Floquetifying the Colour Code

Floquet codes are a recently discovered type of quantum error correction code. They can be thought of as generalising stabilizer codes and subsystem codes, by allowing the logical Pauli operators of the code to vary dynamically over time. In this work, we use the ZX-calculus to create new Floquet codes that are in a definable sense equivalent to known stabilizer codes. In particular, we find a Floquet code that is equivalent to the colour code, but has the advantage that all measurements required to implement it are of weight one or two. Notably, the qubits can even be laid out on a square lattice. This circumvents current difficulties with implementing the colour code fault-tolerantly, while preserving its advantages over other well-studied codes, and could furthermore allow one to benefit from extra features exclusive to Floquet codes. On a higher level, as in arXiv:2303.08829, this work shines a light on the relationship between 'static' stabilizer and subsystem codes and 'dynamic' Floquet codes; at first glance the latter seems a significant generalisation of the former, but in the case of the codes that we find here, the difference is essentially just a few basic ZX-diagram deformations.Comment: 15 + 24 pages, 18 figures. Comments encouraged - email address in paper

Primeiro relato de Dactylonectria novozelandica causando necrose de raiz e coroa em morangos no Uruguay

Since 2015, a high mortality rate of strawberry plants has been observed in the north of Uruguay related to crown and root diseases caused by a pathogens complex. In 2016, associated with the death of plants, Cylindrocarpon spp. was isolated with a frequency of 42.4 %, ranking third, preceded by Neopestalotiopsis sp. and Fusarium spp. Aiming to increase the knowledge of the pathogens that integrate the complex, three isolates of Cylindrocarpon spp. were characterized by molecular, morphological and pathogenicity analyses in strawberry plants. Dactylonectria novozelandica was identified as causal agent of crown and root necrosis of strawberry in Salto, Uruguay.Desde 2015, se observó una alta mortandad de plantas de frutilla en el norte de Uruguay relacionada con enfermedades de corona y raíz causadas por un complejo de patógenos. En 2016, asociado con la muerte de plantas, Cylindrocarpon spp. se aisló con una frecuencia de 42,4 %, ocupando el tercer lugar, precedido por Neopestalotiopsis sp. y Fusarium spp. Con el objetivo de incrementar el conocimiento de los patógenos que integran el complejo, se caracterizaron tres aislados de Cylindrocarpon spp. mediante análisis moleculares, morfológicos y de patogenicidad en plantas de frutilla. Se identificó Dactylonectria novozelandica como agente causal de necrosis de corona y raíz de frutilla en Salto, Uruguay.A partir do ano 2015 um número significativo de mortes se observou em plantas de morango no norte do Uruguai devido a doenças da coroa e raiz causadas por um complexo de patógenos. Associado à morte, Cylindrocarpon spp foi isolado com uma frequência de 42,4% no 2016, ocupando o terceiro lugar de incidência depois de Neopestalotiopsis sp. e Fusarium spp. O objetivo do trabalho foi caracterizar três isolados de Cylindrocarpon spp por meio de análises moleculares, morfológicas e patogênicas em morangueiro. Dactylonectria novozelandica causou necorsis de cora e raiz em uma plantas de morango em Salto, Uruguai

Gain-Reconfigurable Hybrid Metal-Graphene Printed Yagi Antenna for Energy Harvesting Applications

This paper presents a hybrid metal-graphene printed Yagi antenna with reconfigurable gain that operates in the 5.5-GHz band. The balun and the driven elements are made of copper, while the directors are made of graphene. The graphene acts as a tunable material in the design. By switching the conductivity of the graphene, it is achieved a similar effect to adding or subtracting directors in the antenna. Hence the gain of the printed Yagi can be easily controlled. This could be of special interest in RF energy harvesting in the design of reconfigurable harvesting elements.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Determining Group Structure from Sets of Irreducible Character Degrees

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an uncommon heritable disease presenting with syncope or sudden cardiac death. Two genes involved in calcium homeostasis, the ryanodine receptor gene and the calsequestrin 2 (CASQ2) gene, have been implicated in this disease. We describe a young man presenting with exercise-induced syncope, clinically diagnosed as CPVT. Genetic analysis revealed two mutations, p.Y55C (C.164A>G) and p.P308L (c.923C>T), in the CASQ2 gene. Subsequent familial analysis indicates a compound heterozygous form of inheritance. (PACE 2008; 31:916-919). © 2008, The Authors. Journal compilation © 2008, Blackwell Publishing, Inc

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor

ACKNOWLEDGEMENTS We thank J. M. Valverde (IRB) as well as the NMR facilities of the University of Barcelona (CCiT UB) and the Instituto de Química Física Rocasolano (IQFR, CSIC) for their assistance in, respectively, protein production and NMR. This work was supported by IRB, ICREA (X.S.), Obra Social “la Caixa” (Fellowship to E.D.M. and CancerTec grants to X.S.) MICINN (CTQ2009-08850 to X.S.), MINECO (BIO2012-31043 to X.S.; CTQ2014-56361-P to A.R), Marató de TV3 (102030 to X.S. and 102031 to E.E.P) the COFUND programme of the European Commission (C.T.W.P., A. R. and X.S.), the European Research Council (CONCERT, contract number 648201, to X.S.), the Ramón y Cajal program of MICINN (RYC-2011-07873 to C.W.B.) the Serra Hunter Programme (E.E.P.) and AGAUR (SGR-2014-56RR14 to E.E.P). IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from MINECO (Government of Spain)Peer reviewedPostprin

