95 research outputs found
Seasonal and annual fluxes of nutrients and organic matter from large rivers to the Arctic Ocean and surrounding seas
- Author
- A Bring
- ACIA
- Alexander V. Zhulidov
- AV Zhulidov
- AV Zhulidov
- BJ Peterson
- BJ Peterson
- BJ Peterson
- Bruce J. Peterson
- CA Emmerton
- CA Emmerton
- CR Tobias
- D White
- Daniel J. Repeta
- E Sakshaug
- Ekaterina Bulygina
- G Booth
- GW Kling
- IPCC
- J Brown
- J Finlay
- James W. McClelland
- JC Adam
- JC Neff
- JM Lobbes
- JW McClelland
- JW McClelland
- JW McClelland
- JW McClelland
- K Aagaard
- LC Smith
- LR Welp
- LW Cooper
- LW Cooper
- MA Rawlins
- MA Walvoord
- MC Serreze
- MC Serreze
- MM Dornblaser
- PA Raymond
- Peter A. Raymond
- RG Striegl
- RG Striegl
- RGM Spencer
- RGM Spencer
- RM Holmes
- RM Holmes
- RM Holmes
- RM Holmes
- RM Holmes
- Robert G. Striegl
- Robert Max Holmes
- Robin Staples
- Sergey A. Zimov
- SJ Déry
- SJ Déry
- Suzanne E. Tank
- SW Nixon
- T Dittmar
- T Ngo-Duc
- Tatiana Y. Gurtovaya
- Timothy I. Eglinton
- Viacheslav V. Gordeev
- VV Gordeev
- WB Bowden
- WM Kemp
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2011
- Field of study
Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Estuaries and Coasts 35 (2012): 369-382, doi:10.1007/s12237-011-9386-6.River inputs of nutrients and organic matter impact the biogeochemistry of arctic
estuaries and the Arctic Ocean as a whole, yet there is considerable uncertainty about the
magnitude of fluvial fluxes at the pan-arctic scale. Samples from the six largest arctic
rivers, with a combined watershed area of 11.3 x 106 km2, have revealed strong seasonal
variations in constituent concentrations and fluxes within rivers as well as large
differences among the rivers. Specifically, we investigate fluxes of dissolved organic
carbon, dissolved organic nitrogen, total dissolved phosphorus, dissolved inorganic
nitrogen, nitrate, and silica. This is the first time that seasonal and annual constituent
fluxes have been determined using consistent sampling and analytical methods at the pan
arctic scale, and consequently provide the best available estimates for constituent flux
from land to the Arctic Ocean and surrounding seas. Given the large inputs of river water
to the relatively small Arctic Ocean, and the dramatic impacts that climate change is
having in the Arctic, it is particularly urgent that we establish the contemporary river
fluxes so that we will be able to detect future changes and evaluate the impact of the
changes on the biogeochemistry of the receiving coastal and ocean systems.This work was supported by the National Science Foundation through grants
OPP-0229302, OPP-0519840, OPP-0732522, and OPP-0732944. Additional support was
provided by the U. S. Geological Survey (Yukon River) and the Department of Indian
and Northern Affairs (Mackenzie River)
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
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- Abbate A
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- Abhyanakar AD
- Aboyans V
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- Acevedo M
- Adamkova V
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- Sabatino K
- Sabbah E
- Sader M
- Sakagami S
- Sakalyte G
- Sakamoto T
- Salcido Vazquez E
- Salvioni A
- Saminski K
- Sandhu M
- Sansanayudh N
- Santharaj W
- Saporito W
- Sarkar D
- Sarvan M
- Sassone SA
- Sastravaha K
- Savard D
- Sawhney J
- Schaeufele T
- Schellenberg D
- Schiavi LB
- Schiele F
- Schifferdecker B
- Schmalfuss C
- Schmidberg JM
- Schmidt E
- Schuchard T
- Schwartz GG
- Schwartz M
- Schwartz S
- Sciborski R
- Scott D
- Sebastian PJ
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- Seixo F
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- Shah AV
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- Shehova-Yankova NS
- Sheldon W
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- Steg PG
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- Sudnik W
- Sugino H
- Suh D
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- Sukonthasarn A
- Suligoj NC
- Sumner A
- Sun Y
- Sundelin T
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- Sy RAG
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- Thakkar M
- Thew S
- Ticona JRC
- Tirador L
- Tissera N
- Todorov GV
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- Tomala T
- Tonnessen G
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- Toursarkissian N
- Tov N
- Tretyakova TV
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- Triana MAU
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- Troquay RPT
- Trotter C
- Tsai W-C
- Tse H-F
- Tseluyko V
- Tumbev HS
- Tunon Fernandez J
- Tunon J
- Turgeman Y
- Turi T
- Turk S
- Tyrenko VV
- Tzekova ML
- Ueda Y
- Uehara H
- Ueng K-C
- Ungi I
- Ural E
- Ushakov O
- Utsu N
- Vahula V
- Vakaluyk I
- Valgimigli M
- Vallejo GS
- Vallejos JA
- Van Der Wal RMA
- Van Der Zwaan CC
- van Diepen SFP
- Van Huysduynen-Monraats PSH
- Van Zyl LJ
- Vardi G
- Varleta P
- Vatutin M
- Vedere A
- Vejar M
- Velasquez JRD
- Velcheva ES
- Verdel GJE
- Vered Z
- Vervoort G
- Vico ML
- Vida M
- Videbaek L
- Vidotti MH
- Vidovich M
- Viergever EP
- Viigimaa M
- Vijay N
- Vijayaraghavan R
- Vikman S
- Viktorova I
- Violini R
- Vishnevsky AY
- Vizel S
- Vo A
- Voeller H
- Voevoda MI
- Vogel R
- Vohra R
- Vora K
- Voyce S
- Vrolix MCM
- Vulic D
- Vuurmans T
- Wada A
- Waider W
- Waisman GD
- Waites JH
- Wali A
- Walichiewicz PM
- Waltenberger J
- Waltman J
- Wang J
- Wang J
- Wang J
- Wattanakit K
- Wei M
- Weidinger F
- Weil J
- Weintraub H
- Weissbrodt M
- Welka S
- Welker J
- Wells T
- Werner N
- Whitaker J
- White HD
- White L
- White M
- Wiersma JJ
- Wilkins G
- Wilkinson P
- Willems FF
- Wilson MD
- Winkelmann B
- Wiseman A
- Witt N
- Wlodarczak A
- Wojewoda P
- Wollaert B
- Wong Y-K
- Wongpraparut N
- Worner Diz F
- Wright S
- Xatzitolios A
- Xavier D
- Xenakis M
- Xu B
- Xu D
- Xu X
- Yagensky A
- Yakushin S
- Yan AT-K
- Yan BPY
- Yanez M
- Yang E
- Yang X
- Yang X
- Yao Z
- Yazdani S
- Yerra SK
- Yin W-H
- Yong H
- Yoon JH
- Younis L
- Yu Y
- Yuan Z
- Yusoff K
- Zahger D
- Zaidman CJ
- Zainea M
- Zaman A
- Zeiher AM
- Zhang W
- Zhang X
- Zhang Z
- Zhao X
- Zheng Y
- Zheng Z
- Zhou Y
- Zhu H
- Zirlik A
- Zizka J
- Zong W
- Zrazhevsky K
- Zuniga JDH
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial
- Author
- Abaci Adnan
- Abaci Adnan
- Abhaichand Rajpal
- Abhaichand Rajpal
- Adams Kirkwood
- Adams Kirkwood
- Akin Mustafa
- Akin Mustafa
- Alvarenga Pablo
- Alvarenga Pablo
- Apro Dezso
- Apro Dezso
- Arneja Jaspal
- Arneja Jaspal
- Aron Wilma
- Aron Wilma
- Babcak Marian
- Babcak Marian
- Babilonia Noe A.
