Guidelines for the monitoring of Rosalia alpina

Rosalia alpina (Linnaeus, 1758) is a large longhorn beetle (Coleoptera: Cerambycidae) which is protected by the Habitats Directive and which typically inhabits beech forests characterised by the presence of mature, dead (or moribund) and sun-exposed trees. A revision of the current knowledge on systematics, ecology and conservation of R. alpina is reported. The research was carried out as part of the LIFE MIPP project which aims to find a standard monitoring method for saproxylic beetles protected in Europe. For monitoring this species, different methods were tested and compared in two areas of the Apennines, utilising wild trees, logs and tripods (artificially built with beech woods), all potentially suitable for the reproduction of the species. Even if all methods succeeded in the survey of the target species, these results showed that the use of wild trees outperformed other methods. Indeed, the use of wild trees allowed more adults to be observed and required less intensive labour. However, monitoring the rosalia longicorn on wild trees has the main disadvantage that they can hardly be considered “standard sampling units”, as each tree may be differently attractive to adults. Our results demonstrated that the most important factors influencing the attraction of single trunks were wood volume, sun-exposure and decay stage. Based on the results obtained during the project LIFE MIPP, as well as on a literature review, a standard monitoring method for R. alpina was developed

Load bearing capability of three-units 4Y-TZP monolithic fixed dental prostheses: An innovative model for reliable testing

In this work, three-units monolithic fixed dental prostheses (FDPs) have been analysed and a novel model for reliable testing has been proposed. Such model is based on a new design of the polymeric base of the FDP, realised via additive manufacturing (AM) - a solution that conveys at the same time quick manufacturability, low cost, custom-ability, and design freedom. By means of this new model, the load-bearing capability of three-units monolithic FDPs has been thoroughly tested; in particular, three different analyses were performed: (i) analytical with a beam-like model, (ii) numerical, using non-linear three-dimensional Finite Elements (FE) models and (iii) experimental, by static bending test. The FDPs considered in this work were manufactured using a fourth-generation zirconia, namely 4Y-TZP. The findings demonstrated the undoubted advantages of the new base configuration, which minimized the effect of the base (which as a matter of fact is absent in in-vivo conditions) on the stress state of the connectors in the FDPs, and increased the repeatability and reliability of the experimental bending tests, able to determine the load bearing capability of the 4Y-TZP FDPs

A quantitative study of the interactions between oil price and renewable energy sources stock prices

In this article, we apply an integrable nonautonomous Lotka-Volterra model to study the relationship between oil and renewable energy stock prices between 2006 and 2016. The advantage of this innovative approach is that it allows us to study the simultaneous interaction among n stock indices at any point in time. In line with previous studies, we find that the relationship between oil and renewables is characterized by major structural breaks taking place in 2008 and around 2013. The first structural break might be caused by the financial crisis, whereas more studies are required to advance a hypothesis on the causes behind the second structural break. Our main finding is that oil is always in a predator-prey relationship with wind, whereas it proceeds in mutualism with solar after 2012. Moreover, we find that solar and wind proceed in mutualism between 2008 and 2013 but have a rivalrous interaction before (competition) and after (predator-prey) that period. We explore the possible reasons behind these patterns and their policy implications

Senso Comune as a Knowledge Base of Italian language: The Resource and its Development

International audienceSenso Comune is a linguistic knowledge base for the Italian Language, which accommodates the content of a legacy dictionary in a rich formal model. The model is implemented in a platform which allows a community of contributors to enrich the resource. We provide here an overview of the main project features, including the lexical-ontology model, the process of sense classification, and the annotation of meaning definitions (glosses) and lexicographic examples. Also, we will illustrate the latest work of alignment with MultiWordNet, to illustrate the methodologies that have been experimented with, to share some preliminary result, and to highlight some remarkable findings about the semantic coverage of the two resources

Um estudo de aplicação do método FMEA: pesquisa-ação em um processo de fabricação de uma empresa de grande porte do setor metal mecânico / A study in application of FMEA: action research in a manufacturing process of a large-sized company in the metalmechanic sector

