UniBuddy - Business Development Plan

UniBuddy es una plataforma y p?gina web en l?nea que permite realizar los tr?mites m?s necesarios para la reubicaci?n en Alemania, mientras a?n se encuentran en su pa?s de origen. UniBuddy ayuda a arrendar apartamentos privados, configurar una cuenta bloqueada y proporcionar seguro m?dico. UniBuddy "mejora" la burocracia alemana, cambiando la forma en que se brindan los servicios y facilitando los tr?mites. La plataforma es f?cil de navegar y est? dirigida a extranjeros, con dominio limitado o nulo de alem?n. La empresa fue fundada por dos emprendedores trabajado en su tiempo libre para desarrollar un proyecto autosostenible que puede comenzar sin gran inversi?n inicial. Ya hay tres empresas que han decidido colaborar con UniBuddy. Con un mayor crecimiento, UniBuddy puede establecer una colaboraci?n con instituciones p?blicas y mejorar la administraci?n en el sector p?blico. Gracias a la fuerte colaboraci?n con HHL Graduate School of Management en Leipzig, se pudo contactar a la primera base de clientes de 154 estudiantes internacionales. El punto de equilibrio se lograr? entre el tercer y cuarto a?o con tan solo 420 clientes. Los fundadores y el equipo de gesti?n conf?an en el ?xito de la empresa y est?n muy dedicados al r?pido crecimiento y desarrollo

Effect of fermented goat milk on body composition, basal metabolism, and food intake control in rats

Introducción: es conocido que la dieta juega un papel clave en la composición corporal y afecta al balance energético; sin embargo, la información es limitada acerca de la influencia de alimentos y nutrientes específicos como es el caso de los productos lácteos, un grupo básico de alimentos y una importante fuente de nutrientes en la dieta. Objetivos: evaluar la influencia del consumo de leche fermentada de cabra o vaca sobre la composición corporal y la regulación del apetito en animales adultos. Material y métodos: se han utilizado 20 ratas Wistar macho adultas, alimentadas durante 30 días con dietas basadas en leche fermentada de vaca o de cabra. Se analizaron la evolución de la composición corporal y las concentraciones plasmáticas de adipoquinas (leptina y adiponectina), hormonas reguladoras del metabolismo intermediario (grelina, insulina, hormona estimulante de la glándula tiroides, triyodotironina y tiroxina) y ácidos grasos no esterificados (AGNE). Resultados: el peso y el porcentaje de grasa corporal fueron menores (p < 0,001) y la masa magra fue mayor (p < 0,01) en los animales alimentados con la dieta basada en leche fermentada de cabra. No se registraron diferencias entre dietas para las concentraciones plasmáticas de hormonas tiroideas y de insulina. Las concentraciones plasmáticas de grelina y adiponectina disminuyeron (p < 0,001), y las de leptina y AGNE aumentaron (p < 0,001) con la dieta basada en leche fermentada de cabra. Conclusión: el consumo habitual de leche fermentada de cabra disminuye la adiposidad y el peso corporal en las ratas adultas al incrementar el gasto energético, la lipólisis y la sensación de saciedad.Introduction and objective: it is known that diet plays a key role in body composition and affects energy balance. However, scarce information is available in the scientific literature about the influence of food and specific nutrients such us dairy products, a basic food group and an important source of nutrients in the diet. The objective of this work was to evaluate the influence of fermented dairy products (goat or cow milk) on body composition and appetite regulation in adult animals. Material and methods: twenty adult male Wistar albino rats were fed fermented goat or cow milk-based diets for 30 days. The evolution of body composition and plasma concentrations of adipokines (leptine and adiponectine), intermediary metabolism regulating hormones (ghrelin, insulin, thyroid stimulating hormone, triyodotironine, thyroxine), and non-esterified fatty acid (NEFA) were analyzed. Results: body weight and body fat percentage were lower (p < 0.001) in rats fed fermented goat milk versus those fed fermented cow milk, whereas lean mass percentage was higher (p < 0.01). Plasma thyroid hormone and insulin concentrations did not show significant differences between diets. The fermented goat milk-based diet decreased ghrelin and adiponectin levels (p < 0.001), and increased leptine and NEFA concentrations (p < 0.001). Conclusion: fermented goat milk consumption decreases adiposity and body weight in adult rats by increasing energy expenditure, lipolysis, and satiety sensation.Este trabajo ha sido financiado por la Junta de Andalucía en el marco del Proyecto de Excelencia P11-AGR-7648

