Holographic Kondo Model in Various Dimensions

We study the addition of localised impurities to U(N) Supersymmetric Yang-Mills theories in (p+1)-dimensions by using the gauge/gravity correspondence. From the gravity side, the impurities are introduced by considering probe D(8-p)-branes extendingalong the time and radial directions and wrapping an (7-p)-dimensional submanifold of the internal (8-p)-sphere, so that the degrees of freedom are point-like from the gauge theory perspective. We analyse both the configuration in which the branes generate straight flux tubes -corresponding to actual single impurities - and the one in which connected flux tubes are created- corresponding to dimers. We discuss the thermodynamics of both the configurations and the related phase transition. In particular, the specific heat of the straight flux-tube configuration is negative for p<3, while it is never the case for the connected one. We study the stability of the system by looking at the impurity fluctuations. Finally, we characterise the theory by computing one- and two-point correlators of the gauge theory operators dual to the impurity fluctuations. Because of the underlying generalised conformal structure, such correlators can be expressed in terms of an effective coupling constant (which runs because of its dimensionality) and a generalised conformal dimension.Comment: 56 pages, 3 figures; v2: typos correcte

Copernicus Marine Service Ocean State Report

This is the final version. Available from Taylor & Francis via the DOI in this record

A rare case of spontaneous rupture of epithelioid angiomyolipoma

A male patient, 40 years of age, arrived at our Institute with diffuse abdominal tenderness, right flank pain, hematuria and early stage of hemorrhagic shock with anemia and initial hypotension. The immediate clinical history revealed no significant previous trauma, only subsequently was reported inconstant pain in the right flank for 4–5 days with pallor and asthenia, signs and symptoms that the patient had not investigated. Abdominal CT scan with angiographic evaluation was performed showing right kidney mass and perirenal fluid collection by blood component. Immediate nephrectomy was performed and histopathological and further immunohistochemical study, revealed the epithelioid variant of angiomyolipoma

Docetaxel Rechallenge in a Heavily Pretreated Patient with Castration-Resistant Prostate Cancer

Chemotherapy agents for patients with metastatic castration-resistant prostate cancer (mCRPC) include docetaxel and cabazitaxel. Although docetaxel is approved in the first-line treatment setting, a few studies have shown that selected patients can benefit from docetaxel rechallenge. We, here, report the case of a heavily pretreated mCRPC patient who reported clinical benefit from receiving docetaxel after previous exposure to docetaxel, cabazitaxel, abiraterone, and enzalutamide. After 4 cycles of treatment, patient's performance status had improved to 1, the hemoglobin level was 12.9 g/dL and his serum prostate specific antigen levels were reduced by >70%, with no treatment-related adverse events. Although docetaxel rechallenge is a therapeutic option for selected patients, the risk of cumulative toxicity described in literature must be carefully considered. As the risk of cabazitaxel-related cumulative toxicity is probably lower, retreatment with cabazitaxel rather than docetaxel may also be an option in the setting of heavily pretreated mCRPC patients

Third-Line chemotherapy for metastatic Urothelial Cancer: A retrospective observational study

The prognosis of locally advanced (T3/T4 or N1) and metastatic disease urothelial carcinoma is poor. In this retrospective study, we reviewed data about patients receiving third-line chemotherapy for metastatic disease, in view of the lack of data in this setting. We retrospectively analyzed medical records of patients with a pathologic diagnosis of urothelial carcinoma treated with systemic chemotherapy for metastatic disease at 4 participating Institutions between January, 2010, and January, 2015. Cox proportional hazards regression was used to evaluate the association of the chemotherapy agent used versus others with overall survival, adjusted for 5 externally validated prognostic factors in advanced urothelial carcinoma. Of 182 patients that received first-line chemotherapy/adjuvant chemotherapy as defined above, 116 patients (63.73%) received second-line salvage treatment. Fifty-Two patients were finally included in this analysis, whereas 9 were excluded due to missing data. Third-line chemotherapy was based on cyclophosphamide, platinum, vinflunine, taxanes, and gemcitabine in 16, 12, 11, 10, and 3 patients, respectively. Median PFS (progression-free survival) and OS (overall survival) of the population were 13 (10-17) and 31 (28-36) weeks. Single-Agent cyclophosphamide was associated with a PFS of 18 (13-22) and an OS of 38 (33-41) weeks, whereas platinum-based combinations were associated with a PFS of 5 weeks and an OS of 8 weeks. Multivariate analysis showed improved survival in patients treated with cyclophosphamide (hazard ratio (HR)1/40.42; 95% CI: 0.20-0.89; P1/40.025) and a worse survival in those treated with platinum-based regimens (HR: 4.37; 95% CI1/41.95-9.77; P <0.01). We observed a significantly longer overall survival in patients receiving single-Agent cyclophosphamide, with few grade 3 to 4 toxicities. Further studies should assess the efficacy of metronomic single-Agent cyclophosphamide in advanced lines of treatment, as it may yield a survival benefit with low costs and no detrimental effects on quality of life