- Babilonia Noe A.
- Badak Ozer
- Badak Ozer
- Banker Darshan
- Banker Darshan
- Barbiero Mario
- Barbiero Mario
- Barnard Denise
- Barnard Denise
- Baschiera Fabio
- Bassan Roberto
- Bassan Roberto
- Behrens Steffen
- Behrens Steffen
- Belohlavek Jan
- Belohlavek Jan
- Bergin James
- Bergin James
- Berkovich Olga
- Berkovich Olga
- Berkowski Piotr
- Berkowski Piotr
- Bharani Anil
- Bharani Anil
- Blumberg Eduardo Salmon
- Blumberg Eduardo Salmon
- Boccanelli Alessandro
- Boccanelli Alessandro
- Bodanese Luiz
- Bodanese Luiz
- Boldueva Svetlana
- Boldueva Svetlana
- Borghi Claudio
- Borghi Claudio
- Boyarkin Mikhail
- Boyarkin Mikhail
- Brabec Tomas
- Brabec Tomas
- Branzi Angelo
- Branzi Angelo
- Braun-Dullaeus Ruediger
- Braun-Dullaeus Ruediger
- Brottman Michael
- Brottman Michael
- Brown Christopher
- Brown Christopher
- Brunotte Richard
- Brunotte Richard
- Bueno Manuel Gomez
- Bueno Manuel Gomez
- Burnham Kenneth
- Burnham Kenneth
- Böhm Michael
- Cabrera Jose Angel
- Cabrera Jose Angel
- Callister Tracy
- Callister Tracy
- Canesin Manoel
- Canesin Manoel
- Cangemi Dott Francesco
- Cangemi Dott Francesco
- Castagnino Jorge
- Castagnino Jorge
- Cavallini Claudio
- Cavallini Claudio
- Chang Kuan-Cheng
- Chang Kuan-Cheng
- Cherng Wen-Jin
- Cherng Wen-Jin
- Chockalingam Kulasekaran
- Chockalingam Kulasekaran
- Chung Eugene
- Chung Eugene
- Cizinsky Stella
- Cizinsky Stella
- Cohen Ariel
- Cohen Ariel
- Comin Josep
- Comin Josep
- Costard-Jaeckle Angelika
- Costard-Jaeckle Angelika
- Cotes Carlos
- Cotes Carlos
- Dan Gheorghe
- Dan Gheorghe
- De Keulenaer Gilles
- De Keulenaer Gilles
- De Lorenzi Ettore
- De Lorenzi Ettore
- de Sa Esteban Lopez
- de Sa Esteban Lopez
- De Santis Fernando
- De Santis Fernando
- De Servi Stefano
- De Servi Stefano
- Dendale Paul
- Dendale Paul
- Di Biase Matteo
- Di Biase Matteo
- Di Somma Salvatore
- Di Somma Salvatore
- Diez Mirta
- Diez Mirta
- Dizeo Claudio
- Dizeo Claudio
- Dluzniewski Miroslaw
- Dluzniewski Miroslaw
- Dorobantu Maria
- Dorobantu Maria
- Dragulescu Stefan
- Dragulescu Stefan
- Duengen Hans-Dirk
- Duengen Hans-Dirk
- Dunlap Stephanie
- Dunlap Stephanie
- Dzielinska Zofia
- Dzielinska Zofia
- Ebelt Henning
- Ebelt Henning
- Ebinc Haksun
- Ebinc Haksun
- Echeverria Luis
- Echeverria Luis
- Eisen Howard
- Eisen Howard
- Ershova Olga
- Ershova Olga
- Felix Stephan
- Felix Stephan
- Fernandez Alberto
- Fernandez Alberto
- Ferrolino Arthur M.
- Ferrolino Arthur M.
- Figulla Hans-Reiner
- Figulla Hans-Reiner
- Fischer Sven
- Fischer Sven
- Floresta Agata
- Floresta Agata
- Florez Noel
- Florez Noel
- Fomin Igor
- Fomin Igor
- Fonarow Gregg C.
- Freire Ramon Bover
- Freire Ramon Bover
- French William
- French William
- Fulmer James
- Fulmer James
- Gadkari Milind
- Gadkari Milind
- Galinier Michel
- Galinier Michel
- Garcia Magali
- Garcia Magali
- Geiss Ernst
- Geiss Ernst
- Gheorghiade Mihai
- Giannetti Nadia
- Giannetti Nadia
- Gimpelewicz Claudio R.
- Goette Andreas
- Goette Andreas
- Goloschekin Boris
- Goloschekin Boris
- Goncalvesova Eva
- Goncalvesova Eva
- Gonzalez Juanatey Jose Ramon
- Gonzalez Juanatey Jose Ramon
- Gordeev Ivan
- Gordeev Ivan
- Gordienko Alexander
- Gordienko Alexander
- Gosse Philippe
- Gosse Philippe
- Graf Kristof
- Graf Kristof
- Graham Susan
- Graham Susan
- Greco Dott Cosimo
- Greco Dott Cosimo
- Greco Oswaldo
- Greco Oswaldo
- Greene Stephen J.
- Gregor Pavel
- Gregor Pavel
- Guerrero Rodolfo Ahuad
- Guerrero Rodolfo Ahuad
- Gunawardena D.R.
- Gunawardena D.R.
- Gupta Vishal
- Gupta Vishal
- Habet Kalim
- Habet Kalim
- Haddad Haissam
- Haddad Haissam
- Hagerman Inger
- Hagerman Inger
- Hamann Frank
- Hamann Frank
- Hambrecht Rainer
- Hambrecht Rainer
- Hasbani Eduardo
- Hasbani Eduardo
- Hazelrigg Monica
- Hazelrigg Monica
- Heilman Karl
- Heilman Karl
- Heitzer Thomas
- Heitzer Thomas
- Hengstenberg Christian
- Hengstenberg Christian
- Henry Philippe
- Henry Philippe
- Herczeg Bela
- Herczeg Bela
- Hiremath Jagdish
- Hiremath Jagdish
- Hoffmann Stefan
- Hoffmann Stefan
- Hojerova Silvia
- Hojerova Silvia
- Hominal Miguel
- Hominal Miguel
- Hoppe Uta
- Hoppe Uta
- Hradec Jaromir
- Hradec Jaromir
- Hua Tsushung A.