Efficient stereoselective synthesis of 2-acetamido-1,2- dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme

Due to their capacity to inhibit hexosaminidases, 2-acetamido-1,2-dideoxy-iminosugars have been widely studied as potential therapeutic agents for various diseases. An efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc), the most potent inhibitor of human placenta b-Nacetylglucosaminidase (b-hexosaminidase) among the epimeric series, is here described. This novel procedure can be easily scaled up, providing enough material for structural modifications and further biological tests. Thus, two series of sp2-iminosugar conjugates derived from DAJNAc have been prepared, namely monocyclic DAJNAc-thioureas and bicyclic 2-iminothiazolidines, and their glycosidase inhibitory activity evaluated. The data evidence the utmost importance of developing diversity-oriented synthetic strategies allowing optimization of electrostatic and hydrophobic interactions to achieve high inhibitory potencies and selectivities among isoenzymes. Notably, strong differences in the inhibition potency of the compounds towards b-hexosaminidase from human placenta (mature) or cultured fibroblasts (precursor form) were encountered. The ensemble of data suggests that the ratio between them, and not the inhibition potency towards the placenta enzyme, is a good indication of the chaperoning potential of TaySachs disease-associated mutant hexosaminidasePeer reviewe

Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors

2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic potential for the treatment of various diseases, including several lysosomal storage disorders. A stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc), the iminosugar analog of N-acetylglucosamine, with a high overall yield is here described. This novel procedure further allowed accessing ureido-DNJNAc conjugates through derivatization of the endocyclic amine on a key pivotal intermediate. Remarkably, some of the ureido-DNJNAc representatives behaved as potent and selective inhibitors of β-hexosaminidases, including the human enzyme, being the first examples of neutral sp2-iminosugar-type inhibitors reported for these enzymes. Moreover, the amphiphilic character of the new ureido-DNJNAc is expected to confer better drug-like properties.Ministerio de Economía y Competitividad CTQ2011-23620, SAF2013-44021R y CTQ2010-15848Generalitat de Catalunya 2014SGR 234Junta de Andalucía FQM-146

Analysis of the interaction between tryptophan-related compounds and ATP-binding cassette transporter G2 (ABCG2) using targeted metabolomics

ATP-binding cassette transporter G2 (ABCG2) is involved in the secretion of several compounds in milk. The in vitro and in vivo interactions between tryptophan-related compounds and ABCG2 were investigated. The tryptophan metabolome was determined by liquid chromatography-tandem mass spectrometry in milk and plasma from wild-type and Abcg2-/- mice as well as dairy cows carrying the ABCG2 Y581S polymorphism (Y/S) and noncarrier animals (Y/Y). The milk-to-plasma ratios of tryptophan, kynurenic acid, kynurenine, anthranilic acid, and xanthurenic acid were higher in wild-type mice than in Abcg2-/- mice. The ratio was 2-fold higher in Y/S than in Y/Y cows for kynurenine. In vitro transport assays confirmed that some of these compounds were in vitro substrates of the transporter and validated the differences observed between the two variants of the bovine protein. These findings show that the secretion of metabolites belonging to the kynurenine pathway into milk is mediated by ABCG2.SIThis study was supported by the research projects AGL2015-65626-R (MINECO/FEDER, UE) and RTI2018-100903-B-I00 (AEI/FEDER, UE), predoctoral grants from the Ministry of Economy, Industry, and Competitiveness (BES-2016-077235 grant to AMGL), and grants from the Spanish Ministry of Education, Culture, and Sport (FPU14/05131 grant to DGM). Funding was also obtained from a research contract for OJP from the Spanish Health Institute Carlos III (CPII16/00027

Elaboracion de una estrategia Customer Relationship Management (CRM) para Multicentro Ltda

171 p.El estudio que se realizó a Comercial Multicentro Ltda. tuvo como objetivo analizar la base de datos entregada por la empresa con la finalidad de elaborar una estrategia de Administración de Relaciones con los Clientes. Se dió inicio con la revisión bibliográfica la que se enfocó a estudiar las nuevas herramientas del marketing, comenzando con el Marketing Relacional y el surgimiento de herramientas del marketing, comenzando con el Marketing Relacional y el surgimiento de mantener relaciones perdurables en el tiempo con los clientes. La metodología utilizada en el estudio se basó en un análisis secundario descriptivo de una base de datos, con la finalidad de encontrar variables claves del comportamiento de los clientes de comercial Multicentro Talca. Los datos fueron analizados con la ayuda del software estadístico SPSS 15.0. El resultado del análisis permitió encontrar las principales características del cliente de Comercial Multicentro Ltda., lo que a posteriori sirvió para confeccionar una estrategia de Administración de Relaciones con los Clientes (CRM) al segmento C3 y D. Luego se procedió a analizar la plataforma tecnológica de Comercial Multicentro donde se diagnosticó el actual soporte tecnológico que tiene implementado. Se identificó que la empresa posee infraestructura relacionada con un avanzado data warehouse, que es esencial para poder implementar una aplicación CRM, desde donde se pueda administrar el Data Mining. Sin embargo, la empresa aun no tiene incorporado un sistema de planificación de recursos empresariales (ERP), que mantenga todos los procesos operacionales en línea, disponibles para toda la organización. Finalmente se elaboró una estrategia de CRM, de acuerdo a los resultados encontrados en el análisis de la base de datos, con la finalidad que la empresa tenga conocimiento de los beneficios que puede llegar a alcanzar con un enfoque centrado en las relaciones con el cliente