Copernicus marine service ocean state report

The oceans regulate our weather and climate from global to regional scales. They absorb over 90% of accumulated heat in the climate system (IPCC Citation2013) and over a quarter of the anthropogenic carbon dioxide (Le Quéré et al. Citation2016). They provide nearly half of the world’s oxygen. Most of our rain and drinking water is ultimately regulated by the sea. The oceans provide food and energy and are an important source of the planet's biodiversity and ecosystem services. They are vital conduits for trade and transportation and many economic activities depend on them (OECD Citation2016). Our oceans are, however, under threat due to climate change and other human induced activities and it is vital to develop much better, sustainable and science-based reporting and management approaches (UN Citation2017). Better management of our oceans requires long-term, continuous and state-of-the art monitoring of the oceans from physics to ecosystems and global to local scales. The Copernicus Marine Environment Monitoring Service (CMEMS) has been set up to address these challenges at European level. Mercator Ocean was tasked in 2014 by the European Union under a delegation agreement to implement the operational phase of the service from 2015 to 2021 (CMEMS Citation2014). The CMEMS now provides regular and systematic reference information on the physical state, variability and dynamics of the ocean, ice and marine ecosystems for the global ocean and the European regional seas (Figure 0.1; CMEMS Citation2016). This capacity encompasses the description of the current situation (analysis), the prediction of the situation 10 days ahead (forecast), and the provision of consistent retrospective data records for recent years (reprocessing and reanalysis). CMEMS provides a sustainable response to European user needs in four areas of benefits: (i) maritime safety, (ii) marine resources, (iii) coastal and marine environment and (iv) weather, seasonal forecast and climate. Figure 0.1. CMEMS geographical areas on the map are for: 1 – Global Ocean; 2 – Arctic Ocean from 62°N to North Pole; 3 – Baltic Sea, which includes the whole Baltic Sea including Kattegat at 57.5°N from 10.5°E to 12.0°E; 4 – European North-West Shelf Sea, which includes part of the North East Atlantic Ocean from 48°N to 62°N and from 20°W to 13°E. The border with the Baltic Sea is situated in the Kattegat Strait at 57.5°N from 10.5°E.to 12.0°E; 5 – Iberia-Biscay-Ireland Regional Seas, which includes part of the North East Atlantic Ocean from 26 to 48°N and 20°W to the coast. The border with the Mediterranean Sea is situated in the Gibraltar Strait at 5.61°W; 6 – Mediterranean Sea, which includes the whole Mediterranean Sea until the Gibraltar Strait at 5.61°W and the Dardanelles Strait; 7 – Black Sea, which includes the whole Black Sea until the Bosporus Strait

Copernicus Marine Service Ocean State Report

The Compernicus Marine Environmenta and Monitoring Servic

Dual antiplatelet therapy duration after coronary stenting in clinical practice: results of an EAPCI survey

Aims: Our aim was to report on a survey initiated by the EuropeanAssociation of Percutaneous Cardiovascular Interventions (EAPCI) concerning opinion on the evidence relating to dual antiplatelet therapy (DAPT) duration after coronary stenting.Methods and results: Results from three randomised clinical trials were scheduled to be presented at the American Heart Association Scientific Sessions 2014 (ARIA 2014). A web-based survey was distributed to all individuals registered in the EuroIntervention mailing list (n=15,200) both before and after ARIA 2014. A total of 1,134 physicians responded to the first (i.e., before AHA 2014) and 542 to the second (i.e., after ARIA 2014) survey. The majority of respondents interpreted trial results consistent with a substantial equipoise regarding the benefits and risks of an extended versus a standard DAPT strategy. Two respondents out of ten believed extended DAFT should be implemented in selected patients. After ARIA 2014, 46.1% of participants expressed uncertainty about the available evidence on DAFT duration, and 40.0% the need for clinical guidance.Conclusions: This EAPCI survey highlights considerable uncertainty within the medical community with regard to the optimal duration of DAFT after coronary stenting in the light of recent reported trial results. Updated recommendations for practising physicians to guide treatment decisions in routine clinical practice should be provided by international societies