- Hutyra Martin
- Hutyra Martin
- Huynh Thao
- Huynh Thao
- Ibañez Julio
- Ibañez Julio
- Isnard Richard
- Isnard Richard
- Izzo Joseph L.
- Izzo Joseph L.
- Jankowski Piotr
- Jankowski Piotr
- Jansky Petr
- Jansky Petr
- Jaramillo Mónica
- Jaramillo Mónica
- Joseph Susan
- Joseph Susan
- Jourdain Patrick
- Jourdain Patrick
- Juneman Elizabeth
- Juneman Elizabeth
- Kaeaeb Stefan
- Kaeaeb Stefan
- Karpov Yurii
- Karpov Yurii
- Kasperova Viera
- Kasperova Viera
- Katz Amos
- Katz Amos
- Katz Richard
- Katz Richard
- Keren Andre
- Keren Andre
- Kettner Jiri
- Kettner Jiri
- Khan Aziz
- Khan Aziz
- Kislyak Oxana
- Kislyak Oxana
- Kisters Klaus
- Kisters Klaus
- Klapholz Marc
- Klapholz Marc
- Kleinrok Andrzej
- Kleinrok Andrzej
- Knebel Fabian
- Knebel Fabian
- Kornacewicz-Jac Zdzislawa
- Kornacewicz-Jac Zdzislawa
- Kostenko Victor
- Kostenko Victor
- Kovar Frantisek
- Kovar Frantisek
- Krauze-Wielicka Magdalena
- Krauze-Wielicka Magdalena
- Kruells-Muench Juergen
- Kruells-Muench Juergen
- Kuchmin Alexey
- Kuchmin Alexey
- Kumbla Makund
- Kumbla Makund
- Kuo Chi-Tai
- Kuo Chi-Tai
- Kuo Jen-Yuan
- Kuo Jen-Yuan
- Kycina Peter
- Kycina Peter
- Lai Wen-Ter
- Lai Wen-Ter
- Lama Manuel Geraldia
- Lama Manuel Geraldia
- Le Tan Ju
- Le Tan Ju
- Lembo Giuseppe
- Lembo Giuseppe
- Lesogor Anastasia
- Leutermann-Oei Marie-Louise
- Leutermann-Oei Marie-Louise
- Lewis Basil
- Lewis Basil
- Lewis Eldrin F.
- Lippolis Nicholas
- Lippolis Nicholas
- Livarek Bernard
- Livarek Bernard
- Lopez Alejandro
- Lopez Alejandro
- Lopez Mónica
- Lopez Mónica
- Lueders Stephan
- Lueders Stephan
- Luna Alejandra
- Luna Alejandra
- Lundbye Justin
- Lundbye Justin
- Lupkovics Geza
- Lupkovics Geza
- Luquez Hugo
- Luquez Hugo
- Maggioni Aldo P.
- Mahajan Vijay
- Mahajan Vijay
- Maniyal Vijayakukmar
- Maniyal Vijayakukmar
- Manlutac Benjamin
- Manlutac Benjamin
- Marechal Patrick
- Marechal Patrick
- Marino Roberto Luis
- Marino Roberto Luis
- Marmor Alon
- Marmor Alon
- Marquez Lilia Lobo
- Marquez Lilia Lobo
- Martsevich Sergey
- Martsevich Sergey
- Masini Dott Franco
- Masini Dott Franco
- Mathur Atul
- Mathur Atul
- Matoltsy Andras
- Matoltsy Andras
- Mazurek Walentyna
- Mazurek Walentyna
- Mendoza Fernan
- Mendoza Fernan
- Metra Marco
- Metra Marco
- Meymandi Sheba
- Meymandi Sheba
- Milesi Rodolfo
- Milesi Rodolfo
- Militaru Constantin
- Militaru Constantin
- Miriuka Santiago
- Miriuka Santiago
- Mitrovic Veselin
- Mitrovic Veselin
- Mody Freny
- Mody Freny
- Moe Gordon
- Moe Gordon
- Moiseev Valentin
- Moiseev Valentin
- Monhart Zdenek
- Monhart Zdenek
- Mortara Andrea
- Mortara Andrea
- Murali Srinivas
- Murali Srinivas
- Muth Gerhard
- Muth Gerhard
- Najjar Samer
- Najjar Samer
- Nanjappa Manjunath
- Nanjappa Manjunath
- Neuder Yannick
- Neuder Yannick
- Neuenschwande Fernando
- Neuenschwande Fernando
- Nienaber Christoph
- Nienaber Christoph
- Nikolaidis Lazaros
- Nikolaidis Lazaros
- Novikova Nina
- Novikova Nina
- Nowalany-Kozie Ewa
- Nowalany-Kozie Ewa
- Nyman Kai
- Nyman Kai
- Olbrich Hans-Georg
- Olbrich Hans-Georg
- Oliveira Mucio
- Oliveira Mucio
- Omary Muhamad
- Omary Muhamad
- Ong Hean Yee
- Ong Hean Yee
- Oren Ron
- Oren Ron
- Orlikova Olga
- Orlikova Olga
- Pajari Risto
- Pajari Risto
- Pajes Giuseppe
- Pajes Giuseppe
- Pakhomova Inna
- Pakhomova Inna
- Palinkas Attila
- Palinkas Attila
- Parish David
- Parish David
- Patki Nitin
- Patki Nitin
- Peberdy Mary Ann
- Peberdy Mary Ann
- Percoco Dott Giovanni
- Percoco Dott Giovanni
- Perlman Richard
- Perlman Richard
- Perna Eduardo
- Perna Eduardo
- Peterka Martin
- Peterka Martin
- Peura Jennifer
- Peura Jennifer
- Phillips Roland
- Phillips Roland
- Picard François
- Picard François
- Pietilä Mikko
- Pietilä Mikko
- Pinna Jorge Garcia
- Pinna Jorge Garcia
- Piovaccari Giancarlo
- Piovaccari Giancarlo
- Pirelli Salvatore
- Pirelli Salvatore
- Poliacik Pavol
- Poliacik Pavol
- Poy Carlos
- Poy Carlos
- Premchand Rajendra
- Premchand Rajendra
- Prondzinsky Roland
- Prondzinsky Roland
- Quintero Adalberto
- Quintero Adalberto
- Ramos Silvina
- Ramos Silvina
- Ravikishore A.G.
- Ravikishore A.G.
- Reddy P. Naveen
- Reddy P. Naveen
- Reichert Petr
- Reichert Petr
- Reis Gilmar
- Reis Gilmar
- Remppis Bjoern
- Remppis Bjoern
- Roehnisch Jens-Uwe
- Roehnisch Jens-Uwe
- Romanowski Witold
- Romanowski Witold
- Rosocha Stefan
- Rosocha Stefan
- Rossol Siegbert
- Rossol Siegbert
- Rotter Achim
- Rotter Achim
- Santini Alberto
- Santini Alberto
- Santosh M.J.