As empresas atualmente enfrentam vários desafios e dificuldades. Desafios de inserção de novos produtos e dificuldades para se manterem estáveis em um mercado altamente competitivo e garantirem o sucesso empresarial. A utilização de ferramentas da qualidade para a redução de custos decorrentes da falta de qualidade pode ajudar nesta busca pelo sucesso. O objetivo deste artigo é apresentar um estudo sobre a aplicação do FMEA (Failure Mode and Effect Analysis ou Análise dos Modos e Efeito de Falhas) em um processo de fabricação, em uma empresa de grande porte do segmento metal mecânico, detalhando o processo de implantação do FMEA e o resultado alcançado. Durante o processo de desenvolvimento do FMEA, a ferramenta foi além do esperado, revelando modos de falhas em potencial, antes não documentadas e formalizadas, contribuindo com a melhoria do processo e principalmente mostrando que uma ação pode ocasionar grandes efeitos ao cliente e também ao próprio fabricante

EPURAEA DEUBELI REITTER, 1898, A CONFIRMED SAPROXYLIC SAP BEETLE FOR THE ITALIAN FAUNA (Coleoptera, Nitidulidae)

During ecological investigations on saproxylic beetle communities at Monte Baldo (Veneto, Verona province), two specimens of Epuraea deubeli Reitter, 1898 (Coleoptera, Nitidulidae) were recently collected. It is the first known sure record of this species in Italy (previously known from Northern, Eastern, and Central Europe, southwards to Austria, and from Western Siberia)

An Unusual Histology for a Lung Nodule: A Case Report of Primary Pulmonary Paraganglioma

Introduction: Primary pulmonary paraganglioma is a rare tumor with few cases reported in literature and unspecific clinical presentation.Case Presentation: A 49-year-old woman presented to our department with an incidental finding of a pulmonary mass at chest X-ray and no associated clinical symptom. The CT scan and the FDG-PET showed mild uptake of contrast, but a definitive diagnosis was only possible after surgery through histopathological examination.Conclusion: Paragangliomas originating in the pulmonary tissue are generally non-functioning masses discovered incidentally in otherwise asymptomatic patients. Surgery appears to be the best treatment option, with only radiologic follow-up necessary afterwards

The body of evidence of late-life depression: the complex relationship between depressive symptoms, movement, dyspnea and cognition

Background: Physical symptoms play an important role in late-life depression and may contribute to residual symptomatology after antidepressant treatment. In this exploratory study, we examined the role of specific bodily dimensions including movement, respiratory functions, fear of falling, cognition, and physical weakness in older people with depression.Methods: Clinically stable older patients with major depression within a Psychiatric Consultation-Liaison program for Primary Care underwent comprehensive assessment of depressive symptoms, instrumental movement analysis, dyspnea, weakness, activity limitations, cognitive function, and fear of falling. Network analysis was performed to explore the unique adjusted associations between clinical dimensions.Results: Sadness was associated with worse turning and walking ability and movement transitions from walking to sitting, as well as with worse general cognitive abilities. Sadness was also connected with dyspnea, while neurovegetative depressive burden was connected with activity limitations.Discussion: Limitations of motor and cognitive function, dyspnea, and weakness may contribute to the persistence of residual symptoms of late-life depression

Crizotinib in MET-Deregulated or ROS1-Rearranged Pretreated Non-Small Cell Lung Cancer (METROS): A Phase II, Prospective, Multicenter, Two-Arms Trial.

PURPOSE: MET-deregulated NSCLC represents an urgent clinical need because of unfavorable prognosis and lack of specific therapies. Although recent studies have suggested a potential role for crizotinib in patients harboring MET amplification or exon 14 mutations, no conclusive data are currently available. This study aimed at investigating activity of crizotinib in patients harboring MET or ROS1 alterations. PATIENTS AND METHODS: Patients with pretreated advanced NSCLC and evidence of ROS1 rearrangements (cohort A) or MET deregulation (amplification, ratio MET/CEP7 >2.2 or MET exon 14 mutations, cohort B) were treated with crizotinib 250 mg twice daily orally. The coprimary endpoint was objective response rate in the two cohorts. RESULTS: From December 2014 to March 2017, 505 patients were screened and a total of 52 patients (26 patients per cohort) were enrolled onto the study. At data cutoff of September 2017, in cohort A, objective response rate was 65%, and median progression-free survival and overall survival were 22.8 months [95% confidence interval (CI) 15.2-30.3] and not reached, respectively. In cohort B, objective response rate was 27%, median progression-free survival was 4.4 months (95% CI 3.0-5.8), and overall survival was 5.4 months (95% CI, 4.2-6.5). No difference in any clinical endpoint was observed between MET-amplified and exon 14-mutated patients. No response was observed among the 5 patients with cooccurrence of a second gene alteration. No unexpected toxicity was observed in both cohorts. CONCLUSIONS: Crizotinib induces response in a fraction of MET-deregulated NSCLC. Additional studies and innovative therapies are urgently needed