Contamination of Fruits, Soil Water Due to The Use of Agrochemicals in (Passiflora Ligularis), Oxapampa-Peru

The conventional agriculture allowed the farmers being dependent to the mass and frequent use of pesticides, originating contamination of fruits, ground, water of escorrentía. Objective was To Determine the concentration of metals weighed in Passiflora's fruits ligularis produced at grounds and escorrentía's water with remains of metals weighed by intensive agroquímicos's use at Oxapampa's district. Himself I utilize the Experimental Comparative Design No. Determined him Arsénico's concentration, Mercury, Plomo, Cadmio, Cobre in signs collected of fields of production of three (ABC) previous groups you poll farmers. Results: You met the. Arsenic 0.004mg/Kg (Ch1Af), mercury 0,002 mg/Kg (Ab1Af, Ab2Af), lead 0,005 mg/Kg ( Ab1Af ), cadmium 0,004 mg/Kg ( Ab1Af, Ch1Af, PaCf ), copper 0,5 mg/Kg ( Ch2Af ). Ground Arsénico Ch1As, ARP3Cs 0,08 mg/Kg, mercury Ch1As, ARP3Cs, SA2Cs, PaCs 0,08 mg/Kg; I seal with lead Ch1As, ARP2Cs, Ch2As, AcAs, PaCs 0,08 mg/Kg, cadmium Acuzazú AcAs, 0,3 mg/Kg, copper Ab2Bs, Ch1As 30 mg/Kg. Water down of escorrentia; Arsenic SA2Ca 0.005mg/Kg, mercury Ch2Aa 0,008 mg/Kg, lead CaBa, QllAa, Ch3Ba 0,005 mg/Kg, cadmium Ab2Ba, AcAa, SA1Ba 0,004 mg/Kg, copper SA1Ba 1,5 mg/Kg. Conclusion: You had loud moral values of concentration of metals weighed at ground, water, fruits passing the maximum permissible limit

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42\ub74% vs 44\ub72%; absolute difference \u20131\ub769 [\u20139\ub758 to 6\ub711] p=0\ub767; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5\u20138] vs 6 [5\u20138] cm H2O; p=0\ub70011). ICU mortality was higher in MICs than in HICs (30\ub75% vs 19\ub79%; p=0\ub70004; adjusted effect 16\ub741% [95% CI 9\ub752\u201323\ub752]; p&lt;0\ub70001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0\ub780 [95% CI 0\ub775\u20130\ub786]; p&lt;0\ub70001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding

Bases Farmacológicas De La Terapéutica-ME93-201202

Una de las tareas del médico es proponer un plan de trabajo para el paciente que le permita establecer un diagnóstico e instalar las medidas terapéuticas pertinentes. Por ello es importante tener en cuenta que existen medidas farmacológicas y no farmacológicas que forman parte de la terapéutica. Para poder sentar las bases de la terapéutica es necesario que previamente se conozcan los conceptos fundamentales que permitan al alumno identificar los principales grupos farmacológicos mecanismos de acción principales leyes y mecanismos que regulan su disposición en el organismo a través de los fluidos corporales (Farmacocinética) y su dinámica tisular (Farmacodinamia) sin dejar de tener en cuenta las posibles reacciones adversas. El conocimiento de las bases farmacológicas de la terapéutica permitirá al futuro médico hacer un uso racional de medicamentos

Bases Farmacológicas De La Terapéutica-ME14-201102

Una de las tareas del médico es proponer un plan de trabajo para el paciente que le permita establecer un diagnóstico e instalar las medidas terapéuticas pertinentes. Por ello es importante tener en cuenta que existen medidas farmacológicas y no farmacológicas que forman parte de la terapéutica.Para poder sentar las bases de la terapéutica es necesario que previamente se conozcan los conceptos fundamentales que permitan al alumno identificar los principales grupos farmacológicos mecanismos de acción principales leyes y mecanismos que regulan su disposición en el organismo a través de los fluidos corporales (Farmacocinética) y su dinámica tisular (Farmacodinamia) sin dejar de tener en cuenta las posibles reacciones adversas.El conocimiento de las bases farmacológicas de la terapéutica permitirá al futuro médico hacer un uso racional de medicamento