- Santosh M.J.
- Saraiva Jose
- Saraiva Jose
- Schaufelberger Maria
- Schaufelberger Maria
- Schellong Sebastian
- Schellong Sebastian
- Schwinger Robert
- Schwinger Robert
- Schygiel Pablo
- Schygiel Pablo
- Selles Manuel Martinez
- Selles Manuel Martinez
- Severi Silvia
- Severi Silvia
- Sheppard Richard
- Sheppard Richard
- Shochat Michael
- Shochat Michael
- Shogenov Zaur
- Shogenov Zaur
- Shvarts Yury
- Shvarts Yury
- Simanenkov Vladimir
- Simanenkov Vladimir
- Sirotiakova Jana
- Sirotiakova Jana
- Sitnikova Maria
- Sitnikova Maria
- Skalina Ivan
- Skalina Ivan
- Smolders Walter
- Smolders Walter
- Solar Miroslav
- Solar Miroslav
- Solomon Scott D.
- Soriano FranciscoRidocci
- Soriano FranciscoRidocci
- Sosa Carlos
- Sosa Carlos
- Spinar Jindrich
- Spinar Jindrich
- Stancak Branislav
- Stancak Branislav
- Stawowy Philipp
- Stawowy Philipp
- Stewart Robert
- Stewart Robert
- Striekwold Harry
- Striekwold Harry
- Sussex Bruce
- Sussex Bruce
- Szachniewicz Joanna
- Szachniewicz Joanna
- Szelemej Roman
- Szelemej Roman
- Szentivanyi Miroslav
- Szentivanyi Miroslav
- Tebbe Ulrich
- Tebbe Ulrich
- Tereschenko Sergey
- Tereschenko Sergey
- Tomcsanyi Janos
- Tomcsanyi Janos
- Torres Adriana
- Torres Adriana
- Toth Kalman
- Toth Kalman
- Toth Peter
- Toth Peter
- Tranquilino Francisco P.
- Tranquilino Francisco P.
- Tyrenko Vadim
- Tyrenko Vadim
- Tyurina Tatiana
- Tyurina Tatiana
- Ullman Bengt
- Ullman Bengt
- Ural Dilek
- Ural Dilek
- Vandekerckhove Hans
- Vandekerckhove Hans
- Vanhaecke Johan
- Vanhaecke Johan
- Vassanelli Corrado
- Vassanelli Corrado
- Vertes Andras
- Vertes Andras
- Vervoort Geert
- Vervoort Geert
- Vicho Raul
- Vicho Raul
- Vico Marisa
- Vico Marisa
- Viecca Maurizio
- Viecca Maurizio
- Vintila Marius
- Vintila Marius
- Visconti Luigi Oltrona
- Visconti Luigi Oltrona
- Vishnevsky Alexandr
- Vishnevsky Alexandr
- Vita Nestor
- Vita Nestor
- Vladoianu Mircea
- Vladoianu Mircea
- Volpe Massimo
- Volpe Massimo
- von Scheidt Wolfgang
- von Scheidt Wolfgang
- Vrolix Mathias
- Vrolix Mathias
- Werner Dierk
- Werner Dierk
- Werner Nikos
- Werner Nikos
- Wexler Dov
- Wexler Dov
- Wierzchowiecki Jerzy
- Wierzchowiecki Jerzy
- Williams Celeste
- Williams Celeste
- Winterton John
- Winterton John
- Wong Raymond
- Wong Raymond
- Wysokinski Andrzej
- Wysokinski Andrzej
- Yigit Zerrin
- Yigit Zerrin
- Yilmaz Mehmet
- Yilmaz Mehmet
- Yokusoglu Mehmet
- Yokusoglu Mehmet
- Yu Wen-Chung
- Yu Wen-Chung
- Zacà Valerio
- Zacà Valerio
- Zadionchenko Vladimir
- Zadionchenko Vladimir
- Zamolyi Karoly
- Zamolyi Karoly
- Zannad Faiez
- Zolty Ronald
- Zolty Ronald
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Aims The objective of the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) was to determine whether aliskiren, a direct renin inhibitor, would improve post-discharge outcomes in patients with hospitalization for heart failure (HHF) with reduced ejection fraction. Pre-specified subgroup analyses suggested potential heterogeneity in post-discharge outcomes with aliskiren in patients with and without baseline diabetes mellitus (DM). Methods and results ASTRONAUT included 953 patients without DM (aliskiren 489; placebo 464) and 662 patients with DM (aliskiren 319; placebo 343) (as reported by study investigators). Study endpoints included the first occurrence of cardiovascular death or HHF within 6 and 12 months, all-cause death within 6 and 12 months, and change from baseline in N-terminal pro-B-type natriuretic peptide (NT-proBNP) at 1, 6, and 12 months. Data regarding risk of hyperkalaemia, renal impairment, and hypotension, and changes in additional serum biomarkers were collected. The effect of aliskiren on cardiovascular death or HHF within 6 months (primary endpoint) did not significantly differ by baseline DM status (P = 0.08 for interaction), but reached statistical significance at 12 months (non-DM: HR: 0.80, 95% CI: 0.64-0.99; DM: HR: 1.16, 95% CI: 0.91-1.47; P = 0.03 for interaction). Risk of 12-month all-cause death with aliskiren significantly differed by the presence of baseline DM (non-DM: HR: 0.69, 95% CI: 0.50-0.94; DM: HR: 1.64, 95% CI: 1.15-2.33; P < 0.01 for interaction). Among non-diabetics, aliskiren significantly reduced NT-proBNP through 6 months and plasma troponin I and aldosterone through 12 months, as compared to placebo. Among diabetic patients, aliskiren reduced plasma troponin I and aldosterone relative to placebo through 1 month only. There was a trend towards differing risk of post-baseline potassium ≥6 mmol/L with aliskiren by underlying DM status (non-DM: HR: 1.17, 95% CI: 0.71-1.93; DM: HR: 2.39, 95% CI: 1.30-4.42; P = 0.07 for interaction). Conclusion This pre-specified subgroup analysis from the ASTRONAUT trial generates the hypothesis that the addition of aliskiren to standard HHF therapy in non-diabetic patients is generally well-tolerated and improves post-discharge outcomes and biomarker profiles. In contrast, diabetic patients receiving aliskiren appear to have worse post-discharge outcomes. Future prospective investigations are needed to confirm potential benefits of renin inhibition in a large cohort of HHF patients without D
