised interaction parameters reproduce binding affinities in solution simulations. In a separate effort, experimental results for the radius of gyration (R_g) of polyethylene glycol (PEG) in various concentrations of KCl reveal that, while C36e parameters reproduce experimental R_g of PEG in the absence of KCl, adding salt results in underestimation of〖 R〗_g. It is found that the water shell around PEG affects R_g calculated from neutron scattering experiments, and K+-PEG interactions increase the gauche character of PEG

Inspiring a Revolution: A review of Julio Cammarota and Michelle Fine’s Revolutionizing Education: Youth Participatory Action Research in Motion

Multigenerational, diverse voices can be heard throughout Julio Cammarota and Michelle Fine’s Revolutionizing Education: Youth Participatory Action Research in Motion, an edited collection of chapters presenting provocative, transformative participatory action research (PAR)—focusing on youth participatory action research (YPAR). Challenging conventional notions of inquiry, these YPAR projects illustrate “research conducted “with” as opposed to “on” youth,” (p. vii) surrounding issues of injustice, inequality, and struggles in the lives and education of youth and their communities, giving voice to those often silenced due to age, race, ethnicity, sexuality, economic status, gender, language, and abled/disabled identities. Although of interest and targeting action researchers and scholarly audiences in education, Revolutionizing Education also speaks to administrators, youth researchers, documentarians, and teachers, particularly since the work involves co-constructed projects involving adults and youth. It, thus, lends itself to broadening the possibilities of teacher research

Library Monthly - April/May 2015

In this issue: Possible Renovation: Pardon our Dust Jacket Lynn University\u27s Music Library Let the Library Help You Enhance Your Courses Subjects Guide - Targeted Searching The Complete Recap to the Library\u27s Spring Eventshttps://spiral.lynn.edu/libpubs/1002/thumbnail.jp

Library Monthly - February 2015

Inaugural issue of Library Monthly, the Lynn University Library monthly newsletter. In this issue: Amy\u27s Annotations iBooks Catalog Expandinghttps://spiral.lynn.edu/libpubs/1000/thumbnail.jp

Nested negotiations: Landscape and portable material culture in Viking-Age England

This thesis examines transitions in life and landscape in Scandinavian-occupied early medieval England. The Viking Age is here contextualised within a longer view, looking both to Middle Saxon England on the eve of the Scandinavian incursions, and beyond the end of Scandinavian rule to structures of landholding and lordship following the Norman Conquest (c.AD 700-1100). Four local case studies from across three different counties (Lincolnshire, Norfolk, and Leicestershire) provide the basis for analysis. The primary dataset used to identify and assess these places was metal-detected portable material culture recorded with the Portable Antiquities Scheme (PAS). This is combined with data from HERs, Domesday Book, place-names, and landscape evidence in order to identify new early medieval settlements and occupied landscapes. Within these it is possible to identify a range of activities taking place, and socio-cultural negotiations being enacted. This enables the tracking of settlement dynamics over time, and in particular how changing social, political, and cultural contexts affected these transitions

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Overexpression or pharmacological activation of SIRT1 has been shown to extend the lifespan of mice and protect against aging-related diseases. Here we show that pharmacological activation of SIRT1 protects in two models of osteoporosis. Ovariectomized female mice and aged male mice, models for post-menopausal and aging-related osteoporosis, respectively, show significant improvements in bone mass upon treatment with SIRT1 agonist, SRT1720. Further, we find that calorie restriction (CR) results in a two-fold upregulation of sirt1 mRNA expression in bone tissue that is associated with increased bone mass in CR mice. Reciprocally, SIRT1 whole-body knockout (KO) mice, as well as osteoblast and osteoclast specific KOs, show a low bone mass phenotype; though double knockout mice (containing SIRT1 deleted in both osteoblasts and osteoclasts) do not show a more severe phenotype. Altogether, these findings provide strong evidence that SIRT1 is a positive regulator of bone mass and a promising target for the development of novel therapeutics for osteoporosis

Library Monthly - November 2015

In this issue: Don\u27t Cancel Class: A Librarian Can Step in and Help! Record-Breaking Library Influx iBooks Author Conference How to Craft a Quality Research Assignmenthttps://spiral.lynn.edu/libpubs/1004/thumbnail.jp