Bases Farmacológicas de la Terapéutica - ME93 201202

Una de las tareas del médico es proponer un plan de trabajo para el paciente que le permita establecer un diagnóstico e instalar las medidas terapéuticas pertinentes. Por ello es importante tener en cuenta que existen medidas farmacológicas y no farmacológicas que forman parte de la terapéutica. Para poder sentar las bases de la terapéutica, es necesario que previamente se conozcan los conceptos fundamentales que permitan al alumno identificar los principales grupos farmacológicos mecanismos de acción, principales leyes y mecanismos que regulan su disposición en el organismo a través de los fluidos corporales (Farmacocinética) y su dinámica tisular (Farmacodinamia), sin dejar de tener en cuenta las posibles reacciones adversas. El conocimiento de las bases farmacológicas de la terapéutica permitirá al futuro médico hacer un uso racional de medicamentos

Synzoochory: the ecological and evolutionary relevance of a dual interaction

ABSTRACT Synzoochory is the dispersal of seeds by seed-caching animals. The animal partner in this interaction plays a dual role, acting both as seed disperser and seed predator. We propose that this duality gives to synzoochory two distinctive features that have crucial ecological and evolutionary consequences. First, because plants attract animals that have not only positive (seed dispersal) but also negative (seed predation) impacts on their fitness, the evolution of adaptations to synzoochory is strongly constrained. Consequently, it is not easy to identify traits that define a synzoochorous dispersal syndrome. The absence of clear adaptations entails the extra difficulty of identifying synzoochorous plants by relying on dispersal traits, limiting our ability to explore the full geographic, taxonomic and phylogenetic extent of synzoochory. Second, the positive and negative outcomes of interactions with synzoochorous animals are expressed simultaneously. Consequently, synzoochorous interactions are not exclusively mutualistic or antagonistic, but are located at some point along a mutualism-antagonism continuum. What makes synzoochory interesting and unique is that the position of each partner along the continuum can be evaluated for every plant—animal interaction, and thus the continuum can be precisely described by assessing the relative frequency of positive and negative interaction events in each pairwise interaction. Herein we explore these two main features of synzoochory with a comprehensive quantitative survey of published studies on synzoochory. Synzoochory has been recorded for at least 1339 plant species differing in life forms, from annual and short-lived herbs to long-lived trees, belonging to 641 genera and 157 families widely distributed across the globe and across the seed plant phylogeny. Over 30 animal families belonging to five disparate taxonomic groups (rodents, marsupials, birds, insects, and land crabs) potentially act as synzoochorous dispersers. Although synzoochory appears to be fundamentally a secondary dispersal mode, many abundant and dominant trees are primarily synzoochorous. In addition, we found evidence of the existence of diplosynzoochory (caching animals acting both as primary and secondary dispersers of the same individual seed), mostly in nut-bearing trees. Finally, we found that synzoochorous interactions are widely spread across the mutualism—antagonism continuum. Nevertheless, there were some differences among disperser species and functional groups. Corvids and some rodents (cricetids, nesomyids, sciurids) were located in the positive-effects region of the continuum and presumably behave mostly as dispersers, whereas land crabs and insects were located in the negative-effects extreme and behave mostly as seed predators. Our review demonstrates that synzoochory is not an anecdotal ecological interaction. Rather, it is pivotal to the functioning of many ecosystems where the natural regeneration of keystone plant species depends on the activity of granivorous animals that play a dual role. This distinctive interaction should not be ignored if we wish to have an accurate understanding of the functioning of natural systems.J.M.G. and P.J. were supported by CYTED program (Red Temática 418RT0555). E.W.S. is supported by the Ecology Center and the Utah Agricultural Experiment Station (UAES), Utah State University. P.J. is supported by grant CGL2017‐82847‐P from the Spanish Ministry of Science, Innovation, and Universities (AEI)