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
- Author
- Abdel-Rahman Emaad
- Abhayaratna Walter
- Abramof Ness Rosane
- Acosta Idalia
- Adams Atoya
- Adawi Faiad
- Adler Sharon
- Ahmed Fayzal
- Aizenberg Diego
- Ajani Dilawar
- Al-Karadsheh Amer
- Albota Adrian
- Alferi Dino
- Alicic Radica
- Alla Sreedhara
- Allison D
- Almeida Edgar
- Alpizar Salazar Melchor
- Amer Joseph
- Amod Aslam
- Andrawis Nabil
- Antonio Bossi Carlo
- Antsiferov Mikhail
- Antunes Daniela
- Araki Hideo
- Arango Clara
- Arcos Edgar
- Arif Ahmed
- Arif Imrozia
- Arkhipov Mikhail
- Armaly Zaher
- Aroca Gustavo
- Asprusten Emil
- Atar Shaul
- Avila Pardo Sandro
- Awad Ahmed
- Axthelm Christoph
- Azizad Masoud
- Azizah Aziz Nor
- B Brouwer C
- Babikova Jana
- Babkin Andrey
- Badak Ozer
- Bahrami Michael
- Bajcsi Dora
- Baker John
- Bala Cornelia
- Ballesteros Rosa
- Bansal Shweta
- Barag Steven
- Barakzoy Ahmad
- Baranov Vitaliy
- Barbarash Olga
- Barbonta Hortensia
- Barney Mark
- Barre Paul
- Barrera Sandra
- Barreto Carlos
- Barreto Germ\ue1n
- Bartolacci In\ue9s
- Bashir Khalid
- Bashkin Amir
- Bastidas Adrian Miriam
- Bautista Albert
- Bautista Jose
- Bech Jesper
- Beddhu Srinivasan
- Beltr\ue1n L\uf3pez Nelly
- Ben Chetrit Sydney
- Benitez Diego
- Benjamin Sabrina
- Berar Yanay Noa
- Berenji Ramin
- Bertram Pitt
- Bertsch John
- Besada Diego
- Bhana Sindeep
- Bhargava Anuj
- Bilz Stefan
- Birkenfeld Andreas
- Birriel Jose
- Bittar Julio
- Blanco Guillermo
- Bleich David
- Boletis Ioannis
- Bondarets Iryna
- Bonora Enzo
- Bornfreund Jonathan
- Boshnyashka Radostina
- Botelho Roberto
- Botero Rodrigo
- Botsyurko Volodymyr
- Bouarich Hanane
- Brada Michal
- Brandao Ilidio
- Brar Harjeet
- Braun Hermann
- Brezina Jiri
- Brian Susan
- Brietzke Stephen
- Brito Claudia
- Bruchfeld Annette
- Bruno Giorda Carlo
- Brusco Osvaldo
- Bu Ruifang
- Bucek Petr
- Buganova Ingrid
- Burgner Anna
- Busch Klaus
- Busch Robert
- Butrymowicz Patrycja
- C Bakker R
- C\ue1rdenas Tatiana
- Caceaune Elena
- Cai Hanqing
- Calabr\uf2 Paolo
- Calero Francesca
- Canadas Rafael
- Canani Luis
- Caramori Maria
- Cardona Jose
- Cariou Bertrand
- Carlo Maggi Davide
- Carlos Palma Juan
- Carlos Prieto Juan
- Carlson Brian
- Carpio Jose
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- Case Christopher
- Castro Cristina
- Catindig Elizabeth
- Catrinoiu Doina
- Cayli Murat
- Cereto Castro Fernando
- Cerqueira Maria
- Chahin Mariano
- Chang Chiz-Tzung
- Chantrel Fran\ue7ois
- Chen Dejun
- Chen Nan
- Chen Qinkai
- Cheng Jinluo
- Chernikova Viktoriia
- Chernin Gil
- Chernyavskaya Elena
- Chew Wong Alfredo
- Christina Nowack
- Chuang Lee-Ming
- Chung ChoonHee
- Ciechanowski Kazimierz
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- Cigarr\ue1n Guldris Secundino
- Cimino Roberto
- Clavel Sylvaine
- Clodi Martin
- Cobos Jorge
- Colman Peter
- Colquhoun David
- Constantin Ciprian
- Contzen Christel
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- Cruz Humberto
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- Darawsha Mahmud
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- Derwahl Karl
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- Tran Tuan-Huy
- Treger Richard
- Trevisan Roberto
- Trokis J
- Troya Maribel
- Trujillo Freddy
- Trullenque Gretel
- Tsch\uf6pe Diethelm
- Tsoukas George
- Tsunematsu Izumi
- Tu Shih-Te
- Turcu Liana
- Turk Thomas
- Tytus Richard
- Ujihara Makoto
- Ukhanova Olga
- Ulmer Achim
- Umpierrez Guillermo
- Urbach Daniel
- Urbach Dorothea
- Urbanaviciene Egle
- Urbonas Gediminas
- Urina Miguel
- Ustundag Sedat
- Vacaru Georgeta
- Valdes Martin
- Valdez Ortiz Rafael
- Valika Shujauddin
- Vallejos Augusto
- van Buren M
- van den Born Bert-Jan
- van der Giet Markus
- VAN Gaal Luc
- VAN Hoang Lam
- van Zyl Louis
- Vanbelleghem Hilde
- Vandeleur James
- Varleta Paola
- Vasas Szilard
- Vasconcellos Eduardo
- Vasileva Svetla
- Vega Damaris
- Velaviciene Audrone
- Vencio Sergio
- Verges Bruno
- Verlan Nadezhda
- Vi\uf1es Gloria
- Vijayaraman Arutchelvam
- Vila Lobos Ana
- Villagordoa Mesa Juan
- Villegas Iv\ue1n
- Vitou Louise
- Vlad Adrian
- Vlasenko Maryna
- Vorokhobina Natalya
- Wainstein Julio
- Wainstein Julio
- Walsh Michael
- Wan Ronald Ma Ching
- Wang Hao
- Wang Jianqin
- Wang Li
- Wang Lihua
- Wang Xinjun
- Wanner Christoph
- Wasilewska Katarzyna
- Wassermann Alfredo
- Wei Jiali
- Weisnagel Stanley
- Weissman Peter
- Whaley-Connell Adam
- Wierusz-Wysocka Bogna
- Wilderman Igor
- Winston Jonathan
- Wise Jonathan
- Wittert Gary
- Wnetrzak-Michalska Renata
- Wong Yuk-Ki
- Wu Chaoqing
- Wu Mai-Szu
- Wu Ming-Ju
- Wu Tianfeng
- Wudi Krisztina
- Wuerzner Gregoire
- Wynne Katie-Jane
- Xing Changying
- Xiong Fei
- Xu Ning
- Xu Xudong
- Yagil Yoram
- Yajima Ken
- Yakhontov Davyd
- Yale Jean-Francois
- Yamada Daishiro
- Yamada Masayo
- Yamagata Kazuo
- Yamakawa Fumiko
- Yamakawa Ken
- Yamasaki Yoshimitsu
- Yambe Yuko
- Yanai Hidekatsu
- Yang Jinkui
- Yasuda Tetsuyuki
- Yenicerioglu Yavuz
- Yeung Vincent
- Yilmaz Huseyin
- Yin Aiping
- Yoncheva-Mihaylova Mariana
- Young Park Cheol
- Yuan Lee Li
- Yupanqui Hern\ue1n
- Yuryev Michael
- Zakharova Elena
- Zalevskaya Alsu
- Zanozina Olga
- Zaoui Philippe
- Zeig Steven
- Zeng Longyi
- Zhang Hao
- Zhang Yanlin
- Zhang Ying
- Zhao Zhiquan
- Zhdanova Elena
- Zheng Hongguang
- Zhong Ling
- Zhong Liyong
- Zhu Dalong
- Zhukova Larisa
- Zilahi Zsolt
- Zsom Marianna
- Zukermann Robert
- Zykova Tatyana
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2019
- Field of study
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Measurement of Z0 decays to hadrons, and a precise determination of the number of neutrino species
- Author
- A. Aloisio
- A. Arefiev
- A. Bay
- A. Biland
- A. Böhm
- A. Chen
- A. Contin
- A. Degré
- A. Engler
- A. Gordeev
- A. Grimes
- A. Gurtu
- A. Heavey
- A. Hervé
- A. Klimentov
- A. Kuhn
- A. Kunin
- A. Malinin
- A. Marchionni
- A. Pevsner
- A. Savin
- A. Sopczak
- A. Zichichi
- A.A. Syed
- A.A. Vorobyov
- A.C. König
- A.L. Anderson
- A.M. Cartacci
- Aarnio
- Adeva
- Adeva
- Adeva
- Akrawy
- Alexander
- An.A. Vorobyov
- B. Adeva
- B. Bertucci
- B. Blumenfeld
- B. Borgia
- B. Ille
- B. Monteleoni
- B. Spiess
- B. Stöhr
- B. Wysłouch
- B.L. Betev
- B.N. Jin
- B.P. Roe
- B.Z. Yang
- Barber
- Bardin
- Bardin
- Brun
- C. Camps
- C. Chen
- C. Civinini
- C. Dionisi
- C. Goy
- C. Grinnell
- C. Jakobs
- C. Li
- C. Luci
- C. Maña
- C. Rippich
- C. Sciacca
- C. Souyri
- C. Timmermans
- C. Willmott
- C. Zabounidis
- C.F. He
- C.G. Yang
- C.H. Ye
- C.L.A. Pols
- C.R. Wang
- C.Y. Chien
- Caffo
- Cahn
- D. Antreasyan
- D. Bourilkov
- D. Boutigny
- D. Campana
- D. Goujon
- D. Güsewell
- D. Harting
- D. Kaplan
- D. Kirkby
- D. Lanske
- D. Linnhofer
- D. Luckey
- D. Pandoulas
- D. Perret-Gallix
- D. Ren
- D. Schmitz
- D. Wright
- D. Zhang
- D.H. Zhang
- D.J. Schotanus
- D.N. Mao
- D.P. Stickland
- D.S. Yan
- Decamp
- Decamp
- E. Drago
- E. Dénes
- E. Gallo
- E. Gonzalez
- E. Isiksal
- E. Jagel
- E. Longo
- E. Nagy
- E. Perrin
- E. Shumilov
- E. Tarkovsky
- E. Thomas
- E. Valente
- F. Bruyant
- F. Carbonara
- F. Carminati
- F. Cesaroni
- F. Crijns
- F. Denotaristefani
- F. Dittus
- F. Ferroni
- F. Marzano
- F. Wittgenstein
- F.C. Erné
- F.G. Hartjes
- F.J. Eppling
- F.L. Linde
- G. Alverson
- G. Chiefari
- G. Coignet
- G. Conforto
- G. Faber
- G. Fernandez
- G. Forconi
- G. Gratta
- G. Herten
- G. Hu
- G. Landi
- G. Mirabelli
- G. Morand
- G. Paternoster
- G. Rahal-Callot
- G. Sauvage
- G. Schwering
- G. Viertel
- G. Von Dardel
- G. Yang
- G.B. Mills
- G.G.G. Massaro
- G.H. Wang
- G.J. Bobbink
- G.M. Chen
- G.Q. Hu
- Glashow
- Greco
- Gy.L. Bencze
- H. Akbari
- H. Anderhub
- H. Fenker
- H. Fesefeldt
- H. Haan
- H. Hofer
- H. Newman
- H. Rykaczewski
- H. Schopper
- H. Stone
- H. Suter
- H. Van der Graaf
- H. Vogel
- H. Vogt
- H.F. Chen
- H.J. Schreiber
- H.R. Dimitrov
- H.S. Chen
- H.T. Li
- I. Clare
- I. Duran
- I. Leedom
- I. Sheer
- I. Vetlitsky
- I. Vorobiev
- I.C. Brock
- J. Alcaraz
- J. Bao
- J. Berdugo
- J. Fay
- J. Fehlmann
- J. Field
- J. Lettry
- J. Mnich
- J. Onvlee
- J. Perrier
- J. Rose
- J. Salicio
- J. Schwenke
- J. Schütte
- J. Tòth
- J. Ulbricht
- J. Weber
- J. Wenninger
- J. Zoll
- J.A. Bakken
- J.A. Rubio
- J.C. Sens
- J.D. Burger
- J.F. Li
- J.F. Zhou
- J.G. Branson
- J.H. Wang
- J.J. Blaising
- J.M. Le Goff
- J.M. Lubbers
- J.M. Qian
- J.M. Thenard
- J.M. You
- J.P. Burq
- J.P. Martin
- J.Y. Liao
- Jadach
- K. Deiters
- K. Freudenreich
- K. Hangarter
- K. Hilgers
- K. Lanius
- K. Lübelsmeyer
- K. Mazumdar
- K. Read
- K. Schultze
- K. Shmakov
- K. Strauch
- K. Sudhakar
- K.L. Tung
- K.N. Qureshi
- K.S. Yang
- Kleiss
- Kleiss
- Kleiss
- L. Antonov
- L. Baksay
- L. Barone
- L. Leistam
- L. Li
- L. Ludovici
- L. Luminari
- L. Martinez
- L. Merola
- L. Montanet
- L. Niessen
- L. Romero
- L. Urbàn
- L. Vuilleumier
- L. Zehnder
- L.S. Hsu
- L.W. Jones
- M. Aguilar-Benitez
- M. Bocciolini
- M. Bourquin
- M. Capell
- M. Cerrada
- M. Chemarin
- M. Chen
- M. Dhina
- M. Diemoz
- M. Fabre
- M. Fukushima
- M. Gailloud
- M. Gettner
- M. Glaubman
- M. Gruenewald
- M. Guanziroli
- M. Harris
- M. Hebert
- M. Macdermott
- M. Maire
- M. Maolinbay
- M. Merk
- M. Meschini
- M. Micke
- M. Napolitano
- M. Pieri
- M. Pohl
- M. Röhner
- M. Sachwitz
- M. Schneegans
- M. Schöntag
- M. Steuer
- M. Tonutti
- M. Vivargent
- M. Vollmar
- M. White
- M. Zeng
- M.G. Alviggi
- M.L. Chen
- M.M. Ilyas
- N. Colino
- N. Produit
- N. Smirnov
- O. Adriani
- O. Kornadt
- P. Bagnaia
- P. Berges
- P. Blömeke
- P. Denes
- P. Duinker
- P. Extermann
- P. Göttlicher
- P. Kaaret
- P. Le Coultre
- P. Lebrun
- P. Lecomte
- P. Lecoq
- P. Marchesini
- P. McBride
- P. Razis
- P. Schmitt
- P. Schmitz
- P. Spillantini
- P. Vikas
- P.A. Piroué
- P.F. Klok
- P.G. Seiler
- P.J. Li
- P.K. Malhotra
- P.M. Levchenko
- P.V.K.S. Baba
- Ph. Rosselet
- Q. An
- Q. Ye
- Q.F. Wang
- Q.Y. Yang
- R. Bizzarri
- R. Clare
- R. D'Alessandro
- R. Dolin
- R. Fabbretti
- R. Leiste
- R. Liu
- R. Magahiz
- R. Morand
- R. Mount
- R. Raghavan
- R. Schulte
- R. Starosta
- R. Weill
- R. Wilhelm
- R.A. Khan
- R.B. Sutton
- R.C. Ball
- R.J. Wu
- R.L. Sumner
- R.T. Van de Walle
- R.W. Kraemer
- R.Y. Zhu
- S. Banerjee
- S. Beingessner
- S. Falciano
- S. Gentile
- S. Goldfarb
- S. Hancke
- S. Kwan
- S. Lanzano
- S. Lökòs
- S. Morganti
- S. Patricelli
- S. Reucroft
- S. Rodriguez
- S. Rosier-Lees
- S. Schulte
- S. Shevchenko
- S.C. Tonwar
- S.C. Yeh
- S.J. Fan
- S.L. Wu
- S.M. Ting
- S.N. Ganguli
- S.S. Gau
- S.X. Wu
- S.Y. Zhang
- Salam
- Samuel C.C. Ting
- Sjöstrand
- Sjöstrand
- T. Angelov
- T. Azemoon
- T. Aziz
- T. Böhringer
- T. Driever
- T. Ferguson
- T. Foreman
- T. Hebbeker
- T. Kramer
- T. Matsuda
- T. Riemann
- T. Spickermann
- T.J. Wenaus
- T.S. Dai
- Th. Meinholz
- Th. Rombach
- U. Becker
- U. Herten
- U. Micke
- U. Uwer
- U.K. Chaturvedi
- V. Commichau
- V. Innocente
- V. Khoze
- V. Koutsenko
- V. Kumar
- V. Lalieu
- V. Morgunov
- V. Plyaskin
- V. Pojidaev
- V. Schegelsky
- V. Shevchenko
- V. Shoutko
- V.P. Andreev
- V.R. Krastev
- W. Böhlen
- W. Friebel
- W. Kittel
- W. Krenz
- W. Lohmann
- W. Ruckstuhl
- W. Walk
- W. Wallraff
- W.D. Nowak
- W.G. Ma
- W.J. Metzger
- Weinberg
- X. Leytens
- X. Lue
- X.D. Cai
- X.G. Li
- X.L. Wang
- X.R. Shi
- X.W. Tang
- X.Y. Cui
- Y. Karyotakis
- Y. Liu
- Y. Mi
- Y. Mir
- Y. Peng
- Y. Zeng
- Y.F. Mao
- Y.F. Wang
- Y.G. Wu
- Y.H. Chang
- Y.J. Pei
- Y.P. Tong
- Y.S. Lu
- Yu. Galaktionov
- Yu. Kamyshkov
- Z. Ren
- Z.F. Gong
- Z.L. Xue
- Z.M. Wang
- Z.P. Zhang
- Z.Q. Yang
- Z.W. Yin
- Z.Y. Lin
- Z.Z. Xu
- Publication venue
- 'Elsevier BV'
- Publication date
- 24/12/1989
- Field of study
We have made a precise measurement of the cross section for e+e--->Z0-->hadrons with the L3 detector at LEP, covering the range from 88.28 to 95.04 GeV. From a fit to the Z0 mass, total width, and the hadronic cross section to be MZ0=91.160 +/- 0.024 (experiment) +/-0.030(LEP) GeV, [Gamma]Z0=2.539+/-0.054 GeV, and [sigma]h(MZ0)=29.5+/-0.7 nb. We also used the fit to the Z0 peak cross section and the width todetermine [Gamma]invisible=0.548+/-0.029 GeV, which corresponds to 3.29+/-0.17 species of light neutrinos. The possibility of four or more neutrino flavors is thus ruled out at the 4[sigma] confidence level.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28683/3/0000500.pd
ATLAS detector and physics performance: Technical Design Report, 1
- Author
- Abdinov O.B.
- Abolins M.
- Abramowicz H.
- Acerbi E.
- Ackermann K.
- Ackers M.
- Aderholz M.
- Ahlen S.
- Aielli G.
- Airapetian A.
- Akerman D.
- Akesson T.
- Akhmedov A.
- Akhoundov A.
- Akimov A.
- Alam S.
- Aleksa M.
- Aleppo M.
- Alessandria F.
- Alexa C.
- Alexander G.
- Alexandrov I.
- Alexeev G.
- Alforque S.
- Alikov B.
- Allport P.P.
- Almehed S.
- Aloisio A.
- Alviggi M.G.
- Amadon A.
- Amako K.
- Amaral P.
- Ambrosini G.
- Amelin D.V.
- Ammosov V.V.
- Amorim A.
- Anderson B.
- Anderson K.
- Anderssen E.
- Andre F.
- Andreazza A.
- Andricek L.
- Andrieux M.L.
- Anghinolfi F.
- Anosov V.
- Antipov Yu.M.
- Apsimon R.J.
- Arai Y.
- Arik E.
- Armitage J.
- Armstrong W.W.
- Arnaud C.
- Arnault C.
- Arsenescu R.
- Artamonov A.
- Asai M.
- Assamagan K.A.
- Astbury A.
- Astesan F.
- Astvatsaturov A.
- Atag A.
- Athar B.
- Attree D.
- Aubert B.
- Auge E.
- Axen D.
- Ayad R.
- Azhgirei L.
- Azuelos G.
- Bacci C.
- Bachy G.
- Backovic S.
- Badescu E.
- Baer Th.
- Bagnaia P.
- Bailey D.C.
- Baines J.T.
- Baker O.K.
- Ball R.
- Ballester F.
- Ban J.
- Baranov S.
- Baranov S.
- Baranov S.
- Barberio E.
- Barberis D.
- Barnett M.
- Baroncelli A.
- Barrand G.
- Barratt R.
- Barreiro F.
- Bashindjagian G.L.
- Basiladze S.G.
- Batarin V.
- Batley J.R.
- Batrakov A.
- Battistoni G.
- Baturitsky M.A.
- Bauer F.
- Baynham D.E.
- Beaugiraud B.
- Beccherle R.
- Beck G.A.
- Beck H.P.
- Becks K.H.
- Bee C.
- Behrends S.
- Bella G.
- Bellerive A.
- Belorgey J.
- Belot G.
- Belov M.
- Benary O.
- Beney J.L.
- Benincasa G.
- Bensinger J.R.
- Berejnoi A.
- Berger E.L.
- Berglund S.
- Bergsma F.
- Bernabeu J.
- Berriaud C.
- Berthier R.
- Bertinelli F.
- Bertoli W.
- Bhadra S.
- Billat C.
- Bilokon H.
- Bingefors N.
- Bini C.
- Bintinger D.
- Birney P.
- Biscarat C.
- Bjorset L.
- Blagov M.
- Blair G.A.
- Blair R.
- Blanch O.
- Blanchot G.
- Blanquart L.
- Blaquiere M.
- Blocker C.
- Blocki J.
- Bloess D.
- Blucher E.
- Blum W.
- Bobbink G.J.
- Bocian D.
- Bock R.
- Bogaerts J.
- Bogoliubsky M.Yu.
- Bogush A.A.
- Bohm C.
- Bohm J.
- Boldea V.
- Bondarenko V.
- Boniface J.
- Bonino R.
- Bonivento W.
- Boosten M.
- Booth C.N.
- Booth P.S.L.
- Borer K.
- Borgeaud P.
- Borissov A.A.
- Borissov E.
- Bos K.
- Bosman M.
- Boterenbrood H.
- Botner O.
- Botterill D.R.
- Bourdarios C.
- Bouzakis C.
- Boyd R.
- Boyko I.
- Boyle O.
- Bozko N.I.
- Brandenburg G.
- Bratzler U.
- Braun H.
- Bremer J.
- Brenner R.
- Breskin A.
- Breton D.
- Brettel H.
- Breugnon P.
- Bright-Thomas P.
- Brock R.
- Brodbeck T.J.
- Broggi F.
- Bromberg C.
- Brouwer C.
- Bruncko D.
- Bryzgalov V.V.
- Budagov J.
- Bugge L.
- Buira-Clarke D.
- Buis E.J.
- Buran T.
- Burckhart D.
- Burckhart H.J.
- Burnett T.H.
- Burris W.
- Butin F.
- Buttar C.M.
- Butterworth J.
- Bystricky J.
- Bystrom O.
- Cacaut D.
- Caccia M.
- Cailles M.
- Cakir O.
- Callahan J.
- Caloba L.P.
- Caloi R.
- Calvet D.
- Calvet D.
- Camarena F.
- Camarri P.
- Cambiaghi M.
- Camin D.
- Campabadal F.
- Campbell M.
- Candlin D.J.
- Candlin E.R.S.
- Canton B.
- Caprini I.
- Caprini M.
- Capua M.
- Cardarelli R.
- Cardini A.
- Carling H.
- Carlson P.
- Carrasco R.
- Carroll L.J.
- Carter A.A.
- Carter J.R.
- Cartiglia N.
- Carvalho J.
- Casarejos E.
- Cashmore R.
- Caso C.
- Castillo M.V.
- Cataneo F.
- Cauz D.
- Cavallari A.
- Cavalli D.
- Cavalli-Sforza M.
- Cavasinni V.
- Celik O.
- Ceradini F.
- Cerutti F.
- Cetin S.A.
- Cevenini F.
- Chadelas R.
- Chakir H.
- Chalifour M.
- Chapman J.W.
- Charalambous A.
- Chardalas M.
- Charlton D.G.
- Chechik R.
- Chekhtman A.
- Chekulaev S.V.
- Chelkov G.
- Chen C.
- Chen J.
- Chen T-Y.
- Cheng S.
- Cheplakov A.
- Cherkaoui R.
- Chesi E.
- Cheu E.
- Chevalier L.
- Chevalley J.L.
- Chiarella V.
- Chiefari G.
- Chikovani L.
- Chiladze B.
- Chilingarov A.
- Chirikov-Zorin I.
- Chlachidze G.
- Chochula P.
- Chollet C.
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- Chytracek R.
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- Ciocio A.
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- Cologna S.
- Combley F.H.
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- Conka T.
- Constantin F.
- Constantinescu S.
- Conta C.
- Cook V.
- Cooke P.A.
- Costa G.
- Costa M.J.
- Costanzo D.
- Coulon J-P.
- Couyoumtzelis C.
- Cranfield R.
- Crespo J.M.
- Creti P.
- Crijns F.J.G.H.
- Crone G.
- Cros Ph.
- Crouau M.
- Cunitz H.
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- Dabrowski W.
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- Dael A.
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- Publication venue
- Union of Concerned Scientists
- Publication date
- 01/01/1999
- Field of study
Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abdullkutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adamo A
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Agnetti V
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alexopoulos D
- Alings M
- Alonso Martin JJ
- Alonso Orcajo N
- Alsweiler C
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Anchante Hernandez HA
- Andersen D
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arbel Y
- Arif I
- Armaganijan L
- Aroney C
- Arroyo JAC
- Arstall MA
- Asanin MR
- Atar S
- Athyros V
- Auguadro C
- Aylward P
- Aylward PE
- Aylward PE
- Azizad MM
- Badreddine E
- Bagai A
- Bagriy A
- Bahit MC
- Bai F
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- Baldari D
- Balinovac J
- Ball E
- Bang LE
- Banuru S
- Barakovic F
- Baranov E
- Baranova E
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- Barbato E
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- Barone-Rochette G
- Barr C
- Barraud P
- Barrucco R
- Bartels GL
- Bashir R
- Basson MMDV
- Bastos JM
- Bata I
- Batushkin V
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- Bayram Llamas EA
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- Zweiker R
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 04/01/2019
- Field of study
Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
Spatial distribution, host specificity and genetic diversity of Onchobothrium antarcticum in the Southern Ocean
- Publication venue
- Polska Akademia Nauk. Czytelnia Czasopism PAN
- Publication date
- 01/01/2021
- Field of study
Planar arrangement of eukaryotic cells in merged hydrogels combines the advantages of 3-D and 2-D cultures
- Publication venue
- 'Future Science Ltd'
- Publication date
- Field of study
IMPROVING THE EFFICIENCYOF NATIONAL STUDENT COMPETITION
- Author
- Publication venue
- 'Moscow Polytechnic University'
- Publication date
- 01/12/2016
- Field of study
The article considers the new ways and methods for improving the efficiency of national student contests and Olympiads as a tool for identifying and supporting young talents. The authors suggest a new approach to the organization of the Olympiad movement including such principles as the limitation of the state’s role (it should be only a general initiator and supporter), segmentation of contest types, determination of contestants’ level, finding the optimal combinationbetween of the system’s stability and its capability to develop
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